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QVEKRRIVVVGAGSGIGAAVAAHFHDNGDHVLAVDLRPNDTPAAAHAQCDLRDPQSIAGLLDDIGADWDV LAHVAGVPGTAPADDVLTVNYLGMRKMVEGMLPRMRRGGSVVAVASIAGIGWEQRLDELSELLAATDPEA VAAWQSRQDPSYPVYTTSKQAVILYAKRLAGTALSRYGVRVNTVSPGPVETPILADFEQTMGKEILDMLR DTYGRHGTVDDIVPVIAFLASDAAQWINGQDVHVDSGFVTSMTAGTPIAL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2008 | - | - | 100% (261) | short-chain dehydrogenase/reductase SDR |
| M. vanbaalenii PYR-1 | Mvan_4241 | - | 2e-23 | 31.97% (244) | 3-alpha-hydroxysteroid dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0614 | - | 1e-19 | 31.82% (264) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1976 | - | 1e-14 | 29.15% (271) | short-chain type dehydrogenase/reductase |
| M. gilvum PYR-GCK | Mflv_4338 | - | 2e-87 | 62.02% (258) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv1941 | - | 1e-14 | 29.15% (271) | short-chain type dehydrogenase/reductase |
| M. leprae Br4923 | MLBr_02565 | fabG | 5e-11 | 25.00% (268) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. abscessus ATCC 19977 | MAB_0691 | - | 2e-16 | 28.52% (270) | short chain dehydrogenase |
| M. marinum M | MMAR_4773 | - | 3e-33 | 35.97% (253) | dehydrogenase/reductase |
| M. avium 104 | MAV_5096 | - | 7e-52 | 43.03% (251) | 3-alpha-hydroxysteroid dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4862 | - | 3e-28 | 30.98% (255) | 3-alpha-hydroxysteroid dehydrogenase |
| M. thermoresistible (build 8) | TH_2988 | - | 1e-111 | 71.65% (261) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_0344 | - | 2e-32 | 35.57% (253) | 3-alpha-hydroxysteroid dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_2008|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2988|M.thermoresistible__bu --------------------------------------------------
Mflv_4338|M.gilvum_PYR-GCK --------------------------------------------------
MAV_5096|M.avium_104 --------------------------------------------------
MMAR_4773|M.marinum_M --------------------------------------------------
MUL_0344|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4862|M.smegmatis_MC2_155 --------------------------------------------------
Mb1976|M.bovis_AF2122/97 --------------------------------------------------
Rv1941|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0691|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 MAPKCSSDLFSQIVSSGPGSFVAKQLGVPRPETLRRYRPSDAPLCGSLLI
Mvan_2008|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2988|M.thermoresistible__bu --------------------------------------------------
Mflv_4338|M.gilvum_PYR-GCK --------------------------------------------------
MAV_5096|M.avium_104 --------------------------------------------------
MMAR_4773|M.marinum_M --------------------------------------------------
MUL_0344|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4862|M.smegmatis_MC2_155 --------------------------------------------------
Mb1976|M.bovis_AF2122/97 --------------------------------------------------
Rv1941|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0691|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 GGDGRLVEPLRATLEKDYDLVSNNLGGRWTDSFGGLVFDATGITAPAELK
Mvan_2008|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2988|M.thermoresistible__bu --------------------------------------------------
Mflv_4338|M.gilvum_PYR-GCK --------------------------------------------------
MAV_5096|M.avium_104 --------------------------------------------------
MMAR_4773|M.marinum_M --------------------------------------------------
MUL_0344|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4862|M.smegmatis_MC2_155 --------------------------------------------------
