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MPTRDDVRIPAHGDEIAAYVYRPPAGVGATACVVMAHGFTGTRDDGLPDYAEAFRDAGYVVVLFDYRHFG ASSGQPRQLLDMARQREDFHTVIEWARRLDGVDPNRIVAWGSSFSGGHVLAVAAEDPRLAAVIAQAPFTD ALATLRNAPLRNIPPMVVAALRDQLGAWRNRPPRMLAAVGPPGDLAALTSPDAEPGFGAILGPESLWRNE FAARLMLRFAFERPGRKAATLQMPVLFCVCDDDVVTPPGPTIEAARRAPCGELRRYPYGHFDIYHDPQVK ADQLEFLHRALARGGR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3976 | - | - | 100% (296) | dienelactone hydrolase |
| M. gilvum PYR-GCK | Mflv_3465 | - | 2e-48 | 39.47% (304) | peptidase S15 |
| M. gilvum PYR-GCK | Mflv_4372 | - | 3e-46 | 37.46% (299) | alpha/beta hydrolase fold |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2330c | - | 5e-08 | 30.25% (119) | hypothetical protein Mb2330c |
| M. tuberculosis H37Rv | Rv2307c | - | 5e-08 | 30.25% (119) | hypothetical protein Rv2307c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2608 | - | 1e-49 | 40.07% (297) | putative hydrolase, alpha/beta fold |
| M. marinum M | MMAR_0385 | - | 3e-66 | 44.52% (301) | hypothetical protein MMAR_0385 |
| M. avium 104 | MAV_2688 | - | 3e-08 | 44.07% (59) | alpha/beta hydrolase |
| M. smegmatis MC2 155 | MSMEG_4450 | - | 5e-60 | 41.31% (305) | alpha/beta hydrolase |
| M. thermoresistible (build 8) | TH_2570 | - | 1e-121 | 70.21% (292) | PUTATIVE alpha/beta hydrolase fold |
| M. ulcerans Agy99 | MUL_1035 | - | 1e-64 | 43.93% (305) | hypothetical protein MUL_1035 |
| M. vanbaalenii PYR-1 | Mvan_2419 | - | 1e-135 | 78.55% (289) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3976|M.gilvum_PYR-GCK -----MPTRDDVRIPAHGDEIAAYVYRPPAGVGA--TACVVMAHGFTGTR
Mvan_2419|M.vanbaalenii_PYR-1 ------MTRQEVQIPADGGQIAAYVYRPQVTGGG--TACIVMAHGFTGTR
TH_2570|M.thermoresistible__bu ---MATTDRRDLRIPAHGEQLAAYFYPPAGAGPT--TPCIVMAHGFTATR
MMAR_0385|M.marinum_M -----MTQRQDVRFPCGEAMISAWLYRPAGADPARPVPMLVMAHGLGAVR
MUL_1035|M.ulcerans_Agy99 -----MTQRQDVRFPCGEALISAWLYRPAGADPARPVPMLVMAHGLGAVR
MAV_2688|M.avium_104 --------------------------------------------------
MAB_2608|M.abscessus_ATCC_1997 ------MNRQSIRFNSHGIDCEAWLYRAQTVEDT--APIVVMAHGVGGTK
MSMEG_4450|M.smegmatis_MC2_155 MAQPLSYTRDDVTFMSDGTSCAAWLYRPDGVNNP---PIVVLAHGFAAFR
Mb2330c|M.bovis_AF2122/97 ---MSLKRCRALPVVAIVALVASGVITFIWSQQR--RLIYFPSAGPVPSA
Rv2307c|M.tuberculosis_H37Rv ---MSLKRCRALPVVAIVALVASGVIMFIWSQQR--RLIYFPSAGPVPSA
Mflv_3976|M.gilvum_PYR-GCK DDGLPDYAEAFRDAGYVVVLFDYRHFGASSGQPRQLLDMARQREDFHTVI
Mvan_2419|M.vanbaalenii_PYR-1 DDGLPDYAEAFCAAGHTVVLFDYRHFGASTGEPRQLLDIAEQRRDYHTVI
TH_2570|M.thermoresistible__bu DDGLPAYAEAFHAAGYAVVLFDYRHFGASTGEPRQLLDITRQHDDYRAVV
MMAR_0385|M.marinum_M TMRLDAYAQRFSAAGYACLVFDYRNFGDSEGQPRQLLDIRMQLQDWAAAV
MUL_1035|M.ulcerans_Agy99 TMRLDAYAQRFSAAGYACLVFDYRNFGDSEGQPRQLLDIRMQLQDWAAAV
MAV_2688|M.avium_104 --------------------------------------------------
MAB_2608|M.abscessus_ATCC_1997 DSGLEPFAVRLAEAGMHALAFDYRGFGASDGFPRQHVSFTHQIGDYHAAV
MSMEG_4450|M.smegmatis_MC2_155 ELRLDAYAARFAQAGYAALVFDYRHWGASDGQPRRILDIPKQQTDWRAAI
Mb2330c|M.bovis_AF2122/97 SSVLPAGRDVVVETQDGMRLGGWYFPHTSGGSGPAVLVCNGNAGDRSMRA
Rv2307c|M.tuberculosis_H37Rv SSVLPAGRDVVVETQDGMRLGGWYFPHTSGGSGPAVLVCNGNAGDRSMRA
Mflv_3976|M.gilvum_PYR-GCK EWARRLDGVDPNRIVAWGSSFSGGHVLAVAAEDPRLAAVIAQAPFTDALA
Mvan_2419|M.vanbaalenii_PYR-1 AWARHLDGVDPNRIVVWGSSFSGGHVLAVAAEDPRIAAVIAQAPFTDALA
TH_2570|M.thermoresistible__bu AWARTQPGVDPDRIVLWGSSFSGGHVLVVAADDPRIAAVISQAPFTDAVP
MMAR_0385|M.marinum_M AYARTCDGVDQARIGLWGTSFGGGHVIATAARLPGIAAVVAQCPFTDGIA
MUL_1035|M.ulcerans_Agy99 AYARTCDGVDQARIGLWGTSFGGGHVIATAARLPGIAAVVAQCPFTDGIA
MAV_2688|M.avium_104 --------------------------------------------------
MAB_2608|M.abscessus_ATCC_1997 NMARRLPGVDPTRIVLWGVSLAGGHVMAVAGARNDVAAVIALTPLVDGIA
MSMEG_4450|M.smegmatis_MC2_155 AYARSLDNVDTTRLVGWGSSFGGGHVLTLAARDHEFAAAIVQVPHVSGPA
Mb2330c|M.bovis_AF2122/97 ELAVALHGLGLSVLLFDYRGYGG--NPGRPSEQGLAADARAAQEWLSGQS
Rv2307c|M.tuberculosis_H37Rv ELAVALHGLGLSVLLFDYRGYGG--NPGRPSEQGLAADARAAQEWLSGQS
Mflv_3976|M.gilvum_PYR-GCK TLRNAPLRNIPPMVVAALRDQLGAWRNRPPRMLAAVGPPGDLAALTSPDA
Mvan_2419|M.vanbaalenii_PYR-1 TLREIPPGNIPLLLIAAVRDQVGAWRGRPPHTVAAVGSPGTVAALTSPDA
TH_2570|M.thermoresistible__bu TLRKVPPATIARLAVAGLRDQIGSWRGRPPRTASAVGAPGAVAAMTTPDA
MMAR_0385|M.marinum_M SVLAIAPTTAIRVTARSMRDLIGSRLGRPPVMIPTAGKPGEVALMTAPDA
MUL_1035|M.ulcerans_Agy99 SVLAIAPTTAIRVTARSMRDLIGSRLGRPPVMIPTAGKPGEVALMTAPDA
MAV_2688|M.avium_104 --------------------------------------------------
MAB_2608|M.abscessus_ATCC_1997 AARSAMTEHSAGTLLRSAVTGLRSRLGRQQRTIPIVGRAGELAALTSDGY
MSMEG_4450|M.smegmatis_MC2_155 SAFSQSPKLVARLIAAGLRDQIGAWFGGAPHRVTSIGRPGEFAMMTSPGA
Mb2330c|M.bovis_AF2122/97 DVDPARIAYFGESLGAAVAVGLAVQ--RPPAALVLRSPFTSLAEVG----
Rv2307c|M.tuberculosis_H37Rv DVDPARIAYFGESLGAAVAVGLAVQ--RPPAALVLRSPFTSLAEVG----
Mflv_3976|M.gilvum_PYR-GCK EPGFGAILGPES--------LWRNEFAARLMLRFAFERPGRKAATLQMPV
Mvan_2419|M.vanbaalenii_PYR-1 KPGFEAIIGPNS--------LWRNEFAARLMFTFAFNRPGRKAAKLRMPV
TH_2570|M.thermoresistible__bu EPGFRAIVEPDS--------LWRNEFAARLMLRFPFYRPVRVAGRINAPL
MMAR_0385|M.marinum_M YPGYLGLMPQGT--------QVPNEVAARIGIKVLGYRPGRSARKIACPI
MUL_1035|M.ulcerans_Agy99 YPGYLGLMPQGT--------QVPNEVAARIGIKVLGYRPGRSARKIACPI
MAV_2688|M.avium_104 ---------------------------------------------MSCPI
MAB_2608|M.abscessus_ATCC_1997 YEAHLAIAGP----------AWRNEIDATVGTQLVSYRPTRCASRIGCPI
MSMEG_4450|M.smegmatis_MC2_155 YELVEEMAGGEAAEHMRAQLEAENDVAARIALRVPLYSPGRHAAKITAPT
Mb2330c|M.bovis_AF2122/97 --------------------AVHYPWLPLRRLLLDHYPSIERIASVHAPV
Rv2307c|M.tuberculosis_H37Rv --------------------AVHYPWLPLRRLLLDHYPSIERIASVHAPV
: *
Mflv_3976|M.gilvum_PYR-GCK LFCVCDDDVVTPPGPTIEAARRAPCG----ELRRYPYGHFDIYHD----P
Mvan_2419|M.vanbaalenii_PYR-1 LLCVCDDDVVTPPGPSVEAAHRAPRG----ELCRYPYGHFDIYHD----P
TH_2570|M.thermoresistible__bu LVCVCDDDAVTPPEPAIEAARRAPRG----QLRRYPYGHFDIYHD----P
MMAR_0385|M.marinum_M LFCVCETDSVAPAGPTLRYAARAPRG----EVIRYPEGHFAIYLG-DAFE
MUL_1035|M.ulcerans_Agy99 LFCVCETDSVAPAGPTLRYAARAPRGEVSGEVIRYPEGHFAIYLG-DAFE
MAV_2688|M.avium_104 LFAICENDTVAPAKATQKYAAQAPRG----EIKLYDAGHFDIYVG-ADFE
MAB_2608|M.abscessus_ATCC_1997 LVQIADFDRAAPPHAAAK-AAFKARA----EVRHYPCDHFGVYHGQECHE
MSMEG_4450|M.smegmatis_MC2_155 LVQLATKDDVTPYAKARKIVARIPNG----EVRSYDITHFEPYVD-PHFE
Mb2330c|M.bovis_AF2122/97 LVIAGGSDDIVPATLSEWLVAAAAEPKRYVVVPGVGHNDPELLDG----R
Rv2307c|M.tuberculosis_H37Rv LVIAGGSDDIVPATLSERLVAAAAEPKRYVVVPGVGHNDPELLDG----R
*. * .* : . . : . .
Mflv_3976|M.gilvum_PYR-GCK QVKADQLEFLHRALARGGR--------
Mvan_2419|M.vanbaalenii_PYR-1 KVKADQLEFLARVVGDRTA--------
TH_2570|M.thermoresistible__bu QVKSDQLDFLRQVLGTG----------
MMAR_0385|M.marinum_M RVVADQLGFLDKHLKPAGQP-------
MUL_1035|M.ulcerans_Agy99 HVVADQLGFLDKHLKPAGQP-------
MAV_2688|M.avium_104 RNVTDQLNFLSRHVPVS----------
MAB_2608|M.abscessus_ATCC_1997 LVIGHQISFLSRHLSIEAVSHTEALHG
MSMEG_4450|M.smegmatis_MC2_155 QIVTDQIDFLNRHVGAGTR--------
Mb2330c|M.bovis_AF2122/97 VMLDAIRRFLTETAVLGQ---------
Rv2307c|M.tuberculosis_H37Rv VMLDAIRRFLTETAVLGQ---------
** .