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TQRQDVRFPCGEAMISAWLYRPAGADPARPVPMLVMAHGLGAVRTMRLDAYAQRFSAAGYACLVFDYRNF GDSEGQPRQLLDIRMQLQDWAAAVAYARTCDGVDQARIGLWGTSFGGGHVIATAARLPGIAAVVAQCPFT DGIASVLAIAPTTAIRVTARSMRDLIGSRLGRPPVMIPTAGKPGEVALMTAPDAYPGYLGLMPQGTQVPN EVAARIGIKVLGYRPGRSARKIACPILFCVCETDSVAPAGPTLRYAARAPRGEVIRYPEGHFAIYLGDAF ERVVADQLGFLDKHLKPAGQP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_0385 | - | - | 100% (302) | hypothetical protein MMAR_0385 |
| M. marinum M | MMAR_3680 | - | 3e-51 | 40.43% (282) | hypothetical protein MMAR_3680 |
| M. marinum M | MMAR_0427 | - | 2e-06 | 27.53% (247) | lysophospholipase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2330c | - | 5e-07 | 28.14% (167) | hypothetical protein Mb2330c |
| M. gilvum PYR-GCK | Mflv_3976 | - | 2e-66 | 44.52% (301) | dienelactone hydrolase |
| M. tuberculosis H37Rv | Rv2307c | - | 5e-07 | 28.14% (167) | hypothetical protein Rv2307c |
| M. leprae Br4923 | MLBr_02603 | - | 2e-05 | 28.67% (143) | hypothetical protein MLBr_02603 |
| M. abscessus ATCC 19977 | MAB_2608 | - | 1e-51 | 39.46% (294) | putative hydrolase, alpha/beta fold |
| M. avium 104 | MAV_2688 | - | 5e-18 | 59.38% (64) | alpha/beta hydrolase |
| M. smegmatis MC2 155 | MSMEG_4450 | - | 2e-66 | 44.52% (301) | alpha/beta hydrolase |
| M. thermoresistible (build 8) | TH_2570 | - | 4e-73 | 49.14% (291) | PUTATIVE alpha/beta hydrolase fold |
| M. ulcerans Agy99 | MUL_1035 | - | 1e-174 | 98.04% (306) | hypothetical protein MUL_1035 |
| M. vanbaalenii PYR-1 | Mvan_2419 | - | 8e-68 | 46.74% (291) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0385|M.marinum_M -----MTQRQDVRFPCGEAMISAWLYRPAGADPARPVPMLVMAHGLGAVR
MUL_1035|M.ulcerans_Agy99 -----MTQRQDVRFPCGEALISAWLYRPAGADPARPVPMLVMAHGLGAVR
MAV_2688|M.avium_104 --------------------------------------------------
MSMEG_4450|M.smegmatis_MC2_155 MAQPLSYTRDDVTFMSDGTSCAAWLYRPDGVNNP---PIVVLAHGFAAFR
Mflv_3976|M.gilvum_PYR-GCK -----MPTRDDVRIPAHGDEIAAYVYRPPAGVGA--TACVVMAHGFTGTR
Mvan_2419|M.vanbaalenii_PYR-1 ------MTRQEVQIPADGGQIAAYVYRPQVTGGG--TACIVMAHGFTGTR
TH_2570|M.thermoresistible__bu ---MATTDRRDLRIPAHGEQLAAYFYPPAGAGPT--TPCIVMAHGFTATR
MAB_2608|M.abscessus_ATCC_1997 ------MNRQSIRFNSHGIDCEAWLYRAQTVEDT--APIVVMAHGVGGTK
Mb2330c|M.bovis_AF2122/97 ---MSLKRCRALPVVAIVALVASGVITFIWSQQR--RLIYFPSAGPVPSA
Rv2307c|M.tuberculosis_H37Rv ---MSLKRCRALPVVAIVALVASGVIMFIWSQQR--RLIYFPSAGPVPSA
MLBr_02603|M.leprae_Br4923 ----MTITRTERNFYGVGGVRIVYDVWMPDTRPR---AVIILAHGFG-EH
