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MLKYRGSGLVKAGLIGVVLAVMVILVGLSPDRFIAWATMVRYQALFTEAGGLATGNPVVVSGMKVGTVSD VKLHRGDALVTFALKGNILLGSETTAHIRTGTLLGERMLTLESAGTGTMHPMALIPVSRTSSPYSLTEAV SDLTTDTAGTNTTALNQSLDTLAATLDQIAPQMGPAFDALTRLSRTLNSRNKNLGELFKSAGDVTGVLSE RSQQVNKLILNSDVLLQVLVARRQEIVDLLANTSAVAKQLTALVHDNESKLAPTLERLNSVTAMLEKNRD NISKALPGLKKFEITVGEAISSMYAYSAFVPNFLAPQLFQPFLDYLWGFRTFDTARGPGHPSPVPRSLIP WPYNGIPVCPGCTLGGRVGGSQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_0950 | - | - | 100% (372) | virulence factor Mce family protein |
| M. avium 104 | MAV_2063 | - | 1e-55 | 37.82% (312) | virulence factor Mce family protein |
| M. avium 104 | MAV_2534 | - | 9e-54 | 37.18% (312) | virulence factor Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3527c | mce4C | 1e-53 | 37.72% (334) | MCE-family protein MCE4C |
| M. gilvum PYR-GCK | Mflv_2510 | - | 1e-121 | 60.89% (358) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv3497c | mce4C | 1e-53 | 37.72% (334) | MCE-family protein MCE4C |
| M. leprae Br4923 | MLBr_02591 | mce1C | 2e-43 | 29.11% (371) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_4151c | - | 2e-48 | 36.52% (293) | MCE-family protein |
| M. marinum M | MMAR_4708 | - | 1e-132 | 66.57% (359) | MCE-family protein |
| M. smegmatis MC2 155 | MSMEG_2857 | - | 1e-112 | 57.98% (357) | virulence factor Mce family protein |
| M. thermoresistible (build 8) | TH_4269 | - | 1e-121 | 62.57% (358) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_3920 | mce3C_1 | 5e-53 | 34.47% (351) | MCE-family protein, Mce3C_1 |
| M. vanbaalenii PYR-1 | Mvan_4148 | - | 1e-120 | 60.61% (358) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3527c|M.bovis_AF2122/97 MLNRKPSSKHERDPLRTGIFGLVLVICVVLIAFGYSGLPFWPQGKTYDAY
Rv3497c|M.tuberculosis_H37Rv MLNRKPSSKHERDPLRTGIFGLVLVICVVLIAFGYSGLPFWPQGKTYDAY
MAB_4151c|M.abscessus_ATCC_199 -MPSKMSDIQEKDPVRTGIFGIAVVSMLVLVAFGYTGLPFWPQGKQYTGY
MUL_3920|M.ulcerans_Agy99 -----MKSFAERNQIVVGAVELAITIGIVVGSLQYDKLPLFQSGKQYSAC
MAV_0950|M.avium_104 -----MLKYRGSGLVKAGLIGVVLAVMVILVGLSPDRFIAWATMVRYQAL
MMAR_4708|M.marinum_M -----MLKYRGAGLIRAGFIGAVLIVLVIAVGLNPEQLLQRATTVRYQAL
Mflv_2510|M.gilvum_PYR-GCK -----MLKYRGSQLIRAGFIGVILIILVIAVGLQPERLLSWATAIRYQAL
Mvan_4148|M.vanbaalenii_PYR-1 -----MLKYRGSQLARAGFIGVVLIILVIAVGLQPERLLSWATAIRYQAL
TH_4269|M.thermoresistible__bu -----MRKYRETNLMRAGFIGFVLIVLVITIGLQPERIIQWATSIRYQAL
MSMEG_2857|M.smegmatis_MC2_155 -----MHKYRGTRLIRTGLLGLVLVVLIIVVGLQPQQLIQMATSVRYHAE
MLBr_02591|M.leprae_Br4923 -----MRTLELPNRLRSGLIGVLVVLLIIGVGQSFTSVPILFARPSYYGQ
* . : :: . . * .
