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MKSFAERNRLAIGTVGIVVVAAVALAALQYQRLPFFNQGTRVSAYFADAGGLRTGNTVEVSGYPVGKVSS ISLDGPGVLVEFKVDTDVRLGNRTEVAIKTKGLLGSKFLDVTPRGDGRLDSPIPIERTTSPYQLPDALGD LAATISGLHTERLSESLATLAQTFADTPAHFRNAIHGVARLAQTLDERDNQLRSLLANAAKATGVLANRT DQIVGLVRDTNVVLAQLRTQSAALDRIWANISAVAEQLRGFIAENRQQLRPALDKLNGVLAIVENRKERV RQAIPLINTYVMSLGESLSSGPFFKAYVVNLLPGQFVQPFISAAFSDLGLDPATLLPSQLTDPPTGQPGT PPLPMPYPRTGQGGEPRLTLPDAITGNPGDPRYPYRPEPPAPPPGGPPPGPPAQQPGDQP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1968 | mce3C | - | 100% (410) | MCE-FAMILY PROTEIN MCE3C |
| M. tuberculosis H37Rv | Rv3497c | mce4C | 1e-61 | 39.47% (337) | MCE-family protein MCE4C |
| M. tuberculosis H37Rv | Rv0591 | mce2C | 3e-58 | 34.08% (446) | MCE-family protein MCE2C |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3527c | mce4C | 1e-61 | 39.47% (337) | MCE-family protein MCE4C |
| M. gilvum PYR-GCK | Mflv_2103 | - | 1e-152 | 62.86% (420) | virulence factor Mce family protein |
| M. leprae Br4923 | MLBr_02591 | mce1C | 7e-53 | 30.27% (413) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_4151c | - | 1e-61 | 37.92% (356) | MCE-family protein |
| M. marinum M | MMAR_2884 | mce3C | 0.0 | 83.50% (406) | MCE-family protein Mce3C |
| M. avium 104 | MAV_2534 | - | 1e-154 | 64.76% (420) | virulence factor Mce family protein |
| M. smegmatis MC2 155 | MSMEG_0348 | - | 1e-160 | 67.74% (403) | mce-family protein mce3c |
| M. thermoresistible (build 8) | TH_4274 | - | 1e-159 | 67.25% (403) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_3920 | mce3C_1 | 1e-158 | 66.75% (406) | MCE-family protein, Mce3C_1 |
| M. vanbaalenii PYR-1 | Mvan_0365 | - | 1e-169 | 70.94% (406) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3527c|M.bovis_AF2122/97 MLNRKPSSKHERDPLRTGIFGLVLVICVVLIAFGYSGLPFWPQGKTYDAY
MAB_4151c|M.abscessus_ATCC_199 -MPSKMSDIQEKDPVRTGIFGIAVVSMLVLVAFGYTGLPFWPQGKQYTGY
Rv1968|M.tuberculosis_H37Rv -----MKSFAERNRLAIGTVGIVVVAAVALAALQYQRLPFFNQGTRVSAY
MMAR_2884|M.marinum_M -----MKSFAERNLLLVGTVGILTAAGVVGGALQYQKLPFFDQGTSVCAY
Mvan_0365|M.vanbaalenii_PYR-1 -----MKTFSERNPVVIGAIGVAVVAVIVTMALQYQKLPFLNPGKQYSAY
MSMEG_0348|M.smegmatis_MC2_155 -MRAEMKAFSERDPRTIGLVGIAITVVIALAALNFDKLPLLSSTKGYSAY
TH_4274|M.thermoresistible__bu -----VKSFSERNLLVVGLVGMATVTALALVALNFQKIPVFNQGRSHVAE
Mflv_2103|M.gilvum_PYR-GCK -----MKPFSERNQLVIGAVGVGITAAIVLGATNYDKIPLFDPGREYTAH
MUL_3920|M.ulcerans_Agy99 -----MKSFAERNQIVVGAVELAITIGIVVGSLQYDKLPLFQSGKQYSAC
MAV_2534|M.avium_104 -----MKTFSERNPFIIGAIGLGAVFTLMLVSLNYDKLPFFHSDRTYSAY
MLBr_02591|M.leprae_Br4923 -----MRTLELPNRLRSGLIGVLVVLLIIGVGQSFTSVPILFARPSYYGQ
: * . : . : . : :*. .
