For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MAEPRSVVITGASRGLGFASALRMYREGWRVVAAMRTPDQGMPLLRRAIRDGTGQDPDDDRLIGVQLDLT DSASVAAAAKAIEEAVGAPYAIVHNAGISAAGMVEETDTALWQRMFATSVLGPVALTQALLPSMRAAGRG RIVLVSSAAGVRGQPGTAPYSAAKGALERWGESLAGEIAPFGLGVTVLVAGTYDTEIITDAGTTDDRNFS GPYARLHTTMNTRGRLAVSFARPPERFTDGLCKALDDRAPFRRRGVGPDASMLLAANRILPASGMHHLSR VVLGIPRQGSMRDGAWPLTHGQRAMVLVARVLPQPVLQRLAALAGRFSSPKSAARQGDQEG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1273 | - | - | 100% (341) | NAD dependent epimerase/dehydratase family protein |
| M. avium 104 | MAV_2098 | - | 1e-26 | 32.86% (280) | short chain dehydrogenase |
| M. avium 104 | MAV_3827 | - | 7e-23 | 36.46% (192) | short chain dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3083c | - | 3e-24 | 36.55% (197) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4152 | - | 1e-142 | 76.31% (325) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv3057c | - | 3e-24 | 36.55% (197) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_01740 | - | 4e-19 | 31.71% (246) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_1305 | - | 1e-26 | 33.33% (288) | short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_4002 | - | 1e-27 | 31.76% (296) | dehydrogenase/decarboxylase protein |
| M. smegmatis MC2 155 | MSMEG_3426 | - | 7e-26 | 30.68% (264) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_3605 | - | 1e-102 | 66.67% (291) | PUTATIVE NAD dependent epimerase/dehydratase family protein |
| M. ulcerans Agy99 | MUL_3423 | - | 4e-24 | 30.98% (255) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_1012 | - | 3e-25 | 38.71% (186) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_1273|M.avium_104 ---MAE-----PRSVVITGASRGLGFASALRMYREGWRVVAAMRTPDQGM
Mflv_4152|M.gilvum_PYR-GCK ---MAERAGAQRRVALITGASRGLGFASAVRLYREGWGVVAAMRTPERGM
TH_3605|M.thermoresistible__bu ---VTDRQPAGPRSVVITGASRGLGLASATHLYRRGWRVVAAMRSVDAGM
MAB_1305|M.abscessus_ATCC_1997 --------MSEHWTVLVTGASSGIGASAARIFAERGHRVFGTSR---NPD
MMAR_4002|M.marinum_M -------MSCTRQHVVVTGASSGIGRSTALRLASAGWHVYAGVRRAADGE
MSMEG_3426|M.smegmatis_MC2_155 -----------MKTFFITGVSSGLGQAFANGALAAGHRVVGTVRKDSDAA
MUL_3423|M.ulcerans_Agy99 -----------MSTWLITGCSTGLGRALAEAVIDAGHHTVATARSVGGVA
Mvan_1012|M.vanbaalenii_PYR-1 -----------MTTVLITGCSSGYGLATAHRFLDEGWNVVATMRTPRQDV
Mb3083c|M.bovis_AF2122/97 MLQRGAGQYFAGKRCFVTGAASGIGRATALRLAAQGAELYLTDRDRDGLA
Rv3057c|M.tuberculosis_H37Rv MLQRGAGQYFAGKRCFVTGAASGIGRATALRLAAQGAELYLTDRDRDGLA
MLBr_01740|M.leprae_Br4923 MVKT--AQYFVGKRCFVTGAASGIGRATALRLAAYGAELYLTDRHCDGLA
.:** : * * : * * *
MAV_1273|M.avium_104 PLLRRAIRDGTGQDPDDDRLIGVQLDLTDSASVAAAAKAIEEAVGAP--Y
Mflv_4152|M.gilvum_PYR-GCK PRLR----EATGASEDDDRLVGVQLDLMDAASIAAAAKSIDEAVGAP--Y
TH_3605|M.thermoresistible__bu ARLA----ETTGAAADDPRLIPVALDLTDAASITAAAKEIEGSVGAP--Y
MAB_1305|M.abscessus_ATCC_1997 TITD---------RVPG--VQYLRLDQTDKASIAECV------AQAGEVD
MMAR_4002|M.marinum_M ALQA---------ASSGGQLSPLLMDVTVAEQIDAAVGIVCEHIGAAGLD
MSMEG_3426|M.smegmatis_MC2_155 AFEST----------APDRAHARQLDVTDDAAVTAVVAEVEK--NIGPID
