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MHKYRGTRLIRTGLLGLVLVVLIIVVGLQPQQLIQMATSVRYHAEFAEAGGLTAGNEVKVSGVTVGTVSD VELVNGRARVTFALDGKTRLGQDTTAHIRTGTLLGQRVLTVEPKGSGRIGPSGVIPVSRTGSPYSLTDAV GDFTTNTAETDTAAINQSLDVLSETIERIAPQLAPTFDGITRLSQSLNNRNESLADLLKSASEITGILSE RSEQVNRLILNANDLLAVVRDRRYVIVNLLANTSAVARQLSALVSDNEAELAPALEKLNKVLAMLERNRD NLTASLKGLAKYQLTQGEAVNNGFYYYGFASNLLPGPAIQPFLDYALGFRRGVNAGQPPDNAGPRAEFPF PNNGIPGG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2857 | - | - | 100% (358) | virulence factor Mce family protein |
| M. smegmatis MC2 155 | MSMEG_0136 | - | 9e-62 | 36.74% (362) | virulence factor Mce family protein, putative |
| M. smegmatis MC2 155 | MSMEG_5898 | - | 4e-61 | 40.92% (325) | virulence factor Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3527c | mce4C | 6e-61 | 40.32% (315) | MCE-family protein MCE4C |
| M. gilvum PYR-GCK | Mflv_4536 | - | 1e-152 | 74.86% (358) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv3497c | mce4C | 6e-61 | 40.32% (315) | MCE-family protein MCE4C |
| M. leprae Br4923 | MLBr_02591 | mce1C | 7e-49 | 31.44% (353) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_4151c | - | 2e-54 | 37.22% (317) | MCE-family protein |
| M. marinum M | MMAR_4708 | - | 1e-122 | 62.57% (358) | MCE-family protein |
| M. avium 104 | MAV_0950 | - | 1e-112 | 57.98% (357) | virulence factor Mce family protein |
| M. thermoresistible (build 8) | TH_2834 | - | 1e-170 | 83.24% (358) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_3920 | mce3C_1 | 5e-61 | 38.61% (360) | MCE-family protein, Mce3C_1 |
| M. vanbaalenii PYR-1 | Mvan_2853 | - | 1e-153 | 75.14% (358) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3527c|M.bovis_AF2122/97 MLNRKPSSKHERDPLRTGIFGLVLVICVVLIAFGYSGLPFWPQGKTYDAY
Rv3497c|M.tuberculosis_H37Rv MLNRKPSSKHERDPLRTGIFGLVLVICVVLIAFGYSGLPFWPQGKTYDAY
MAB_4151c|M.abscessus_ATCC_199 -MPSKMSDIQEKDPVRTGIFGIAVVSMLVLVAFGYTGLPFWPQGKQYTGY
MUL_3920|M.ulcerans_Agy99 -----MKSFAERNQIVVGAVELAITIGIVVGSLQYDKLPLFQSGKQYSAC
MSMEG_2857|M.smegmatis_MC2_155 -----MHKYRGTRLIRTGLLGLVLVVLIIVVGLQPQQLIQMATSVRYHAE
TH_2834|M.thermoresistible__bu MRGALMHKYRESALIRSGVIGLVLVVLIIVVGLQTQQLWTMATSVRYHAE
Mflv_4536|M.gilvum_PYR-GCK -----MQKYRGASLVRAGFLGAVLIALVIVVGLQPQQLWAMATSVRYQAV
Mvan_2853|M.vanbaalenii_PYR-1 -----MQKYRGSSLVRAGFIGAVLIALVIVVGLQPQQLWSMATSVRYQAV
MMAR_4708|M.marinum_M -----MLKYRGAGLIRAGFIGAVLIVLVIAVGLNPEQLLQRATTVRYQAL
MAV_0950|M.avium_104 -----MLKYRGSGLVKAGLIGVVLAVMVILVGLSPDRFIAWATMVRYQAL
MLBr_02591|M.leprae_Br4923 -----MRTLELPNRLRSGLIGVLVVLLIIGVGQSFTSVPILFARPSYYGQ
: * . : :: . . * .