Mb3527c|M.bovis_AF2122/97 FTDAGGITPGNSVYVSGLKVGAVSAVSLAGNSAKVTFSVDRSIVVGDQSL
MAB_4151c|M.abscessus_ATCC_199 FADSGGLESGGNVFVSGIKVGQVKDVSLAGNKVRVDFTVDRSIRLGDQSL
Rv1968|M.tuberculosis_H37Rv FADAGGLRTGNTVEVSGYPVGKVSSISLDGPGVLVEFKVDTDVRLGNRTE
MMAR_2884|M.marinum_M FADVGGLRTGNTVEVSGYPVGKVSSIELDEPGARVTFKVDKNIRLGERTE
Mvan_0365|M.vanbaalenii_PYR-1 FADAGGLFTGAGVEVSGYPVGKVSDISLDGPRVLVTFKILGNINLGEQTE
MSMEG_0348|M.smegmatis_MC2_155 FADAGGLNTGATVRVSGFAVGKVERIRLDGRKVLVDFTVDSAIHLGEQSE
TH_4274|M.thermoresistible__bu FADAGGLYIGATVEVSGYPAGRVARIDLDGSRVVVAFTVDRDIHLGEKSE
Mflv_2103|M.gilvum_PYR-GCK FAEAGGLTTDAAVQVSGFKVGQVKSIELDGPQVLVTFTVDKGIRLGDRTE
MUL_3920|M.ulcerans_Agy99 FADAGGLTTGVRVQVSGFRVGEVSSIELDGPQVLVKFTVDKHIRLGDHTE
MAV_2534|M.avium_104 FAEAGGLEPGNHVQISGYRVGQVDSVELDGPRVLVTFTVASNLRLGERTE
MLBr_02591|M.leprae_Br4923 FTDTGGLNKGDKVRIAGMDVGKVEALKIDGDHVVIKFSIG-TNRIGTASR
*:: **: . * ::* .* * : : . : *.: :* :
Mb3527c|M.bovis_AF2122/97 AAIRTDTILGERSIAVSPAGSGKST---TIPLSRTTTPYTLNGVLQDLGR
MAB_4151c|M.abscessus_ATCC_199 AAIRTTTVLGEKSLSVTPAGAGRIT---EIPLGRTTTPYTLNSALSDLGA
Rv1968|M.tuberculosis_H37Rv VAIKTKGLLGSKFLDVTPRGDGRLDS--PIPIERTTSPYQLPDALGDLAA
MMAR_2884|M.marinum_M AAIKTKGLLGSKFVEVIPRGEGHLTG--PIPVERTMSPYQLPDALGDLAS
Mvan_0365|M.vanbaalenii_PYR-1 ATIRTKSLLGTKVLNVMPRGAGKLDG--PIPIERTSSPYQLPDALGDLAR
MSMEG_0348|M.smegmatis_MC2_155 AAIKVKSLLGTKVIDVIPRGGGQLHE--PIPLERTTSPYQLPDALGDLAT
TH_4274|M.thermoresistible__bu ARIRAKSLLGTKVLEVLPRGEEPLDA--PIPLSRTTSPYQLPDALGDLAS
Mflv_2103|M.gilvum_PYR-GCK AAIKTKGLLGTKILEVIARGEGQQDG--TIPIDRTTSPYQLPDALGELSA
MUL_3920|M.ulcerans_Agy99 AAIKTRGLLGTKMLEVISRGDGQLQG--TIPLDRTRSPYQLPDALGDLAT
MAV_2534|M.avium_104 AAIKLRTVLGSKVLEVSPRGEGQLTG--PIPLQRTTSAYQLPDALGDLTA
MLBr_02591|M.leprae_Br4923 LGIRTDTVLGKKVLEVETRGTQLLRPGDSLPLGQSTTPYQSYDAFFDATK
*: :** : : * . * :*: :: :.* ..: :
Mb3527c|M.bovis_AF2122/97 NANDLNRPQFEQALNVFTQALHDATPQVRGAVDGLTSLSRALNRRDEALQ
MAB_4151c|M.abscessus_ATCC_199 SAGGIDKAQLDQSLQVITEAMRDATPQLRGALDGVASLSRTLNARDAALE
Rv1968|M.tuberculosis_H37Rv TISGLHTERLSESLATLAQTFADTPAHFRNAIHGVARLAQTLDERDNQLR
MMAR_2884|M.marinum_M TISGLNTGQLSESLDTLAQTFADTPADFRNAVQGVARLARTLNQRDVQLR
