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AQIEQLWRYDGRRAVVTGCASGIGERAVHRLTGLGAQVVGLDQRQPGYEISEFHQIDLADPGSIDRAVEA IGGPVDALFNIAGVSSGIGDPLLVVTINFLGLRHLTEALLPMMGPGSAIVSVSSLAAAGYREHHRAVAPL LNTTTMVEGIDWCKRHLEVLGAGYQLSKEAVILYTMRSAVGLGARGIRINCTGPGVTETPILDQLTTAYG AEFPDDIAKPLGRVATPGEQASVLVFLNGHSASYISGQVVRVDGGNVAASIAGELGEGRA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_0344 | - | - | 100% (271) | 3-alpha-hydroxysteroid dehydrogenase |
| M. ulcerans Agy99 | MUL_0136 | - | 8e-39 | 37.74% (265) | short-chain type dehydrogenase/reductase |
| M. ulcerans Agy99 | MUL_0315 | fabG2 | 7e-16 | 29.30% (256) | 3-oxoacyl- |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0792 | - | 3e-16 | 29.89% (281) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_2405 | - | 5e-78 | 57.47% (261) | 3-alpha-hydroxysteroid dehydrogenase |
| M. tuberculosis H37Rv | Rv0769 | - | 2e-16 | 29.89% (281) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_01807 | fabG1 | 7e-11 | 26.10% (249) | 3-oxoacyl- |
| M. abscessus ATCC 19977 | MAB_1219 | - | 4e-16 | 29.54% (281) | short chain dehydrogenase |
| M. marinum M | MMAR_4773 | - | 1e-148 | 97.42% (271) | dehydrogenase/reductase |
| M. avium 104 | MAV_0882 | - | 1e-112 | 75.93% (270) | 3-alpha-hydroxysteroid dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4862 | - | 3e-79 | 57.63% (262) | 3-alpha-hydroxysteroid dehydrogenase |
| M. thermoresistible (build 8) | TH_3914 | - | 2e-47 | 41.18% (255) | PUTATIVE 3-alpha-hydroxysteroid dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_4241 | - | 7e-70 | 55.10% (245) | 3-alpha-hydroxysteroid dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_0344|M.ulcerans_Agy99 ---------MAQIEQLWRYDGRRAVVTGCASGIGERAVHRLTGLGAQVVG
MMAR_4773|M.marinum_M ---------MAQIEQLWRYDGRRAVVTGCASGIGERAVHQLTGLGAQVVG
MAV_0882|M.avium_104 ---------MAEIDALWRYDGRRAVVTGCASGIGEQVVRQLGQLGADVIG
Mflv_2405|M.gilvum_PYR-GCK ----------------MRYDGRHVVVTGCASGIGAQAARLLRDLGARVTG
Mvan_4241|M.vanbaalenii_PYR-1 ------------------------------------MAHQLGSLGARVTG
MSMEG_4862|M.smegmatis_MC2_155 ---------MAALDALVRYDGRHVVVTGCSSGIGAKVTDQLRCLGARVTG
TH_3914|M.thermoresistible__bu ---------------MSEFTNRRYVVTGAASGIGDATARKLLAAGAEVTS
Mb0792|M.bovis_AF2122/97 -----------------MFDSKVAIVTGAAQGIGQAYAQALAREGASVVV
