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RSRGWAGSTPASDEEAIARILDAVDDVVAERGPAMRLADVARRLGVTRQTVYRYFPNADALLIASAMRTA DGFIDQVAAHAAGIPDPVTALVECVSFGVQNLTGDPQLEGLLTPRHEGDAVISLTSDAAMTFCLSIFRRL DVDWALHGFDDTALTELAEMTLRTVHSILVDPGEPPRDESELRRFVTRWLGPAILYPRITVLAGARR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4281 | - | - | 100% (208) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_0364 | - | 2e-69 | 60.50% (200) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_1606 | - | 1e-47 | 45.92% (196) | TetR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3277c | - | 6e-08 | 32.14% (112) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv1255c | - | 2e-09 | 24.59% (183) | transcriptional regulatory protein |
| M. leprae Br4923 | MLBr_00316 | - | 8e-05 | 42.55% (47) | putative TetR/AcrR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_4765 | - | 4e-44 | 45.64% (195) | putative regulatory protein TetR |
| M. marinum M | MMAR_0226 | - | 4e-41 | 43.88% (196) | hypothetical protein MMAR_0226 |
| M. avium 104 | MAV_2960 | - | 7e-68 | 58.50% (200) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_5854 | - | 6e-52 | 50.26% (195) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_1262 | - | 6e-52 | 50.26% (195) | transcriptional regulator, TetR family protein |
| M. ulcerans Agy99 | MUL_4888 | - | 2e-32 | 41.42% (169) | hypothetical protein MUL_4888 |
| M. vanbaalenii PYR-1 | Mvan_0372 | - | 3e-78 | 69.00% (200) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4281|M.gilvum_PYR-GCK ---------MRSRGWAGSTPASDEEAIARILDAVDDVVAERG-PAMRLAD
Mvan_0372|M.vanbaalenii_PYR-1 ---------MRSRGWSGRWPASDEEAINRILDAADDIVAEHG-AAMRLTD
MAV_2960|M.avium_104 ---------MRSHGWAGNTPASDAEAIERILDAADRIIAERG-SALRIAD
MSMEG_5854|M.smegmatis_MC2_155 ---------MRTHGWSGSAPATDEEAIARILAAAGKAIDERG-ADFSIAD
TH_1262|M.thermoresistible__bu ---------MRTHGWGGSAPASDEEAIARILEAAKRTIEERG-AEFSIAD
MMAR_0226|M.marinum_M --------MARRRGWNGAPPASDEEASRRIVDTAVRLIAETG-SDVSLAQ
MUL_4888|M.ulcerans_Agy99 --------MVSRPKRRGVSRIG------RGVRRHRRGIAETG-SDVSLAQ
MAB_4765|M.abscessus_ATCC_1997 --------MARRRGWDGQPPSSDEEAAERIVAAAVKLIGETG-SAVSLAD
Rv1255c|M.tuberculosis_H37Rv ---------MAGTDWLS--ARRTELAADRILDAAERLFTQRDPASIGMNE
Mb3277c|M.bovis_AF2122/97 --MSTPSATVAPVKRIPYAEASRALLRDSVLDAMRDLLLTRDWSAITLSD
MLBr_00316|M.leprae_Br4923 MSVPRSGLSVQMAQPARPLRADAARNRARILGVAYEAFATEG-LSVPIDE
: . . . : :
Mflv_4281|M.gilvum_PYR-GCK VARRLGVTRQTVYRYFPNADALLIASAMRTADGFIDQVAAHAAG-IPDPV
Mvan_0372|M.vanbaalenii_PYR-1 VARALGVTRQTVYRYFPGPEAIVVACAMRAADGFIDQLAAHVRG-LTDPV
MAV_2960|M.avium_104 VARALGVTRQTVYRYFPGTQALLVASAMRSADGFLDRMAAHLDG-VTDPV
MSMEG_5854|M.smegmatis_MC2_155 VARTLGVTRQTVYRYFPSTDALLVAAAVHAASGFLDRLAAHLSG-ITDPV
TH_1262|M.thermoresistible__bu VARAVGVTRQTVYRYFPSTDALLVAAAMHAAGDFLDRLAVHLQG-ITDPV
MMAR_0226|M.marinum_M VAASLGVIRQTVYRYYPTADALMRAAAIASVDGFLDRLTEAVRG-MRDPA
