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MLKYRRASTVRAGFIGVVLIVLVIAVGLAPERITGWATAIRYQAVFADLSGLSVGNDVTVSGMTLGKVTA VQLQDPNALVTFTVDDTTPLGSQSTAHIRTGTLLGQRVLTVQSEGDGSMSAMDIIPLTRTSSPYTLTEAL GDLTTNSTGTDTAALNEALNTLSDTIDQISPQLGPTFDGLARISEALNTRNTALRRLFGSGRDVTAVLAE RSEEVSALILNADDLVAMLAERRHTIVELLAHISAVARDVTGLVHDNEQQLAPTLEKLNTVLAMLERQRD NIALALPRLAKYQVTLGETVASGPYYSAYIPNLDLPPILQPFLDYAFGFRRGVDAGQPPDDAGPRAELPF PRNGIPERPPR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4162 | - | - | 100% (361) | virulence factor Mce family protein |
| M. gilvum PYR-GCK | Mflv_2510 | - | e-124 | 59.38% (357) | virulence factor Mce family protein |
| M. gilvum PYR-GCK | Mflv_4536 | - | e-118 | 58.43% (356) | virulence factor Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3527c | mce4C | 5e-58 | 38.36% (318) | MCE-family protein MCE4C |
| M. tuberculosis H37Rv | Rv1968 | mce3C | 3e-59 | 35.28% (360) | MCE-family protein MCE3C |
| M. leprae Br4923 | MLBr_02591 | mce1C | 7e-51 | 32.04% (362) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_4151c | - | 2e-53 | 38.64% (295) | MCE-family protein |
| M. marinum M | MMAR_4708 | - | 1e-118 | 60.39% (356) | MCE-family protein |
| M. avium 104 | MAV_0950 | - | 1e-110 | 55.68% (361) | virulence factor Mce family protein |
| M. smegmatis MC2 155 | MSMEG_2857 | - | 1e-117 | 57.58% (356) | virulence factor Mce family protein |
| M. thermoresistible (build 8) | TH_4269 | - | 1e-127 | 63.20% (356) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_3920 | mce3C_1 | 4e-61 | 36.14% (368) | MCE-family protein, Mce3C_1 |
| M. vanbaalenii PYR-1 | Mvan_4148 | - | 1e-126 | 60.50% (357) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3527c|M.bovis_AF2122/97 MLNRKPSSKHERDPLRTGIFGLVLVICVVLIAFGYSGLPFWPQGKTYDAY
MAB_4151c|M.abscessus_ATCC_199 -MPSKMSDIQEKDPVRTGIFGIAVVSMLVLVAFGYTGLPFWPQGKQYTGY
Rv1968|M.tuberculosis_H37Rv -----MKSFAERNRLAIGTVGIVVVAAVALAALQYQRLPFFNQGTRVSAY
MUL_3920|M.ulcerans_Agy99 -----MKSFAERNQIVVGAVELAITIGIVVGSLQYDKLPLFQSGKQYSAC
TH_4269|M.thermoresistible__bu -----MRKYRETNLMRAGFIGFVLIVLVITIGLQPERIIQWATSIRYQAL
Mvan_4148|M.vanbaalenii_PYR-1 -----MLKYRGSQLARAGFIGVVLIILVIAVGLQPERLLSWATAIRYQAL
MSMEG_2857|M.smegmatis_MC2_155 -----MHKYRGTRLIRTGLLGLVLVVLIIVVGLQPQQLIQMATSVRYHAE
MMAR_4708|M.marinum_M -----MLKYRGAGLIRAGFIGAVLIVLVIAVGLNPEQLLQRATTVRYQAL
MAV_0950|M.avium_104 -----MLKYRGSGLVKAGLIGVVLAVMVILVGLSPDRFIAWATMVRYQAL
Mflv_4162|M.gilvum_PYR-GCK -----MLKYRRASTVRAGFIGVVLIVLVIAVGLAPERITGWATAIRYQAV
MLBr_02591|M.leprae_Br4923 -----MRTLELPNRLRSGLIGVLVVLLIIGVGQSFTSVPILFARPSYYGQ
* . : : . . .