MMAR_0385|M.marinum_M TMRLDAYAQRFSAAGYACLVFDYRNFGDSEGQPRQLLDIRMQLQDWAAAV
MUL_1035|M.ulcerans_Agy99 TMRLDAYAQRFSAAGYACLVFDYRNFGDSEGQPRQLLDIRMQLQDWAAAV
MAV_2688|M.avium_104 --------------------------------------------------
MSMEG_4450|M.smegmatis_MC2_155 ELRLDAYAARFAQAGYAALVFDYRHWGASDGQPRRILDIPKQQTDWRAAI
Mflv_3976|M.gilvum_PYR-GCK DDGLPDYAEAFRDAGYVVVLFDYRHFGASSGQPRQLLDMARQREDFHTVI
Mvan_2419|M.vanbaalenii_PYR-1 DDGLPDYAEAFCAAGHTVVLFDYRHFGASTGEPRQLLDIAEQRRDYHTVI
TH_2570|M.thermoresistible__bu DDGLPAYAEAFHAAGYAVVLFDYRHFGASTGEPRQLLDITRQHDDYRAVV
MAB_2608|M.abscessus_ATCC_1997 DSGLEPFAVRLAEAGMHALAFDYRGFGASDGFPRQHVSFTHQIGDYHAAV
Mb2330c|M.bovis_AF2122/97 SSVLPAGRDVVVETQDGMRLGGWYFPHTSGGSGPAVLVCNGNAGDRSMRA
Rv2307c|M.tuberculosis_H37Rv SSVLPAGRDVVVETQDGMRLGGWYFPHTSGGSGPAVLVCNGNAGDRSMRA
MLBr_02603|M.leprae_Br4923 ARRYDHVAHYFAAAGLATYALDLRGHGRSAGKRVLVRDLSEYNADFDILV
MMAR_0385|M.marinum_M AYARTCDGVDQARIGLWGTSFGGGHVIATAARLPGIAAVVAQCPFTDGIA
MUL_1035|M.ulcerans_Agy99 AYARTCDGVDQARIGLWGTSFGGGHVIATAARLPGIAAVVAQCPFTDGIA
MAV_2688|M.avium_104 --------------------------------------------------
MSMEG_4450|M.smegmatis_MC2_155 AYARSLDNVDTTRLVGWGSSFGGGHVLTLAARDHEFAAAIVQVPHVSGPA
Mflv_3976|M.gilvum_PYR-GCK EWARRLDGVDPNRIVAWGSSFSGGHVLAVAAEDPRLAAVIAQAPFTDALA
Mvan_2419|M.vanbaalenii_PYR-1 AWARHLDGVDPNRIVVWGSSFSGGHVLAVAAEDPRIAAVIAQAPFTDALA
TH_2570|M.thermoresistible__bu AWARTQPGVDPDRIVLWGSSFSGGHVLVVAADDPRIAAVISQAPFTDAVP
MAB_2608|M.abscessus_ATCC_1997 NMARRLPGVDPTRIVLWGVSLAGGHVMAVAGARNDVAAVIALTPLVDGIA
Mb2330c|M.bovis_AF2122/97 ELAVALHGLGLSVLLFDYRGYGG-----NPGRPSEQGLAADARAAQEWLS
Rv2307c|M.tuberculosis_H37Rv ELAVALHGLGLSVLLFDYRGYGG-----NPGRPSEQGLAADARAAQEWLS
MLBr_02603|M.leprae_Br4923 GIATRDHPG--LKRIVAGHSMGGAIVFAYGVERPDNYDLMVLSGPAVAAQ
MMAR_0385|M.marinum_M SVLAIAPTTAIRVTARSMRDLIGSRLGRPPVMIPTAGKPGEVALMTAPDA
MUL_1035|M.ulcerans_Agy99 SVLAIAPTTAIRVTARSMRDLIGSRLGRPPVMIPTAGKPGEVALMTAPDA
MAV_2688|M.avium_104 --------------------------------------------------
MSMEG_4450|M.smegmatis_MC2_155 SAFSQSPKLVARLIAAGLRDQIGAWFGGAPHRVTSIGRPGEFAMMTSPGA
Mflv_3976|M.gilvum_PYR-GCK TLRNAPLRNIPPMVVAALRDQLGAWRNRPPRMLAAVGPPGDLAALTSPDA
Mvan_2419|M.vanbaalenii_PYR-1 TLREIPPGNIPLLLIAAVRDQVGAWRGRPPHTVAAVGSPGTVAALTSPDA
TH_2570|M.thermoresistible__bu TLRKVPPATIARLAVAGLRDQIGSWRGRPPRTASAVGAPGAVAAMTTPDA
MAB_2608|M.abscessus_ATCC_1997 AARSAMTEHSAGTLLRSAVTGLRSRLGRQQRTIPIVGRAGELAALTSDGY
Mb2330c|M.bovis_AF2122/97 GQSDVDPARIA---------YFGESLGAAVAVGLAVQRPPAALVLRSPFT
Rv2307c|M.tuberculosis_H37Rv GQSDVDPARIA---------YFGESLGAAVAVGLAVQRPPAALVLRSPFT
