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LKYRGAGLIRAGFIGAVLIVLVIAVGLNPEQLLQRATTVRYQALFSDAGGLAVGNDVTVSGIKVGTVSGM SLQRGDVLVTFTVNGGVELGADSTAHIRTGSLLGQRVLTVESAGGHTLRPMAVIPVSRTSSPYSLSEAVS DAATDIAGTNTDALNQSLDTLSETLNQIAPQLGPSFDGLTRLSQALNGRNQTLGELLKGAADVTGILSQR SQQLNTLILNADDLLSMLVARRQAIVRLLASTSAVAKQLSGLVHDNESKLAPTLERLNAVTAMLEKNRDN LAKALPGLAKYELTQGETVSSGFYYNPFIPNLFTIQFFQWFIDYAFGFRAHGAPGQPPDNAGPRALFPFP FNQNPGGSR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4708 | - | - | 100% (360) | MCE-family protein |
| M. marinum M | MMAR_4053 | mce3C_1 | 2e-55 | 38.68% (318) | MCE-family protein, Mce3C_1 |
| M. marinum M | MMAR_4985 | mce4C | 8e-54 | 37.35% (332) | MCE-family protein Mce4C |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3527c | mce4C | 5e-53 | 36.45% (332) | MCE-family protein MCE4C |
| M. gilvum PYR-GCK | Mflv_2510 | - | 1e-131 | 66.29% (356) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv1968 | mce3C | 2e-53 | 34.95% (372) | MCE-family protein MCE3C |
| M. leprae Br4923 | MLBr_02591 | mce1C | 9e-46 | 30.77% (351) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_4151c | - | 2e-48 | 36.75% (302) | MCE-family protein |
| M. avium 104 | MAV_0950 | - | 1e-132 | 66.57% (359) | virulence factor Mce family protein |
| M. smegmatis MC2 155 | MSMEG_2857 | - | 1e-122 | 62.57% (358) | virulence factor Mce family protein |
| M. thermoresistible (build 8) | TH_4269 | - | 1e-129 | 65.00% (360) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_3920 | mce3C_1 | 2e-55 | 39.24% (316) | MCE-family protein, Mce3C_1 |
| M. vanbaalenii PYR-1 | Mvan_4148 | - | 1e-130 | 66.57% (356) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3527c|M.bovis_AF2122/97 MLNRKPSSKHERDPLRTGIFGLVLVICVVLIAFGYSGLPFWPQGKTYDAY
MAB_4151c|M.abscessus_ATCC_199 -MPSKMSDIQEKDPVRTGIFGIAVVSMLVLVAFGYTGLPFWPQGKQYTGY
Rv1968|M.tuberculosis_H37Rv -----MKSFAERNRLAIGTVGIVVVAAVALAALQYQRLPFFNQGTRVSAY
MUL_3920|M.ulcerans_Agy99 -----MKSFAERNQIVVGAVELAITIGIVVGSLQYDKLPLFQSGKQYSAC
MMAR_4708|M.marinum_M -----MLKYRGAGLIRAGFIGAVLIVLVIAVGLNPEQLLQRATTVRYQAL
MAV_0950|M.avium_104 -----MLKYRGSGLVKAGLIGVVLAVMVILVGLSPDRFIAWATMVRYQAL
Mflv_2510|M.gilvum_PYR-GCK -----MLKYRGSQLIRAGFIGVILIILVIAVGLQPERLLSWATAIRYQAL
Mvan_4148|M.vanbaalenii_PYR-1 -----MLKYRGSQLARAGFIGVVLIILVIAVGLQPERLLSWATAIRYQAL
TH_4269|M.thermoresistible__bu -----MRKYRETNLMRAGFIGFVLIVLVITIGLQPERIIQWATSIRYQAL
MSMEG_2857|M.smegmatis_MC2_155 -----MHKYRGTRLIRTGLLGLVLVVLIIVVGLQPQQLIQMATSVRYHAE
MLBr_02591|M.leprae_Br4923 -----MRTLELPNRLRSGLIGVLVVLLIIGVGQSFTSVPILFARPSYYGQ
* . : : . . .