Mb3527c|M.bovis_AF2122/97 FTDAGGITPGNSVYVSGLKVGAVSAVSLAGNSAKVTFSVDRSIVVGDQSL
MAB_4151c|M.abscessus_ATCC_199 FADSGGLESGGNVFVSGIKVGQVKDVSLAGNKVRVDFTVDRSIRLGDQSL
Rv1968|M.tuberculosis_H37Rv FADAGGLRTGNTVEVSGYPVGKVSSISLDGPGVLVEFKVDTDVRLGNRTE
MUL_3920|M.ulcerans_Agy99 FADAGGLTTGVRVQVSGFRVGEVSSIELDGPQVLVKFTVDKHIRLGDHTE
TH_4269|M.thermoresistible__bu FSEAGGITVGNDVTISGIKVGTVNEVTLHDGDALVTFTVAGKHQLGAQTT
Mvan_4148|M.vanbaalenii_PYR-1 FAEAGGLTVGNDVTVSGIKVGSVSSIELDNGDALVGFTIDGKYALGSDTT
MSMEG_2857|M.smegmatis_MC2_155 FAEAGGLTAGNEVKVSGVTVGTVSDVELVNGRARVTFALDGKTRLGQDTT
MMAR_4708|M.marinum_M FSDAGGLAVGNDVTVSGIKVGTVSGMSLQRGDVLVTFTVNGGVELGADST
MAV_0950|M.avium_104 FTEAGGLATGNPVVVSGMKVGTVSDVKLHRGDALVTFALKGNILLGSETT
Mflv_4162|M.gilvum_PYR-GCK FADLSGLSVGNDVTVSGMTLGKVTAVQLQDPNALVTFTVDDTTPLGSQST
MLBr_02591|M.leprae_Br4923 FTDTGGLNKGDKVRIAGMDVGKVEALKIDGDHVVIKFSIG-TNRIGTASR
*:: .*: * * ::* :* * : : . : * : :* :
Mb3527c|M.bovis_AF2122/97 AAIRTDTILGERSIAVSPAGSGKST---TIPLSRTTTPYTLNGVLQDLGR
MAB_4151c|M.abscessus_ATCC_199 AAIRTTTVLGEKSLSVTPAGAGRIT---EIPLGRTTTPYTLNSALSDLGA
Rv1968|M.tuberculosis_H37Rv VAIKTKGLLGSKFLDVTPRGDGRLDS--PIPIERTTSPYQLPDALGDLAA
MUL_3920|M.ulcerans_Agy99 AAIKTRGLLGTKMLEVISRGDGQLQG--TIPLDRTRSPYQLPDALGDLAT
TH_4269|M.thermoresistible__bu AHIRTGSLLGERVITLESYGSEPLRGTDVIPTSRTSSPYSLTDAVGDLAT
Mvan_4148|M.vanbaalenii_PYR-1 AHIRTGTLLGERVLALDSDGSGTLDPQQVIPTTRTSSPYSLTDAVSELTA
MSMEG_2857|M.smegmatis_MC2_155 AHIRTGTLLGQRVLTVEPKGSGRIGPSGVIPVSRTGSPYSLTDAVGDFTT
MMAR_4708|M.marinum_M AHIRTGSLLGQRVLTVESAGGHTLRPMAVIPVSRTSSPYSLSEAVSDAAT
MAV_0950|M.avium_104 AHIRTGTLLGERMLTLESAGTGTMHPMALIPVSRTSSPYSLTEAVSDLTT
Mflv_4162|M.gilvum_PYR-GCK AHIRTGTLLGQRVLTVQSEGDGSMSAMDIIPLTRTSSPYTLTEALGDLTT
MLBr_02591|M.leprae_Br4923 LGIRTDTVLGKKVLEVETRGTQLLRPGDSLPLGQSTTPYQSYDAFFDATK
*:* :** : : : . * :* :: :** .. :
