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SLKRCRALPVVAIVALVASGVIMFIWSQQRRLIYFPSAGPVPSASSVLPAGRDVVVETQDGMRLGGWYFP HTSGGSGPAVLVCNGNAGDRSMRAELAVALHGLGLSVLLFDYRGYGGNPGRPSEQGLAADARAAQEWLSG QSDVDPARIAYFGESLGAAVAVGLAVQRPPAALVLRSPFTSLAEVGAVHYPWLPLRRLLLDHYPSIERIA SVHAPVLVIAGGSDDIVPATLSERLVAAAAEPKRYVVVPGVGHNDPELLDGRVMLDAIRRFLTETAVLGQ *
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2307c | - | - | 100% (281) | hypothetical protein Rv2307c |
| M. tuberculosis H37Rv | Rv2385 | mbtJ | 9e-06 | 30.77% (156) | putative acetyl hydrolase MBTJ |
| M. tuberculosis H37Rv | Rv2715 | - | 6e-05 | 30.51% (118) | hydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2330c | - | 1e-158 | 99.29% (281) | hypothetical protein Mb2330c |
| M. gilvum PYR-GCK | Mflv_3465 | - | 3e-11 | 33.61% (122) | peptidase S15 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2608 | - | 1e-06 | 30.58% (121) | putative hydrolase, alpha/beta fold |
| M. marinum M | MMAR_3699 | mbtJ | 2e-08 | 33.77% (151) | acetyl hydrolase MbtJ |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | MSMEG_2203 | - | 2e-11 | 33.59% (128) | alpha/beta hydrolase |
| M. thermoresistible (build 8) | TH_0434 | - | 1e-98 | 68.75% (256) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_3642 | mbtJ | 2e-08 | 33.77% (151) | acetyl hydrolase MbtJ |
| M. vanbaalenii PYR-1 | Mvan_2419 | - | 8e-09 | 27.89% (190) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
Rv2307c|M.tuberculosis_H37Rv ----------MSLKRCRALPVVAIVALVASGVIMFIWSQQRRLIYFPSAG
Mb2330c|M.bovis_AF2122/97 ----------MSLKRCRALPVVAIVALVASGVITFIWSQQRRLIYFPSAG
TH_0434|M.thermoresistible__bu ---------------------------VATGVLGLLWSQQRRLIYFPSPG
Mflv_3465|M.gilvum_PYR-GCK ----------------------------------MTAGWTTSAVSFPC--
Mvan_2419|M.vanbaalenii_PYR-1 --------------------------------------MTRQEVQIPA--
MAB_2608|M.abscessus_ATCC_1997 --------------------------------------MNRQSIRFNS--
MSMEG_2203|M.smegmatis_MC2_155 --------------------------------------MTYTEFTFHS--
MMAR_3699|M.marinum_M MTDVVPVRGSLRSRTAVAVSSIMMPPITAAIPPERAWGIWMTRQLIARLM
MUL_3642|M.ulcerans_Agy99 MTDVVPVRGSLRSRTAVAVSSIMMPPIIAAIPPERAWGIWMTRQVIARLM
:
Rv2307c|M.tuberculosis_H37Rv PVPSASSVLPAGRDVVVETQDGMRLG-----GWYFPHTSGGSG-PAVLVC
Mb2330c|M.bovis_AF2122/97 PVPSASSVLPAGRDVVVETQDGMRLG-----GWYFPHTSGGSG-PAVLVC
TH_0434|M.thermoresistible__bu PVPSATTVSVDARDVVLRTADGLELG-----AWYFPAPGGRPS-PAVLVS
Mflv_3465|M.gilvum_PYR-GCK --------------------DGEQIA-----GVLYRPEGGAPPFPCVVFA
Mvan_2419|M.vanbaalenii_PYR-1 --------------------DGGQIA-----AYVYRPQVTGGGTACIVMA
MAB_2608|M.abscessus_ATCC_1997 --------------------HGIDCE-----AWLYRAQTVEDTAPIVVMA
MSMEG_2203|M.smegmatis_MC2_155 --------------------GGQRCS-----AWHFPAGSGGSGNPVVVMA
MMAR_3699|M.marinum_M GTLGPSLSGTHVKPVNSVLPDGRRVVGEWVHGPHLPTGPAPNRSGAIYFV
MUL_3642|M.ulcerans_Agy99 GTLGPSLSGTHVKPVNSVLPDGRRVVGEWVHGPHLPTGPAPNRSGAIYFV
* . : .
