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VRSRGWSGQWPASDEEAITRILDAADELVAADASVLRIADVARALGVTRQTVYRYFPHPEAIRLACAMRA ADGFFDRLAKQVGGMTDPVAVMVECVASAVERLAGDPQFEALVTARRHGARAVSLTSDTALTFARTILHR FDIDWEQHGFDTAGLDRLAELSIRTVHSILVDPGDPAREGAELRRFVAGWLGPAILYPRLARAVDAITAP GVSPASPMRY
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0364 | - | - | 100% (220) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_4281 | - | 2e-69 | 60.50% (200) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_1606 | - | 4e-46 | 47.45% (196) | TetR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0482c | - | 3e-06 | 21.91% (178) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv1255c | - | 3e-10 | 26.84% (190) | transcriptional regulatory protein |
| M. leprae Br4923 | MLBr_02457 | - | 3e-06 | 21.74% (184) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_4765 | - | 6e-40 | 42.05% (195) | putative regulatory protein TetR |
| M. marinum M | MMAR_0226 | - | 1e-37 | 41.84% (196) | hypothetical protein MMAR_0226 |
| M. avium 104 | MAV_2960 | - | 1e-69 | 59.81% (209) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_5854 | - | 2e-48 | 48.21% (195) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_1262 | - | 2e-48 | 48.21% (195) | transcriptional regulator, TetR family protein |
| M. ulcerans Agy99 | MUL_4888 | - | 5e-28 | 37.87% (169) | hypothetical protein MUL_4888 |
| M. vanbaalenii PYR-1 | Mvan_0372 | - | 9e-86 | 73.08% (208) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0364|M.gilvum_PYR-GCK ---------MRSRGWSGQWPASDEEAITRILDAADELVAADA-SVLRIAD
Mvan_0372|M.vanbaalenii_PYR-1 ---------MRSRGWSGRWPASDEEAINRILDAADDIVAEHG-AAMRLTD
MAV_2960|M.avium_104 ---------MRSHGWAGNTPASDAEAIERILDAADRIIAERG-SALRIAD
MSMEG_5854|M.smegmatis_MC2_155 ---------MRTHGWSGSAPATDEEAIARILAAAGKAIDERG-ADFSIAD
TH_1262|M.thermoresistible__bu ---------MRTHGWGGSAPASDEEAIARILEAAKRTIEERG-AEFSIAD
MMAR_0226|M.marinum_M --------MARRRGWNGAPPASDEEASRRIVDTAVRLIAETG-SDVSLAQ
MUL_4888|M.ulcerans_Agy99 --------MVSRPKRRGVSRIG------RGVRRHRRGIAETG-SDVSLAQ
MAB_4765|M.abscessus_ATCC_1997 --------MARRRGWDGQPPSSDEEAAERIVAAAVKLIGETG-SAVSLAD
Mb0482c|M.bovis_AF2122/97 MAERIPAVTVKTDGRKRRWHQHKVERRNELVDGTIEAIRRHG-RFLSMDE
MLBr_02457|M.leprae_Br4923 MAEHIPAVAVKTDGRKRRWHQHKVERRNELVDGTIDAIRRQG-RFLSMDE
Rv1255c|M.tuberculosis_H37Rv -----------MAGTDWLSARRTELAADRILDAAERLFTQRDPASIGMNE
. : . . : :
Mflv_0364|M.gilvum_PYR-GCK VARALGVTRQTVYRYFPHPEAIRLACAMRAADG-FFDRLAKQVGGMTDPV
Mvan_0372|M.vanbaalenii_PYR-1 VARALGVTRQTVYRYFPGPEAIVVACAMRAADG-FIDQLAAHVRGLTDPV
MAV_2960|M.avium_104 VARALGVTRQTVYRYFPGTQALLVASAMRSADG-FLDRMAAHLDGVTDPV
MSMEG_5854|M.smegmatis_MC2_155 VARTLGVTRQTVYRYFPSTDALLVAAAVHAASG-FLDRLAAHLSGITDPV
TH_1262|M.thermoresistible__bu VARAVGVTRQTVYRYFPSTDALLVAAAMHAAGD-FLDRLAVHLQGITDPV
MMAR_0226|M.marinum_M VAASLGVIRQTVYRYYPTADALMRAAAIASVDG-FLDRLTEAVRGMRDPA
MUL_4888|M.ulcerans_Agy99 VAASLGVIRQTVYRYYPTADALMRAAAIASVDG-FLDRLTEAVRGMRDPA