Mb3527c|M.bovis_AF2122/97 FTDAGGITPGNSVYVSGLKVGAVSAVSLAGNSAKVTFSVDRSIVVGDQSL
Rv3497c|M.tuberculosis_H37Rv FTDAGGITPGNSVYVSGLKVGAVSAVSLAGNSAKVTFSVDRSIVVGDQSL
MAB_4151c|M.abscessus_ATCC_199 FADSGGLESGGNVFVSGIKVGQVKDVSLAGNKVRVDFTVDRSIRLGDQSL
MUL_3920|M.ulcerans_Agy99 FADAGGLTTGVRVQVSGFRVGEVSSIELDGPQVLVKFTVDKHIRLGDHTE
MAV_0950|M.avium_104 FTEAGGLATGNPVVVSGMKVGTVSDVKLHRGDALVTFALKGNILLGSETT
MMAR_4708|M.marinum_M FSDAGGLAVGNDVTVSGIKVGTVSGMSLQRGDVLVTFTVNGGVELGADST
Mflv_2510|M.gilvum_PYR-GCK FTEAGGLTVGNDVTVSGIKVGSVSSIKLDNGDALVGFTIDGKYALGSDTT
Mvan_4148|M.vanbaalenii_PYR-1 FAEAGGLTVGNDVTVSGIKVGSVSSIELDNGDALVGFTIDGKYALGSDTT
TH_4269|M.thermoresistible__bu FSEAGGITVGNDVTISGIKVGTVNEVTLHDGDALVTFTVAGKHQLGAQTT
MSMEG_2857|M.smegmatis_MC2_155 FAEAGGLTAGNEVKVSGVTVGTVSDVELVNGRARVTFALDGKTRLGQDTT
MLBr_02591|M.leprae_Br4923 FTDTGGLNKGDKVRIAGMDVGKVEALKIDGDHVVIKFSIG-TNRIGTASR
*:::**: * * ::*. ** *. : : . : *:: :* :
Mb3527c|M.bovis_AF2122/97 AAIRTDTILGERSIAVSPAGSGKST---TIPLSRTTTPYTLNGVLQDLGR
Rv3497c|M.tuberculosis_H37Rv AAIRTDTILGERSIAVSPAGSGKST---TIPLSRTTTPYTLNGVLQDLGR
MAB_4151c|M.abscessus_ATCC_199 AAIRTTTVLGEKSLSVTPAGAGRIT---EIPLGRTTTPYTLNSALSDLGA
MUL_3920|M.ulcerans_Agy99 AAIKTRGLLGTKMLEVISRGDGQLQG--TIPLDRTRSPYQLPDALGDLAT
MAV_0950|M.avium_104 AHIRTGTLLGERMLTLESAGTGTMHPMALIPVSRTSSPYSLTEAVSDLTT
MMAR_4708|M.marinum_M AHIRTGSLLGQRVLTVESAGGHTLRPMAVIPVSRTSSPYSLSEAVSDAAT
Mflv_2510|M.gilvum_PYR-GCK AHIRTGTLLGERVLALDSEGSGTLDPQQVIPTTRTSSPYSLTDAVSELTS
Mvan_4148|M.vanbaalenii_PYR-1 AHIRTGTLLGERVLALDSDGSGTLDPQQVIPTTRTSSPYSLTDAVSELTA
TH_4269|M.thermoresistible__bu AHIRTGSLLGERVITLESYGSEPLRGTDVIPTSRTSSPYSLTDAVGDLAT
MSMEG_2857|M.smegmatis_MC2_155 AHIRTGTLLGQRVLTVEPKGSGRIGPSGVIPVSRTGSPYSLTDAVGDFTT
MLBr_02591|M.leprae_Br4923 LGIRTDTVLGKKVLEVETRGTQLLRPGDSLPLGQSTTPYQSYDAFFDATK
*:* :** : : : . * :* :: :** .. :
Mb3527c|M.bovis_AF2122/97 NANDLNRPQFEQALNVFTQALHDATPQVRGAVDGLTSLSRALNRRDEALQ
Rv3497c|M.tuberculosis_H37Rv NANDLNRPQFEQALNVFTQALHDATPQVRGAVDGLTSLSRALNRRDEALQ
MAB_4151c|M.abscessus_ATCC_199 SAGGIDKAQLDQSLQVITEAMRDATPQLRGALDGVASLSRTLNARDAALE
MUL_3920|M.ulcerans_Agy99 TISGLNTNQLSDSLRVLADTFSDTPPQLRVAIEGVARFSQTLDERDAQLR
