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QRDQRHSDHYEWFSDFLQARGVAVYVRAGVAAIGLLMAVSSVILVLGAGGPTSQPQVAMMWVAAAGGVAS AALWVRRWPTRGQSAAFAAVTTCSITLACLAYPDALAALLGCITFMTIGAYLAFFHSTRSVLGVVALAIV VASLHAVELAVAGRPALAAVDLFIVVQANLAMPLAIHSLLRALRGDLVHALTDANHDPLTGLLNRRAFRT QTLGLFERGGDGHHLVVALIDLDKFKALNDTHGHHVGDQALVAVADALRATATSSAVISRSGGEEFLIAD VAPADEALARYQGLCDAVAALHIPVTASVGTATAALDVVSDHDPDGVVDHLIAAADMAMYRAKRNGGNQC HHHGSWPTLGSPP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1914 | - | - | 100% (364) | diguanylate cyclase |
| M. gilvum PYR-GCK | Mflv_1453 | - | 2e-62 | 41.04% (346) | diguanylate cyclase |
| M. gilvum PYR-GCK | Mflv_3822 | - | 4e-62 | 40.12% (344) | diguanylate cyclase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1389c | - | 9e-15 | 33.76% (157) | hypothetical protein Mb1389c |
| M. tuberculosis H37Rv | Rv1354c | - | 9e-15 | 33.76% (157) | hypothetical protein Rv1354c |
| M. leprae Br4923 | MLBr_00397 | - | 1e-16 | 36.75% (166) | putative transporter protein |
| M. abscessus ATCC 19977 | MAB_3940c | - | 2e-43 | 33.33% (351) | hypothetical protein MAB_3940c |
| M. marinum M | - | - | - | - | - |
| M. avium 104 | MAV_1995 | - | 8e-68 | 41.62% (346) | diguanylate cyclase |
| M. smegmatis MC2 155 | MSMEG_2774 | - | 9e-30 | 30.09% (349) | diguanylate cyclase |
| M. thermoresistible (build 8) | TH_3406 | - | 4e-47 | 31.27% (355) | PUTATIVE diguanylate cyclase |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_4819 | - | 1e-123 | 63.54% (362) | diguanylate cyclase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1389c|M.bovis_AF2122/97 ---------------------------MCNDTATPQLEELVTTVANQLMT
Rv1354c|M.tuberculosis_H37Rv ---------------------------MCNDTATPQLEELVTTVANQLMT
Mflv_1914|M.gilvum_PYR-GCK -----------MQRDQ---RHSDHYEWFSDFLQARGVAVYVRAGVAAIGL
Mvan_4819|M.vanbaalenii_PYR-1 -----------MQWDQ---RRVDHYEWFSGFLDARGAKPAVRLLIASIAL
MAV_1995|M.avium_104 -----------MKWLAAWWGQPDHFDWLTGYLQDHGFGTATRRAMAVVGA
MAB_3940c|M.abscessus_ATCC_199 MIVSYIRSTAWMGFLRQWWTEPVPTGWLRGFLHARKLDRTVRNLIGGYAL
MSMEG_2774|M.smegmatis_MC2_155 ------------------MSPFDHYYARTAMLSAQGQRSRMRRIIGVTIT
TH_3406|M.thermoresistible__bu ----------MLKALRRTWRKPDHYYWFTSFLAARRARTSTCRFIASITL
MLBr_00397|M.leprae_Br4923 ---------------MDHTTKCDAEQYFQAIVTSMADGVIVVDIDGRIES
Mb1389c|M.bovis_AF2122/97 VDAATSAEVSQRVLAYLVEQLGVDVSFLRHNDRDRRATRLVAEWPPRLNI
Rv1354c|M.tuberculosis_H37Rv VDAATSAEVSQRVLAYLVEQLGVDVSFLRHNDRDRRATRLVAEWPPRLNI
Mflv_1914|M.gilvum_PYR-GCK LMAVSSVILVLGAGGPTSQPQVAMMWVAAAGGVASAALWVRR-WPTRG--
Mvan_4819|M.vanbaalenii_PYR-1 LMAGSVLLLIFSAGGPEGQPQRAMMWLSVAGGVAGVMLWLWH-WPSRL--
MAV_1995|M.avium_104 SLVLVPANVLWGATPFFPGLTLTVSVLAGMVGLGMAVLWLHG-WPTRR--
MAB_3940c|M.abscessus_ATCC_199 IFAAICIAVQFSDTGPRSMIGRVIVGLCAVGSLGWALRWAVGPWPSLR--
MSMEG_2774|M.smegmatis_MC2_155 ALAFVPVLMLASPAGPAGAL-RYVPLGATACGVLMSVWWWRRKWPSRN--
TH_3406|M.thermoresistible__bu ILGLMPMVMLAGPAGPQSMPGRLIAVAVTVTALVITLIWLRDRWPSRN--
MLBr_00397|M.leprae_Br4923 INPAATRILGLRAHDVVDMKHGHPFCFYDTDNQRVDLEREVMRVVRREVT
:
Mb1389c|M.bovis_AF2122/97 ---------PDPDPLRLIYFADADPVFALCEHAKEPLVFRPEPATEDYQR
Rv1354c|M.tuberculosis_H37Rv ---------PDPDPLRLIYFADADPVFALCEHAKEPLVFRPEPATEDYQR
Mflv_1914|M.gilvum_PYR-GCK ---------QSAAFAAVTTCSITLACLAYPDALAALLGCITFMTIGAYLA
Mvan_4819|M.vanbaalenii_PYR-1 ---------QSAAFATVTAFSVALAGLAYPDPLAALLGCIAFTTNGAYLA
MAV_1995|M.avium_104 ---------QSVVFALTGSVAIGAGCLWQTEPLVGLMACSALSVTGGYNA
MAB_3940c|M.abscessus_ATCC_199 ---------EAVAFVAFADIGIAVACWQDSDPLAGLVGTVLFTPVGAYVS
MSMEG_2774|M.smegmatis_MC2_155 ---------QSWLVVGIGTVGIAVTLSSMSDPTVGLLSSSVFSLVTTYSA
TH_3406|M.thermoresistible__bu ---------QSRVVSLAAGLAIAVFAFTLPDPSAGLVWTAAFAVLAGYVA
MLBr_00397|M.leprae_Br4923 TVSKVVGIDQHSGQRLWLSVNVSLLAYKAPPHSALVVSFSDISAHHLSIE
:
Mb1389c|M.bovis_AF2122/97 LIEEARGVPVTSAAAVPLVSG-EITTGLLG---FIKFGDRKWHEAELNAL
Rv1354c|M.tuberculosis_H37Rv LIEEARGVPVTSAAAVPLVSG-EITTGLLG---FIKFGDRKWHEAELNAL
Mflv_1914|M.gilvum_PYR-GCK FFHSTRSVLGVVALAIVVASLHAVELAVAG---RPALAAVDLFIVVQANL
Mvan_4819|M.vanbaalenii_PYR-1 FFHTTRLLLGNIVIAIGVATVEAIQLAAQG---RIALAAVDLFLVVQINI
MAV_1995|M.avium_104 FFHTAKFMGLNFGLAGAIGALQAARLAASG---QAMLAFTGYFLVLELNV
MAB_3940c|M.abscessus_ATCC_199 FFLANRLLVAHVAWCAPMIIALSSRLFAEGTVGAAMTALVKVTSMLLVVV
MSMEG_2774|M.smegmatis_MC2_155 FLHSRRVLVLSWIASGLTVGFLAIRVAFTS----IPMALSGALVSGLVIA
TH_3406|M.thermoresistible__bu LFHSARYATFTVLFAAITAGVLSFELAKTAG---VAAAVCGFVFITVVTF
MLBr_00397|M.leprae_Br4923 RLTYEATHDCLTGLANRRFAEDQITKSLQHDERSRLAAVLLLDLDDFKVI
: . .
Mb1389c|M.bovis_AF2122/97 MTIATLFAQVQARVAAEARLRYLADHDDLTGLHNRRALLQHLDQRLAPG-
Rv1354c|M.tuberculosis_H37Rv MTIATLFAQVQARVAAEARLRYLADHDDLTGLHNRRALLQHLDQRLAPG-
Mflv_1914|M.gilvum_PYR-GCK AMPLAIHSLLRALRGDLVHALTDANHDPLTGLLNRRAFRTQTLGLFER--
Mvan_4819|M.vanbaalenii_PYR-1 AVPLAIRILLHALRGDLHY----ADHDPLTGLLNRRAFRRQILSLLARS-
MAV_1995|M.avium_104 IVPLSIQIVVRALWLDLLR----ANRDPLTGLLNRRACNRAIIGRMLT--
MAB_3940c|M.abscessus_ATCC_199 LIPAVIQFGIAVVRWDALA----AQRDPLTGLLNRRGIYAEWQRLYGELR
MSMEG_2774|M.smegmatis_MC2_155 TTSMLCRMAIRLLDAGNVQHP--NEIDRLTGLLNREAFEIQAATMLGSHS
TH_3406|M.thermoresistible__bu AVVCACNLLVGLLDVDVLDA----DIEPLTGLLNRDAFYRSAGHLI-SRS
MLBr_00397|M.leprae_Br4923 NDSLGHDVGDAVLQTVAQRLRSAVRPDDVVARLGGDEFIVLLRGPLSDMN
: :.. .