MUL_3423|M.ulcerans_Agy99 DLAQR----------SPERVLPLALDITEPDQITAAMQAAQQ--RFGGID
Mvan_1012|M.vanbaalenii_PYR-1 LPPS-------------DRLRVIALDVTRPDSIAAAVAAAG------PID
Mb3083c|M.bovis_AF2122/97 QTVCDAR------ALGAQVPEHRVLDVSDYQDVAAFAADIHA--RHPSMD
Rv3057c|M.tuberculosis_H37Rv QTVCDAR------ALGAQVPEHRVLDVSDYQDVAAFAADIHA--RHPSMD
MLBr_01740|M.leprae_Br4923 QTVSEAR------ALGAQVPEYRALDISDYDEVAAFGADIHA--RHPSMD
:* :
MAV_1273|M.avium_104 AIVHNAGISAAGMVEETDTALWQRMFATSVLGPVALTQALLPSMRAAGRG
Mflv_4152|M.gilvum_PYR-GCK AVVHNAGISAAGVVEETDIELWERMFTTHVMGPVALTKALLPSMRAAGQG
TH_3605|M.thermoresistible__bu AVVHNAGISAAGMVEETPLSLWEQMFATTVFGPVALTRELLPGMRRAGRG
MAB_1305|M.abscessus_ATCC_1997 ILVNNAGESQIGALEDVSMDDFEKLYMTNVFGPVALTKAVLPGMRERRRG
MMAR_4002|M.marinum_M GLVDNAGIGVASPVEMVPLDALRQQLEVNVVGQIAVTQAFLPLLR-RAAG
MSMEG_3426|M.smegmatis_MC2_155 VVIANAGYGVEGIFEETPIAEMRAQFATNVFGVAATLQAALPYLRERRKG
MUL_3423|M.ulcerans_Agy99 VLVNNAGYGYRAAVEEGDDAEVRDLFETHFFGTVALIKAVLPDMRARRSG
Mvan_1012|M.vanbaalenii_PYR-1 VLVNNAGIGAVGAFEATPMQTVRELFDTNTFGVMAMTQAVVPQMRARRSG
Mb3083c|M.bovis_AF2122/97 VVLNIAGVSAWGTVDQLTHDQWSRMVAINLMGPIHVIETLVPPMVAAGRG
Rv3057c|M.tuberculosis_H37Rv VVLNIAGVSAWGTVDQLTHDQWSRMVAINLMGPIHVIETLVPPMVAAGRG
MLBr_01740|M.leprae_Br4923 IVMNIAGVSVWGTVDRLTHDQWSNVVAINLMGPIHIIETFVPAILAAGRG
:: ** . . .: .* . :* : *
MAV_1273|M.avium_104 R-IVLVSSAAGVRGQPGTAPYSAAKGALERWGESLAGEIAPFGLGVTVLV
Mflv_4152|M.gilvum_PYR-GCK R-IVLVSSASGVRGQPATAPYSAAKGALERWGEAMAVEIAPFGLGVTILV
TH_3605|M.thermoresistible__bu R-IVLVSSQQGVWGMPSTAPYSAAKGALERWAEAMAGEVNPFGIGVTVLV
MAB_1305|M.abscessus_ATCC_1997 A-VVMVGSMAGTLHVPFRSTYSSAKSALHTVADCLRYEVAPFGITVSTVE
MMAR_4002|M.marinum_M R-IVVIASIGDRFTPPFGGPLAASKAAIATLADALRQEVAPWGIKVVMIE
MSMEG_3426|M.smegmatis_MC2_155 H-LMAVTSMGGLMAVPGMSAYCASKFAVEGMLESIRKEISGFGIHVTAIE
MUL_3423|M.ulcerans_Agy99 A-IVNISSIAVALTPVGSGYYAAAKAAMEGMSGALHGELAPLGISVTVVE
Mvan_1012|M.vanbaalenii_PYR-1 V-VVNVTSSVTLAAMPLAAAYTASKAAIEGFTGSLALELGFFGVRAKLVE
Mb3083c|M.bovis_AF2122/97 GHLVNVSSAAGLVGLPWHAAYSASKYGLRGLSEVLRFDLARHGIGVSVVV
Rv3057c|M.tuberculosis_H37Rv GHLVNVSSAAGLVGLPWHAAYSASKYGLRGLSEVLRFDLARHGIGVSVVV
MLBr_01740|M.leprae_Br4923 GHLVNVSSAAGLVALPWHAAYSASKYGLRGLSEVLRFDLARYRIGVSVVV
:: : * . ::* .: : :: : . :
MAV_1273|M.avium_104 AGTYDTEIITDAGTTD-------DRNFSGPYARLHTTMNTRGRLAVS-FA
Mflv_4152|M.gilvum_PYR-GCK TGTYDTDIITDAGTTD-------NRDLAGPYARIHQTMDSRGRFAMG-MA
TH_3605|M.thermoresistible__bu TGVYDTEIITDAGTTD-------CRDLQGVYARHHRTMDKRGRAAVAKAA
MAB_1305|M.abscessus_ATCC_1997 PGVIATGIETRRNR--------IVPDGS-PYRDAFRTVDAAMAAREE-HG
MMAR_4002|M.marinum_M PASINSGAADKLERDAKKAIDEFGADGARLYRDAYLGMVKAALSRER-RG
MSMEG_3426|M.smegmatis_MC2_155 PGS-FRTDWAGRSMTR-------ADRSIADYDELFEPIRAARLKASGNQL
MUL_3423|M.ulcerans_Agy99 PGA-FRTDFAGRSLVQ-------STRMINDYAATAGQRRKENDTMHGNQP
Mvan_1012|M.vanbaalenii_PYR-1 PGYGPGTQFASNGSHR-------MADLIPDEYQDFAAPIMESFGSP-AAV
Mb3083c|M.bovis_AF2122/97 PGAVKTPLVNTVEIAG---------------VDRDDPRVNRWVERFSGHA
Rv3057c|M.tuberculosis_H37Rv PGAVKTPLVNTVEIAG---------------VDRDDPRVNRWVERFSGHA
MLBr_01740|M.leprae_Br4923 PGAVRTPLVDTIEIAG---------------VDRQDPRFSRWVDRFRGHA
..