MAV_0950|M.avium_104 DTAGTNTTALNQSLDTLAATLDQIAPQMGPAFDALTRLSRTLNSRNKNLG
MMAR_4708|M.marinum_M DIAGTNTDALNQSLDTLSETLNQIAPQLGPSFDGLTRLSQALNGRNQTLG
Mflv_2510|M.gilvum_PYR-GCK NTRDTDTEALNQSLDTLSQTLDQIAPQLGPTFDGLSRLSQSLNSRNDSLA
Mvan_4148|M.vanbaalenii_PYR-1 NTRDTDTASLNQSLDTLAQTLDQVAPQLGPTFDGLSRLSQSLNSRNESLA
TH_4269|M.thermoresistible__bu NTAGTDTAALNQALDTLSATIDQIAPRLGPTFDGLSRLSRSLNDRNENLA
MSMEG_2857|M.smegmatis_MC2_155 NTAETDTAAINQSLDVLSETIERIAPQLAPTFDGITRLSQSLNNRNESLA
MLBr_02591|M.leprae_Br4923 VASGWNIDTIKQSLKVVSETIDQTYPHLSAALDGVAKFSDTIGARDKEIK
: :.::* ..: :: *:: :.:.:: :* ::. *: :
Mb3527c|M.bovis_AF2122/97 GLLAHAKSVTSVLSERAEQVNKLVEDGNQLFAALDARRAALSALISGIDD
Rv3497c|M.tuberculosis_H37Rv GLLAHAKSVTSVLSERAEQVNKLVEDGNQLFAALDARRAALSALISGIDD
MAB_4151c|M.abscessus_ATCC_199 QLLTHAKSVSGILSERAGQVNKLVTDGNQLFAALDERRLAISELINRIQG
MUL_3920|M.ulcerans_Agy99 GLLTNANKATTVLAERSNQVVSLIANTNALLAELTTQRAALDHISGNIAA
MAV_0950|M.avium_104 ELFKSAGDVTGVLSERSQQVNKLILNSDVLLQVLVARRQEIVDLLANTSA
MMAR_4708|M.marinum_M ELLKGAADVTGILSQRSQQLNTLILNADDLLSMLVARRQAIVRLLASTSA
Mflv_2510|M.gilvum_PYR-GCK ELLRTAGEVTGIFSERSKQVNTLILNSNDLLAVLNERRYAITSLLSNISA
Mvan_4148|M.vanbaalenii_PYR-1 ELLRTAGDVTGIFSERSSQVNALILNANDLLAVLNERRYAITSLLANISA
TH_4269|M.thermoresistible__bu GLLASAGEVTKVLAERSQQLNTLILNANDLLAVLNERREAIVTLLANTSA
MSMEG_2857|M.smegmatis_MC2_155 DLLKSASEITGILSERSEQVNRLILNANDLLAVVRDRRYVIVNLLANTSA
MLBr_02591|M.leprae_Br4923 HLIAQANQVASVLGDRGAQVDRLLVNTKTLIAAFNERGRAVDALLGNVAA
*: * . : ::.:*. *: *: : . *: . : : :
Mb3527c|M.bovis_AF2122/97 VAAQISGFVADNRKEFGPALSKLNLVLANLNERRDYITEALKRLPTYATT
Rv3497c|M.tuberculosis_H37Rv VAAQISGFVADNRKEFGPALSKLNLVLANLNERRDYITEALKRLPTYATT
MAB_4151c|M.abscessus_ATCC_199 LSQQISGFVADNRQEFRPTMEKLSVVLDDLLDRKAHISEALKRLPGYGTA
MUL_3920|M.ulcerans_Agy99 LGQQLHGLIAENEATMRPALDKLNGVLTILDNRKERLQKAIKLLDDYTMS
MAV_0950|M.avium_104 VAKQLTALVHDNESKLAPTLERLNSVTAMLEKNRDNISKALPGLKKFEIT
MMAR_4708|M.marinum_M VAKQLSGLVHDNESKLAPTLERLNAVTAMLEKNRDNLAKALPGLAKYELT
Mflv_2510|M.gilvum_PYR-GCK VSQQLSGLVADNEAELAPALERLNNVTRMLEKNRDNLARMLPGAAKYYLT
Mvan_4148|M.vanbaalenii_PYR-1 VSQQLSGVVADNEAELAPALERLNNVTQMLEKNRDNLAKMLPGAAKYYLT
