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VKSFAERNQIVVGAVELAITIGIVVGSLQYDKLPLFQSGKQYSACFADAGGLTTGVRVQVSGFRVGEVSS IELDGPQVLVKFTVDKHIRLGDHTEAAIKTRGLLGTKMLEVISRGDGQLQGTIPLDRTRSPYQLPDALGD LATTISGLNTNQLSDSLRVLADTFSDTPPQLRVAIEGVARFSQTLDERDAQLRGLLTNANKATTVLAERS NQVVSLIANTNALLAELTTQRAALDHISGNIAALGQQLHGLIAENEATMRPALDKLNGVLTILDNRKERL QKAIKLLDDYTMSLGESVSSGPFFKTYVANLAPGQFVQPFIDAAFSDLGLDPNVLLPSQRTDPPIGQPGT PPLPLPFPRTGQGGEPHRKLPDAITGNPDDPRYPYREPLPAPPPGGPPPGPPAPAPPELASIPQPTPSSV LVPAPGEVSAPQTAGAGR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_3920 | mce3C_1 | - | 100% (438) | MCE-family protein, Mce3C_1 |
| M. ulcerans Agy99 | MUL_1064 | mce1C | 5e-66 | 34.59% (451) | MCE-family protein Mce1C |
| M. ulcerans Agy99 | MUL_4060 | mce4C | 1e-58 | 40.00% (320) | MCE-family protein Mce4C |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0177 | mce1C | 2e-65 | 32.78% (479) | MCE-family protein MCE1C |
| M. gilvum PYR-GCK | Mflv_2103 | - | 0.0 | 73.02% (441) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv1968 | mce3C | 1e-158 | 66.75% (406) | MCE-family protein MCE3C |
| M. leprae Br4923 | MLBr_02591 | mce1C | 3e-58 | 32.07% (421) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_4151c | - | 2e-62 | 41.25% (320) | MCE-family protein |
| M. marinum M | MMAR_4053 | mce3C_1 | 0.0 | 98.86% (438) | MCE-family protein, Mce3C_1 |
| M. avium 104 | MAV_2534 | - | 1e-161 | 65.31% (441) | virulence factor Mce family protein |
| M. smegmatis MC2 155 | MSMEG_0348 | - | 1e-164 | 64.38% (438) | mce-family protein mce3c |
| M. thermoresistible (build 8) | TH_4453 | - | 1e-155 | 62.56% (430) | PUTATIVE virulence factor Mce family protein |
| M. vanbaalenii PYR-1 | Mvan_4602 | - | 0.0 | 72.73% (451) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_3920|M.ulcerans_Agy99 ----MKSFAERNQIVVGAVELAITIGIVVGSLQYDKLPLFQSGKQYSACF
MMAR_4053|M.marinum_M ----MKSFAERNQIVVGAVGLAITIGIVVGSLQYDKLPFFQSGKQYSAYF
Mflv_2103|M.gilvum_PYR-GCK ----MKPFSERNQLVIGAVGVGITAAIVLGATNYDKIPLFDPGREYTAHF
Mvan_4602|M.vanbaalenii_PYR-1 ----MKSFSERNQFVVGIVGLALTIGIVLVSLNYDRLPFLQ-GKEYKAYF
MAV_2534|M.avium_104 ----MKTFSERNPFIIGAIGLGAVFTLMLVSLNYDKLPFFHSDRTYSAYF
Rv1968|M.tuberculosis_H37Rv ----MKSFAERNRLAIGTVGIVVVAAVALAALQYQRLPFFNQGTRVSAYF
MSMEG_0348|M.smegmatis_MC2_155 MRAEMKAFSERDPRTIGLVGIAITVVIALAALNFDKLPLLSSTKGYSAYF
TH_4453|M.thermoresistible__bu VCTEMKPFAERNKRVMGAVGIGVGTIIIAGALQYDNLPVVSSDTRYSAYF
MAB_4151c|M.abscessus_ATCC_199 MPSKMSDIQEKDPVRTGIFGIAVVSMLVLVAFGYTGLPFWPQGKQYTGYF
Mb0177|M.bovis_AF2122/97 ----MRTLEPPNRMRIGLMGIVVALLVVAVGQSFTSVPMLFAKPSYYGQF
MLBr_02591|M.leprae_Br4923 ----MRTLELPNRLRSGLIGVLVVLLIIGVGQSFTSVPILFARPSYYGQF
* : : * . : : . : :*. . *
MUL_3920|M.ulcerans_Agy99 ADAGGLTTGVRVQVSGFRVGEVSSIELDGPQVLVKFTVDKHIRLGDHTEA
MMAR_4053|M.marinum_M ADAGGLTTGVRVQVSGFRVGEVSSIELDGPRVLVKFTVDKHIRLGDHTEA
Mflv_2103|M.gilvum_PYR-GCK AEAGGLTTDAAVQVSGFKVGQVKSIELDGPQVLVTFTVDKGIRLGDRTEA
Mvan_4602|M.vanbaalenii_PYR-1 AEAGGLKTGEDVQVSGFTVGDVKSIELDGSLALVTFTVARDIRLGERTEA
MAV_2534|M.avium_104 AEAGGLEPGNHVQISGYRVGQVDSVELDGPRVLVTFTVASNLRLGERTEA
Rv1968|M.tuberculosis_H37Rv ADAGGLRTGNTVEVSGYPVGKVSSISLDGPGVLVEFKVDTDVRLGNRTEV
MSMEG_0348|M.smegmatis_MC2_155 ADAGGLNTGATVRVSGFAVGKVERIRLDGRKVLVDFTVDSAIHLGEQSEA
TH_4453|M.thermoresistible__bu AESGGLRAGAAVQVSGMRVGKVSAVELDGPHVRVEFRVRPNIRLGELSEA
MAB_4151c|M.abscessus_ATCC_199 ADSGGLESGGNVFVSGIKVGQVKDVSLAGNKVRVDFTVDRSIRLGDQSLA
Mb0177|M.bovis_AF2122/97 TDSGGLHKGDRVRIAGLGVGTVEGLKIDGDHIVVKFSIGTNT-IGTESRL
MLBr_02591|M.leprae_Br4923 TDTGGLNKGDKVRIAGMDVGKVEALKIDGDHVVIKFSIGTNR-IGTASRL
:::*** . * ::* ** *. : : * : * : :* :
MUL_3920|M.ulcerans_Agy99 AIKTRGLLGTKMLEVISRGDGQLQG--TIPLDRTRSPYQLPDALGDLATT
MMAR_4053|M.marinum_M AIKTRGLLGTKMLEVISRGDGQLQG--TIPLDRTRSPYQLPDALGDLATT
Mflv_2103|M.gilvum_PYR-GCK AIKTKGLLGTKILEVIARGEGQQDG--TIPIDRTTSPYQLPDALGELSAT
Mvan_4602|M.vanbaalenii_PYR-1 AIKTRGLLGTKMLEITSRGEGQLDG--PIPLERTTSPYQLPDALGDLAMT
MAV_2534|M.avium_104 AIKLRTVLGSKVLEVSPRGEGQLTG--PIPLQRTTSAYQLPDALGDLTAT
Rv1968|M.tuberculosis_H37Rv AIKTKGLLGSKFLDVTPRGDGRLDS--PIPIERTTSPYQLPDALGDLAAT
MSMEG_0348|M.smegmatis_MC2_155 AIKVKSLLGTKVIDVIPRGGGQLHE--PIPLERTTSPYQLPDALGDLATT
TH_4453|M.thermoresistible__bu AIKTKSLLGAKILDITSRGEGRLSA--SIPVERTVSPYELPDALGDLAST
MAB_4151c|M.abscessus_ATCC_199 AIRTTTVLGEKSLSVTPAGAGRIT---EIPLGRTTTPYTLNSALSDLGAS
Mb0177|M.bovis_AF2122/97 AIRTDTILGRKVLEIEPRGAQALPPGGVLPVGQSTTPYQIYDAFFDVTKA
MLBr_02591|M.leprae_Br4923 GIRTDTVLGKKVLEVETRGTQLLRPGDSLPLGQSTTPYQSYDAFFDATKV
.*: :** * :.: . * :*: :: :.* .*: :