Mb3527c|M.bovis_AF2122/97 FTDAGGITPGNSVYVSGLKVGAVSAVSLAGNSAKVTFSVDRSIVVGDQSL
Rv3497c|M.tuberculosis_H37Rv FTDAGGITPGNSVYVSGLKVGAVSAVSLAGNSAKVTFSVDRSIVVGDQSL
MAB_4151c|M.abscessus_ATCC_199 FADSGGLESGGNVFVSGIKVGQVKDVSLAGNKVRVDFTVDRSIRLGDQSL
MUL_3920|M.ulcerans_Agy99 FADAGGLTTGVRVQVSGFRVGEVSSIELDGPQVLVKFTVDKHIRLGDHTE
MSMEG_2857|M.smegmatis_MC2_155 FAEAGGLTAGNEVKVSGVTVGTVSDVELVNGRARVTFALDGKTRLGQDTT
TH_2834|M.thermoresistible__bu FAEAGGLAAGNEVKVSGMTVGTVSDVRLQGGHAVVTFALNARIRLGEETT
Mflv_4536|M.gilvum_PYR-GCK FAEAGGLAAGNEVKVSGVTVGSVSDVALDRGSALVTFSVDSAVRVGDATT
Mvan_2853|M.vanbaalenii_PYR-1 FAESGGLAAGNNVKVSGVTVGSVSDVELDRGTAVVTFSVAGAVPLGGDTT
MMAR_4708|M.marinum_M FSDAGGLAVGNDVTVSGIKVGTVSGMSLQRGDVLVTFTVNGGVELGADST
MAV_0950|M.avium_104 FTEAGGLATGNPVVVSGMKVGTVSDVKLHRGDALVTFALKGNILLGSETT
MLBr_02591|M.leprae_Br4923 FTDTGGLNKGDKVRIAGMDVGKVEALKIDGDHVVIKFSIG-TNRIGTASR
*:::**: * * ::*. ** *. : : . : *:: :* :
Mb3527c|M.bovis_AF2122/97 AAIRTDTILGERSIAVSPAGSGKST---TIPLSRTTTPYTLNGVLQDLGR
Rv3497c|M.tuberculosis_H37Rv AAIRTDTILGERSIAVSPAGSGKST---TIPLSRTTTPYTLNGVLQDLGR
MAB_4151c|M.abscessus_ATCC_199 AAIRTTTVLGEKSLSVTPAGAGRIT---EIPLGRTTTPYTLNSALSDLGA
MUL_3920|M.ulcerans_Agy99 AAIKTRGLLGTKMLEVISRGDGQLQG--TIPLDRTRSPYQLPDALGDLAT
MSMEG_2857|M.smegmatis_MC2_155 AHIRTGTLLGQRVLTVEPKGSGRIGPSGVIPVSRTGSPYSLTDAVGDFTT
TH_2834|M.thermoresistible__bu AHIRTGTLLGERVLTVEPRGNGRIRPAGVIPLSRTGSPYSLTDAVGDFTA
Mflv_4536|M.gilvum_PYR-GCK ATVGISTVLGERVLVLKPDGSRSLGSMGVIPLTRTGSPYSLTDAVGEFTT
Mvan_2853|M.vanbaalenii_PYR-1 ASIGIATVLGERVLVLRPAGRESLGAMGVIPLSRTGSPYSLTDAIGEFTS
MMAR_4708|M.marinum_M AHIRTGSLLGQRVLTVESAGGHTLRPMAVIPVSRTSSPYSLSEAVSDAAT
MAV_0950|M.avium_104 AHIRTGTLLGERMLTLESAGTGTMHPMALIPVSRTSSPYSLTEAVSDLTT
MLBr_02591|M.leprae_Br4923 LGIRTDTVLGKKVLEVETRGTQLLRPGDSLPLGQSTTPYQSYDAFFDATK
: :** : : : . * :*: :: :** .. :
Mb3527c|M.bovis_AF2122/97 NANDLNRPQFEQALNVFTQALHDATPQVRGAVDGLTSLSRALNRRDEALQ
Rv3497c|M.tuberculosis_H37Rv NANDLNRPQFEQALNVFTQALHDATPQVRGAVDGLTSLSRALNRRDEALQ
MAB_4151c|M.abscessus_ATCC_199 SAGGIDKAQLDQSLQVITEAMRDATPQLRGALDGVASLSRTLNARDAALE
MUL_3920|M.ulcerans_Agy99 TISGLNTNQLSDSLRVLADTFSDTPPQLRVAIEGVARFSQTLDERDAQLR