Mb3527c|M.bovis_AF2122/97 NANDLNRPQFEQALNVFTQALHDATPQVRGAVDGLTSLSRALNRRDEALQ
MAB_4151c|M.abscessus_ATCC_199 SAGGIDKAQLDQSLQVITEAMRDATPQLRGALDGVASLSRTLNARDAALE
Rv1968|M.tuberculosis_H37Rv TISGLHTERLSESLATLAQTFADTPAHFRNAIHGVARLAQTLDERDNQLR
MUL_3920|M.ulcerans_Agy99 TISGLNTNQLSDSLRVLADTFSDTPPQLRVAIEGVARFSQTLDERDAQLR
TH_4269|M.thermoresistible__bu NTAGTDTAALNQALDTLSATIDQIAPRLGPTFDGLSRLSRSLNDRNENLA
Mvan_4148|M.vanbaalenii_PYR-1 NTRDTDTASLNQSLDTLAQTLDQVAPQLGPTFDGLSRLSQSLNSRNESLA
MSMEG_2857|M.smegmatis_MC2_155 NTAETDTAAINQSLDVLSETIERIAPQLAPTFDGITRLSQSLNNRNESLA
MMAR_4708|M.marinum_M DIAGTNTDALNQSLDTLSETLNQIAPQLGPSFDGLTRLSQALNGRNQTLG
MAV_0950|M.avium_104 DTAGTNTTALNQSLDTLAATLDQIAPQMGPAFDALTRLSRTLNSRNKNLG
Mflv_4162|M.gilvum_PYR-GCK NSTGTDTAALNEALNTLSDTIDQISPQLGPTFDGLARISEALNTRNTALR
MLBr_02591|M.leprae_Br4923 VASGWNIDTIKQSLKVVSETIDQTYPHLSAALDGVAKFSDTIGARDKEIK
. :.::* ..: :: .:. :...:: :: ::. *: :
Mb3527c|M.bovis_AF2122/97 GLLAHAKSVTSVLSERAEQVNKLVEDGNQLFAALDARRAALSALISGIDD
MAB_4151c|M.abscessus_ATCC_199 QLLTHAKSVSGILSERAGQVNKLVTDGNQLFAALDERRLAISELINRIQG
Rv1968|M.tuberculosis_H37Rv SLLANAAKATGVLANRTDQIVGLVRDTNVVLAQLRTQSAALDRIWANISA
MUL_3920|M.ulcerans_Agy99 GLLTNANKATTVLAERSNQVVSLIANTNALLAELTTQRAALDHISGNIAA
TH_4269|M.thermoresistible__bu GLLASAGEVTKVLAERSQQLNTLILNANDLLAVLNERREAIVTLLANTSA
Mvan_4148|M.vanbaalenii_PYR-1 ELLRTAGDVTGIFSERSSQVNALILNANDLLAVLNERRYAITSLLANISA
MSMEG_2857|M.smegmatis_MC2_155 DLLKSASEITGILSERSEQVNRLILNANDLLAVVRDRRYVIVNLLANTSA
MMAR_4708|M.marinum_M ELLKGAADVTGILSQRSQQLNTLILNADDLLSMLVARRQAIVRLLASTSA
MAV_0950|M.avium_104 ELFKSAGDVTGVLSERSQQVNKLILNSDVLLQVLVARRQEIVDLLANTSA
Mflv_4162|M.gilvum_PYR-GCK RLFGSGRDVTAVLAERSEEVSALILNADDLVAMLAERRHTIVELLAHISA
MLBr_02591|M.leprae_Br4923 HLIAQANQVASVLGDRGAQVDRLLVNTKTLIAAFNERGRAVDALLGNVAA
*: . . : ::.:* :: *: : . :. . : : :