Mb1976|M.bovis_AF2122/97 --------------------------------------------------
Rv1941|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0691|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 GLHNFFTPLLRNLGRCARVVVIGTTPDATTSTDERIAQRALEGFSRSLGK
Mvan_2008|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2988|M.thermoresistible__bu --------------------------------------------------
Mflv_4338|M.gilvum_PYR-GCK ---------------------------MTRMGGKTVITTVEITRLVVPTM
MAV_5096|M.avium_104 --------------------------------------------------
MMAR_4773|M.marinum_M --------------------------------------------------
MUL_0344|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4862|M.smegmatis_MC2_155 --------------------------------------------------
Mb1976|M.bovis_AF2122/97 --------------------------------------------------
Rv1941|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0691|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 ELRRGATVALVYLSPDAKPAATGLESTMRFILSAKSAYVNGQVFYVGAAD
Mvan_2008|M.vanbaalenii_PYR-1 --------MQVEKRRIVVVGAGSGIGAAVAAHFHDNGDHVLAVDLRPN--
TH_2988|M.thermoresistible__bu --------MGAEPRRIVVVGAGSGIGAATAAHFHNRGEHVVAVDIKPN--
Mflv_4338|M.gilvum_PYR-GCK EGYQEGSAMSAEGRRVVVVGAGSGIGAATAAWFHSRGDHVLAVDARPR--
MAV_5096|M.avium_104 -------MAHFQGKRYVVTGAASGIGNAVAERLLAAGAEVYCLDRNQP--
MMAR_4773|M.marinum_M -MAQIEQLWRYDGRRAVVTGCASGIGERAVHQLTGLGAQVVGLDQRQP--
MUL_0344|M.ulcerans_Agy99 -MAQIEQLWRYDGRRAVVTGCASGIGERAVHRLTGLGAQVVGLDQRQP--
MSMEG_4862|M.smegmatis_MC2_155 -MAALDALVRYDGRHVVVTGCSSGIGAKVTDQLRCLGARVTGLDLRAPDS
Mb1976|M.bovis_AF2122/97 -----MNHPDLAGKVAIVTGAGAGIGLAVARRLADEGCHVLCADIDGDAA
Rv1941|M.tuberculosis_H37Rv -----MNHPDLAGKVAIVTGAGAGIGLAVARRLADEGCHVLCADIDGDAA
MAB_0691|M.abscessus_ATCC_1997 -MPDEVVVVIGVGGMGRVIARRQGIGKALLLADHNEQALQAVVDELKADG
MLBr_02565|M.leprae_Br4923 STPPTNWDRPLENKVAIVTGAARGIGAAIAEVVARDGARVVAIDVESAAE
* . *** *
Mvan_2008|M.vanbaalenii_PYR-1 DTPAAAHAQCDLRDPQSIAGLLDDIGADWDVLAHVAGVP-GTAPADDVLT
TH_2988|M.thermoresistible__bu DTPAARHVRCDLRDPADIAGTLDEIGTGWDLLAHVAGVP-GTAAAADVLK
Mflv_4338|M.gilvum_PYR-GCK SGPFAEWLVCDLRSADEIEGALGRIGHGWDVLAHVAGIP-GTADARDVLT
MAV_5096|M.avium_104 AANVTRHIEVDLANPHSIDAAVGQLDGDFDGLMNVAGIP-GTAPADLVLA
MMAR_4773|M.marinum_M GYEISEFHQIDLADPGSIGRAVEAIGGPVDALFNIAGVSSGIGDPLLVVT
MUL_0344|M.ulcerans_Agy99 GYEISEFHQIDLADPGSIDRAVEAIGGPVDALFNIAGVSSGIGDPLLVVT
MSMEG_4862|M.smegmatis_MC2_155 GAGPDAFREMDLADPDSVDAAAAAIDGPVHALFNVAGVSSGIGDPLLVVR
Mb1976|M.bovis_AF2122/97 DAAATKIGCGAAACRVDVSDEQQIIAMVDACVAAFGGVDKLVANAGVVHL
Rv1941|M.tuberculosis_H37Rv DAAATKIGCGAAACRVDVSDEQQIIAMVDACVAAFGGVDKLVANAGVVHL
MAB_0691|M.abscessus_ATCC_1997 HNVIGQRVDVSSRASVSGLAQAAAGLGRVAQVAHTAGLSPAQSPTAAILA
MLBr_02565|M.leprae_Br4923 ALDETANRVGGTTLSLDVTADDAVDKITEHLHDYQGGHADILVNNAGITR
. .* :
Mvan_2008|M.vanbaalenii_PYR-1 VNYLG-MRKMVEGMLPRMRRGGSVVAVASIAGIGWEQRLDELSELLAATD
TH_2988|M.thermoresistible__bu INYLG-MRLITEGMLPRLRQGGAVVAVASTAAVGWEQRTETLAGLLDATD
Mflv_4338|M.gilvum_PYR-GCK VNYLG-ARLMLDGMLPLMNHGGSMVAVASTAALGWDSNIGLLSGLLDARD
MAV_5096|M.avium_104 VNSLA-VRHLTELFFDRLKPGGSVTIVSSTAGFGWPHRLDAIRDLLATDT
MMAR_4773|M.marinum_M INFLG-LRQLTEALLPMMGPGSAIVSVSSLAAAGYREHHRAVAPLVNTTT
MUL_0344|M.ulcerans_Agy99 INFLG-LRHLTEALLPMMGPGSAIVSVSSLAAAGYREHHRAVAPLLNTTT
MSMEG_4862|M.smegmatis_MC2_155 INFLG-TRQFTEALVDRIADGGSITSVSSLAASAYRENRAVTAGLVSTGS
Mb1976|M.bovis_AF2122/97 ASLID-TTVEDFDRVIAINLRGAWLCTKHAAPRMIERGGGAIVNLSSLAG
Rv1941|M.tuberculosis_H37Rv ASLID-TTVEDFDRVIAINLRGAWLCTKHAAPRMIERGGGAIVNLSSLAG
MAB_0691|M.abscessus_ATCC_1997 VDLVG-VALVVEEFGKIVASGGAGVVIASMAGHMPYELTAEQEQELGTTH
MLBr_02565|M.leprae_Br4923 DKLLANMDDCRWDAVLEVNLLAPQRLTEGLVGNGSISKGGRVIVLSSMAG
. : : .. .