Mb3527c|M.bovis_AF2122/97 FTDAGGITPGNSVYVSGLKVGAVSAVSLAGNSAKVTFSVDRSIVVGDQSL
MAB_4151c|M.abscessus_ATCC_199 FADSGGLESGGNVFVSGIKVGQVKDVSLAGNKVRVDFTVDRSIRLGDQSL
Rv1968|M.tuberculosis_H37Rv FADAGGLRTGNTVEVSGYPVGKVSSISLDGPGVLVEFKVDTDVRLGNRTE
MUL_3920|M.ulcerans_Agy99 FADAGGLTTGVRVQVSGFRVGEVSSIELDGPQVLVKFTVDKHIRLGDHTE
MMAR_4708|M.marinum_M FSDAGGLAVGNDVTVSGIKVGTVSGMSLQRGDVLVTFTVNGGVELGADST
MAV_0950|M.avium_104 FTEAGGLATGNPVVVSGMKVGTVSDVKLHRGDALVTFALKGNILLGSETT
Mflv_2510|M.gilvum_PYR-GCK FTEAGGLTVGNDVTVSGIKVGSVSSIKLDNGDALVGFTIDGKYALGSDTT
Mvan_4148|M.vanbaalenii_PYR-1 FAEAGGLTVGNDVTVSGIKVGSVSSIELDNGDALVGFTIDGKYALGSDTT
TH_4269|M.thermoresistible__bu FSEAGGITVGNDVTISGIKVGTVNEVTLHDGDALVTFTVAGKHQLGAQTT
MSMEG_2857|M.smegmatis_MC2_155 FAEAGGLTAGNEVKVSGVTVGTVSDVELVNGRARVTFALDGKTRLGQDTT
MLBr_02591|M.leprae_Br4923 FTDTGGLNKGDKVRIAGMDVGKVEALKIDGDHVVIKFSIG-TNRIGTASR
*:::**: * * ::* ** *. : : . : * : :* :
Mb3527c|M.bovis_AF2122/97 AAIRTDTILGERSIAVSPAGSGKST---TIPLSRTTTPYTLNGVLQDLGR
MAB_4151c|M.abscessus_ATCC_199 AAIRTTTVLGEKSLSVTPAGAGRIT---EIPLGRTTTPYTLNSALSDLGA
Rv1968|M.tuberculosis_H37Rv VAIKTKGLLGSKFLDVTPRGDGRLDS--PIPIERTTSPYQLPDALGDLAA
MUL_3920|M.ulcerans_Agy99 AAIKTRGLLGTKMLEVISRGDGQLQG--TIPLDRTRSPYQLPDALGDLAT
MMAR_4708|M.marinum_M AHIRTGSLLGQRVLTVESAGGHTLRPMAVIPVSRTSSPYSLSEAVSDAAT
MAV_0950|M.avium_104 AHIRTGTLLGERMLTLESAGTGTMHPMALIPVSRTSSPYSLTEAVSDLTT
Mflv_2510|M.gilvum_PYR-GCK AHIRTGTLLGERVLALDSEGSGTLDPQQVIPTTRTSSPYSLTDAVSELTS
Mvan_4148|M.vanbaalenii_PYR-1 AHIRTGTLLGERVLALDSDGSGTLDPQQVIPTTRTSSPYSLTDAVSELTA
TH_4269|M.thermoresistible__bu AHIRTGSLLGERVITLESYGSEPLRGTDVIPTSRTSSPYSLTDAVGDLAT
MSMEG_2857|M.smegmatis_MC2_155 AHIRTGTLLGQRVLTVEPKGSGRIGPSGVIPVSRTGSPYSLTDAVGDFTT
MLBr_02591|M.leprae_Br4923 LGIRTDTVLGKKVLEVETRGTQLLRPGDSLPLGQSTTPYQSYDAFFDATK
*:* :** : : : . * :* :: :** .. :
