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PASDRQWWRQTDQFEWFSNYLRERGMQQRWRWATFTFTVVLGALPLVMLASPLGPDTDLTRGVAIVSGAA GAGASLLWLSGWPSRTQSLVYNALCSGGIAMGCLALSNPYSGLMGCTLFAVIGGFLAYFHSVGQVAANFA VAAICATITAARLVTETGDVALTAAAAINVIALNTGVPFGIHSLVHSLHTDLRAADRDPLTGLLNRRAFY SAVNQLLADTHAVDAAFNVTVIDLDKFKSLNDTRGHAVGDAALVYVAEILHRHAGASAVSGRLGGEEFVV ADVDLPVLQRRTADLIREGIAAGPFGITASLGICSARIAWEDSAAGGMSPDFLDKLIESADAAMYVSKRA GGDRVEHRRLDGADLADA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4002 | - | - | 100% (369) | diguanylate cyclase |
| M. gilvum PYR-GCK | Mflv_1453 | - | 3e-61 | 40.66% (364) | diguanylate cyclase |
| M. gilvum PYR-GCK | Mflv_3822 | - | 8e-61 | 38.06% (360) | diguanylate cyclase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1389c | - | 2e-14 | 29.92% (244) | hypothetical protein Mb1389c |
| M. tuberculosis H37Rv | Rv1354c | - | 2e-14 | 29.92% (244) | hypothetical protein Rv1354c |
| M. leprae Br4923 | MLBr_00397 | - | 3e-12 | 33.33% (162) | putative transporter protein |
| M. abscessus ATCC 19977 | MAB_3940c | - | 1e-40 | 30.75% (361) | hypothetical protein MAB_3940c |
| M. marinum M | - | - | - | - | - |
| M. avium 104 | MAV_1995 | - | 5e-59 | 39.15% (355) | diguanylate cyclase |
| M. smegmatis MC2 155 | MSMEG_2774 | - | 1e-21 | 26.49% (336) | diguanylate cyclase |
| M. thermoresistible (build 8) | TH_3406 | - | 7e-47 | 32.02% (356) | PUTATIVE diguanylate cyclase |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_2385 | - | 1e-119 | 59.66% (357) | diguanylate cyclase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1389c|M.bovis_AF2122/97 ------------------MCNDTATPQLEELVTT--VANQLMTVDAATSA
Rv1354c|M.tuberculosis_H37Rv ------------------MCNDTATPQLEELVTT--VANQLMTVDAATSA
Mflv_4002|M.gilvum_PYR-GCK ----------MPASDRQWWRQTDQFEWFSNYLRERGMQQRWRWATFTFTV
Mvan_2385|M.vanbaalenii_PYR-1 ----------MLGWWRGWWQRPDQFDWFSAYLRDRGLQVRWRMATFVFTV
MAB_3940c|M.abscessus_ATCC_199 MIVSYIRSTAWMGFLRQWWTEPVPTGWLRGFLHARKLDRTVRNLIGGYAL
MAV_1995|M.avium_104 -----------MKWLAAWWGQPDHFDWLTGYLQDHGFGTATRRAMAVVGA
MSMEG_2774|M.smegmatis_MC2_155 ------------------MSPFDHYYARTAMLSAQGQRSRMRRIIGVTIT
TH_3406|M.thermoresistible__bu ----------MLKALRRTWRKPDHYYWFTSFLAARRARTSTCRFIASITL
MLBr_00397|M.leprae_Br4923 --------MDHTTKCDAEQYFQAIVTSMADGVIVVDIDGRIESINPAATR
:
Mb1389c|M.bovis_AF2122/97 EVSQRVLAYLVEQLGV----DVSFLRHNDRDRRATRLVAEWPPRLN-IPD
Rv1354c|M.tuberculosis_H37Rv EVSQRVLAYLVEQLGV----DVSFLRHNDRDRRATRLVAEWPPRLN-IPD
Mflv_4002|M.gilvum_PYR-GCK VLGALPLVMLASPLGP----DTDLTRGVAIVSGAAGAGASLLWLSG-WPS
Mvan_2385|M.vanbaalenii_PYR-1 LLVAVPVVMVGSPAGP----GGPLQTWIVIGAAASALAASLLWLFR-WPS
MAB_3940c|M.abscessus_ATCC_199 IFAAICIAVQFSDTGP----RSMIGRVIVGLCAVGSLGWALRWAVGPWPS
MAV_1995|M.avium_104 SLVLVPANVLWGATPF----FPGLTLTVSVLAGMVGLGMAVLWLHG-WPT
MSMEG_2774|M.smegmatis_MC2_155 ALAFVPVLMLASPAGP----AGAL-RYVPLGATACGVLMSVWWWRRKWPS
TH_3406|M.thermoresistible__bu ILGLMPMVMLAGPAGP----QSMPGRLIAVAVTVTALVITLIWLRDRWPS
MLBr_00397|M.leprae_Br4923 ILGLRAHDVVDMKHGHPFCFYDTDNQRVDLEREVMRVVRREVTTVSKVVG
.