Mvan_2008|M.vanbaalenii_PYR-1 PEAVAAWQSRQD--PSYPVYTTSKQAVILYAKRLAGTALSRYGVRVNTVS
TH_2988|M.thermoresistible__bu ADAVERWQAEQD--PAYPVYSSSKQAVILYAKRLAGPAWTKYGVRINTVS
Mflv_4338|M.gilvum_PYR-GCK TTAVTRWLEAQD--PSMAYYLS-KQALVLYAKRLSGVAWREYGVRVNTVS
MAV_5096|M.avium_104 YEEGAAWFKAHP--QQGNAYNFSKEVSTVYTLSMG-LAFAEMGFRINAVL
MMAR_4773|M.marinum_M MVEGIDWCKRHLEVLGAG-YQLSKEAVILYTMRSA-VGLGARGIRINCTG
MUL_0344|M.ulcerans_Agy99 MVEGIDWCKRHLEVLGAG-YQLSKEAVILYTMRSA-VGLGARGIRINCTG
MSMEG_4862|M.smegmatis_MC2_155 VDEGLRWCAENPDALADGGYRLSKEAIILYGMSKA-VELGARGIRVNCTG
Mb1976|M.bovis_AF2122/97 QVAVG----------GTGAYGMSKAGIIQLSRITA-AELRSSGIRSNTLL
Rv1941|M.tuberculosis_H37Rv QVAVG----------GTGAYGMSKAGIIQLSRITA-AELRSSGIRSNTLL
MAB_0691|M.abscessus_ATCC_1997 AEDLLSLPYVRDIEHPAVAYQVSKRANHIRVRFAA-RQWGTRGARINSIS
MLBr_02565|M.leprae_Br4923 IAGNR----------GQTNYATAKAGVIGLTQALA-PGLAEKGITINAVA
* * . * *
Mvan_2008|M.vanbaalenii_PYR-1 PGPVETPILADFEQTMG-----KEILDMLRDTYGR-HGTVDDIVPVIAFL
TH_2988|M.thermoresistible__bu PGPVETPILPDFERTMG-----KDILDMVRATVGR-HATVDDVVPVIDFL
Mflv_4338|M.gilvum_PYR-GCK PGPTETPILGDFEESMG-----RDMLDGVRTTIGR-HGTVDDMTPAIGFL
MAV_5096|M.avium_104 PGPVQTPILPDFEESMG-----KDTLDGLKNLLGR-HADPGDIADVVLFL
MMAR_4773|M.marinum_M PGVTETPILDQLTTAYG-----AEFLDDIAKPLGR-VATPGEQASVLVFL
MUL_0344|M.ulcerans_Agy99 PGVTETPILDQLTTAYG-----AEFPDDIAKPLGR-VATPGEQASVLVFL
MSMEG_4862|M.smegmatis_MC2_155 PGVTDTPILDQLRSAYG-----QQYLDSFTTPLGR-NSEPDEQAALLVFL
Mb1976|M.bovis_AF2122/97 PAFVDTPMQQTAMAMFDGALGAGGARSMIARLQGR-MAAPEEMAGIVVFL
Rv1941|M.tuberculosis_H37Rv PAFVDTPMQQTAMAMFDGALGAGGARSMIARLQGR-MAAPEEMAGIVVFL
MAB_0691|M.abscessus_ATCC_1997 PGVVSTPMGHQELASETG----AITKAMVDGSASRRIGTSDDIAAAAAFL
MLBr_02565|M.leprae_Br4923 PGFIETQMTAAIPLATR------EVGRRLNSLLQG--GLPVDVAETIAYF
*. .* : . . : . ::
Mvan_2008|M.vanbaalenii_PYR-1 ASDAAQWINGQDVHVDSGFVTSMTAGTPIAL------
TH_2988|M.thermoresistible__bu GSPAARWITGQDIHVDAGYITSLTCGIPIEL------
Mflv_4338|M.gilvum_PYR-GCK SSPEARWINGQDIHVDGGFTAALVHPMPERAQV----
MAV_5096|M.avium_104 ASDDARWVNGQALAADGGISGAVASGVVPAPEI----
MMAR_4773|M.marinum_M NGHAASYISGQVVWVDGGNVAASIAGELGEGRA----
MUL_0344|M.ulcerans_Agy99 NGHSASYISGQVVRVDGGNVAASIAGELGEGRA----
MSMEG_4862|M.smegmatis_MC2_155 GSAAASYVTGQVIWADGGIIAQRETALIESTRATQES
Mb1976|M.bovis_AF2122/97 LSDDASMITGTTQIADGGTIAALW-------------
Rv1941|M.tuberculosis_H37Rv LSDDASMITGTTQIADGGTIAALW-------------
MAB_0691|M.abscessus_ATCC_1997 LGPESSYVTGTDLLVDGGVIAAVRSGQLFN-------
MLBr_02565|M.leprae_Br4923 AIPASNAVTGNVIRVCGQAMLGA--------------
: :.* . .