Mb3527c|M.bovis_AF2122/97 NANDLNRPQFEQALNVFTQALHDATPQVRGAVDGLTSLSRALNRRDEALQ
MAB_4151c|M.abscessus_ATCC_199 SAGGIDKAQLDQSLQVITEAMRDATPQLRGALDGVASLSRTLNARDAALE
Rv1968|M.tuberculosis_H37Rv TISGLHTERLSESLATLAQTFADTPAHFRNAIHGVARLAQTLDERDNQLR
MUL_3920|M.ulcerans_Agy99 TISGLNTNQLSDSLRVLADTFSDTPPQLRVAIEGVARFSQTLDERDAQLR
MMAR_4708|M.marinum_M DIAGTNTDALNQSLDTLSETLNQIAPQLGPSFDGLTRLSQALNGRNQTLG
MAV_0950|M.avium_104 DTAGTNTTALNQSLDTLAATLDQIAPQMGPAFDALTRLSRTLNSRNKNLG
Mflv_2510|M.gilvum_PYR-GCK NTRDTDTEALNQSLDTLSQTLDQIAPQLGPTFDGLSRLSQSLNSRNDSLA
Mvan_4148|M.vanbaalenii_PYR-1 NTRDTDTASLNQSLDTLAQTLDQVAPQLGPTFDGLSRLSQSLNSRNESLA
TH_4269|M.thermoresistible__bu NTAGTDTAALNQALDTLSATIDQIAPRLGPTFDGLSRLSRSLNDRNENLA
MSMEG_2857|M.smegmatis_MC2_155 NTAETDTAAINQSLDVLSETIERIAPQLAPTFDGITRLSQSLNNRNESLA
MLBr_02591|M.leprae_Br4923 VASGWNIDTIKQSLKVVSETIDQTYPHLSAALDGVAKFSDTIGARDKEIK
. :.::* ..: :: .:. :...:: :: ::. *: :
Mb3527c|M.bovis_AF2122/97 GLLAHAKSVTSVLSERAEQVNKLVEDGNQLFAALDARRAALSALISGIDD
MAB_4151c|M.abscessus_ATCC_199 QLLTHAKSVSGILSERAGQVNKLVTDGNQLFAALDERRLAISELINRIQG
Rv1968|M.tuberculosis_H37Rv SLLANAAKATGVLANRTDQIVGLVRDTNVVLAQLRTQSAALDRIWANISA
MUL_3920|M.ulcerans_Agy99 GLLTNANKATTVLAERSNQVVSLIANTNALLAELTTQRAALDHISGNIAA
MMAR_4708|M.marinum_M ELLKGAADVTGILSQRSQQLNTLILNADDLLSMLVARRQAIVRLLASTSA
MAV_0950|M.avium_104 ELFKSAGDVTGVLSERSQQVNKLILNSDVLLQVLVARRQEIVDLLANTSA
Mflv_2510|M.gilvum_PYR-GCK ELLRTAGEVTGIFSERSKQVNTLILNSNDLLAVLNERRYAITSLLSNISA
Mvan_4148|M.vanbaalenii_PYR-1 ELLRTAGDVTGIFSERSSQVNALILNANDLLAVLNERRYAITSLLANISA
TH_4269|M.thermoresistible__bu GLLASAGEVTKVLAERSQQLNTLILNANDLLAVLNERREAIVTLLANTSA
MSMEG_2857|M.smegmatis_MC2_155 DLLKSASEITGILSERSEQVNRLILNANDLLAVVRDRRYVIVNLLANTSA
MLBr_02591|M.leprae_Br4923 HLIAQANQVASVLGDRGAQVDRLLVNTKTLIAAFNERGRAVDALLGNVAA
*: * . : ::.:* *: *: : . :: . : : :