Rv0769|M.tuberculosis_H37Rv -----------------MFDSKVAIVTGAAQGIGQAYAQALAREGASVVV
MAB_1219|M.abscessus_ATCC_1997 ---------------MGEFDNKVAIVTGAAQGIGEAYAHALAREGAAVVV
MLBr_01807|M.leprae_Br4923 MTDAAAKVSAAPGRGKPAFVSRSILVTGGNRGIGLAVARRLVADGHRVAV
. * * *
MUL_0344|M.ulcerans_Agy99 LDQRQP--GYEISEFHQIDLADPGSIDRAVEAIGGPVDALFNIAGVSSGI
MMAR_4773|M.marinum_M LDQRQP--GYEISEFHQIDLADPGSIGRAVEAIGGPVDALFNIAGVSSGI
MAV_0882|M.avium_104 LDQRRP--GCALGEFHEVDLADPESIDRAAAGIDGPVDALFNIAGVSSGI
Mflv_2405|M.gilvum_PYR-GCK LDVRAPEDVSALTDFISVDLADQDSVRAAAAAVDGAVDALFNVAGVSSGI
Mvan_4241|M.vanbaalenii_PYR-1 LDLREPDAQSAIQDFVQLDLAEPRSVDAAAAAVDGRVDALFNVAGVSSGI
MSMEG_4862|M.smegmatis_MC2_155 LDLRAPDSGAGPDAFREMDLADPDSVDAAAAAIDGPVHALFNVAGVSSGI
TH_3914|M.thermoresistible__bu MDRNPP--SAPVSRHIEVDLANPRSIDAAVEQLEGSYDGLMNIAGIP-GT
Mb0792|M.bovis_AF2122/97 ADINADG-AAAVAKQIVADGGTVIHVPVDVSDEDSAKAMVDRAVGAFGGI
Rv0769|M.tuberculosis_H37Rv ADINADG-AAAVAKQIVADGGTAIHVPVDVSDEDSAKAMVDRAVGAFGGI
MAB_1219|M.abscessus_ATCC_1997 ADINAEM-GEGVAKQIVADGGRAIFAGVDVSDPDSAIAMADKAVSEFGGI
MLBr_01807|M.leprae_Br4923 THRASVVPDWFFG--VECDVTDNDAIGAAFKAVEEHQG-PVEVLVANAGI
. * . *
MUL_0344|M.ulcerans_Agy99 GDPLLVVTINFLGLRHLTEALLPMMGPGSAIVSVSSLAAAGYREHHRAVA
MMAR_4773|M.marinum_M GDPLLVVTINFLGLRQLTEALLPMMGPGSAIVSVSSLAAAGYREHHRAVA
MAV_0882|M.avium_104 GNPPLVVTVNFLGTRQLTEALIPKMVAGSSIVSVSSLAAAGYREHLRQVA
Mflv_2405|M.gilvum_PYR-GCK GDPLLVLRINFLGMRQFTESLLDRMPAGGAVTNVSSLAASAYRENAHVTA
Mvan_4241|M.vanbaalenii_PYR-1 KDPLLVMRINFLGMRQFTEALIARMPEGSSITNVSSLAASAYLENAATTA
MSMEG_4862|M.smegmatis_MC2_155 GDPLLVVRINFLGTRQFTEALVDRIADGGSITSVSSLAASAYRENRAVTA
TH_3914|M.thermoresistible__bu APGETVLAVNSLAVRHLTEAFLDRLNSGGTVTTVSSTAGFGWPERLEAIR
Mb0792|M.bovis_AF2122/97 DY--LVNNAAIYGGMKLDLLLTVPLDYYKKFMSVNHDGVLVCTRAVYKHM
Rv0769|M.tuberculosis_H37Rv DY--LVNNAAIYGGMKLDLLLTVPLDYYKKFMSVNHDGVLVCTRAVYKHM
MAB_1219|M.abscessus_ATCC_1997 DY--LVNNAAIYGGMKLDLLLSVPWDYYKKFMSVNQDGALVCTRAVYKHI
MLBr_01807|M.leprae_Br4923 TSDMLIMRMSEE---QFQKVIDVNLTGVFRVAKLASRNMIKQRFGRYIFM
: :: : . .:
MUL_0344|M.ulcerans_Agy99 PLLNTTTMVEGIDWCKRHLEVLGAG-YQLSKEAVILYTMRSAVGLGARGI
MMAR_4773|M.marinum_M PLVNTTTMVEGIDWCKRHLEVLGAG-YQLSKEAVILYTMRSAVGLGARGI
MAV_0882|M.avium_104 PLLDTATMREGIDWCTSHPEELGTG-YQLSKEALILYTMRSVTPLGARGI