Rv2307c|M.tuberculosis_H37Rv NGNAGDR-SMRAELAVALHGLGLSVLLFDYRGYGGNPGRPSE----QGLA
Mb2330c|M.bovis_AF2122/97 NGNAGDR-SMRAELAVALHGLGLSVLLFDYRGYGGNPGRPSE----QGLA
TH_0434|M.thermoresistible__bu NGNGGDR-SGRVALAVSLRRLGMAVLLFDYRGYGGNPGRPSE----EGLA
Mflv_3465|M.gilvum_PYR-GCK HGFSGTMDWILPDFAAVFCAAGLAVLTFDYRGFGSSEGTPRQIVNSARQL
Mvan_2419|M.vanbaalenii_PYR-1 HGFTGTRDDGLPDYAEAFCAAGHTVVLFDYRHFGASTGEPRQLLDIAEQR
MAB_2608|M.abscessus_ATCC_1997 HGVGGTKDSGLEPFAVRLAEAGMHALAFDYRGFGASDGFPRQHVSFTHQI
MSMEG_2203|M.smegmatis_MC2_155 HGFGGTKDSGLQPFAERFSAAGLDAVAFDYRGFGASEGEPRQSISVERQL
MMAR_3699|M.marinum_M HGSGYTMCSPRTHRRLTAWLSSLTGLPVFSVDYRLAPRHRFP-----TAA
MUL_3642|M.ulcerans_Agy99 HGSGYTMCSPRTHRRLTAWLSSLTGLPVFSVDYRLAPRHRFP-----TAA
:* . : . :
Rv2307c|M.tuberculosis_H37Rv ADARAAQEWLSGQSDVDPARIAYFGESLGA----AVAVGLAVQRP-PAAL
Mb2330c|M.bovis_AF2122/97 ADARAAQEWLSGQSDVDPARIAYFGESLGA----AVAVGLAVQRP-PAAL
TH_0434|M.thermoresistible__bu LDIRAAHDWLREQPDVDPARMVYFGESLGA----AVALELAVERP-PAAL
Mflv_3465|M.gilvum_PYR-GCK EDIRAALDVVRNRADVDPGRIGLWGTSLGG----SHVLQIAAEDPRVAAV
Mvan_2419|M.vanbaalenii_PYR-1 RDYHTVIAWARHLDGVDPNRIVVWGSSFSG----GHVLAVAAEDPRIAAV
MAB_2608|M.abscessus_ATCC_1997 GDYHAAVNMARRLPGVDPTRIVLWGVSLAG----GHVMAVAGARNDVAAV
MSMEG_2203|M.smegmatis_MC2_155 ADYDAAIRAAQAMPGVDPRKVVLWGSSFSG----SHVLRAAARNTDVAAV
MMAR_3699|M.marinum_M DDVRAGWDWLPGACGLSPERMVVVADSAGGHLSVDLLLQPDVAARPPASL
MUL_3642|M.ulcerans_Agy99 DDVRAGWDWLPGACGLSPERMVVVADSAGGHLSVDLLLQPDVAARPPASL
* : .:.* :: . * .. : *::
Rv2307c|M.tuberculosis_H37Rv VLRSPFTSLAEVGA------------------------------------
Mb2330c|M.bovis_AF2122/97 VLRSPFTSLAEVGA------------------------------------
TH_0434|M.thermoresistible__bu VLRSPFTSLADVAR------------------------------------
Mflv_3465|M.gilvum_PYR-GCK VANVPALDMYTGLRGRHRSPDYRPGPAQIVVAVARLLSAAVVDEVRGRLG
Mvan_2419|M.vanbaalenii_PYR-1 IAQAPFTDALATLR------EIPPG------NIPLLLIAAVRDQVGAWRG
MAB_2608|M.abscessus_ATCC_1997 IALTPLVDGIAAAR--------SAMTEHSAGTLLRSAVTGLRSR----LG
MSMEG_2203|M.smegmatis_MC2_155 IAMTPLTSGLAASR--------AAVTQRDVATALRWTLKGVKSRVAAAVG
MMAR_3699|M.marinum_M VLFSPLIDLTFGLS------------------------------------
MUL_3642|M.ulcerans_Agy99 VLFSPLIDLTFGLS------------------------------------
: * .
