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STAAPSVFEADLPTFTYGFAATPHDIFDDVREAQSRAPIALGPLGPEILSYELARDMLRDNRFRLPPGIT LAAQGITSGPLYDKITGSLLGLNGPPHVRLRKLVSKAFTPRATARLQDTIHEVVNGLVDRVLDAGRCDVV TDIARPYPTPIICALLGAPREDWPLFADWTEEVFKAFNFQPELTFDEAQIMRAWGELDAYVDDMVAARRS NLTDDLLSELIRAESDGDRLNLDELRGLVAGFLMAGTDTTRNQLAASVQVLLEHPDQWTKLRDHPELAMQ AVEESMRHSPAASIVPRAATEDAEFGGYMFPAGTFILVNTFVANRDPAIYHDADRFDITRTDLPPILTFG GGAHYCLGANLARRELAEALVVLTRRLAPPRRIGPAPWKSLLGMTGPTTLPIEVTSEQPVTANA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4282 | - | - | 100% (415) | cytochrome P450 |
| M. gilvum PYR-GCK | Mflv_0363 | - | e-152 | 64.76% (403) | cytochrome P450 |
| M. gilvum PYR-GCK | Mflv_1763 | - | e-143 | 61.39% (404) | cytochrome P450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2289 | cyp124 | 4e-44 | 35.76% (316) | cytochrome P450 124 CYP124 |
| M. tuberculosis H37Rv | Rv2266 | cyp124 | 4e-44 | 35.76% (316) | cytochrome P450 124 CYP124 |
| M. leprae Br4923 | MLBr_02088 | - | 2e-50 | 32.30% (421) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_0276 | - | 5e-48 | 35.49% (324) | cytochrome P450 |
| M. marinum M | MMAR_0122 | cyp279A2 | 1e-140 | 60.75% (400) | cytochrome P450 279A2 Cyp279A2 |
| M. avium 104 | MAV_4569 | - | 1e-151 | 65.59% (404) | cytochrome P450 superfamily protein |
| M. smegmatis MC2 155 | MSMEG_4213 | - | 1e-117 | 55.29% (378) | cytochrome P450 hydroxylase |
| M. thermoresistible (build 8) | TH_4410 | - | 3e-50 | 33.76% (388) | PUTATIVE putative cytochrome P450 107B1 |
| M. ulcerans Agy99 | MUL_1282 | cyp124A1 | 4e-43 | 35.25% (295) | cytochrome P450 124A1, Cyp124A1 |
| M. vanbaalenii PYR-1 | Mvan_0373 | - | 1e-157 | 66.83% (404) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_4569|M.avium_104 ------------------------MTVGAAPPSVFDSDLPTLHYHSDETP
Mvan_0373|M.vanbaalenii_PYR-1 ------------------------MVVSPTVANVFDAGLPTLTYDVFSTP
Mflv_4282|M.gilvum_PYR-GCK --------------------------MSTAAPSVFEADLPTFTYGFAATP
MMAR_0122|M.marinum_M ---------------------MTSTVDRQVAPNVFAAGLPNIDYQNAQSP
MSMEG_4213|M.smegmatis_MC2_155 ------------------------------MTRMTVAELTPISYHHATMP
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
MAB_0276|M.abscessus_ATCC_1997 ---------------------MPITTDPG------TLLLQVLDPANRANP
Mb2289|M.bovis_AF2122/97 -------------MGLNTAIATRVNGTPPPEVPIADIELGSLDFWALDDD
Rv2266|M.tuberculosis_H37Rv -------------MGLNTAIATRVNGTPPPEVPIADIELGSLDFWALDDD
MUL_1282|M.ulcerans_Agy99 ---------MDLSTNLNTGLLPRVNGTPPPEVPLADIELGSLEFWGRDDD
TH_4410|M.thermoresistible__bu ----------------------------------VTVLFDPLDEEQLADP
: :
MAV_4569|M.avium_104 AQVYPRLREAQRRAAVAIG---------PHGPEVLS-YHLVRSVLRDPRF
Mvan_0373|M.vanbaalenii_PYR-1 AQVWPDLHDAQRTAPIAIG---------PMGPEVLS-YEMARAVLRDTRF
Mflv_4282|M.gilvum_PYR-GCK HDIFDDVREAQSRAPIALG---------PLGPEILS-YELARDMLRDNRF
MMAR_0122|M.marinum_M DEAHQILAEARCRSPIALG---------PHGPELLT-YDLVHTVLRDPRF
MSMEG_4213|M.smegmatis_MC2_155 AEVHDIIRQARANGPLALG---------PYGPEILG-YELVRAVLRDERF
MLBr_02088|M.leprae_Br4923 FPVYRALIDY---GPMQLP---------GMPLTVFSSFSDCDEALRHPLS
MAB_0276|M.abscessus_ATCC_1997 YPVYGQLVEQTQAGPVHPP---------GMDVSVLATFADCNAVLRHPQA
Mb2289|M.bovis_AF2122/97 VRDGAFATLRREAPISFWPTIELPGFVAGNGHWALTKYDDVFYASRHPDI
Rv2266|M.tuberculosis_H37Rv VRDGAFATLRREAPISFWPTIELPGFVAGNGHWALTKYDDVFYASRHPDI
MUL_1282|M.ulcerans_Agy99 FRDGAFATLRREAPISFWPPIELAGLTAGKGHWALTKHDDIHFASRHPEI
TH_4410|M.thermoresistible__bu IPT--YRALREQDPVQRIP--------VGGGTWVVSRYEDVRRLLRTTAG
. . *
MAV_4569|M.avium_104 QIPPGINLLAQGIDSG--PLWDKVANSLLCLEGDAHHRLRSLCSKAFTPR
Mvan_0373|M.vanbaalenii_PYR-1 TIPPGINLAAQGITSG--PLFDKVMSTLLCLEGSEHQRLRKLVSKAFTPR
Mflv_4282|M.gilvum_PYR-GCK RLPPGITLAAQGITSG--PLYDKITGSLLGLNGPPHVRLRKLVSKAFTPR
MMAR_0122|M.marinum_M RMPPGMFLAAQGITSG--PLWDRLAANLISLDGPAHHRLRRLVSQAFTPR
MSMEG_4213|M.smegmatis_MC2_155 EVPRGMFLAAQGITSG--PLWERANNTLVGLGGPAHLRLRRLVARAFIPK
MLBr_02088|M.leprae_Br4923 ASDRLKATLAQQAIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPK
MAB_0276|M.abscessus_ATCC_1997 SSDRRKSNIVQRQLAQ--NPNLIARPSFLGLDAPDHTRLRKLASKAFAPR
Mb2289|M.bovis_AF2122/97 FSSYPNITINDQTP-----ELAEYFGSMIVLDDPRHQRLRSIVSRAFTPK
Rv2266|M.tuberculosis_H37Rv FSSYPNITINDQTP-----ELAEYFGSMIVLDDPRHQRLRSIVSRAFTPK
MUL_1282|M.ulcerans_Agy99 FHSSPNIVIHDQTP-----ELAEYFGSMIVLDDPRHQRLRSIVSRAFTPK
TH_4410|M.thermoresistible__bu LMQPPGATVPVELAGG--PAERIYRGLMVLNDPPVHTRLRKLTEKAMTRG
:: * *** : :*:
MAV_4569|M.avium_104 TVARLHDTMAAVMNELVDRVAAA---GRCDVVTDIARPYPVPIICALLGA
Mvan_0373|M.vanbaalenii_PYR-1 ATERLHDTIVAVVDELVDNIAGA---RRCDVVADIARPYPIPIICALLGA
Mflv_4282|M.gilvum_PYR-GCK ATARLQDTIHEVVNGLVDRVLDA---GRCDVVTDIARPYPTPIICALLGA
MMAR_0122|M.marinum_M ATGRLNTTITEVITDLVDRCADR---GRCDVVADIARRYPIPIICALLGA
MSMEG_4213|M.smegmatis_MC2_155 AAERLRATCVDIVTELVARCVPA---GRCDVVADLAVPYAVPVICALLGA
MLBr_02088|M.leprae_Br4923 VVQALEGDIAALVDSLLDKGAAA---GQFDVIADLAFPLAVAVICRLLGV
MAB_0276|M.abscessus_ATCC_1997 VINAMAEDIQTFVDKMLDDIALR---GTFNLVTEFAYPLPVAVICRMLGV
Mb2289|M.bovis_AF2122/97 VVARIEAAVRDRAHRLVSSMIANNPDRQADLVSELAGPLPLQIICDMMGI
Rv2266|M.tuberculosis_H37Rv VVARIEAAVRDRAHRLVSSMIANNPDRQADLVSELAGPLPLQIICDMMGI
MUL_1282|M.ulcerans_Agy99 VVARIEASVRERAHRLVAAMIENHPDGQADLVSELAGPLPLQIICDMMGI
TH_4410|M.thermoresistible__bu AVEKLRADVERVASEALDAMLEQ---GEADAMTELAFTVPLRVICGMLGI
. : : : ::::* . :** ::*
MAV_4569|M.avium_104 PREDWRRFSSWADDVFK----AFSFTVDLREVEPVVMRAWRELDDYVDEM
Mvan_0373|M.vanbaalenii_PYR-1 PREDWRLFSDWTEDVFR----AFSFSTDVATVQDDVMRAWNELDDYVDRM
Mflv_4282|M.gilvum_PYR-GCK PREDWPLFADWTEEVFK----AFNFQPELTFDEAQIMRAWGELDAYVDDM
MMAR_0122|M.marinum_M PAGDWKLFSGWTDDILK----AFSW--DAAAQQPAILAAWDELDAYIDDM
MSMEG_4213|M.smegmatis_MC2_155 PARDWARFSAWADEIFK----MFSW--DLGEHAEAVETAWKELDAYVDDM
MLBr_02088|M.leprae_Br4923 PYEDAPEFGRVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQL
MAB_0276|M.abscessus_ATCC_1997 PIEDEPEFGRASALLGQGLDPVYALTGQSPANMDERFQAARWMWDYFIDL
Mb2289|M.bovis_AF2122/97 PKADHQRIFHWTN--VILG----FGDPDLATDFDEFMQVSADIGAYATAL
Rv2266|M.tuberculosis_H37Rv PKADHQRIFHWTN--VILG----FGDPDLATDFDEFMQVSADIGAYATAL
MUL_1282|M.ulcerans_Agy99 PEEDHEQIFHWTN--VILG----FGDPDLTTDFDDFLQVSMAIGGYATAL
TH_4410|M.thermoresistible__bu PEADRAQMLDWTPDFFRIF----LPQANDADGIAACHRACQNFIDYLSEQ
* * : : : . : *
MAV_4569|M.avium_104 VARRRHSLTDDLLSDLIRAGDEGDRLDAAELRMLAGGLLLAGTDTTRNQV
Mvan_0373|M.vanbaalenii_PYR-1 VAHRRRHLTDDLLSDLIRAEDDGDRLSTSELQMLAASLLMAGTDTTRNQL
Mflv_4282|M.gilvum_PYR-GCK VAARRSNLTDDLLSELIRAESDGDRLNLDELRGLVAGFLMAGTDTTRNQL
MMAR_0122|M.marinum_M VAARRGSLTEDLISALIRAEDDGDCLSSDELRMLVAGLLIGGTDTTRNQL
MSMEG_4213|M.smegmatis_MC2_155 VVRRRHTLTDDLLSDLIRAEDDGDRLTHHELLMLAGGVLLAGTDTTRNQL
MLBr_02088|M.leprae_Br4923 VKCRRGTPGEDLISRLIELDESGDQLTEEEIIATCGLLLVAGHETTVNLI
MAB_0276|M.abscessus_ATCC_1997 IASRRRNLGDDLLSALIQVEEAGDQLTEEEIISTCTLLLIAGHETTVNLI
Mb2289|M.bovis_AF2122/97 AEDRRVNHHDDLTSSLVEAEVDGERLSSREIASFFILLVVAGNETTRNAI
Rv2266|M.tuberculosis_H37Rv AEDRRVNHHDDLTSSLVEAEVDGERLSSREIASFFILLVVAGNETTRNAI
MUL_1282|M.ulcerans_Agy99 ADDRRVNHHGDLTTSLVEAEVDGERLSSSEIAMFFILLVVAGNETTRNTI
TH_4410|M.thermoresistible__bu IEYRRRTPADDIFSALVSAEDEGDRLSRDELVATVLSLLTGGFDTTMGMI
** *: : *: *: * *: .: .* :** . :
MAV_4569|M.avium_104 AASVQVLCEHPHQWELLRQRPE-LAMRAVEETMRHSPIACGTLRLVVEDA
Mvan_0373|M.vanbaalenii_PYR-1 AASVQALSERPDQWALLADRPE-LAMRAVEETMRHSPVVCGAPRIVLDDV
Mflv_4282|M.gilvum_PYR-GCK AASVQVLLEHPDQWTKLRDHPE-LAMQAVEESMRHSPAASIVPRAATEDA
MMAR_0122|M.marinum_M AASAQALCDHPDQWVLLAQHPD-LAANAAEETMRHSPITFSTLRIALDDV
MSMEG_4213|M.smegmatis_MC2_155 AAAVETLCDHPREWDLLAEHPE-LAPTFVEELMRFSPATLGTVRIAKEEV
MLBr_02088|M.leprae_Br4923 ANAVLAMLRNPSQWKALSSNPQ-RAPLVVEETLRYDPAIHLIGRVAAKDM
MAB_0276|M.abscessus_ATCC_1997 ANASLAMLRHPEQWKLLGQNAD-RAPLVVEETLRYDPPVHMVARVADGEM
Mb2289|M.bovis_AF2122/97 THGVLALSRYPEQRDRWWSDFDGLAPTAVEEIVRWASPVVYMRRTLTQDI
Rv2266|M.tuberculosis_H37Rv THGVLALSRYPEQRDRWWSDFDGLAPTAVEEIVRWASPVVYMRRTLTQDI
MUL_1282|M.ulcerans_Agy99 SHGMLALSRYPDERAKWWSDFDGLAATAVEEIVRWASPVVYMRRTLNQDV
TH_4410|M.thermoresistible__bu GAGVFGLARQPEQLAALREDPAGLARTAVEEFIRWESPVAVTYRHFVEDV
. : * : . * .** :* . * :
MAV_4569|M.avium_104 ELDGHLFPAGTAVLVNTFAANRDPAVYDDPDRVDITREAAPPILTFGGGV
Mvan_0373|M.vanbaalenii_PYR-1 EFDGYLFPAGTFVFVNTFAANRDPAVYADADRLDLTREQAPAILTFGGGV
Mflv_4282|M.gilvum_PYR-GCK EFGGYMFPAGTFILVNTFVANRDPAIYHDADRFDITRTDLPPILTFGGGA
MMAR_0122|M.marinum_M ELAGVMIPTGTLVIANTGAANRDPALYRDPDRLDISRPIAGPIQTFGAGM
MSMEG_4213|M.smegmatis_MC2_155 EIAGVTIPAGTLVTVNTAAANRDPQVFADPDRFDVHRRASPPMLGFGGGL
MLBr_02088|M.leprae_Br4923 TIGQTTLTEGDTMVLLLAAANRDPAVYSRPDEFDPDRPSS-RHLAFAVGS
MAB_0276|M.abscessus_ATCC_1997 AIRDFILPDGEWVLLMLAAAQRDPDVGPDLDVFNPDRSEI-KHLAFGHGP
Mb2289|M.bovis_AF2122/97 ELRGTKMAAGDKVSLWYCSANRDESKFADPWTFDLARNPNPHLGFGGGGA
Rv2266|M.tuberculosis_H37Rv ELRGTKMAAGDKVSLWYCSANRDESKFADPWTFDLARNPNPHLGFGGGGA
MUL_1282|M.ulcerans_Agy99 DLRGTKMAAGDKVTLWYCSANRDEEKFADPWTFDVTRNPNPQVGFGGGGA
TH_4410|M.thermoresistible__bu TIADTTIPAGEPIWLLLLSANRDDTRFHDPDGFDVRRKPNQHVAFGGG-R
: :. * : *:** .: * .
MAV_4569|M.avium_104 HYCLGANLARREIAEALNVLANRLRNPRLAGPAPWKPMVSLSGPTSLPIE
Mvan_0373|M.vanbaalenii_PYR-1 HYCLGANLARRELAEALRILAGRLSNPRRSGSAPWKPMLGMTGPTVLELE
Mflv_4282|M.gilvum_PYR-GCK HYCLGANLARRELAEALVVLTRRLAPPRRIGPAPWKSLLGMTGPTTLPIE
MMAR_0122|M.marinum_M HYCLGANLARRELTEALRIITQRMPGARRTGAAPWKSLTGLSGPTTLPIE
MSMEG_4213|M.smegmatis_MC2_155 HYCLGVHLARVELAEALCVITAAMRHPHRDGPPPGNR-------------
MLBr_02088|M.leprae_Br4923 HFCLGAALARLEATVTLSAISARFPQVQLAGELVYKPNVAMRGMSALPVQ
MAB_0276|M.abscessus_ATCC_1997 HFCLGAPLARLEARLALSSITARFPGARLMDEPTYKPNVTLRGLAELPVS
Mb2289|M.bovis_AF2122/97 HFCLGANLARREIRVAFDELRRQMPDVVATEEPARLLSQFIHGIKTLPVT
Rv2266|M.tuberculosis_H37Rv HFCLGANLARREIRVAFDELRRQMPDVVATEEPARLLSQFIHGIKTLPVT
MUL_1282|M.ulcerans_Agy99 HFCLGANLARREIRVVFDELRRQMPDVVATEEPARLLSQFIHGIKRLPVA
TH_4410|M.thermoresistible__bu HHCIGSHLARLEGEVVFAEIARRIETIEITGDSPRRPNFQFRSFTTLPVK
*.*:* *** * .: : :
MAV_4569|M.avium_104 FDR--------
Mvan_0373|M.vanbaalenii_PYR-1 FDA--------
Mflv_4282|M.gilvum_PYR-GCK VTSEQPVTANA
MMAR_0122|M.marinum_M FDAGH------
MSMEG_4213|M.smegmatis_MC2_155 -----------
MLBr_02088|M.leprae_Br4923 V----------
MAB_0276|M.abscessus_ATCC_1997 IA---------
Mb2289|M.bovis_AF2122/97 WS---------
Rv2266|M.tuberculosis_H37Rv WS---------
MUL_1282|M.ulcerans_Agy99 WSR--------
TH_4410|M.thermoresistible__bu MTGRSR-----