MLBr_02603|M.leprae_Br4923 DMVSPLRAVVGKGLG-----LVAPGLPVHQLEVDAISRNRAVVAAYKDDP
MMAR_0385|M.marinum_M YPGYLGLMP--------QGTQVPNEVAARIGIKVLGYRPGRSARKIACPI
MUL_1035|M.ulcerans_Agy99 YPGYLGLMP--------QGTQVPNEVAARIGIKVLGYRPGRSARKIACPI
MAV_2688|M.avium_104 ---------------------------------------------MSCPI
MSMEG_4450|M.smegmatis_MC2_155 YELVEEMAGGEAAEHMRAQLEAENDVAARIALRVPLYSPGRHAAKITAPT
Mflv_3976|M.gilvum_PYR-GCK EPGFGAILG--------PESLWRNEFAARLMLRFAFERPGRKAATLQMPV
Mvan_2419|M.vanbaalenii_PYR-1 KPGFEAIIG--------PNSLWRNEFAARLMFTFAFNRPGRKAAKLRMPV
TH_2570|M.thermoresistible__bu EPGFRAIVE--------PDSLWRNEFAARLMLRFPFYRPVRVAGRINAPL
MAB_2608|M.abscessus_ATCC_1997 YEAHLAIAG----------PAWRNEIDATVGTQLVSYRPTRCASRIGCPI
Mb2330c|M.bovis_AF2122/97 SLAEVGAVH--------------YPWLPLRRLLLDHYPSIERIASVHAPV
Rv2307c|M.tuberculosis_H37Rv SLAEVGAVH--------------YPWLPLRRLLLDHYPSIERIASVHAPV
MLBr_02603|M.leprae_Br4923 LVYHGKVPAG----------------VGRVMLQVG-ETMTRRAPVLTTPL
: *
MMAR_0385|M.marinum_M LFCVCETDSVAPAGPTLRYAARAPRG----EVIRYPEGHFAIYLGDAFER
MUL_1035|M.ulcerans_Agy99 LFCVCETDSVAPAGPTLRYAARAPRGEVSGEVIRYPEGHFAIYLGDAFEH
MAV_2688|M.avium_104 LFAICENDTVAPAKATQKYAAQAPRG----EIKLYDAGHFDIYVGADFER
MSMEG_4450|M.smegmatis_MC2_155 LVQLATKDDVTPYAKARKIVARIPNG----EVRSYDITHFEPYVDPHFEQ
Mflv_3976|M.gilvum_PYR-GCK LFCVCDDDVVTPPGPTIEAARRAPCG----ELRRYPYGHFDIYHDPQVK-
Mvan_2419|M.vanbaalenii_PYR-1 LLCVCDDDVVTPPGPSVEAAHRAPRG----ELCRYPYGHFDIYHDPKVK-
TH_2570|M.thermoresistible__bu LVCVCDDDAVTPPEPAIEAARRAPRG----QLRRYPYGHFDIYHDPQVK-
MAB_2608|M.abscessus_ATCC_1997 LVQIADFDRAAPPHAAAKAAFKARAE-----VRHYPCDHFGVYHGQECHE
Mb2330c|M.bovis_AF2122/97 LVIAGGSDDIVPATLSEWLVAAAAEP------KRYVVVPGVGHNDPELLD
Rv2307c|M.tuberculosis_H37Rv LVIAGGSDDIVPATLSERLVAAAAEP------KRYVVVPGVGHNDPELLD
MLBr_02603|M.leprae_Br4923 LVVHGSEDRLVLVDGSHRLVECVGST--DVELKVYPGLYHEVFNEPERDQ
*. * . : . * .
MMAR_0385|M.marinum_M -VVADQLGFLDKHLKPAGQP-------
MUL_1035|M.ulcerans_Agy99 -VVADQLGFLDKHLKPAGQP-------
MAV_2688|M.avium_104 -NVTDQLNFLSRHVPVS----------
MSMEG_4450|M.smegmatis_MC2_155 -IVTDQIDFLNRHVGAGTR--------
Mflv_3976|M.gilvum_PYR-GCK ---ADQLEFLHRALARGGR--------
Mvan_2419|M.vanbaalenii_PYR-1 ---ADQLEFLARVVGDRTA--------
TH_2570|M.thermoresistible__bu ---SDQLDFLRQVLGTG----------
MAB_2608|M.abscessus_ATCC_1997 LVIGHQISFLSRHLSIEAVSHTEALHG
Mb2330c|M.bovis_AF2122/97 --GRVMLDAIRRFLTETAVLGQ-----
Rv2307c|M.tuberculosis_H37Rv --GRVMLDAIRRFLTETAVLGQ-----
MLBr_02603|M.leprae_Br4923 -VLEDVVCWILKRL-------------
: : : :