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MRSHGWAGNTPASDAEAIERILDAADRIIAERGSALRIADVARALGVTRQTVYRYFPGTQALLVASAMRS ADGFLDRMAAHLDGVTDPVVAITEGMAFAVEELASDHQVEFVLNQRHRGGQKVSIISDTALAFGRSMLHR YDIDWESYGFDEAGLEELNEFSLRVLHSFLTDPGRPPRTGADLRRYLTRWIGPAIAYPQLLRAMDALGAA EPQQRPRRRASKAS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2960 | - | - | 100% (224) | transcriptional regulator, TetR family protein |
| M. avium 104 | MAV_1115 | - | 1e-55 | 51.28% (195) | transcriptional regulator, TetR family protein |
| M. avium 104 | MAV_4189 | - | 4e-39 | 43.37% (196) | transcriptional regulator, TetR family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3277c | - | 3e-09 | 28.88% (187) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_0364 | - | 1e-69 | 59.81% (209) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv3249c | - | 3e-09 | 28.88% (187) | TetR family transcriptional regulator |
| M. leprae Br4923 | MLBr_02457 | - | 4e-05 | 25.26% (194) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_4765 | - | 7e-47 | 45.36% (194) | putative regulatory protein TetR |
| M. marinum M | MMAR_0226 | - | 1e-41 | 43.59% (195) | hypothetical protein MMAR_0226 |
| M. smegmatis MC2 155 | MSMEG_5854 | - | 6e-60 | 55.38% (195) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_1262 | - | 2e-58 | 54.87% (195) | transcriptional regulator, TetR family protein |
| M. ulcerans Agy99 | MUL_4888 | - | 2e-33 | 41.76% (170) | hypothetical protein MUL_4888 |
| M. vanbaalenii PYR-1 | Mvan_0372 | - | 1e-74 | 61.35% (207) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3277c|M.bovis_AF2122/97 --MSTPSATVAPVKRIPYAEASRALLRDSVLDAMRDLLLTRDWSAITLSD
Rv3249c|M.tuberculosis_H37Rv --MSTPSATVAPVKRIPYAEASRALLRDSVLDAMRDLLLTRDWSAITLSD
Mflv_0364|M.gilvum_PYR-GCK ---------MRSRGWSGQWPASDEEAITRILDAADELVAA-DASVLRIAD
Mvan_0372|M.vanbaalenii_PYR-1 ---------MRSRGWSGRWPASDEEAINRILDAADDIVAE-HGAAMRLTD
MAV_2960|M.avium_104 ---------MRSHGWAGNTPASDAEAIERILDAADRIIAE-RGSALRIAD
MSMEG_5854|M.smegmatis_MC2_155 ---------MRTHGWSGSAPATDEEAIARILAAAGKAIDE-RGADFSIAD
TH_1262|M.thermoresistible__bu ---------MRTHGWGGSAPASDEEAIARILEAAKRTIEE-RGAEFSIAD
MMAR_0226|M.marinum_M --------MARRRGWNGAPPASDEEASRRIVDTAVRLIAE-TGSDVSLAQ
MUL_4888|M.ulcerans_Agy99 --------MVSRPKRRGVSRIG------RGVRRHRRGIAE-TGSDVSLAQ
MAB_4765|M.abscessus_ATCC_1997 --------MARRRGWDGQPPSSDEEAAERIVAAAVKLIGE-TGSAVSLAD
MLBr_02457|M.leprae_Br4923 MAEHIPAVAVKTDGRKRRWHQHKVERRNELVDGTIDAIRR-QGRFLSMDE
: : . : :
Mb3277c|M.bovis_AF2122/97 VARAAGISRQTIYNEFGSRQGLAQGYALRLADR-LVDNVHASLDANVGNF
Rv3249c|M.tuberculosis_H37Rv VARAAGISRQTIYNEFGSRQGLAQGYALRLADR-LVDNVHASLDANVGNF
Mflv_0364|M.gilvum_PYR-GCK VARALGVTRQTVYRYFPHPEAIRLACAMRAADG-FFDRLAKQVGG-MTDP
Mvan_0372|M.vanbaalenii_PYR-1 VARALGVTRQTVYRYFPGPEAIVVACAMRAADG-FIDQLAAHVRG-LTDP
MAV_2960|M.avium_104 VARALGVTRQTVYRYFPGTQALLVASAMRSADG-FLDRMAAHLDG-VTDP
MSMEG_5854|M.smegmatis_MC2_155 VARTLGVTRQTVYRYFPSTDALLVAAAVHAASG-FLDRLAAHLSG-ITDP