Mb1389c|M.bovis_AF2122/97 PDPLRLIYFADADPVFALCEHAKEP---LVFRPEP--ATEDYQRLIEEAR
Rv1354c|M.tuberculosis_H37Rv PDPLRLIYFADADPVFALCEHAKEP---LVFRPEP--ATEDYQRLIEEAR
Mflv_4002|M.gilvum_PYR-GCK RTQSLVYNALCSGGIAMGCLALSNPYSGLMGCTLF--AVIGGFLAYFHSV
Mvan_2385|M.vanbaalenii_PYR-1 RAQSLAYSTVCSVSIAAGCLAIQDPYAGLMGCTMF--AAIGGFVAYFHAL
MAB_3940c|M.abscessus_ATCC_199 LREAVAFVAFADIGIAVACWQDSDPLAGLVGTVLF--TPVGAYVSFFLAN
MAV_1995|M.avium_104 RRQSVVFALTGSVAIGAGCLWQTEPLVGLMACSAL--SVTGGYNAFFHTA
MSMEG_2774|M.smegmatis_MC2_155 RNQSWLVVGIGTVGIAVTLSSMSDPTVGLLSSSVF--SLVTTYSAFLHSR
TH_3406|M.thermoresistible__bu RNQSRVVSLAAGLAIAVFAFTLPDPSAGLVWTAAF--AVLAGYVALFHSA
MLBr_00397|M.leprae_Br4923 IDQHSGQRLWLSVNVSLLAYKAPPHSALVVSFSDISAHHLSIERLTYEAT
: :: :
Mb1389c|M.bovis_AF2122/97 GVPVTSAAAVPLVSGEITTGLLGFIKFGDRKWHEAELNALMTIATLFAQV
Rv1354c|M.tuberculosis_H37Rv GVPVTSAAAVPLVSGEITTGLLGFIKFGDRKWHEAELNALMTIATLFAQV
Mflv_4002|M.gilvum_PYR-GCK GQVAANFAVAAICATITAARLVTET--GDVALTAAAAINVIALNTGVPFG
Mvan_2385|M.vanbaalenii_PYR-1 AHVVANLVVALSCATINAVRILVET--DDIRIVAGSAALVLGLNLGVPFG
MAB_3940c|M.abscessus_ATCC_199 RLLVAHVAWCAPMIIALSSRLFAEGTVGAAMTALVKVTSMLLVVVLIPAV
MAV_1995|M.avium_104 KFMGLNFGLAGAIGALQAARLAAS---GQAMLAFTGYFLVLELNVIVPLS
MSMEG_2774|M.smegmatis_MC2_155 RVLVLSWIASGLTVGFLAIRVAFTS----IPMALSGALVSGLVIATTSML
TH_3406|M.thermoresistible__bu RYATFTVLFAAITAGVLSFELAKTAG---VAAAVCGFVFITVVTFAVVCA
MLBr_00397|M.leprae_Br4923 HDCLTGLANRRFAEDQITKSLQHDERSRLAAVLLLDLDDFKVINDSLGHD
: : :
Mb1389c|M.bovis_AF2122/97 QARVAAEARLRYLAD---HDDLTGLHNRRALLQHLDQRLAPGQPGP----
Rv1354c|M.tuberculosis_H37Rv QARVAAEARLRYLAD---HDDLTGLHNRRALLQHLDQRLAPGQPGP----
Mflv_4002|M.gilvum_PYR-GCK IHSLVHSLHTDLRAA--DRDPLTGLLNRRAFYSAVNQLLADTHAVD----
Mvan_2385|M.vanbaalenii_PYR-1 IHTLVHSLHIDLRDS--DRDPLTGLLNRRSFYNMVRDLIAARRQVN----
MAB_3940c|M.abscessus_ATCC_199 IQFGIAVVRWDALAA--QRDPLTGLLNRRGIYAEWQRLYGELRREQPLDG
MAV_1995|M.avium_104 IQIVVRALWLDLLRA--NRDPLTGLLNRR---ACNRAIIGRMLTG---AS
MSMEG_2774|M.smegmatis_MC2_155 CRMAIRLLDAGNVQHPNEIDRLTGLLNREAFEIQAATMLGSHSRHD----
TH_3406|M.thermoresistible__bu CNLLVGLLDVDVLDA--DIEPLTGLLNRDAFYRSAGHLI-SRSRDD----
MLBr_00397|M.leprae_Br4923 VGDAVLQTVAQRLRSAVRPDDVVARLGGDEFIVLLRGPLSDMNAND---V
: :.. .