Mb3527c|M.bovis_AF2122/97 VAAQISGFVADNRKEFGPALSKLNLVLANLNERRDYITEALKRLPTYATT
MAB_4151c|M.abscessus_ATCC_199 LSQQISGFVADNRQEFRPTMEKLSVVLDDLLDRKAHISEALKRLPGYGTA
Rv1968|M.tuberculosis_H37Rv VAEQLRGFIAENRQQLRPALDKLNGVLAIVENRKERVRQAIPLINTYVMS
MUL_3920|M.ulcerans_Agy99 LGQQLHGLIAENEATMRPALDKLNGVLTILDNRKERLQKAIKLLDDYTMS
MMAR_4708|M.marinum_M VAKQLSGLVHDNESKLAPTLERLNAVTAMLEKNRDNLAKALPGLAKYELT
MAV_0950|M.avium_104 VAKQLTALVHDNESKLAPTLERLNSVTAMLEKNRDNISKALPGLKKFEIT
Mflv_2510|M.gilvum_PYR-GCK VSQQLSGLVADNEAELAPALERLNNVTRMLEKNRDNLARMLPGAAKYYLT
Mvan_4148|M.vanbaalenii_PYR-1 VSQQLSGVVADNEAELAPALERLNNVTQMLEKNRDNLAKMLPGAAKYYLT
TH_4269|M.thermoresistible__bu VAQELTALVADNEAELAPTLERLNSVMEMLERNRDNIAKILPNLKKFILA
MSMEG_2857|M.smegmatis_MC2_155 VARQLSALVSDNEAELAPALEKLNKVLAMLERNRDNLTASLKGLAKYQLT
MLBr_02591|M.leprae_Br4923 FAAQVQRLINDN-PNLNHVLEQLHQLSGILVQHKDDLANTLIQVAAFLPS
.. :: .: :* : .:.:* : : .: : : : :
Mb3527c|M.bovis_AF2122/97 LGEVVGSGPGFNVNVYSVLPGPLVATVFDLVF------------------
MAB_4151c|M.abscessus_ATCC_199 LGEVVSSGPGFHVNVYGFPPATLTAVAFDTYF------------------
Rv1968|M.tuberculosis_H37Rv LGESLSSGPFFKAYVVNLLPGQFVQPFISAAFSDLGLDPATLLPSQ----
MUL_3920|M.ulcerans_Agy99 LGESVSSGPFFKTYVANLAPGQFVQPFIDAAFSDLGLDPNVLLPSQ----
MMAR_4708|M.marinum_M QGETVSSGFYYNPFIPNLFTIQFFQWFIDYAFGFRAHG------------
MAV_0950|M.avium_104 VGEAISSMYAYSAFVPNFLAPQLFQPFLDYLWGFRTFDT-----------
Mflv_2510|M.gilvum_PYR-GCK QGEIVSNGAYYNALVPNVQPAQLLQPFLEYAFGFRNGV------------
Mvan_4148|M.vanbaalenii_PYR-1 QGEIVSNGAYYNALIPNIQPAQLLQPFLDYAFGFRNGV------------
TH_4269|M.thermoresistible__bu QGETLANGPYYNAFVPNLNPAQILQPFLDYAFGFRRGT------------
MSMEG_2857|M.smegmatis_MC2_155 QGEAVNNGFYYYGFASNLLPGPAIQPFLDYALGFRRGV------------
MLBr_02591|M.leprae_Br4923 LNEAIGSGPFFKVVLHNLAPYQILQPWVDAAFKKRGIDPENFWRSAGLPE
.* : . : .. . ..