MSMEG_2857|M.smegmatis_MC2_155 NTAETDTAAINQSLDVLSETIERIAPQLAPTFDGITRLSQSLNNRNESLA
TH_2834|M.thermoresistible__bu NTAQTDTAAINQSLDVLAETIDRIAPQLGPTFDGVTRLSQSLNSRNESLA
Mflv_4536|M.gilvum_PYR-GCK NTEGTDTAAINQSLDTLSETIERVAPQLGPTFDGVSRLSKSLNSRNESLG
Mvan_2853|M.vanbaalenii_PYR-1 NTEQTDTAAINQSLDTLSDTIERIAPQLAPTFDGVTRLSKSLNSRNESLS
MMAR_4708|M.marinum_M DIAGTNTDALNQSLDTLSETLNQIAPQLGPSFDGLTRLSQALNGRNQTLG
MAV_0950|M.avium_104 DTAGTNTTALNQSLDTLAATLDQIAPQMGPAFDALTRLSRTLNSRNKNLG
MLBr_02591|M.leprae_Br4923 VASGWNIDTIKQSLKVVSETIDQTYPHLSAALDGVAKFSDTIGARDKEIK
: :.::* ..: :: *:: :.:.:: :* ::. *: :
Mb3527c|M.bovis_AF2122/97 GLLAHAKSVTSVLSERAEQVNKLVEDGNQLFAALDARRAALSALISGIDD
Rv3497c|M.tuberculosis_H37Rv GLLAHAKSVTSVLSERAEQVNKLVEDGNQLFAALDARRAALSALISGIDD
MAB_4151c|M.abscessus_ATCC_199 QLLTHAKSVSGILSERAGQVNKLVTDGNQLFAALDERRLAISELINRIQG
MUL_3920|M.ulcerans_Agy99 GLLTNANKATTVLAERSNQVVSLIANTNALLAELTTQRAALDHISGNIAA
MSMEG_2857|M.smegmatis_MC2_155 DLLKSASEITGILSERSEQVNRLILNANDLLAVVRDRRYVIVNLLANTSA
TH_2834|M.thermoresistible__bu ELLESASKVTGILSERSEQVNRMLLNANDLMGVLQQRRHAIVTLLANTSA
Mflv_4536|M.gilvum_PYR-GCK ALLDAAADVTGVLSERSAQVNTLLLNANDLLAVLQDRRYAIVNLLASTTA
Mvan_2853|M.vanbaalenii_PYR-1 GLLEAASDVTGVLSERSAQVNSLLLNANDLLAVLQQRRYAIVNLLASTTA
MMAR_4708|M.marinum_M ELLKGAADVTGILSQRSQQLNTLILNADDLLSMLVARRQAIVRLLASTSA
MAV_0950|M.avium_104 ELFKSAGDVTGVLSERSQQVNKLILNSDVLLQVLVARRQEIVDLLANTSA
MLBr_02591|M.leprae_Br4923 HLIAQANQVASVLGDRGAQVDRLLVNTKTLIAAFNERGRAVDALLGNVAA
*: * . : :*.:*. *: :: : . *: . : : :
Mb3527c|M.bovis_AF2122/97 VAAQISGFVADNRKEFGPALSKLNLVLANLNERRDYITEALKRLPTYATT
Rv3497c|M.tuberculosis_H37Rv VAAQISGFVADNRKEFGPALSKLNLVLANLNERRDYITEALKRLPTYATT
MAB_4151c|M.abscessus_ATCC_199 LSQQISGFVADNRQEFRPTMEKLSVVLDDLLDRKAHISEALKRLPGYGTA
MUL_3920|M.ulcerans_Agy99 LGQQLHGLIAENEATMRPALDKLNGVLTILDNRKERLQKAIKLLDDYTMS
MSMEG_2857|M.smegmatis_MC2_155 VARQLSALVSDNEAELAPALEKLNKVLAMLERNRDNLTASLKGLAKYQLT
TH_2834|M.thermoresistible__bu VAQQLSGLVADNEEELAPALEKLNRVLELLERNEDNLTQSLKGLAKYQLT
Mflv_4536|M.gilvum_PYR-GCK VAQELSGMVEDNEQELAPTLEKLNTVSEMLERNRDNISASLKGLAKYQVT