TH_1262|M.thermoresistible__bu VARAVGVTRQTVYRYFPSTDALLVAAAMHAAGD-FLDRLAVHLQG-ITDP
MMAR_0226|M.marinum_M VAASLGVIRQTVYRYYPTADALMRAAAIASVDG-FLDRLTEAVRG-MRDP
MUL_4888|M.ulcerans_Agy99 VAASLGVIRQTVYRYYPTADALMRAAAIASVDG-FLDRLTEAVRG-MRDP
MAB_4765|M.abscessus_ATCC_1997 VAAELGVIRQTVYRYFPTADALMHAASLASVDG-FLDRLTHVVRG-ITDP
MLBr_02457|M.leprae_Br4923 IAGKIGVSKTVLYRYFIDKNDLTTAVMMRFAQTTLIPNMAAALST-NLDG
:* *: : .:*. : : : . : . :. .: : :
Mb3277c|M.bovis_AF2122/97 YEAFLQGFRSFFAESAADPLVISLLTGVAKPDLLQLITTDSAPIITRASA
Rv3249c|M.tuberculosis_H37Rv YEAFLQGFRSFFAESAADPLVISLLTGVAKPDLLQLITTDSAPIITRASA
Mflv_0364|M.gilvum_PYR-GCK VAVMVECVASAVERLAGDPQFEALVTARRHGARAVSLTSDTALTFARTIL
Mvan_0372|M.vanbaalenii_PYR-1 VAAMVESVSYSVERLAGDHQFENLLTSRRRGNVTTSLTSETAMTFARSIL
MAV_2960|M.avium_104 VVAITEGMAFAVEELASDHQVEFVLNQRHRGGQKVSIISDTALAFGRSML
MSMEG_5854|M.smegmatis_MC2_155 VEAVTEAIATALEWVPQDKHLGLLISPGRADAHTESVTSDVAVDFARAML
TH_1262|M.thermoresistible__bu VEAVAEAIATTLEWLPEDTHIGLLVAPGRPTAHTESVTSDVAIDFANRML
MMAR_0226|M.marinum_M AEAMAEAVMFTLRDVVRTPHLGILIAQPYAHTHPENLTSEEAQVFGVRML
MUL_4888|M.ulcerans_Agy99 AEAMAEAVMFTLRDVVRTPHLGILIAQPYAHTHPENLTSEEAQVFGVRML
MAB_4765|M.abscessus_ATCC_1997 AEALTEGVLYTLEEVTRTPHLGIMMSEPYAHSHTSDMTSDEAQAFGLRML
MLBr_02457|M.leprae_Br4923 FDLTREIIRVYVKTVAAEPEPYQFVMAN-SSASKSKVIADSERIIARMLA
: . . .: : :: :
Mb3277c|M.bovis_AF2122/97 RLAPAFTDTWVATTDNDANVLSRAIVR----LCLSYVSMP---PEADHDV
Rv3249c|M.tuberculosis_H37Rv RLAPAFTDTWVATTDNDANVLSRAIVR----LCLSYVSMP---PEADHDV
Mflv_0364|M.gilvum_PYR-GCK HRFDIDWEQHGF-DTAGLDRLAELSIR----TVHSILVDPGDPAREGAEL
Mvan_0372|M.vanbaalenii_PYR-1 QRFDIDWKQHGF-DETALDELAELSLR----TMHSLLVDPGEPPRDGVAL
MAV_2960|M.avium_104 HRYDIDWESYGF-DEAGLEELNEFSLR----VLHSFLTDPGRPPRTGADL
MSMEG_5854|M.smegmatis_MC2_155 RKFDVDWAGLGF-GDDDLDELAEHLLR----IIQSFIIDPGRPPRTGATL
TH_1262|M.thermoresistible__bu RRFDVDWAAVGY-SDADLDELAEHLLR----VIQSFVIDPGRPPRDGQSL
MMAR_0226|M.marinum_M ERFDVDWAEYGFADESARHDLVEFLLR----VLLSFFVAPNVPSRSDDEL
MUL_4888|M.ulcerans_Agy99 ERFDVDWAEYGFADESARHDLVEFLLR----VLLSFFVAPNVPSRSDDEL
MAB_4765|M.abscessus_ATCC_1997 DRFDVDWVQYGY-DDAAKRELVEFALR----IMLSFFVSPNEATRSRDEL
MLBr_02457|M.leprae_Br4923 VMIRRRMQEAGM-DAGGVEPWAYLIVGGVQLATHSWMSDPRMSADELIDY
: * . * .
Mb3277c|M.bovis_AF2122/97 AADLAR-LITPFAERHGVINVP--------------------
Rv3249c|M.tuberculosis_H37Rv AADLAR-LITPFAERHGVINVP--------------------
Mflv_0364|M.gilvum_PYR-GCK RRFVAG-WLGPAILYPRLARAVDAITAPGVSPASPMRY----
Mvan_0372|M.vanbaalenii_PYR-1 RRFVAR-WLGPAILYPRLARAVDVIS--------PRR-----
MAV_2960|M.avium_104 RRYLTR-WIGPAIAYPQLLRAMDALGAAEPQQRPRRRASKAS
MSMEG_5854|M.smegmatis_MC2_155 RSYLRR-WVGAAVKPAQASVQSPRV-----------------
TH_1262|M.thermoresistible__bu RAYLRR-WVGAAVTGAR-------------------------
MMAR_0226|M.marinum_M KSFIKR-WVGGAILAQKR------------------------
MUL_4888|M.ulcerans_Agy99 KSFIRR-WVGGAIVAQKR------------------------
MAB_4765|M.abscessus_ATCC_1997 RGFLKR-WLGGAVLAQGR------------------------
MLBr_02457|M.leprae_Br4923 LTMLSWNALCGIVEVGGSLEKFRKQPHPSPIIPPRGP-----
: :