MAV_1273|M.avium_104 RPPERFTDGLCKALDDRAPFRRRGVGPDASMLLAANRILPASGMHHLSRV
Mflv_4152|M.gilvum_PYR-GCK RPPERFTDGLVKALEDTAAFRRHGVGPDASMLLLSNRILPAAGMHHMSRV
TH_3605|M.thermoresistible__bu RPPEKFALALSKALDNPQPFVKRPAGPSARMLMIANRILPPATLHQMIRL
MAB_1305|M.abscessus_ATCC_1997 TATDELGRLVVDVALSPSPKPLYAKGSNAPIIMTAQRLLPARLFLKFLAR
MMAR_4002|M.marinum_M SPPTVVADLVLKVLTMARPHARNVVGKDARMLATVSRWLPTPALDALRRR
MSMEG_3426|M.smegmatis_MC2_155 GNPVKAAEAVLAILDEPEPPAHLVLGSDALRLVGAARAAVDEDIRRWEEL
MUL_3423|M.ulcerans_Agy99 GDPAKAAAAIITAVESPAPPAFLLLGPDALMAYRHIAQRRDVEITDWEQL
Mvan_1012|M.vanbaalenii_PYR-1 TTPDDVAEVVYLAATDASDRLRYAAGADAVALAQ----------------
Mb3083c|M.bovis_AF2122/97 VTPEKAADKILAGVTRNRYLVYTSADIRALYAFKRYAWWPYTLVMRRVNV
Rv3057c|M.tuberculosis_H37Rv VTPEKAADKILAGVTRNRYLVYTSADIRALYAFKRYAWWPYTLVMRRVNV
MLBr_01740|M.leprae_Br4923 VSAERAAEKILAGVAKNRYLIYTSHDIRVLYGFKRLAWWPYGVVMKQVNV
. : . .
MAV_1273|M.avium_104 VLGIPRQGSMRDGAWPLTHGQRAMVLVARVLPQPVLQRLAALAGRFSSPK
Mflv_4152|M.gilvum_PYR-GCK VLGIPRQGAMRDGAWPLTTAQRAMVAAAKVIPQPVMQRLVQWS---TRRA
TH_3605|M.thermoresistible__bu SLGLPRFG-------RLTTREDTHA-------------------------
MAB_1305|M.abscessus_ATCC_1997 MHGLKVR-------------------------------------------
MMAR_4002|M.marinum_M VFGLPKPGSLAISRSA----------------------------------
MSMEG_3426|M.smegmatis_MC2_155 SRSTDFADGAQLAST-----------------------------------
MUL_3423|M.ulcerans_Agy99 TAGTNLTP------------------------------------------
Mvan_1012|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb3083c|M.bovis_AF2122/97 FFTRALRPGP----------------------------------------
Rv3057c|M.tuberculosis_H37Rv FFTRALRPGP----------------------------------------
MLBr_01740|M.leprae_Br4923 VFTRALRPSPATMRCVEPIKVGVYSQPRSGEGGKSGN-------------
MAV_1273|M.avium_104 SAARQGDQEG
Mflv_4152|M.gilvum_PYR-GCK AGSGGGTSEG
TH_3605|M.thermoresistible__bu ----------
MAB_1305|M.abscessus_ATCC_1997 ----------
MMAR_4002|M.marinum_M ----------
MSMEG_3426|M.smegmatis_MC2_155 ----------
MUL_3423|M.ulcerans_Agy99 ----------
Mvan_1012|M.vanbaalenii_PYR-1 ----------
Mb3083c|M.bovis_AF2122/97 ----------
Rv3057c|M.tuberculosis_H37Rv ----------
MLBr_01740|M.leprae_Br4923 ----------