Mb1389c|M.bovis_AF2122/97 ---VAALFLDLDRLKAINDYLGHAAGDQFIHVFAQRIGDALVGESLIARL
Rv1354c|M.tuberculosis_H37Rv ---VAALFLDLDRLKAINDYLGHAAGDQFIHVFAQRIGDALVGESLIARL
Mflv_4002|M.gilvum_PYR-GCK -AAFNVTVIDLDKFKSLNDTRGHAVGDAALVYVAEILHRHAGASAVSGRL
Mvan_2385|M.vanbaalenii_PYR-1 -TPVNVTMVDLDDFKLLNDTHGHAVGDAALVSVAAVLQEHTEPGTVLGRL
MAB_3940c|M.abscessus_ATCC_199 DQVTAAAIVDIDRFKSINDRYGHGTGDRVLIDVAHALTCGTTGTSVVGRS
MAV_1995|M.avium_104 HMFLAVAMVDLDRFKALNDTHGHAAGDEALIAVAGALTAACGDTTVVGRV
MSMEG_2774|M.smegmatis_MC2_155 DQYLVILAVGIDDMSLLSDMDGTHSTLHARVAVAQALRETVRHRVPLAHV
TH_3406|M.thermoresistible__bu DRQLVIALINIDNLRLLRDTQGQAAADRARVAIGQTLRENTRHNAFVAHL
MLBr_00397|M.leprae_Br4923 AKRLHTTLSESLVVDQLTVPIGASVGILEVRPDDRRRAADILRDADSAMY
. : * .
Mb1389c|M.bovis_AF2122/97 GGDEFVLIPASPMSADAAQPLAERLRDQLKDHVAIG----GEVLTRTVSI
Rv1354c|M.tuberculosis_H37Rv GGDEFVLIPASPMSADAAQPLAERLRDQLKDHVAIG----GEVLTRTVSI
Mflv_4002|M.gilvum_PYR-GCK GGEEFVVADVDLPVL--QRRTADLIREGIAAGPFG---ITASLGICSARI
Mvan_2385|M.vanbaalenii_PYR-1 GGEEFVIADVDAAAR--HAITAERIRRGIAATPFQ---ITASFGICSTTV
MAB_3940c|M.abscessus_ATCC_199 GGEEFLVVTVCPASA--VAEFATRLRQAVTASMPAGIAVTASVGVAAQAV
MAV_1995|M.avium_104 GGEEFLVADIVTTEQ--LPGWGQQLCEAVAALDPP---VTASVGTATLPL
MSMEG_2774|M.smegmatis_MC2_155 SDSEFLIADVFKTND--PSPLVERMRLAISTTPMR---LTASIGTVCSPL
TH_3406|M.thermoresistible__bu GQDEFLIADTFSSTD--SFPLVERVRGAIATTPPR---LTASIGVVSTPM
MLBr_00397|M.leprae_Br4923 AAKNKKQCAVTPQQLVPFVALIALFVFFTAAAGAKFYAPSNLLVILQQTV
. .: . . :
Mb1389c|M.bovis_AF2122/97 GVASGTP---GQHTPSDLLRRADQAALAAKHAGGDSVAIFTADMSVSGEL
Rv1354c|M.tuberculosis_H37Rv GVASGTP---GQHTPSDLLRRADQAALAAKHAGGDSVAIFTADMSVSGEL
Mflv_4002|M.gilvum_PYR-GCK AWEDSAAGGMSPDFLDKLIESADAAMYVSKRAGGDRVEHRRLDGADLADA
Mvan_2385|M.vanbaalenii_PYR-1 AAGAEID---HPGFLDRLIRAADAAMYQSKRAGGNRVVHDRLDIPG----
MAB_3940c|M.abscessus_ATCC_199 SRVVSAT---SQEAIEVLTACADRAMYEAKHDGGDQSRILHADDDSEGRY
MAV_1995|M.avium_104 RDLVSEY---AEHAFHQLVAQADSAMYEAKRCGGNQTRHRPAQVST----
MSMEG_2774|M.smegmatis_MC2_155 APLASLP---AEQVLQELIDVAMRAMNESRAAGGNQTISVNYPTPTPNQE
TH_3406|M.thermoresistible__bu RGLAVCP---PETLLDELIAVASATMYEARRAGGNQARYRKYPNPTAVTE
MLBr_00397|M.leprae_Br4923 VLAIVGYG-MTFVIMAGSVDLSVGSIVALTGVTAALVAAQNQFAAIVTAL
: : .
Mb1389c|M.bovis_AF2122/97 RNDIELHLRRGIESDALRLVYLPEVDLRTGDIVGTEALVRWQHPTRGLLA
Rv1354c|M.tuberculosis_H37Rv RNDIELHLRRGIESDALRLVYLPEVDLRTGDIVGTEALVRWQHPTRGLLA
Mflv_4002|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2385|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_3940c|M.abscessus_ATCC_199 LWRSGA--------------------------------------------
MAV_1995|M.avium_104 --------------------------------------------------
MSMEG_2774|M.smegmatis_MC2_155 --------------------------------------------------
TH_3406|M.thermoresistible__bu AHYPEQAADDF---------------------------------------
MLBr_00397|M.leprae_Br4923 LVGLAAGMVNGIVFAYGKIPSFVSTLGMLQVCRGITLMISDSSAKPMPFH
Mb1389c|M.bovis_AF2122/97 PGCFIPVAESINLAGELDRWVLRRACNEFSEWQSAGLGHDALLRINVSAG
Rv1354c|M.tuberculosis_H37Rv PGCFIPVAESINLAGELDRWVLRRACNEFSEWQSAGLGHDALLRINVSAG
Mflv_4002|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2385|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_3940c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_1995|M.avium_104 --------------------------------------------------
MSMEG_2774|M.smegmatis_MC2_155 --------------------------------------------------
TH_3406|M.thermoresistible__bu --------------------------------------------------
MLBr_00397|M.leprae_Br4923 GILGAMGAMPWILIVCLFVTILAGILFQFTMFGRWVKAIGGNERVATLAG
Mb1389c|M.bovis_AF2122/97 QLVTGGFVDFVADTIGQHGLDASSVCLEITENVVVQDLHTARATLARLKE
Rv1354c|M.tuberculosis_H37Rv QLVTGGFVDFVADTIGQHGLDASSVCLEITENVVVQDLHTARATLARLKE
Mflv_4002|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2385|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_3940c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_1995|M.avium_104 --------------------------------------------------
MSMEG_2774|M.smegmatis_MC2_155 --------------------------------------------------
TH_3406|M.thermoresistible__bu --------------------------------------------------
MLBr_00397|M.leprae_Br4923 VPTRGIKVAIFAICGLTAGLGGIVLASRLGAGTPTAATGFEIDVIAAVVI
Mb1389c|M.bovis_AF2122/97 VGVHIAIDDFGTGYSAISLLQTLPIDTLKIDKTFVRQLGTNTSDLVIVRG
Rv1354c|M.tuberculosis_H37Rv VGVHIAIDDFGTGYSAISLLQTLPIDTLKIDKTFVRQLGTNTSDLVIVRG
Mflv_4002|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2385|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_3940c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_1995|M.avium_104 --------------------------------------------------
MSMEG_2774|M.smegmatis_MC2_155 --------------------------------------------------
TH_3406|M.thermoresistible__bu --------------------------------------------------
MLBr_00397|M.leprae_Br4923 GGTPLTGGLGRLSGTLIGAIIISMLSNGMVFMGVGNAASQIIKGIMLAAA
Mb1389c|M.bovis_AF2122/97 IMTLAEGFQLDVVAEGVETEAAARILLDQRCYRAQGFLFSRPVPGEAMRH
Rv1354c|M.tuberculosis_H37Rv IMTLAEGFQLDVVAEGVETEAAARILLDQRCYRAQGFLFSRPVPGEAMRH
Mflv_4002|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2385|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_3940c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_1995|M.avium_104 --------------------------------------------------
MSMEG_2774|M.smegmatis_MC2_155 --------------------------------------------------
TH_3406|M.thermoresistible__bu --------------------------------------------------
MLBr_00397|M.leprae_Br4923 VFVFLQRRKIGIIK------------------------------------
Mb1389c|M.bovis_AF2122/97 MLSARRLPPTCIPATDPALS
Rv1354c|M.tuberculosis_H37Rv MLSARRLPPTCIPATDPALS
Mflv_4002|M.gilvum_PYR-GCK --------------------
Mvan_2385|M.vanbaalenii_PYR-1 --------------------
MAB_3940c|M.abscessus_ATCC_199 --------------------
MAV_1995|M.avium_104 --------------------
MSMEG_2774|M.smegmatis_MC2_155 --------------------
TH_3406|M.thermoresistible__bu --------------------
MLBr_00397|M.leprae_Br4923 --------------------