Mvan_0365|M.vanbaalenii_PYR-1 TVSGIDTNQLSDSLSMLAQTFADTPPHLKTAVEGVARFAETINQHDDQMR
MSMEG_0348|M.smegmatis_MC2_155 TVENLNTDDLSAALDTMAQTFAGTPPDVKIAVAGVARLSETINKRDTELR
TH_4274|M.thermoresistible__bu TISDLETDQLSESLATLSETFAHTPEQLKRAVAGVGRIAQTLGERDTNLR
Mflv_2103|M.gilvum_PYR-GCK TISGLDTDQLSESLRVLSATFADTPPQLKIAVEGVARFSDTLNARDAQLR
MUL_3920|M.ulcerans_Agy99 TISGLNTNQLSDSLRVLADTFSDTPPQLRVAIEGVARFSQTLDERDAQLR
MAV_2534|M.avium_104 TISGLNTDQLSKSLAVLANTFTDTPPDLKAAVQGVARFSQTLDERDGQLR
MLBr_02591|M.leprae_Br4923 VASGWNIDTIKQSLKVVSETIDQTYPHLSAALDGVAKFSDTIGARDKEIK
. . :. :* .: :: : .. *: *: :: ::. :* :.
Mb3527c|M.bovis_AF2122/97 GLLAHAKSVTSVLSERAEQVNKLVEDGNQLFAALDARRAALSALISGIDD
MAB_4151c|M.abscessus_ATCC_199 QLLTHAKSVSGILSERAGQVNKLVTDGNQLFAALDERRLAISELINRIQG
Rv1968|M.tuberculosis_H37Rv SLLANAAKATGVLANRTDQIVGLVRDTNVVLAQLRTQSAALDRIWANISA
MMAR_2884|M.marinum_M SLLDNAARATGVLANRTDQIAGLVRDTNALLVQLRTQSAALDQIWANISA
Mvan_0365|M.vanbaalenii_PYR-1 SLLDNAAKVTAVLAERTEQVVTLVHDTNALLAQLRTQSEALDAIWFNISA
MSMEG_0348|M.smegmatis_MC2_155 NLLANARKATAVLATRTDQVVGLVQDSNALLAELRTQSDALDRVSQDISR
TH_4274|M.thermoresistible__bu NLLDNAAAATGVLARRTDQVVALVRESNNLLAELRMQSAALDQIWHSLSA
Mflv_2103|M.gilvum_PYR-GCK GLLANANKATTVLAERSEQVVGLVSNTNALLAELQNQSAAVDQISGNISA
MUL_3920|M.ulcerans_Agy99 GLLTNANKATTVLAERSNQVVSLIANTNALLAELTTQRAALDHISGNIAA
MAV_2534|M.avium_104 TLLSNANKATTVLAERSDEVAKLVRDTNALLRQLRSQSSALEQISNNLAA
MLBr_02591|M.leprae_Br4923 HLIAQANQVASVLGDRGAQVDRLLVNTKTLIAAFNERGRAVDALLGNVAA
*: :* .: :*. * :: *: : : :: : : *:. : :
Mb3527c|M.bovis_AF2122/97 VAAQISGFVADNRKEFGPALSKLNLVLANLNERRDYITEALKRLPTYATT
MAB_4151c|M.abscessus_ATCC_199 LSQQISGFVADNRQEFRPTMEKLSVVLDDLLDRKAHISEALKRLPGYGTA
Rv1968|M.tuberculosis_H37Rv VAEQLRGFIAENRQQLRPALDKLNGVLAIVENRKERVRQAIPLINTYVMS
MMAR_2884|M.marinum_M VARQLKGFIADNRQELRPALDKLNGVLDIVEARKERLQQAIPLINTYVMS
Mvan_0365|M.vanbaalenii_PYR-1 VSEQLRGFIAENRQELKPALEKLNGVLTIVDNRKDRLQKAVKLLNSYAMS
MSMEG_0348|M.smegmatis_MC2_155 AATQLRGFMADNRQQLRPMLDKLNGVLTIVDNRKDRLQEAVKLLNKYALS
TH_4274|M.thermoresistible__bu AARQLEGFIDENRTELRPALEKLNGVLTIIDNRKERVQLALEGLHTYALA