Mflv_2405|M.gilvum_PYR-GCK GLLATRSVDEGLRWCADHPEALADGGYRQSKEAIILYGMQRVTDLGARGI
Mvan_4241|M.vanbaalenii_PYR-1 GLLETGSVAEGLQWCADHPEALADGGYRQSKEAIILYGMRRTADLGARGI
MSMEG_4862|M.smegmatis_MC2_155 GLVSTGSVDEGLRWCAENPDALADGGYRLSKEAIILYGMSKAVELGARGI
TH_3914|M.thermoresistible__bu DLLATESFEDGARWFKEHP--QQGNAYNFSKEVTTVYTMTMGLTAAQRGI
Mb0792|M.bovis_AF2122/97 AKRGGGAIVN----QSSTAAWLYSNFYGLAKVGVNGLTQQLARELGGMKI
Rv0769|M.tuberculosis_H37Rv AKRGGGAIVN----QSSTAAWLYSNFYGLAKVGVNGLTQQLARELGGMKI
MAB_1219|M.abscessus_ATCC_1997 AQRGGGAIVN----QSSTAAWLYSGFYGLAKVGINGLTQQLSRELGGQKI
MLBr_01807|M.leprae_Br4923 GSVVGLSGVPG------------QANYAASKSGLIGMARSLARELGSRSI
: * :* . *
MUL_0344|M.ulcerans_Agy99 RINCTGPGVTETPILDQLTTAYGAEFPDDIAKPLGRVATPGEQASVLVFL
MMAR_4773|M.marinum_M RINCTGPGVTETPILDQLTTAYGAEFLDDIAKPLGRVATPGEQASVLVFL
MAV_0882|M.avium_104 RINCTGPGVTETPILDQLRTAYGQGFLDDIPKPLGRVSRPAEQAAVLLFL
Mflv_2405|M.gilvum_PYR-GCK RVNCTAPGVTETPILDQLRSAYGQQYLDSFTAPLGRVSTPEEQAAVLVFL
Mvan_4241|M.vanbaalenii_PYR-1 RINCSAPGVTETPILDQLRSAYGQQYLDSFTAPLGRVSTAEEQAAMLIFL
MSMEG_4862|M.smegmatis_MC2_155 RVNCTGPGVTDTPILDQLRSAYGQQYLDSFTTPLGRNSEPDEQAALLVFL
TH_3914|M.thermoresistible__bu RINAVLPGPVETPILADFEESMGKDTLDGVKALLGRHASPDDIADVVVFL
Mb0792|M.bovis_AF2122/97 RINAIAPGPIDTEATRTVTPAELVKNMVQT-IPLSRMGTPEDLVGMCLFL
Rv0769|M.tuberculosis_H37Rv RINAIAPGPIDTEATRTVTPAELVKNMVQT-IPLSRMGTPEDLVGMCLFL
MAB_1219|M.abscessus_ATCC_1997 RINAIAPGPTDTEATRGTVPEQFRSELVKN-IPLSRMGTVDDMVGMCLFL
MLBr_01807|M.leprae_Br4923 TANVVAPGFIDTEMTRAMDSKYQEAALQAI--PLGRIGAVEEIAGAVSFL
* ** :* *.* . : . **
MUL_0344|M.ulcerans_Agy99 NGHSASYISGQVVRVDGGNVAASIAGELGEGRA----
MMAR_4773|M.marinum_M NGHAASYISGQVVWVDGGNVAASIAGELGEGRA----
MAV_0882|M.avium_104 NSDAASYISGQVVWVDGGNVGAAIARELEEGRTPWPV
Mflv_2405|M.gilvum_PYR-GCK GSRAAGYISGQVLWTDGGILGRRIASQMFDEPLTQGN
Mvan_4241|M.vanbaalenii_PYR-1 GSRAAGYLTGQVVWTDGGILAQRISAQMTDIQAAQGS
MSMEG_4862|M.smegmatis_MC2_155 GSAAASYVTGQVIWADGGIIAQRETALIESTRATQES
TH_3914|M.thermoresistible__bu ASDAARWINGQAVAVDGGITGAVASGVVPKPEF----
Mb0792|M.bovis_AF2122/97 LSDSASWITGQIFNVDGGQIIRS--------------
Rv0769|M.tuberculosis_H37Rv LSDSASWITGQIFNVDGGQIIRS--------------
MAB_1219|M.abscessus_ATCC_1997 LSDKASWITGQVFNVDGGQIIRS--------------
MLBr_01807|M.leprae_Br4923 ASEDAGYISGAVIPVDGGLGMGH--------------
. * ::.* . .***