MAB_4765|M.abscessus_ATCC_1997 VAAELGVIRQTVYRYFPTADALMHAASLASVDG-FLDRLTHVVRGITDPA
Mb0482c|M.bovis_AF2122/97 IAAEIGVSKTVLYRYFVDKNDLTTAVMMRFTQTTLIPNMIAALSADMDGF
MLBr_02457|M.leprae_Br4923 IAGKIGVSKTVLYRYFIDKNDLTTAVMMRFAQTTLIPNMAAALSTNLDGF
Rv1255c|M.tuberculosis_H37Rv IAKAAGCSRATLYRYFDSREALRTAYVHRETRR-LGREIMVKIADVVEPA
:* * : .:***: : : * . : .: : :
Mflv_0364|M.gilvum_PYR-GCK AVMVECVASAVERLAGDPQFEALVTARRHGARAVSLT-SDTALTFARTIL
Mvan_0372|M.vanbaalenii_PYR-1 AAMVESVSYSVERLAGDHQFENLLTSRRRGNVTTSLT-SETAMTFARSIL
MAV_2960|M.avium_104 VAITEGMAFAVEELASDHQVEFVLNQRHRGGQKVSII-SDTALAFGRSML
MSMEG_5854|M.smegmatis_MC2_155 EAVTEAIATALEWVPQDKHLGLLISPGRADAHTESVT-SDVAVDFARAML
TH_1262|M.thermoresistible__bu EAVAEAIATTLEWLPEDTHIGLLVAPGRPTAHTESVT-SDVAIDFANRML
MMAR_0226|M.marinum_M EAMAEAVMFTLRDVVRTPHLGILIAQPYAHTHPENLT-SEEAQVFGVRML
MUL_4888|M.ulcerans_Agy99 EAMAEAVMFTLRDVVRTPHLGILIAQPYAHTHPENLT-SEEAQVFGVRML
MAB_4765|M.abscessus_ATCC_1997 EALTEGVLYTLEEVTRTPHLGIMMSEPYAHSHTSDMT-SDEAQAFGLRML
Mb0482c|M.bovis_AF2122/97 ELTREIIRVYVETVAAQPEPYRFVMAN-SSASKSKVI-ADSERIIARMLA
MLBr_02457|M.leprae_Br4923 DLTREIIRVYVKTVAAEPEPYQFVMAN-SSASKSKVI-ADSERIIARMLA
Rv1255c|M.tuberculosis_H37Rv ERLLVSITTTLRMVRDNPALAAWFTTTRPPIGGEMAGRSEVIAALAAAFL
: :. : . :: :. :
Mflv_0364|M.gilvum_PYR-GCK HRFDIDWEQHGF-DTAGLDRLAELSIR----TVHSILVDPGDPAREGAEL
Mvan_0372|M.vanbaalenii_PYR-1 QRFDIDWKQHGF-DETALDELAELSLR----TMHSLLVDPGEPPRDGVAL
MAV_2960|M.avium_104 HRYDIDWESYGF-DEAGLEELNEFSLR----VLHSFLTDPGRPPRTGADL
MSMEG_5854|M.smegmatis_MC2_155 RKFDVDWAGLGF-GDDDLDELAEHLLR----IIQSFIIDPGRPPRTGATL
TH_1262|M.thermoresistible__bu RRFDVDWAAVGY-SDADLDELAEHLLR----VIQSFVIDPGRPPRDGQSL
MMAR_0226|M.marinum_M ERFDVDWAEYGFADESARHDLVEFLLR----VLLSFFVAPNVPSRSDDEL
MUL_4888|M.ulcerans_Agy99 ERFDVDWAEYGFADESARHDLVEFLLR----VLLSFFVAPNVPSRSDDEL
MAB_4765|M.abscessus_ATCC_1997 DRFDVDWVQYGY-DDAAKRELVEFALR----IMLSFFVSPNEATRSRDEL
Mb0482c|M.bovis_AF2122/97 VMLRRRMQEAGM-DTGGVEPWAYLIVGGVQLATHSWMSDPRMSSDELIDY
MLBr_02457|M.leprae_Br4923 VMIRRRMQEAGM-DAGGVEPWAYLIVGGVQLATHSWMSDPRMSADELIDY
Rv1255c|M.tuberculosis_H37Rv NSLGPD-------DPTTVERRARWVVR----MLTSLLMFPG---RDEADE
. : * . *
Mflv_0364|M.gilvum_PYR-GCK RRFVAGWLGPAILYPRLARAVDAITAPGVSPASPMRY----
Mvan_0372|M.vanbaalenii_PYR-1 RRFVARWLGPAILYPRLARAVDVIS--------PRR-----
MAV_2960|M.avium_104 RRYLTRWIGPAIAYPQLLRAMDALGAAEPQQRPRRRASKAS
MSMEG_5854|M.smegmatis_MC2_155 RSYLRRWVGAAVKPAQASVQSPRV-----------------
TH_1262|M.thermoresistible__bu RAYLRRWVGAAVTGAR-------------------------
MMAR_0226|M.marinum_M KSFIKRWVGGAILAQKR------------------------
MUL_4888|M.ulcerans_Agy99 KSFIRRWVGGAIVAQKR------------------------
MAB_4765|M.abscessus_ATCC_1997 RGFLKRWLGGAVLAQGR------------------------
Mb0482c|M.bovis_AF2122/97 LTMLSWSALCGIVEAGGSLEKFREQPHPSPIVPAWGQV---
MLBr_02457|M.leprae_Br4923 LTMLSWNALCGIVEVGGSLEKFRKQPHPSPIIPPRGP----
Rv1255c|M.tuberculosis_H37Rv RAMIAEFVVPIVTPASAAARKAGHPGPE-------------
: :