MUL_4888|M.ulcerans_Agy99 VAASLGVIRQTVYRYYPTADALMRAAAIASVDGFLDRLTEAVRG-MRDPA
MAB_4765|M.abscessus_ATCC_1997 VAAELGVIRQTVYRYFPTADALMHAASLASVDGFLDRLTHVVRG-ITDPA
Rv1255c|M.tuberculosis_H37Rv IAKAAGCSRATLYRYFDSREALRTAYVHRETRRLGREIMVKIAD-VVEPA
Mb3277c|M.bovis_AF2122/97 VARAAGISRQTIYNEFGSRQGLAQGYALRLADRLVDNVHASLDANVGNFY
MLBr_00316|M.leprae_Br4923 IARRAGVGAGTVYRHFPTKEALCAAVIGDRMPHLVDDGYVLLKS--AGPG
:* * *:*. : :.: . :
Mflv_4281|M.gilvum_PYR-GCK TALVECVSFGVQNLTGDPQLEGLLTPRHEGDA-VISLTSDAAMTFCLSIF
Mvan_0372|M.vanbaalenii_PYR-1 AAMVESVSYSVERLAGDHQFENLLTSRRRGNV-TTSLTSETAMTFARSIL
MAV_2960|M.avium_104 VAITEGMAFAVEELASDHQVEFVLNQRHRGGQ-KVSIISDTALAFGRSML
MSMEG_5854|M.smegmatis_MC2_155 EAVTEAIATALEWVPQDKHLGLLISPGRADAH-TESVTSDVAVDFARAML
TH_1262|M.thermoresistible__bu EAVAEAIATTLEWLPEDTHIGLLVAPGRPTAH-TESVTSDVAIDFANRML
MMAR_0226|M.marinum_M EAMAEAVMFTLRDVVRTPHLGILIAQPYAHTH-PENLTSEEAQVFGVRML
MUL_4888|M.ulcerans_Agy99 EAMAEAVMFTLRDVVRTPHLGILIAQPYAHTH-PENLTSEEAQVFGVRML
MAB_4765|M.abscessus_ATCC_1997 EALTEGVLYTLEEVTRTPHLGIMMSEPYAHSH-TSDMTSDEAQAFGLRML
Rv1255c|M.tuberculosis_H37Rv ERLLVSITTTLRMVRDNPALAAWFTTTRPPIGGEMAGRSEVIAALAAAFL
Mb3277c|M.bovis_AF2122/97 EAFLQGFRSFFAESAADPLVISLLTGVAKPDL-LQLITTDSAPIITRASA
MLBr_00316|M.leprae_Br4923 EALFTYLRSLVLHWG-ATDRGLVDALAGAGGIDILGVAPDAEDAFLTILS
. . . .: :
Mflv_4281|M.gilvum_PYR-GCK RRLDVDWALHGF-DDTALTELAEMTLRTVHSILVDPGEPPRDE-SELRRF
Mvan_0372|M.vanbaalenii_PYR-1 QRFDIDWKQHGF-DETALDELAELSLRTMHSLLVDPGEPPRDG-VALRRF
MAV_2960|M.avium_104 HRYDIDWESYGF-DEAGLEELNEFSLRVLHSFLTDPGRPPRTG-ADLRRY
MSMEG_5854|M.smegmatis_MC2_155 RKFDVDWAGLGF-GDDDLDELAEHLLRIIQSFIIDPGRPPRTG-ATLRSY
TH_1262|M.thermoresistible__bu RRFDVDWAAVGY-SDADLDELAEHLLRVIQSFVIDPGRPPRDG-QSLRAY
MMAR_0226|M.marinum_M ERFDVDWAEYGFADESARHDLVEFLLRVLLSFFVAPNVPSRSD-DELKSF
MUL_4888|M.ulcerans_Agy99 ERFDVDWAEYGFADESARHDLVEFLLRVLLSFFVAPNVPSRSD-DELKSF
MAB_4765|M.abscessus_ATCC_1997 DRFDVDWVQYGY-DDAAKRELVEFALRIMLSFFVSPNEATRSR-DELRGF
Rv1255c|M.tuberculosis_H37Rv NSLGPD-------DPTTVERRARWVVRMLTSLLMFPGRDEADERAMIAEF
Mb3277c|M.bovis_AF2122/97 RLAPAFTDTWVATTDNDANVLSRAIVRLCLSYVSMPPEADHDVAADLARL
MLBr_00316|M.leprae_Br4923 DLLYAA--------QYAGTARTDVGVREVKSILVGCQAMEAYN-SALAER
:* * . :
Mflv_4281|M.gilvum_PYR-GCK VTRWLGPAILYPRIT---VLAGA-------RR------
Mvan_0372|M.vanbaalenii_PYR-1 VARWLGPAILYPRLARAVDVISP-------RR------
MAV_2960|M.avium_104 LTRWIGPAIAYPQLLRAMDALGAAEPQQRPRRRASKAS
MSMEG_5854|M.smegmatis_MC2_155 LRRWVGAAVKPAQASVQSPRV-----------------
TH_1262|M.thermoresistible__bu LRRWVGAAVTGAR-------------------------
MMAR_0226|M.marinum_M IKRWVGGAILAQKR------------------------
MUL_4888|M.ulcerans_Agy99 IRRWVGGAIVAQKR------------------------
MAB_4765|M.abscessus_ATCC_1997 LKRWLGGAVLAQGR------------------------
Rv1255c|M.tuberculosis_H37Rv VVPIVTPASAAARKAGHPGPE-----------------
Mb3277c|M.bovis_AF2122/97 ITPFAERHGVINVP------------------------
MLBr_00316|M.leprae_Br4923 VTDVVVDGLRAAR-------------------------
: