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LKYRGSQLARAGFIGVVLIILVIAVGLQPERLLSWATAIRYQALFAEAGGLTVGNDVTVSGIKVGSVSSI ELDNGDALVGFTIDGKYALGSDTTAHIRTGTLLGERVLALDSDGSGTLDPQQVIPTTRTSSPYSLTDAVS ELTANTRDTDTASLNQSLDTLAQTLDQVAPQLGPTFDGLSRLSQSLNSRNESLAELLRTAGDVTGIFSER SSQVNALILNANDLLAVLNERRYAITSLLANISAVSQQLSGVVADNEAELAPALERLNNVTQMLEKNRDN LAKMLPGAAKYYLTQGEIVSNGAYYNALIPNIQPAQLLQPFLDYAFGFRNGVDIGQPPDNAGPRAQLPFP VNSLPQPGDLPNDGNP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4148 | - | - | 100% (367) | virulence factor Mce family protein |
| M. vanbaalenii PYR-1 | Mvan_2853 | - | e-130 | 64.33% (356) | virulence factor Mce family protein |
| M. vanbaalenii PYR-1 | Mvan_0136 | - | 4e-62 | 32.91% (395) | virulence factor Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3527c | mce4C | 2e-59 | 38.80% (317) | MCE-family protein MCE4C |
| M. gilvum PYR-GCK | Mflv_2510 | - | 0.0 | 94.01% (367) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv3497c | mce4C | 2e-59 | 38.80% (317) | MCE-family protein MCE4C |
| M. leprae Br4923 | MLBr_02591 | mce1C | 2e-49 | 29.97% (367) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_4151c | - | 4e-55 | 37.54% (317) | MCE-family protein |
| M. marinum M | MMAR_4708 | - | 1e-130 | 66.57% (356) | MCE-family protein |
| M. avium 104 | MAV_0950 | - | 1e-120 | 60.61% (358) | virulence factor Mce family protein |
| M. smegmatis MC2 155 | MSMEG_2857 | - | 1e-133 | 64.61% (356) | virulence factor Mce family protein |
| M. thermoresistible (build 8) | TH_4269 | - | 1e-142 | 68.82% (356) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_3920 | mce3C_1 | 4e-63 | 39.71% (350) | MCE-family protein, Mce3C_1 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3527c|M.bovis_AF2122/97 MLNRKPSSKHERDPLRTGIFGLVLVICVVLIAFGYSGLPFWPQGKTYDAY
Rv3497c|M.tuberculosis_H37Rv MLNRKPSSKHERDPLRTGIFGLVLVICVVLIAFGYSGLPFWPQGKTYDAY
MAB_4151c|M.abscessus_ATCC_199 -MPSKMSDIQEKDPVRTGIFGIAVVSMLVLVAFGYTGLPFWPQGKQYTGY
MUL_3920|M.ulcerans_Agy99 -----MKSFAERNQIVVGAVELAITIGIVVGSLQYDKLPLFQSGKQYSAC
Mvan_4148|M.vanbaalenii_PYR-1 -----MLKYRGSQLARAGFIGVVLIILVIAVGLQPERLLSWATAIRYQAL
Mflv_2510|M.gilvum_PYR-GCK -----MLKYRGSQLIRAGFIGVILIILVIAVGLQPERLLSWATAIRYQAL
TH_4269|M.thermoresistible__bu -----MRKYRETNLMRAGFIGFVLIVLVITIGLQPERIIQWATSIRYQAL
MMAR_4708|M.marinum_M -----MLKYRGAGLIRAGFIGAVLIVLVIAVGLNPEQLLQRATTVRYQAL
MAV_0950|M.avium_104 -----MLKYRGSGLVKAGLIGVVLAVMVILVGLSPDRFIAWATMVRYQAL
MSMEG_2857|M.smegmatis_MC2_155 -----MHKYRGTRLIRTGLLGLVLVVLIIVVGLQPQQLIQMATSVRYHAE
MLBr_02591|M.leprae_Br4923 -----MRTLELPNRLRSGLIGVLVVLLIIGVGQSFTSVPILFARPSYYGQ
* . : :: . . * .
Mb3527c|M.bovis_AF2122/97 FTDAGGITPGNSVYVSGLKVGAVSAVSLAGNSAKVTFSVDRSIVVGDQSL
Rv3497c|M.tuberculosis_H37Rv FTDAGGITPGNSVYVSGLKVGAVSAVSLAGNSAKVTFSVDRSIVVGDQSL
MAB_4151c|M.abscessus_ATCC_199 FADSGGLESGGNVFVSGIKVGQVKDVSLAGNKVRVDFTVDRSIRLGDQSL
MUL_3920|M.ulcerans_Agy99 FADAGGLTTGVRVQVSGFRVGEVSSIELDGPQVLVKFTVDKHIRLGDHTE
Mvan_4148|M.vanbaalenii_PYR-1 FAEAGGLTVGNDVTVSGIKVGSVSSIELDNGDALVGFTIDGKYALGSDTT
Mflv_2510|M.gilvum_PYR-GCK FTEAGGLTVGNDVTVSGIKVGSVSSIKLDNGDALVGFTIDGKYALGSDTT
TH_4269|M.thermoresistible__bu FSEAGGITVGNDVTISGIKVGTVNEVTLHDGDALVTFTVAGKHQLGAQTT
MMAR_4708|M.marinum_M FSDAGGLAVGNDVTVSGIKVGTVSGMSLQRGDVLVTFTVNGGVELGADST
MAV_0950|M.avium_104 FTEAGGLATGNPVVVSGMKVGTVSDVKLHRGDALVTFALKGNILLGSETT
MSMEG_2857|M.smegmatis_MC2_155 FAEAGGLTAGNEVKVSGVTVGTVSDVELVNGRARVTFALDGKTRLGQDTT
MLBr_02591|M.leprae_Br4923 FTDTGGLNKGDKVRIAGMDVGKVEALKIDGDHVVIKFSIG-TNRIGTASR
*:::**: * * ::*. ** *. : : . : *:: :* :
Mb3527c|M.bovis_AF2122/97 AAIRTDTILGERSIAVSPAGSGKST---TIPLSRTTTPYTLNGVLQDLGR
Rv3497c|M.tuberculosis_H37Rv AAIRTDTILGERSIAVSPAGSGKST---TIPLSRTTTPYTLNGVLQDLGR
MAB_4151c|M.abscessus_ATCC_199 AAIRTTTVLGEKSLSVTPAGAGRIT---EIPLGRTTTPYTLNSALSDLGA
MUL_3920|M.ulcerans_Agy99 AAIKTRGLLGTKMLEVISRGDGQLQG--TIPLDRTRSPYQLPDALGDLAT
Mvan_4148|M.vanbaalenii_PYR-1 AHIRTGTLLGERVLALDSDGSGTLDPQQVIPTTRTSSPYSLTDAVSELTA
Mflv_2510|M.gilvum_PYR-GCK AHIRTGTLLGERVLALDSEGSGTLDPQQVIPTTRTSSPYSLTDAVSELTS
TH_4269|M.thermoresistible__bu AHIRTGSLLGERVITLESYGSEPLRGTDVIPTSRTSSPYSLTDAVGDLAT
MMAR_4708|M.marinum_M AHIRTGSLLGQRVLTVESAGGHTLRPMAVIPVSRTSSPYSLSEAVSDAAT
MAV_0950|M.avium_104 AHIRTGTLLGERMLTLESAGTGTMHPMALIPVSRTSSPYSLTEAVSDLTT
MSMEG_2857|M.smegmatis_MC2_155 AHIRTGTLLGQRVLTVEPKGSGRIGPSGVIPVSRTGSPYSLTDAVGDFTT
MLBr_02591|M.leprae_Br4923 LGIRTDTVLGKKVLEVETRGTQLLRPGDSLPLGQSTTPYQSYDAFFDATK
*:* :** : : : . * :* :: :** .. :
Mb3527c|M.bovis_AF2122/97 NANDLNRPQFEQALNVFTQALHDATPQVRGAVDGLTSLSRALNRRDEALQ
Rv3497c|M.tuberculosis_H37Rv NANDLNRPQFEQALNVFTQALHDATPQVRGAVDGLTSLSRALNRRDEALQ
MAB_4151c|M.abscessus_ATCC_199 SAGGIDKAQLDQSLQVITEAMRDATPQLRGALDGVASLSRTLNARDAALE
MUL_3920|M.ulcerans_Agy99 TISGLNTNQLSDSLRVLADTFSDTPPQLRVAIEGVARFSQTLDERDAQLR
Mvan_4148|M.vanbaalenii_PYR-1 NTRDTDTASLNQSLDTLAQTLDQVAPQLGPTFDGLSRLSQSLNSRNESLA
Mflv_2510|M.gilvum_PYR-GCK NTRDTDTEALNQSLDTLSQTLDQIAPQLGPTFDGLSRLSQSLNSRNDSLA
TH_4269|M.thermoresistible__bu NTAGTDTAALNQALDTLSATIDQIAPRLGPTFDGLSRLSRSLNDRNENLA
MMAR_4708|M.marinum_M DIAGTNTDALNQSLDTLSETLNQIAPQLGPSFDGLTRLSQALNGRNQTLG
MAV_0950|M.avium_104 DTAGTNTTALNQSLDTLAATLDQIAPQMGPAFDALTRLSRTLNSRNKNLG
MSMEG_2857|M.smegmatis_MC2_155 NTAETDTAAINQSLDVLSETIERIAPQLAPTFDGITRLSQSLNNRNESLA
MLBr_02591|M.leprae_Br4923 VASGWNIDTIKQSLKVVSETIDQTYPHLSAALDGVAKFSDTIGARDKEIK
: :.::* ..: :: *:: :.:.:: :* ::. *: :
Mb3527c|M.bovis_AF2122/97 GLLAHAKSVTSVLSERAEQVNKLVEDGNQLFAALDARRAALSALISGIDD
Rv3497c|M.tuberculosis_H37Rv GLLAHAKSVTSVLSERAEQVNKLVEDGNQLFAALDARRAALSALISGIDD
MAB_4151c|M.abscessus_ATCC_199 QLLTHAKSVSGILSERAGQVNKLVTDGNQLFAALDERRLAISELINRIQG
MUL_3920|M.ulcerans_Agy99 GLLTNANKATTVLAERSNQVVSLIANTNALLAELTTQRAALDHISGNIAA
Mvan_4148|M.vanbaalenii_PYR-1 ELLRTAGDVTGIFSERSSQVNALILNANDLLAVLNERRYAITSLLANISA
Mflv_2510|M.gilvum_PYR-GCK ELLRTAGEVTGIFSERSKQVNTLILNSNDLLAVLNERRYAITSLLSNISA
TH_4269|M.thermoresistible__bu GLLASAGEVTKVLAERSQQLNTLILNANDLLAVLNERREAIVTLLANTSA
MMAR_4708|M.marinum_M ELLKGAADVTGILSQRSQQLNTLILNADDLLSMLVARRQAIVRLLASTSA
MAV_0950|M.avium_104 ELFKSAGDVTGVLSERSQQVNKLILNSDVLLQVLVARRQEIVDLLANTSA
MSMEG_2857|M.smegmatis_MC2_155 DLLKSASEITGILSERSEQVNRLILNANDLLAVVRDRRYVIVNLLANTSA
MLBr_02591|M.leprae_Br4923 HLIAQANQVASVLGDRGAQVDRLLVNTKTLIAAFNERGRAVDALLGNVAA
*: * . : ::.:*. *: *: : . *: . : : :
Mb3527c|M.bovis_AF2122/97 VAAQISGFVADNRKEFGPALSKLNLVLANLNERRDYITEALKRLPTYATT
Rv3497c|M.tuberculosis_H37Rv VAAQISGFVADNRKEFGPALSKLNLVLANLNERRDYITEALKRLPTYATT
MAB_4151c|M.abscessus_ATCC_199 LSQQISGFVADNRQEFRPTMEKLSVVLDDLLDRKAHISEALKRLPGYGTA
MUL_3920|M.ulcerans_Agy99 LGQQLHGLIAENEATMRPALDKLNGVLTILDNRKERLQKAIKLLDDYTMS
Mvan_4148|M.vanbaalenii_PYR-1 VSQQLSGVVADNEAELAPALERLNNVTQMLEKNRDNLAKMLPGAAKYYLT
Mflv_2510|M.gilvum_PYR-GCK VSQQLSGLVADNEAELAPALERLNNVTRMLEKNRDNLARMLPGAAKYYLT
TH_4269|M.thermoresistible__bu VAQELTALVADNEAELAPTLERLNSVMEMLERNRDNIAKILPNLKKFILA
MMAR_4708|M.marinum_M VAKQLSGLVHDNESKLAPTLERLNAVTAMLEKNRDNLAKALPGLAKYELT
MAV_0950|M.avium_104 VAKQLTALVHDNESKLAPTLERLNSVTAMLEKNRDNISKALPGLKKFEIT
MSMEG_2857|M.smegmatis_MC2_155 VARQLSALVSDNEAELAPALEKLNKVLAMLERNRDNLTASLKGLAKYQLT
MLBr_02591|M.leprae_Br4923 FAAQVQRLINDN-PNLNHVLEQLHQLSGILVQHKDDLANTLIQVAAFLPS
.. :: .: :* : .:.:* : * .: : : : :
Mb3527c|M.bovis_AF2122/97 LGEVVGSGPGFNVNVYSVLPGPLVATVFDLVF------------------
Rv3497c|M.tuberculosis_H37Rv LGEVVGSGPGFNVNVYSVLPGPLVATVFDLVF------------------
MAB_4151c|M.abscessus_ATCC_199 LGEVVSSGPGFHVNVYGFPPATLTAVAFDTYF------------------
MUL_3920|M.ulcerans_Agy99 LGESVSSGPFFKTYVANLAPGQFVQPFIDAAFSDLGLDPNVLLPSQRTDP
Mvan_4148|M.vanbaalenii_PYR-1 QGEIVSNGAYYNALIPNIQPAQLLQPFLDYAFG-----------------
Mflv_2510|M.gilvum_PYR-GCK QGEIVSNGAYYNALVPNVQPAQLLQPFLEYAFG-----------------
TH_4269|M.thermoresistible__bu QGETLANGPYYNAFVPNLNPAQILQPFLDYAFG-----------------
MMAR_4708|M.marinum_M QGETVSSGFYYNPFIPNLFTIQFFQWFIDYAFG-----------------
MAV_0950|M.avium_104 VGEAISSMYAYSAFVPNFLAPQLFQPFLDYLWG-----------------
MSMEG_2857|M.smegmatis_MC2_155 QGEAVNNGFYYYGFASNLLPGPAIQPFLDYALG-----------------
MLBr_02591|M.leprae_Br4923 LNEAIGSGPFFKVVLHNLAPYQILQPWVDAAFKKRGIDPENFWRSAGLPE
.* : . : .. . .:
Mb3527c|M.bovis_AF2122/97 ---QPGK---------------------------LPDS---------LAD
Rv3497c|M.tuberculosis_H37Rv ---QPGK---------------------------LPDS---------LAD
MAB_4151c|M.abscessus_ATCC_199 ---QPGK---------------------------LPAS---------LSD
MUL_3920|M.ulcerans_Agy99 PIGQPGTPPLPLP---------------------FPRTGQGGEPHRKLPD
Mvan_4148|M.vanbaalenii_PYR-1 --FRNGV-------------------------------------DIGQPP
Mflv_2510|M.gilvum_PYR-GCK --FRNGV-------------------------------------DIGQPP
TH_4269|M.thermoresistible__bu --FRRGT-------------------------------------NAGQPP
MMAR_4708|M.marinum_M --FRAHG-------------------------------------APGQPP
MAV_0950|M.avium_104 --FRTFDT------------------------------------ARGPGH
MSMEG_2857|M.smegmatis_MC2_155 --FRRGV-------------------------------------NAGQPP
MLBr_02591|M.leprae_Br4923 FRFPDPNGTRFPNGAPPPAPPVLEGTPENPGPAVPPGSPCSYTPAHPGGN
Mb3527c|M.bovis_AF2122/97 YLRGFIQE-RWIIRPKSP--------------------------------
Rv3497c|M.tuberculosis_H37Rv YLRGFIQE-RWIIRPKSP--------------------------------