Mb3527c|M.bovis_AF2122/97 -----------QPGKLPD--------------------------------
MAB_4151c|M.abscessus_ATCC_199 -----------QPGKLPA--------------------------------
Rv1968|M.tuberculosis_H37Rv ----LTDPPTGQPGTPPLPMPYPR--------------------------
MUL_3920|M.ulcerans_Agy99 ----RTDPPIGQPGTPPLPLPFPR--------------------------
MMAR_4708|M.marinum_M -----------APGQPPD--------------------------------
MAV_0950|M.avium_104 -----------ARGPGHP--------------------------------
Mflv_2510|M.gilvum_PYR-GCK -----------DIGQPPD--------------------------------
Mvan_4148|M.vanbaalenii_PYR-1 -----------DIGQPPD--------------------------------
TH_4269|M.thermoresistible__bu -----------NAGQPPD--------------------------------
MSMEG_2857|M.smegmatis_MC2_155 -----------NAGQPPD--------------------------------
MLBr_02591|M.leprae_Br4923 FRFPDPNGTRFPNGAPPPAPPVLEGTPENPGPAVPPGSPCSYTPAHPGGN
*
Mb3527c|M.bovis_AF2122/97 -----------------------------SLADYLRGFIQE-RWIIRPKS
MAB_4151c|M.abscessus_ATCC_199 -----------------------------SLSDYLNGLIGE-RQIMRPKS
Rv1968|M.tuberculosis_H37Rv --------------------TGQGGEPRLTLPDAITGNPGDPRYPYRPEP
MUL_3920|M.ulcerans_Agy99 --------------------TGQGGEPHRKLPDAITGNPDDPRYPYREPL
MMAR_4708|M.marinum_M -----------------------NAGPRALFPFPFNQNP-----------
MAV_0950|M.avium_104 -----------------------SPVPRSLIPWPYNGIPVCPGCTLGGRV
Mflv_2510|M.gilvum_PYR-GCK -----------------------NAGPRAQLPFPVNSLPQPGDLP----N
Mvan_4148|M.vanbaalenii_PYR-1 -----------------------NAGPRAQLPFPVNSLPQPGDLP----N
TH_4269|M.thermoresistible__bu -----------------------TVGPRAELPLPYNAIPG----------
MSMEG_2857|M.smegmatis_MC2_155 -----------------------NAGPRAEFPFPNNGIPG----------
MLBr_02591|M.leprae_Br4923 NTIGDEMGLPRPWNPLPCAGATAGPYGGPAFPAPIDVQTSPPNPDGLPLL
:.
Mb3527c|M.bovis_AF2122/97 P-------------------------------------------------
MAB_4151c|M.abscessus_ATCC_199 P-------------------------------------------------
Rv1968|M.tuberculosis_H37Rv PAPPPGGPPPGPPAQQPGDQP-----------------------------
MUL_3920|M.ulcerans_Agy99 PAPPPGGPPPGPPAPAPPELASIPQPTPSSVLVPAPGEVSAPQTAGAGR-
MMAR_4708|M.marinum_M GGSR----------------------------------------------
MAV_0950|M.avium_104 GGSQ----------------------------------------------
Mflv_2510|M.gilvum_PYR-GCK DGNP----------------------------------------------
Mvan_4148|M.vanbaalenii_PYR-1 DGNP----------------------------------------------
TH_4269|M.thermoresistible__bu -GTR----------------------------------------------
MSMEG_2857|M.smegmatis_MC2_155 -G------------------------------------------------
MLBr_02591|M.leprae_Br4923 PGIAIAGRPGDPAPNVPGTPVPLPPNAPPGARTEQLAPAAPAQDSSAPHE
Mb3527c|M.bovis_AF2122/97 --------------------------
MAB_4151c|M.abscessus_ATCC_199 --------------------------
Rv1968|M.tuberculosis_H37Rv --------------------------
MUL_3920|M.ulcerans_Agy99 --------------------------
MMAR_4708|M.marinum_M --------------------------
MAV_0950|M.avium_104 --------------------------
Mflv_2510|M.gilvum_PYR-GCK --------------------------
Mvan_4148|M.vanbaalenii_PYR-1 --------------------------
TH_4269|M.thermoresistible__bu --------------------------
MSMEG_2857|M.smegmatis_MC2_155 --------------------------
MLBr_02591|M.leprae_Br4923 PREQLSAPLINPGGTGGSGGAGGSRN