Rv2307c|M.tuberculosis_H37Rv ------------------------------------VHYPWLPLRRLLLD
Mb2330c|M.bovis_AF2122/97 ------------------------------------VHYPWLPLRRLLLD
TH_0434|M.thermoresistible__bu ------------------------------------VHYPWLPARWLLLD
Mflv_3465|M.gilvum_PYR-GCK RSPRYLPVYGRLG-RAFFADPALAQRFRAVEAQAPSWRNAVAPRFLLHAP
Mvan_2419|M.vanbaalenii_PYR-1 RPPHTVAAVGSPGTVAALTSPDAKPGFEAIIGPNSLWRNEFAARLMFTFA
MAB_2608|M.abscessus_ATCC_1997 RQQRTIPIVGRAGELAALTSDGYYEAHLAIAG--PAWRNEIDATVGTQLV
MSMEG_2203|M.smegmatis_MC2_155 GAPTMMPLTAKPGEPGALALDGAYESYLSIAG--PTWRNEVDAGVGMELA
MMAR_3699|M.marinum_M -----------------AARERTKPDPAVRAATAARVVGLYHAGIDPTHH
MUL_3642|M.ulcerans_Agy99 -----------------AARERTKPDPAVRAATAARVVGLYHAGIDPTHH
.
Rv2307c|M.tuberculosis_H37Rv HYPSIERIASVHAPVLVIAGGSDDIVPATLSERLVAAAAEPKRYVVVPGV
Mb2330c|M.bovis_AF2122/97 HYPSIERIASVHAPVLVIAGGSDDIVPATLSEWLVAAAAEPKRYVVVPGV
TH_0434|M.thermoresistible__bu RYPSIDRIGSLRAPLLIVAGDRDDIVPESQSRRLFDAAPEPKRYVLVPDA
Mflv_3465|M.gilvum_PYR-GCK RYRDG-TIERVRCPVLVTLARDDAEVST-PFVERKVRRGRDVEIRKYPAG
Mvan_2419|M.vanbaalenii_PYR-1 FNRPGRKAAKLRMPVLLCVCDDDVVTPPGPSVEAAHRAPR-GELCRYPYG
MAB_2608|M.abscessus_ATCC_1997 SYRPTRCASRIGCPILVQIADFDRAAPPHAAAKAAFKARA--EVRHYPCD
MSMEG_2203|M.smegmatis_MC2_155 RVRTAAAAKALKCPVLVQIADFDRFVPADSVAKTAVQARA--QVHHYACD
MMAR_3699|M.marinum_M RLSLDVAGGSPLPSTLIQAGAAEMLEADARQLAADIRTAGGRCELQVWPD
MUL_3642|M.ulcerans_Agy99 RLSLDVAGGSPLPSTLIQAGAAEMLEADARQLAADIRTAGGRCELQVWPD
. *: : .
Rv2307c|M.tuberculosis_H37Rv GHNDPE-LLDGRVMLDAIRRFLTETAVLGQ---------
Mb2330c|M.bovis_AF2122/97 GHNDPE-LLDGRVMLDAIRRFLTETAVLGQ---------
TH_0434|M.thermoresistible__bu GHNDLT-LLAGRQMIGAIEEFLAPILHTA----------
Mflv_3465|M.gilvum_PYR-GCK HFDMYHGAVRDEVAR-DQREFLIRHLQPDRAARKDR---
Mvan_2419|M.vanbaalenii_PYR-1 HFDIYH---DPKVKA-DQLEFLARVVG-DRTA-------
MAB_2608|M.abscessus_ATCC_1997 HFGVYHGQECHELVIGHQISFLSRHLSIEAVSHTEALHG
MSMEG_2203|M.smegmatis_MC2_155 HFDVWPGHDWFDTAVTDQIAFLRRTLSLR----------
MMAR_3699|M.marinum_M QMHVFQALPRMTPEAAKAMAYASAFIAGSLQDNATAEAV
MUL_3642|M.ulcerans_Agy99 QMHVFQALPRMTPEAAKAMAYASAFIAGSLQDNATAEAV
: