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TVWFITGASRGLGAQIARTALDHGADVAVGVRNPDLLPSDIAERAFAVRLDVTHDADISAAVAAVVERFG RIDVLVNNAGRGLLGALEEVTDAEARSLFDLNVFGLINVTRAVLPHMRASGGGKLVHIGSRSGFEGEPGV GLYSASKFAVAGISEALSAELAPFGIQSMVVEPGVFRTDFLDGSSLSMPANRIDAYDGTPAHDTLDWVDD ANHTQLGDPVKGAALIYEVANEDKLPRHLLLGRDAVERWRVKAAQMADDVTAWEMKSLATAHLA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0524 | - | - | 100% (275) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2808 | - | 4e-59 | 47.37% (266) | short-chain dehydrogenase/reductase SDR |
| M. smegmatis MC2 155 | MSMEG_1628 | - | 5e-54 | 40.88% (274) | oxidoreductase, short chain dehydrogenase/reductase family |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2025 | fabG3 | 9e-25 | 34.78% (184) | 20-beta-hydroxysteroid dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0295 | - | 4e-43 | 40.83% (289) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv2002 | fabG3 | 9e-25 | 34.78% (184) | 20-beta-hydroxysteroid dehydrogenase |
| M. leprae Br4923 | MLBr_01094 | - | 5e-20 | 30.58% (206) | short chain alcohol dehydrogenase |
| M. abscessus ATCC 19977 | MAB_1305 | - | 7e-29 | 39.13% (207) | short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_1614 | - | 7e-45 | 41.09% (275) | short chain dehydrogenase |
| M. avium 104 | MAV_3827 | - | 9e-50 | 43.28% (268) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_3670 | - | 5e-39 | 38.78% (245) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_3423 | - | 1e-44 | 40.73% (275) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_5466 | - | 1e-58 | 45.99% (274) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_0524|M.smegmatis_MC2_155 -------MTVWFITGASRGLGAQIARTALDHGADVAVGVRNPDLLP--SD
Mvan_5466|M.vanbaalenii_PYR-1 MPYPTDNPATWFVTGASRGLGAELVRQLLRRGDNVAATTRSAERLS--AA
MMAR_1614|M.marinum_M -------MSTWLITGCSTGLGRALAEAVIDAGHHTVATARSVGGV---AD
MUL_3423|M.ulcerans_Agy99 -------MSTWLITGCSTGLGRALAEAVIDAGHHTVATARSVGGV---AD
MAV_3827|M.avium_104 -------MARWLITGCSTGLGREIAGAALQAGHRVVVTARRADAV---RG
Mflv_0295|M.gilvum_PYR-GCK ------MSKVLLISGASRGLGRAITESALAAGHLVVAGVRATSSL---SD
TH_3670|M.thermoresistible__bu MGSNVWGSKVWFITGASRGFGREWAIAALDRGDRVAATARDVSTL---DD
Mb2025|M.bovis_AF2122/97 -MSGRLIGKVALVSGGARGMGASHVRAMVAEGAKVVFGDILDEEG---KA
Rv2002|M.tuberculosis_H37Rv -MSGRLIGKVALVSGGARGMGASHVRAMVAEGAKVVFGDILDEEG---KA
MAB_1305|M.abscessus_ATCC_1997 ----MSEHWTVLVTGASSGIGASAARIFAERGHRVFGTSRNPDTIT--DR
MLBr_01094|M.leprae_Br4923 --MEGFAGKVAVVTGAGSGIGQALAIELARSGAKLAISDVDGEGLAQTEG
.::* . *:* . *
MSMEG_0524|M.smegmatis_MC2_155 IA----ERAFAVRLDVTHDADISAAVAAVVERFGRIDVLVNNAGRGLLGA
Mvan_5466|M.vanbaalenii_PYR-1 LAGVDTGRLLPLVVDLTDAAAVDGAVAAALDRFGRLDVVVNNAGYGFLGA
MMAR_1614|M.marinum_M LVQRSPERVLPLALDITEPDQITAAVQAAQQRFGGIDVLVNNAGYGYRAA
MUL_3423|M.ulcerans_Agy99 LAQRSPERVLPLALDITEPDQITAAMQAAQQRFGGIDVLVNNAGYGYRAA
MAV_3827|M.avium_104 FAEEFGELALPVALDVTDRDQIAAAVAAADAAFGGIDVLVNNAGHGYLSA
Mflv_0295|M.gilvum_PYR-GCK LATREPDRLAVVELDVTDDRHARAAVATAVERFGRLDVLVNNAGYANMSA
TH_3670|M.thermoresistible__bu LRDRFGDAVLAMTLDVTDRAADFAAVQRAHDHFGRLDIVVNNAGYGHFGF
Mb2025|M.bovis_AF2122/97 VAAELADAARYVHLDVTQPAQWTAAVDTAVTAFGGLHVLVNNAGILNIGT
Rv2002|M.tuberculosis_H37Rv VAAELADAARYVHLDVTQPAQWTAAVDTAVTAFGGLHVLVNNAGILNIGT
MAB_1305|M.abscessus_ATCC_1997 VPG-----VQYLRLDQTDK----ASIAECVAQAGEVDILVNNAGESQIGA
MLBr_01094|M.leprae_Br4923 QLKAIGASARTDRLDVTEREAFLTYADVVHENFGKVNQIYNNAGIAFTGD
:* *. * :. : **** .
MSMEG_0524|M.smegmatis_MC2_155 LEEVTDAEARSLFDLNVFGLINVTRAVLPHMRASGGGKLVHIGSRSGFEG
Mvan_5466|M.vanbaalenii_PYR-1 VEETTDAEIRQMLDVQVSGVWNVLRSAVPHLRAARSGHIINVSSILGLTA
MMAR_1614|M.marinum_M VEEGDDAEVRDLFETHFFGTVALIKAVLPDMRARRSGAIVNISSIAVALT
MUL_3423|M.ulcerans_Agy99 VEEGDDAEVRDLFETHFFGTVALIKAVLPDMRARRSGAIVNISSIAVALT
MAV_3827|M.avium_104 VEEGEDAEVRKLFDVNYFGAVDMIKAVLPGMRARGCGHIVNISSMTGLVA
Mflv_0295|M.gilvum_PYR-GCK IEDVDVDDFRAQIETNFFGVVNLTRAALPAMRRQRDGHIVQISSVGGRLV
TH_3670|M.thermoresistible__bu VEELTETEVRDQMETNFFGALWVTQAALPYLRRQRSGHIIQVSSIGGVSA
Mb2025|M.bovis_AF2122/97 IEDYALTEWQRILDVNLTGVFLGIRAVVKPMKEAGRGSIINISSIEGLAG
Rv2002|M.tuberculosis_H37Rv IEDYALTEWQRILDVNLTGVFLGIRAVVKPMKEAGRGSIINISSIEGLAG
MAB_1305|M.abscessus_ATCC_1997 LEDVSMDDFEKLYMTNVFGPVALTKAVLPGMRERRRGAVVMVGSMAGTLH
MLBr_01094|M.leprae_Br4923 VEVSHFKDIERVMDVDYWGVVNGTKAFLPYLISSGDGHVINISSVFGLFS
:* : . . * :: : : * :: :.*
MSMEG_0524|M.smegmatis_MC2_155 EPGVGLYSASKFAVAGISEALSAELAPFG--IQSMVVEPGVFRTDFLDGS
Mvan_5466|M.vanbaalenii_PYR-1 VPGWGLYCAGKFALNGMSEALAAELAGFG--IRVTIVEPGYFRTDFLTTE
MMAR_1614|M.marinum_M PVGSGYYAAAKAAMEGMSGALHGELAPLG--ISVTVVEPGAFRTDFAG-R
MUL_3423|M.ulcerans_Agy99 PVGSGYYAAAKAAMEGMSGALHGELAPLG--ISVTVVEPGAFRTDFAG-R
MAV_3827|M.avium_104 NPPNAYYSSTKFALEAVTEALAAEVRPLG--IKVTAIEPGAFRTDWAT-R
Mflv_0295|M.gilvum_PYR-GCK RPGLAAYQSAKWAVTGFSGVLAVEVAPLG--IKVTVLEPGGMRTDWAG--
TH_3670|M.thermoresistible__bu FADLGAYHASKWALEGLSQSLSLEVAPFG--IHVTLIEPGGYATDWGG--
Mb2025|M.bovis_AF2122/97 TVACHGYTATKFAVRGLTKSTALELGPSG--IRVNSIHPGLVKTPMTD--
Rv2002|M.tuberculosis_H37Rv TVACHGYTATKFAVRGLTKSTALELGPSG--IRVNSIHPGLVKTPMTD--
MAB_1305|M.abscessus_ATCC_1997 VPFRSTYSSAKSALHTVADCLRYEVAPFG--ITVSTVEPGVIATGIET--
MLBr_01094|M.leprae_Br4923 VPGQAAYNSAKFAVRGFTEALREEMALAGRPVNVTTVYPGGIKTAIAR--
* : * *: .: *: * : : ** *
MSMEG_0524|M.smegmatis_MC2_155 SLSMPANRIDAYDGTPAHDTLDWVDDANHTQLGDPVKGAALIYEVANEDK
Mvan_5466|M.vanbaalenii_PYR-1 SLALPTAAGDAYP--AIREMTEQHLQLQGSQLGDPVKGAAAVIHVAVTGG