Mflv_2103|M.gilvum_PYR-GCK LSAQLQGFIGENRDTMKPALDKLNGVLTILDNRKERLQKSLSLLNDYSMS
MUL_3920|M.ulcerans_Agy99 LGQQLHGLIAENEATMRPALDKLNGVLTILDNRKERLQKAIKLLDDYTMS
MAV_2534|M.avium_104 LARQLKGFIAENRDTLKPALDKLNSVLAIVDNRKENVQKALVGLNKYALG
MLBr_02591|M.leprae_Br4923 FAAQVQRLINDN-PNLNHVLEQLHQLSGILVQHKDDLANTLIQVAAFLPS
. *: :: :* : :.:* : : :: : :: : :
Mb3527c|M.bovis_AF2122/97 LGEVVGSGPGFNVNVYSVLPGPLVATVFDLVF------------------
MAB_4151c|M.abscessus_ATCC_199 LGEVVSSGPGFHVNVYGFPPATLTAVAFDTYF------------------
Rv1968|M.tuberculosis_H37Rv LGESLSSGPFFKAYVVNLLPGQFVQPFISAAFSDLGLDPA----------
MMAR_2884|M.marinum_M LGESVSSGPFFKAYVVNLLPGQFVQPFIGAAFSDLGLDPA----------
Mvan_0365|M.vanbaalenii_PYR-1 LGESVSSGPFFKAYVANLLPGQFVQPFIDAAFSDLGLDPN----------
MSMEG_0348|M.smegmatis_MC2_155 LGESVGSGPFFKAYIPNLIPGQFSQPFIDAAFSDLGLDPA----------
TH_4274|M.thermoresistible__bu LGESLGSGPFFKAYLSNLLPGQFVQPFVEAAFSDLGLDPA----------
Mflv_2103|M.gilvum_PYR-GCK LGESVSAGPFFKTYVANLLPGQFLQPFIDVAFSDLGLDPN----------
MUL_3920|M.ulcerans_Agy99 LGESVSSGPFFKTYVANLAPGQFVQPFIDAAFSDLGLDPN----------
MAV_2534|M.avium_104 LGESVSSGPFFKAYVVNLFPGQFVQPFIDAAFSDLGLDPN----------
MLBr_02591|M.leprae_Br4923 LNEAIGSGPFFKVVLHNLAPYQILQPWVDAAFKKRGIDPENFWRSAGLPE
*.* :.:** *:. : .. * : . *
Mb3527c|M.bovis_AF2122/97 ----------------------------------QPGK------------
MAB_4151c|M.abscessus_ATCC_199 ----------------------------------QPGK------------
Rv1968|M.tuberculosis_H37Rv ---------------------TLLPSQLTDPPTGQPGTPP----------
MMAR_2884|M.marinum_M ---------------------TLLPSQLTDPPTGQPGTPP----------
Mvan_0365|M.vanbaalenii_PYR-1 ---------------------VLAPSELTDPQLGQPGTPA----------
MSMEG_0348|M.smegmatis_MC2_155 ---------------------TLLPSQLVDPPVGQPGTPA----------
TH_4274|M.thermoresistible__bu ---------------------VLAPSELSDPQTGRPGTPA----------
Mflv_2103|M.gilvum_PYR-GCK ---------------------VLLPSQRSDPQVGQPGTPA----------
MUL_3920|M.ulcerans_Agy99 ---------------------VLLPSQRTDPPIGQPGTPP----------
MAV_2534|M.avium_104 ---------------------VLLPSQRADPQVGQPATPP----------
MLBr_02591|M.leprae_Br4923 FRFPDPNGTRFPNGAPPPAPPVLEGTPENPGPAVPPGSPCSYTPAHPGGN
*..
Mb3527c|M.bovis_AF2122/97 ---------------LPD-------------SLADYLRGFIQER------
MAB_4151c|M.abscessus_ATCC_199 ---------------LPA-------------SLSDYLNGLIGER------
Rv1968|M.tuberculosis_H37Rv ---------------LPMPYPRTGQGGEPRLTLPDAITGNPGDP------
MMAR_2884|M.marinum_M ---------------LPMPYPRTGQGGEPRLTLPDAITGNPGDP------
Mvan_0365|M.vanbaalenii_PYR-1 ---------------LPVPFPRTGQGGPPMLNLPDAITGNPGDP------
MSMEG_0348|M.smegmatis_MC2_155 ---------------LPVPYPRTGQGGEPRLNLPDAITGNPGDP------
TH_4274|M.thermoresistible__bu ---------------LPVPYPRTGQGGEPRTTVPDAITGKPGDP------
Mflv_2103|M.gilvum_PYR-GCK ---------------MPVPFPRTGQGGEPRMTIPDAITGNPGDAGCGPPG
MUL_3920|M.ulcerans_Agy99 ---------------LPLPFPRTGQGGEPHRKLPDAITGNPDDP------
MAV_2534|M.avium_104 ---------------LPMPFPRTGQGGEPRMTLPDAITGNPGDHPCGSPG
MLBr_02591|M.leprae_Br4923 NTIGDEMGLPRPWNPLPCAGATAGPYGGPAFPAPIDVQTSPPNPDGLPLL
:* . : :
Mb3527c|M.bovis_AF2122/97 ---------WIIRPKSP---------------------------------
MAB_4151c|M.abscessus_ATCC_199 ---------QIMRPKSP---------------------------------
Rv1968|M.tuberculosis_H37Rv --------RYPYRPEPPAPPPGGPPPGP----------------------
MMAR_2884|M.marinum_M --------RYPYREPPPAPPPGGPPPGPPAVAPPGLASTP----------
Mvan_0365|M.vanbaalenii_PYR-1 --------RYPYREPLPAPAPGGPPPGPPAIAPPGIASTPDPDPSAVFVP
MSMEG_0348|M.smegmatis_MC2_155 --------RYPYREPPPAPAPGGPPPGPPAPPVPGLESTPSPTPSPVYVP
TH_4274|M.thermoresistible__bu --------HYPYRQPPPAPEPGGPPPGPP---------------------
Mflv_2103|M.gilvum_PYR-GCK IPLPGPTGCYPYREPLPAPPPGGPPPGPPAVSPPGLASTPTPDTG-LLVP
MUL_3920|M.ulcerans_Agy99 --------RYPYREPLPAPPPGGPPPGPPAPAPPELASIPQPTPSSVLVP
MAV_2534|M.avium_104 AASSGP-GCYPYREPLPAPPPGGPPPGPPAQ-PGQGAGQSAPLPG----P
MLBr_02591|M.leprae_Br4923 PGIAIAGRPGDPAPNVPGTPVPLPPNAPPGARTEQLAPAAPAQDSSAPHE
*
Mb3527c|M.bovis_AF2122/97 --------------------------
MAB_4151c|M.abscessus_ATCC_199 --------------------------
Rv1968|M.tuberculosis_H37Rv -PAQQP--GDQP--------------
MMAR_2884|M.marinum_M GPVQVP--APQPGGPS----------
Mvan_0365|M.vanbaalenii_PYR-1 APGEAP--SVTAGAQS----------
MSMEG_0348|M.smegmatis_MC2_155 APGEPT--TPIPAGEGR---------
TH_4274|M.thermoresistible__bu APAAPA--SEESGGRQ----------
Mflv_2103|M.gilvum_PYR-GCK APGEAPPLVPVPGEGTR---------
MUL_3920|M.ulcerans_Agy99 APGEVS--APQTAGAGR---------
MAV_2534|M.avium_104 AQ-------PGEGGEGR---------
MLBr_02591|M.leprae_Br4923 PREQLSAPLINPGGTGGSGGAGGSRN