MAB_4151c|M.abscessus_ATCC_199 YLNGLIGE-RQIMRPKSP--------------------------------
MUL_3920|M.ulcerans_Agy99 AITGNPDDPRYPYREPLPAPPPGGPPPGPPAPAPPELASIPQPTPSSVLV
Mvan_4148|M.vanbaalenii_PYR-1 DNAGPRAQLPFPVNSLPQPGDLP----NDGNP------------------
Mflv_2510|M.gilvum_PYR-GCK DNAGPRAQLPFPVNSLPQPGDLP----NDGNP------------------
TH_4269|M.thermoresistible__bu DTVGPRAELPLPYNAIPG-----------GTR------------------
MMAR_4708|M.marinum_M DNAGPRALFPFPFNQNP-----------GGSR------------------
MAV_0950|M.avium_104 PSPVPRSLIPWPYNGIPVCPGCTLGGRVGGSQ------------------
MSMEG_2857|M.smegmatis_MC2_155 DNAGPRAEFPFPNNGIPG-----------G--------------------
MLBr_02591|M.leprae_Br4923 NTIGDEMGLPRPWNPLPCAGATAGPYGGPAFPAPIDVQTSPPNPDGLPLL
.
Mb3527c|M.bovis_AF2122/97 --------------------------------------------------
Rv3497c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4151c|M.abscessus_ATCC_199 --------------------------------------------------
MUL_3920|M.ulcerans_Agy99 PAPGEVSAPQTAGAGR----------------------------------
Mvan_4148|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2510|M.gilvum_PYR-GCK --------------------------------------------------
TH_4269|M.thermoresistible__bu --------------------------------------------------
MMAR_4708|M.marinum_M --------------------------------------------------
MAV_0950|M.avium_104 --------------------------------------------------
MSMEG_2857|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_02591|M.leprae_Br4923 PGIAIAGRPGDPAPNVPGTPVPLPPNAPPGARTEQLAPAAPAQDSSAPHE
Mb3527c|M.bovis_AF2122/97 --------------------------
Rv3497c|M.tuberculosis_H37Rv --------------------------
MAB_4151c|M.abscessus_ATCC_199 --------------------------
MUL_3920|M.ulcerans_Agy99 --------------------------
Mvan_4148|M.vanbaalenii_PYR-1 --------------------------
Mflv_2510|M.gilvum_PYR-GCK --------------------------
TH_4269|M.thermoresistible__bu --------------------------
MMAR_4708|M.marinum_M --------------------------
MAV_0950|M.avium_104 --------------------------
MSMEG_2857|M.smegmatis_MC2_155 --------------------------
MLBr_02591|M.leprae_Br4923 PREQLSAPLINPGGTGGSGGAGGSRN