MUL_3920|M.ulcerans_Agy99 ISGLNTNQLSDSLRVLADTFSDTPPQLRVAIEGVARFSQTLDERDAQLRG
MMAR_4053|M.marinum_M ISGLNTNQLSDSLRVLADTFSDTPPQLRVAIEGVARFSQTLDERDAQLRG
Mflv_2103|M.gilvum_PYR-GCK ISGLDTDQLSESLRVLSATFADTPPQLKIAVEGVARFSDTLNARDAQLRG
Mvan_4602|M.vanbaalenii_PYR-1 ISGLNTDQLSESLRVLSATFADTPPQLRVAVEGVARFSETLNERDAELRS
MAV_2534|M.avium_104 ISGLNTDQLSKSLAVLANTFTDTPPDLKAAVQGVARFSQTLDERDGQLRT
Rv1968|M.tuberculosis_H37Rv ISGLHTERLSESLATLAQTFADTPAHFRNAIHGVARLAQTLDERDNQLRS
MSMEG_0348|M.smegmatis_MC2_155 VENLNTDDLSAALDTMAQTFAGTPPDVKIAVAGVARLSETINKRDTELRN
TH_4453|M.thermoresistible__bu IAGLDTAGVSESLATLAETFENTPAEVQAAVRGVTRFSESLGRRDQQLRQ
MAB_4151c|M.abscessus_ATCC_199 AGGIDKAQLDQSLQVITEAMRDATPQLRGALDGVASLSRTLNARDAALEQ
Mb0177|M.bovis_AF2122/97 ASGWDIETVKRSLNVLSETVDQTYPHLSAALDGVAKFSDTIGKRDEQITH
MLBr_02591|M.leprae_Br4923 ASGWNIDTIKQSLKVVSETIDQTYPHLSAALDGVAKFSDTIGARDKEIKH
. . :. :* .:: :. : ... *: **: :: ::. ** :
MUL_3920|M.ulcerans_Agy99 LLTNANKATTVLAERSNQVVSLIANTNALLAELTTQRAALDHISGNIAAL
MMAR_4053|M.marinum_M LLTNANKATTVLAERSNQVVSLIANTNALLAELTTQRAALDHISGNIAAL
Mflv_2103|M.gilvum_PYR-GCK LLANANKATTVLAERSEQVVGLVSNTNALLAELQNQSAAVDQISGNISAL
Mvan_4602|M.vanbaalenii_PYR-1 LLGNADKATTVLAERSNQVVSLIANSNALLIELENQSAALDQISGNISAL
MAV_2534|M.avium_104 LLSNANKATTVLAERSDEVAKLVRDTNALLRQLRSQSSALEQISNNLAAL
Rv1968|M.tuberculosis_H37Rv LLANAAKATGVLANRTDQIVGLVRDTNVVLAQLRTQSAALDRIWANISAV
MSMEG_0348|M.smegmatis_MC2_155 LLANARKATAVLATRTDQVVGLVQDSNALLAELRTQSDALDRVSQDISRA
TH_4453|M.thermoresistible__bu LLENARKATGVLGERSQQIAALVRDSNALLVQLRTESAALDQLSANISAL
MAB_4151c|M.abscessus_ATCC_199 LLTHAKSVSGILSERAGQVNKLVTDGNQLFAALDERRLAISELINRIQGL
Mb0177|M.bovis_AF2122/97 LLAQANQVASILGDRSDQVDRLLVNAKTLIAAFNERGRAVDALLGNISAF
MLBr_02591|M.leprae_Br4923 LIAQANQVASVLGDRGAQVDRLLVNTKTLIAAFNERGRAVDALLGNVAAF
*: :* ..: :*. * :: *: : : :: : . *:. : :
MUL_3920|M.ulcerans_Agy99 GQQLHGLIAENEATMRPALDKLNGVLTILDNRKERLQKAIKLLDDYTMSL
MMAR_4053|M.marinum_M GQQLHGLIAENEATMRPALDKLNGVLTILDNRKERLQKAIKLLDDYTMSL
Mflv_2103|M.gilvum_PYR-GCK SAQLQGFIGENRDTMKPALDKLNGVLTILDNRKERLQKSLSLLNDYSMSL
Mvan_4602|M.vanbaalenii_PYR-1 SDQLVGFIAENRETLKPALDKLNGVLTIIDNRKERLQKSIHLLQQYSMSL
MAV_2534|M.avium_104 ARQLKGFIAENRDTLKPALDKLNSVLAIVDNRKENVQKALVGLNKYALGL
Rv1968|M.tuberculosis_H37Rv AEQLRGFIAENRQQLRPALDKLNGVLAIVENRKERVRQAIPLINTYVMSL
MSMEG_0348|M.smegmatis_MC2_155 ATQLRGFMADNRQQLRPMLDKLNGVLTIVDNRKDRLQEAVKLLNKYALSL
TH_4453|M.thermoresistible__bu AQQVSGFISENHDTLSPALEKLNGVLTIVENRKEQVQDALHLAQGYHTRL
MAB_4151c|M.abscessus_ATCC_199 SQQISGFVADNRQEFRPTMEKLSVVLDDLLDRKAHISEALKRLPGYGTAL
Mb0177|M.bovis_AF2122/97 SAQVQNLINDN-PNLNHVLEQLRILTDLLVDRKEDLAETLTILGRFSASF
MLBr_02591|M.leprae_Br4923 AAQVQRLINDN-PNLNHVLEQLHQLSGILVQHKDDLANTLIQVAAFLPSL
. *: :: :* : :::* : : ::* : .:: : :
MUL_3920|M.ulcerans_Agy99 GESVSSGPFFKTYVANLAPGQFVQPFIDAAFSDLGLDPNVLLPSQ-----
MMAR_4053|M.marinum_M GESVSSGPFFKTYVANLAPGQFVQPFIDAAFSDLGLDPNVLLPSQ-----
Mflv_2103|M.gilvum_PYR-GCK GESVSAGPFFKTYVANLLPGQFLQPFIDVAFSDLGLDPNVLLPSQ-----
Mvan_4602|M.vanbaalenii_PYR-1 GESVASGPFFKTYVANLLPGQFLQPFIDSAFSDLGVDPSVLLPSE-----
MAV_2534|M.avium_104 GESVSSGPFFKAYVVNLFPGQFVQPFIDAAFSDLGLDPNVLLPSQ-----
Rv1968|M.tuberculosis_H37Rv GESLSSGPFFKAYVVNLLPGQFVQPFISAAFSDLGLDPATLLPSQ-----
MSMEG_0348|M.smegmatis_MC2_155 GESVGSGPFFKAYIPNLIPGQFSQPFIDAAFSDLGLDPATLLPSQ-----
TH_4453|M.thermoresistible__bu GEAVSSGPFFNSYVANLLPGQFVQPFIDAAFSDLGLDPNVLLPSQ-----
MAB_4151c|M.abscessus_ATCC_199 GEVVSSGPGFHVNVYGFPPATLTAVAFDTYF-------------------
Mb0177|M.bovis_AF2122/97 GETFASGPYFKVLLANLVPGQILQPFVDAAFKKRGISPEDFWRSAGLPAY
MLBr_02591|M.leprae_Br4923 NEAIGSGPFFKVVLHNLAPYQILQPWVDAAFKKRGIDPENFWRSAGLPEF
.* ..:** *: : .: * : .. *
MUL_3920|M.ulcerans_Agy99 ----------------------RTDPPIGQPGTP----------------
MMAR_4053|M.marinum_M ----------------------RTDPPIGQPGTP----------------
Mflv_2103|M.gilvum_PYR-GCK ----------------------RSDPQVGQPGTP----------------
Mvan_4602|M.vanbaalenii_PYR-1 ----------------------LTDPPVGQPGTP----------------
MAV_2534|M.avium_104 ----------------------RADPQVGQPATP----------------
Rv1968|M.tuberculosis_H37Rv ----------------------LTDPPTGQPGTP----------------
MSMEG_0348|M.smegmatis_MC2_155 ----------------------LVDPPVGQPGTP----------------
TH_4453|M.thermoresistible__bu ----------------------LNDPQVGQPGTP----------------
MAB_4151c|M.abscessus_ATCC_199 -----------------------------QPGKL----------------
Mb0177|M.bovis_AF2122/97 RWPDPNGTRFPNGAPPPPPPVLEGTPEHPGPAVPPGSPCSYTPPADG---
MLBr_02591|M.leprae_Br4923 RFPDPNGTRFPNGAPPPAPPVLEGTPENPGPAVPPGSPCSYTPAHPGGNN
*.