Mb3527c|M.bovis_AF2122/97 VAAQISGFVADNRKEFGPALSKLNLVLANLNERRDYITEALKRLPTYATT
MAB_4151c|M.abscessus_ATCC_199 LSQQISGFVADNRQEFRPTMEKLSVVLDDLLDRKAHISEALKRLPGYGTA
Rv1968|M.tuberculosis_H37Rv VAEQLRGFIAENRQQLRPALDKLNGVLAIVENRKERVRQAIPLINTYVMS
MUL_3920|M.ulcerans_Agy99 LGQQLHGLIAENEATMRPALDKLNGVLTILDNRKERLQKAIKLLDDYTMS
TH_4269|M.thermoresistible__bu VAQELTALVADNEAELAPTLERLNSVMEMLERNRDNIAKILPNLKKFILA
Mvan_4148|M.vanbaalenii_PYR-1 VSQQLSGVVADNEAELAPALERLNNVTQMLEKNRDNLAKMLPGAAKYYLT
MSMEG_2857|M.smegmatis_MC2_155 VARQLSALVSDNEAELAPALEKLNKVLAMLERNRDNLTASLKGLAKYQLT
MMAR_4708|M.marinum_M VAKQLSGLVHDNESKLAPTLERLNAVTAMLEKNRDNLAKALPGLAKYELT
MAV_0950|M.avium_104 VAKQLTALVHDNESKLAPTLERLNSVTAMLEKNRDNISKALPGLKKFEIT
Mflv_4162|M.gilvum_PYR-GCK VARDVTGLVHDNEQQLAPTLEKLNTVLAMLERQRDNIALALPRLAKYQVT
MLBr_02591|M.leprae_Br4923 FAAQVQRLINDN-PNLNHVLEQLHQLSGILVQHKDDLANTLIQVAAFLPS
.. :: .: :* : .:.:* : : .: : : : :
Mb3527c|M.bovis_AF2122/97 LGEVVGSGPGFNVNVYSVLPGPLVATVFDLVF------------------
MAB_4151c|M.abscessus_ATCC_199 LGEVVSSGPGFHVNVYGFPPATLTAVAFDTYF------------------
Rv1968|M.tuberculosis_H37Rv LGESLSSGPFFKAYVVNLLPGQFVQPFISAAFSDLGLDPATLLPSQ----
MUL_3920|M.ulcerans_Agy99 LGESVSSGPFFKTYVANLAPGQFVQPFIDAAFSDLGLDPNVLLPSQ----
TH_4269|M.thermoresistible__bu QGETLANGPYYNAFVPNLNPAQILQPFLDYAFGFRRGT------------
Mvan_4148|M.vanbaalenii_PYR-1 QGEIVSNGAYYNALIPNIQPAQLLQPFLDYAFGFRNGV------------
MSMEG_2857|M.smegmatis_MC2_155 QGEAVNNGFYYYGFASNLLPGPAIQPFLDYALGFRRGV------------
MMAR_4708|M.marinum_M QGETVSSGFYYNPFIPNLFTIQFFQWFIDYAFGFRAHG------------
MAV_0950|M.avium_104 VGEAISSMYAYSAFVPNFLAPQLFQPFLDYLWGFRTFDT-----------
Mflv_4162|M.gilvum_PYR-GCK LGETVASGPYYSAYIPNLDLPPILQPFLDYAFGFRRGV------------
MLBr_02591|M.leprae_Br4923 LNEAIGSGPFFKVVLHNLAPYQILQPWVDAAFKKRGIDPENFWRSAGLPE
.* : . : .. ..