Mvan_2853|M.vanbaalenii_PYR-1 VAQQLSGMVADNERELAPTLEKLNTVAEMLERNRDNITASLKGLAKYQVT
MMAR_4708|M.marinum_M VAKQLSGLVHDNESKLAPTLERLNAVTAMLEKNRDNLAKALPGLAKYELT
MAV_0950|M.avium_104 VAKQLTALVHDNESKLAPTLERLNSVTAMLEKNRDNISKALPGLKKFEIT
MLBr_02591|M.leprae_Br4923 FAAQVQRLINDN-PNLNHVLEQLHQLSGILVQHKDDLANTLIQVAAFLPS
.. :: :: :* : .:.:* : * .. : :: : : :
Mb3527c|M.bovis_AF2122/97 LGEVVGSGPGFNVNVYSVLPGPLVATVFDLVF------------------
Rv3497c|M.tuberculosis_H37Rv LGEVVGSGPGFNVNVYSVLPGPLVATVFDLVF------------------
MAB_4151c|M.abscessus_ATCC_199 LGEVVSSGPGFHVNVYGFPPATLTAVAFDTYF------------------
MUL_3920|M.ulcerans_Agy99 LGESVSSGPFFKTYVANLAPGQFVQPFIDAAFSDLGLDPNVLLPSQ----
MSMEG_2857|M.smegmatis_MC2_155 QGEAVNNGFYYYGFASNLLPGPAIQPFLDYALGFRRGV------------
TH_2834|M.thermoresistible__bu QGEAVNNGFYYYGFASNLLPGPAIQPFLDYALGFRRGV------------
Mflv_4536|M.gilvum_PYR-GCK QGEAVNNGFFYNGFASNLLPGPAIQPFLDYALGFRRGV------------
Mvan_2853|M.vanbaalenii_PYR-1 QGEAVNNGFFYNGFASNLLPGPAIQPFLDYALGYRRGV------------
MMAR_4708|M.marinum_M QGETVSSGFYYNPFIPNLFTIQFFQWFIDYAFGFRAHG------------
MAV_0950|M.avium_104 VGEAISSMYAYSAFVPNFLAPQLFQPFLDYLWGFRTFDT-----------
MLBr_02591|M.leprae_Br4923 LNEAIGSGPFFKVVLHNLAPYQILQPWVDAAFKKRGIDPENFWRSAGLPE
.* :.. : .. . .*
Mb3527c|M.bovis_AF2122/97 ----------------------------QPGK------LPDS--------
Rv3497c|M.tuberculosis_H37Rv ----------------------------QPGK------LPDS--------
MAB_4151c|M.abscessus_ATCC_199 ----------------------------QPGK------LPAS--------
MUL_3920|M.ulcerans_Agy99 ---------------------RTDPPIGQPGTPPLPLPFPRTGQGGEPHR
MSMEG_2857|M.smegmatis_MC2_155 ----------------------------NAGQP------PDN--------
TH_2834|M.thermoresistible__bu ----------------------------NAGQP------PDN--------
Mflv_4536|M.gilvum_PYR-GCK ----------------------------NAGQP------PDN--------
Mvan_2853|M.vanbaalenii_PYR-1 ----------------------------DAGQP------PDN--------
MMAR_4708|M.marinum_M ----------------------------APGQP------PDN--------
MAV_0950|M.avium_104 ----------------------------ARGPG------HPS--------
MLBr_02591|M.leprae_Br4923 FRFPDPNGTRFPNGAPPPAPPVLEGTPENPGPAVP----PGSPCSYTPAH
* .