MUL_3920|M.ulcerans_Agy99 -------------PLPLPFPRTGQGGEPHRKLPDAITGNPDDP-------
MMAR_4053|M.marinum_M -------------PLPLPFPRTGQGGEPHLKLPDAITGNPDDP-------
Mflv_2103|M.gilvum_PYR-GCK -------------AMPVPFPRTGQGGEPRMTIPDAITGNPGDAGCGPPGI
Mvan_4602|M.vanbaalenii_PYR-1 -------------AMPGQYPRTGQGGEPRLTVPDAITGNPGDQACGLPGL
MAV_2534|M.avium_104 -------------PLPMPFPRTGQGGEPRMTLPDAITGNPGDHPCGSPGA
Rv1968|M.tuberculosis_H37Rv -------------PLPMPYPRTGQGGEPRLTLPDAITGNPGDP-------
MSMEG_0348|M.smegmatis_MC2_155 -------------ALPVPYPRTGQGGEPRLNLPDAITGNPGDP-------
TH_4453|M.thermoresistible__bu -------------AAPVPYPRTGQGGGPRLTLPDAITGNPGDP-------
MAB_4151c|M.abscessus_ATCC_199 -------------PASLSDYLNGLIGERQIMRPKSP--------------
Mb0177|M.bovis_AF2122/97 -------LPRPWDPLPCANLTQGPFGGPDFPAPLDVATSPPNPDGPPPAP
MLBr_02591|M.leprae_Br4923 TIGDEMGLPRPWNPLPCAGATAGPYGGPAFPAPIDVQTSPPNPDGLPLLP
. . * * *
MUL_3920|M.ulcerans_Agy99 -------RYPYREPLPAPPPGGPPPGPPAPAPPELASIPQPTPSSVLVPA
MMAR_4053|M.marinum_M -------RYPYREPLPAPPPGGPPPGPPAPAPPELASIPQPTPSSVLVPA
Mflv_2103|M.gilvum_PYR-GCK PLPGPTGCYPYREPLPAPPPGGPPPGPPAVSPPGLASTPTPDTG-LLVPA
Mvan_4602|M.vanbaalenii_PYR-1 PLPGP-GCYPYREPLPAPPPGGPPPGPPAEAQPGQQSIPGPTPAPVLVPA
MAV_2534|M.avium_104 ASSGP-GCYPYREPLPAPPPGGPPPGPPAQ--PGQGAGQS-------APL
Rv1968|M.tuberculosis_H37Rv -------RYPYRPEPPAPPPGGPPPGPPAQ-------------------Q
MSMEG_0348|M.smegmatis_MC2_155 -------RYPYREPPPAPAPGGPPPGPPAPPVPGLESTPSPTPSPVYVPA
TH_4453|M.thermoresistible__bu -------RYPYREPLPAPPPGGPPPGPPAAIPPVPVREPVFVPAPN-EVS
MAB_4151c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0177|M.bovis_AF2122/97 GLPIAGRPGEVPPNVPGTPVPIPQEAPPGARTLPLGPAPGPAPPPAAPGP
MLBr_02591|M.leprae_Br4923 GIAIAGRPGDPAPNVPGTPVPLPPNAPPGARTEQLAPA---AP---AQDS
MUL_3920|M.ulcerans_Agy99 PGEVSAPQ--TAGAGR---------------
MMAR_4053|M.marinum_M PGEVSAPQ--TAGAGR---------------
Mflv_2103|M.gilvum_PYR-GCK PGEAPPLVPVPGEGTR---------------
Mvan_4602|M.vanbaalenii_PYR-1 PGETPHLG--SAEAGQ---------------
MAV_2534|M.avium_104 PGPAQPGE---GGEGR---------------
Rv1968|M.tuberculosis_H37Rv PGDQP--------------------------
MSMEG_0348|M.smegmatis_MC2_155 PGEPTTPI--PAGEGR---------------
TH_4453|M.thermoresistible__bu AGEPDTPE--IDGESQ---------------
MAB_4151c|M.abscessus_ATCC_199 -------------------------------
Mb0177|M.bovis_AF2122/97 PAPPGPGPQLPAPFINPGGTGGSGVTGGSEN
MLBr_02591|M.leprae_Br4923 SAPHEPREQLSAPLINPGGTGGSGGAGGSRN