TH_4269|M.thermoresistible__bu VAQELTALVADNEAELAPTLERLNSVMEMLERNRDNIAKILPNLKKFILA
MSMEG_2857|M.smegmatis_MC2_155 VARQLSALVSDNEAELAPALEKLNKVLAMLERNRDNLTASLKGLAKYQLT
MLBr_02591|M.leprae_Br4923 FAAQVQRLINDN-PNLNHVLEQLHQLSGILVQHKDDLANTLIQVAAFLPS
.. :: .: :* : .:.:* : * .: : : : :
Mb3527c|M.bovis_AF2122/97 LGEVVGSGPGFNVNVYSVLPGPLVATVFDLVF------------------
Rv3497c|M.tuberculosis_H37Rv LGEVVGSGPGFNVNVYSVLPGPLVATVFDLVF------------------
MAB_4151c|M.abscessus_ATCC_199 LGEVVSSGPGFHVNVYGFPPATLTAVAFDTYF------------------
MUL_3920|M.ulcerans_Agy99 LGESVSSGPFFKTYVANLAPGQFVQPFIDAAFSDLGLDPNVLLPSQRTDP
MAV_0950|M.avium_104 VGEAISSMYAYSAFVPNFLAPQLFQPFLDYLWG-----------------
MMAR_4708|M.marinum_M QGETVSSGFYYNPFIPNLFTIQFFQWFIDYAFG-----------------
Mflv_2510|M.gilvum_PYR-GCK QGEIVSNGAYYNALVPNVQPAQLLQPFLEYAFG-----------------
Mvan_4148|M.vanbaalenii_PYR-1 QGEIVSNGAYYNALIPNIQPAQLLQPFLDYAFG-----------------
TH_4269|M.thermoresistible__bu QGETLANGPYYNAFVPNLNPAQILQPFLDYAFG-----------------
MSMEG_2857|M.smegmatis_MC2_155 QGEAVNNGFYYYGFASNLLPGPAIQPFLDYALG-----------------
MLBr_02591|M.leprae_Br4923 LNEAIGSGPFFKVVLHNLAPYQILQPWVDAAFKKRGIDPENFWRSAGLPE
.* : . : .. . .:
Mb3527c|M.bovis_AF2122/97 ---QPGK---------------------------LPDS---------LAD
Rv3497c|M.tuberculosis_H37Rv ---QPGK---------------------------LPDS---------LAD
MAB_4151c|M.abscessus_ATCC_199 ---QPGK---------------------------LPAS---------LSD
MUL_3920|M.ulcerans_Agy99 PIGQPGTPPLPLP---------------------FPRTGQGGEPHRKLPD
MAV_0950|M.avium_104 --FRTFDT------------------------------------ARGPGH
MMAR_4708|M.marinum_M --FRAHG-------------------------------------APGQPP
Mflv_2510|M.gilvum_PYR-GCK --FRNGV-------------------------------------DIGQPP
Mvan_4148|M.vanbaalenii_PYR-1 --FRNGV-------------------------------------DIGQPP
TH_4269|M.thermoresistible__bu --FRRGT-------------------------------------NAGQPP
MSMEG_2857|M.smegmatis_MC2_155 --FRRGV-------------------------------------NAGQPP
MLBr_02591|M.leprae_Br4923 FRFPDPNGTRFPNGAPPPAPPVLEGTPENPGPAVPPGSPCSYTPAHPGGN
Mb3527c|M.bovis_AF2122/97 YLRGFIQE-RWIIRPKSP--------------------------------
Rv3497c|M.tuberculosis_H37Rv YLRGFIQE-RWIIRPKSP--------------------------------
MAB_4151c|M.abscessus_ATCC_199 YLNGLIGE-RQIMRPKSP--------------------------------
MUL_3920|M.ulcerans_Agy99 AITGNPDDPRYPYREPLPAPPPGGPPPGPPAPAPPELASIPQPTPSSVLV
MAV_0950|M.avium_104 PSPVPRSLIPWPYNGIPVCPGCTLGGRVGGSQ------------------
MMAR_4708|M.marinum_M DNAGPRALFPFPFNQNP-----------GGSR------------------
Mflv_2510|M.gilvum_PYR-GCK DNAGPRAQLPFPVNSLPQPGDLP----NDGNP------------------
Mvan_4148|M.vanbaalenii_PYR-1 DNAGPRAQLPFPVNSLPQPGDLP----NDGNP------------------
TH_4269|M.thermoresistible__bu DTVGPRAELPLPYNAIPG-----------GTR------------------
MSMEG_2857|M.smegmatis_MC2_155 DNAGPRAEFPFPNNGIPG-----------G--------------------
MLBr_02591|M.leprae_Br4923 NTIGDEMGLPRPWNPLPCAGATAGPYGGPAFPAPIDVQTSPPNPDGLPLL
.
Mb3527c|M.bovis_AF2122/97 --------------------------------------------------
Rv3497c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4151c|M.abscessus_ATCC_199 --------------------------------------------------
MUL_3920|M.ulcerans_Agy99 PAPGEVSAPQTAGAGR----------------------------------
MAV_0950|M.avium_104 --------------------------------------------------
MMAR_4708|M.marinum_M --------------------------------------------------
Mflv_2510|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4148|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_4269|M.thermoresistible__bu --------------------------------------------------
MSMEG_2857|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_02591|M.leprae_Br4923 PGIAIAGRPGDPAPNVPGTPVPLPPNAPPGARTEQLAPAAPAQDSSAPHE
Mb3527c|M.bovis_AF2122/97 --------------------------
Rv3497c|M.tuberculosis_H37Rv --------------------------
MAB_4151c|M.abscessus_ATCC_199 --------------------------
MUL_3920|M.ulcerans_Agy99 --------------------------
MAV_0950|M.avium_104 --------------------------
MMAR_4708|M.marinum_M --------------------------
Mflv_2510|M.gilvum_PYR-GCK --------------------------
Mvan_4148|M.vanbaalenii_PYR-1 --------------------------
TH_4269|M.thermoresistible__bu --------------------------
MSMEG_2857|M.smegmatis_MC2_155 --------------------------
MLBr_02591|M.leprae_Br4923 PREQLSAPLINPGGTGGSGGAGGSRN