Mb3527c|M.bovis_AF2122/97 -LADYLRGFIQE-RWIIRPKSP----------------------------
Rv3497c|M.tuberculosis_H37Rv -LADYLRGFIQE-RWIIRPKSP----------------------------
MAB_4151c|M.abscessus_ATCC_199 -LSDYLNGLIGE-RQIMRPKSP----------------------------
MUL_3920|M.ulcerans_Agy99 KLPDAITGNPDDPRYPYREPLPAPPPGGPPPGPPAPAPPELASIPQPTPS
MSMEG_2857|M.smegmatis_MC2_155 ------AGPRAEFPFPNNGIP-----------GG----------------
TH_2834|M.thermoresistible__bu ------VGPRAEFPFPYNGIP-----------GG----------------
Mflv_4536|M.gilvum_PYR-GCK ------AGPRAEFPWPYNGIP-----------GGSR--------------
Mvan_2853|M.vanbaalenii_PYR-1 ------AGPRAEFPFPYNGIP-----------GGSR--------------
MMAR_4708|M.marinum_M ------AGPRALFPFPFNQNP-----------GGSR--------------
MAV_0950|M.avium_104 ------PVPRSLIPWPYNGIPVCPGCTLGGRVGGSQ--------------
MLBr_02591|M.leprae_Br4923 PGGNNTIGDEMGLPRPWNPLPCAGATAGPYGGPAFPAPIDVQTSPPNPDG
.
Mb3527c|M.bovis_AF2122/97 --------------------------------------------------
Rv3497c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4151c|M.abscessus_ATCC_199 --------------------------------------------------
MUL_3920|M.ulcerans_Agy99 SVLVPAPGEVSAPQTAGAGR------------------------------
MSMEG_2857|M.smegmatis_MC2_155 --------------------------------------------------
TH_2834|M.thermoresistible__bu --------------------------------------------------
Mflv_4536|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2853|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_4708|M.marinum_M --------------------------------------------------
MAV_0950|M.avium_104 --------------------------------------------------
MLBr_02591|M.leprae_Br4923 LPLLPGIAIAGRPGDPAPNVPGTPVPLPPNAPPGARTEQLAPAAPAQDSS
Mb3527c|M.bovis_AF2122/97 ------------------------------
Rv3497c|M.tuberculosis_H37Rv ------------------------------
MAB_4151c|M.abscessus_ATCC_199 ------------------------------
MUL_3920|M.ulcerans_Agy99 ------------------------------
MSMEG_2857|M.smegmatis_MC2_155 ------------------------------
TH_2834|M.thermoresistible__bu ------------------------------
Mflv_4536|M.gilvum_PYR-GCK ------------------------------
Mvan_2853|M.vanbaalenii_PYR-1 ------------------------------
MMAR_4708|M.marinum_M ------------------------------
MAV_0950|M.avium_104 ------------------------------
MLBr_02591|M.leprae_Br4923 APHEPREQLSAPLINPGGTGGSGGAGGSRN