Mb3527c|M.bovis_AF2122/97 -----------QPGKLPD--------------------------------
MAB_4151c|M.abscessus_ATCC_199 -----------QPGKLPA--------------------------------
Rv1968|M.tuberculosis_H37Rv ----LTDPPTGQPGTPPLPMPYPR------------------------TG
MUL_3920|M.ulcerans_Agy99 ----RTDPPIGQPGTPPLPLPFPR------------------------TG
TH_4269|M.thermoresistible__bu -----------NAGQPPD--------------------------------
Mvan_4148|M.vanbaalenii_PYR-1 -----------DIGQPPD--------------------------------
MSMEG_2857|M.smegmatis_MC2_155 -----------NAGQPPD--------------------------------
MMAR_4708|M.marinum_M -----------APGQPPD--------------------------------
MAV_0950|M.avium_104 -----------ARGPGHP--------------------------------
Mflv_4162|M.gilvum_PYR-GCK -----------DAGQPPD--------------------------------
MLBr_02591|M.leprae_Br4923 FRFPDPNGTRFPNGAPPPAPPVLEGTPENPGPAVPPGSPCSYTPAHPGGN
*
Mb3527c|M.bovis_AF2122/97 -------SLADYLRGFIQE-RWIIRPKSP---------------------
MAB_4151c|M.abscessus_ATCC_199 -------SLSDYLNGLIGE-RQIMRPKSP---------------------
Rv1968|M.tuberculosis_H37Rv QGGEPRLTLPDAITGNPGDPRYPYRPEPPAPPPGGPPPGPPAQQPGDQP-
MUL_3920|M.ulcerans_Agy99 QGGEPHRKLPDAITGNPDDPRYPYREPLPAPPPGGPPPGPPAPAPPELAS
TH_4269|M.thermoresistible__bu -TVGPRAELPLPYNAIPG-----------GTR------------------
Mvan_4148|M.vanbaalenii_PYR-1 -NAGPRAQLPFPVNSLPQPGDLP----NDGNP------------------
MSMEG_2857|M.smegmatis_MC2_155 -NAGPRAEFPFPNNGIPG-----------G--------------------
MMAR_4708|M.marinum_M -NAGPRALFPFPFNQNP-----------GGSR------------------
MAV_0950|M.avium_104 -SPVPRSLIPWPYNGIPVCPGCTLGGRVGGSQ------------------
Mflv_4162|M.gilvum_PYR-GCK -DAGPRAELPFPRNGIPE----------RPPR------------------
MLBr_02591|M.leprae_Br4923 NTIGDEMGLPRPWNPLPCAGATAGPYGGPAFPAPIDVQTSPPNPDGLPLL
:.
Mb3527c|M.bovis_AF2122/97 --------------------------------------------------
MAB_4151c|M.abscessus_ATCC_199 --------------------------------------------------
Rv1968|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3920|M.ulcerans_Agy99 IPQPTPSSVLVPAPGEVSAPQTAGAGR-----------------------
TH_4269|M.thermoresistible__bu --------------------------------------------------
Mvan_4148|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2857|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_4708|M.marinum_M --------------------------------------------------
MAV_0950|M.avium_104 --------------------------------------------------
Mflv_4162|M.gilvum_PYR-GCK --------------------------------------------------
MLBr_02591|M.leprae_Br4923 PGIAIAGRPGDPAPNVPGTPVPLPPNAPPGARTEQLAPAAPAQDSSAPHE
Mb3527c|M.bovis_AF2122/97 --------------------------
MAB_4151c|M.abscessus_ATCC_199 --------------------------
Rv1968|M.tuberculosis_H37Rv --------------------------
MUL_3920|M.ulcerans_Agy99 --------------------------
TH_4269|M.thermoresistible__bu --------------------------
Mvan_4148|M.vanbaalenii_PYR-1 --------------------------
MSMEG_2857|M.smegmatis_MC2_155 --------------------------
MMAR_4708|M.marinum_M --------------------------
MAV_0950|M.avium_104 --------------------------
Mflv_4162|M.gilvum_PYR-GCK --------------------------
MLBr_02591|M.leprae_Br4923 PREQLSAPLINPGGTGGSGGAGGSRN