MMAR_1614|M.marinum_M SLVQSTRMINDYA-ATAGQRRKENDTMHGNQPGDPAKAAAAIITAVESPA
MUL_3423|M.ulcerans_Agy99 SLVQSTRMINDYA-ATAGQRRKENDTMHGNQPGDPAKAAAAIITAVESPA
MAV_3827|M.avium_104 SMKESGTPIADYT-DVAA-RKDLIKQFADHLPGDPRKVAEAVLMVTGLDE
Mflv_0295|M.gilvum_PYR-GCK SSMRIAPVREEYA--ATVGAAASLSDPNVLGASDPAKVAGLLLDVIGMPD
TH_3670|M.thermoresistible__bu SSARRSATMPEYA--ESRAEADRVRSQRVARPGDPKASAAALLKVVDAEK
Mb2025|M.bovis_AF2122/97 ------------------WVPEDIFQTALGRAAEPVEVSNLVVYLASDES
Rv2002|M.tuberculosis_H37Rv ------------------WVPEDIFQTALGRAAEPVEVSNLVVYLASDES
MAB_1305|M.abscessus_ATCC_1997 RRNRIVPDGSPYR--DAFRTVDAAMAAREEHGTATDELGRLVVDVALSPS
MLBr_01094|M.leprae_Br4923 -----------NATAAEGLDVSKIASRFDTWVAHTSPQHAARIILKAVRK
.
MSMEG_0524|M.smegmatis_MC2_155 LPRHLLLGRDAVERWRVKAAQMADDVTAWEMKSLATAHLA----------
Mvan_5466|M.vanbaalenii_PYR-1 GPLHQLLGSDAVSYAEAKIDALVADVKAGRDLALTTDHR-----------
MMAR_1614|M.marinum_M PPAFLLLGPDALMAYRHIAQRRDVEITDWEQLTAGTNLTP----------
MUL_3423|M.ulcerans_Agy99 PPAFLLLGPDALMAYRHIAQRRDVEITDWEQLTAGTNLTP----------
MAV_3827|M.avium_104 PPLRLLLGRDVLKAMRDKIAAMSASIDEWEAVTKDVNFPGA---------
Mflv_0295|M.gilvum_PYR-GCK PPRRLLVGPDAYRYATAAGRDLLAVDERWRTLSMSTAADDVSPEQLDPLG
TH_3670|M.thermoresistible__bu PPLRVFFGELPLQIVNADYQSRLQTWEEWQPIAVLAQG------------
Mb2025|M.bovis_AF2122/97 S---YSTGAEFVVDGGTVAGLAHNDFGAVEVSSQPEWVT-----------
Rv2002|M.tuberculosis_H37Rv S---YSTGAEFVVDGGTVAGLAHNDFGAVEVSSQPEWVT-----------
MAB_1305|M.abscessus_ATCC_1997 PKPLYAKGSNAPIIMTAQRLLPARLFLKFLARMHGLKVR-----------
MLBr_01094|M.leprae_Br4923 KKARVLVGPDAKVANVVVRFSGGAGYQRLFAQVASRLILNQR--------
*
MSMEG_0524|M.smegmatis_MC2_155 ----
Mvan_5466|M.vanbaalenii_PYR-1 ----
MMAR_1614|M.marinum_M ----
MUL_3423|M.ulcerans_Agy99 ----
MAV_3827|M.avium_104 ----
Mflv_0295|M.gilvum_PYR-GCK SASR
TH_3670|M.thermoresistible__bu ----
Mb2025|M.bovis_AF2122/97 ----
Rv2002|M.tuberculosis_H37Rv ----
MAB_1305|M.abscessus_ATCC_1997 ----
MLBr_01094|M.leprae_Br4923 ----