Mb1389c|M.bovis_AF2122/97 ------QPGPVAALFLDLDRLKAINDYLG----------------HAAGD
Rv1354c|M.tuberculosis_H37Rv ------QPGPVAALFLDLDRLKAINDYLG----------------HAAGD
Mflv_1914|M.gilvum_PYR-GCK ----GGDGHHLVVALIDLDKFKALNDTHG----------------HHVGD
Mvan_4819|M.vanbaalenii_PYR-1 ----HGEGRYLVVALMDLDHFKALNDARG----------------HIAGD
MAV_1995|M.avium_104 ----GASHMFLAVAMVDLDRFKALNDTHG----------------HAAGD
MAB_3940c|M.abscessus_ATCC_199 REQPLDGDQVTAAAIVDIDRFKSINDRYG----------------HGTGD
MSMEG_2774|M.smegmatis_MC2_155 RH----DDQYLVILAVGIDDMSLLSDMDG----------------THSTL
TH_3406|M.thermoresistible__bu RD----DDRQLVIALINIDNLRLLRDTQG----------------QAAAD
MLBr_00397|M.leprae_Br4923 ANDVAKRLHTTLSESLVVDQLTVPIGASVGILEVRPDDRRRAADILRDAD
: :* : .
Mb1389c|M.bovis_AF2122/97 QFIHVFAQRIGDALVGESLIARLGGDEFVLIPASPMSADAAQP------L
Rv1354c|M.tuberculosis_H37Rv QFIHVFAQRIGDALVGESLIARLGGDEFVLIPASPMSADAAQP------L
Mflv_1914|M.gilvum_PYR-GCK QALVAVADALRATATSSAVISRSGGEEFLIADVAPA--DEALA------R
Mvan_4819|M.vanbaalenii_PYR-1 QALIAVADALRTTATSTAVVARSGGEEFLIADVTGS--PSAAA------H
MAV_1995|M.avium_104 EALIAVAGALTAACGDTTVVGRVGGEEFLVADIVTT--EQLPG------W
MAB_3940c|M.abscessus_ATCC_199 RVLIDVAHALTCGTTGTSVVGRSGGEEFLVVTVCPA--SAVAE------F
MSMEG_2774|M.smegmatis_MC2_155 HARVAVAQALRETVRHRVPLAHVSDSEFLIADVFKT--NDPSP------L
TH_3406|M.thermoresistible__bu RARVAIGQTLRENTRHNAFVAHLGQDEFLIADTFSS--TDSFP------L
MLBr_00397|M.leprae_Br4923 SAMYAAKNKKQCAVTPQQLVPFVALIALFVFFTAAAGAKFYAPSNLLVIL
: . :.:
Mb1389c|M.bovis_AF2122/97 AERLRDQLKDHVAIG----GEVLTRTVSIGVASGTPGQHTPSDLLRRADQ
Rv1354c|M.tuberculosis_H37Rv AERLRDQLKDHVAIG----GEVLTRTVSIGVASGTPGQHTPSDLLRRADQ
Mflv_1914|M.gilvum_PYR-GCK YQGLCDAVAALHIP---VTASVGTATAALDVVSDHDPDGVVDHLIAAADM
Mvan_4819|M.vanbaalenii_PYR-1 YQQVCDAITALPVG---LTASIGTAVAALRDVPVEAFESTIDRLVSAADM
MAV_1995|M.avium_104 GQQLCEAVAALDPP---VTASVGTATLPLRDLVSEYAEHAFHQLVAQADS
MAB_3940c|M.abscessus_ATCC_199 ATRLRQAVTASMPAGIAVTASVGVAAQAVSRVVSATSQEAIEVLTACADR
MSMEG_2774|M.smegmatis_MC2_155 VERMRLAISTTPMR---LTASIGTVCSPLAPLASLPAEQVLQELIDVAMR
TH_3406|M.thermoresistible__bu VERVRGAIATTPPR---LTASIGVVSTPMRGLAVCPPETLLDELIAVASA
MLBr_00397|M.leprae_Br4923 QQTVVLAIVGYGMTFVIMAGSVDLSVGSIVALTGVTAALVAAQNQFAAIV
: : ..: .: *
Mb1389c|M.bovis_AF2122/97 AALAAKHAGGDSVAIFTADMSVSGELRNDIELHLRRGIESDALRLVYLPE
Rv1354c|M.tuberculosis_H37Rv AALAAKHAGGDSVAIFTADMSVSGELRNDIELHLRRGIESDALRLVYLPE
Mflv_1914|M.gilvum_PYR-GCK AMYRAKRNGGNQCHHHGSWPTLGSPP------------------------
Mvan_4819|M.vanbaalenii_PYR-1 AMYRAKRNGGNQCHHLDAWPPPGPA-------------------------
MAV_1995|M.avium_104 AMYEAKRCGGNQTRHRPAQVST----------------------------
MAB_3940c|M.abscessus_ATCC_199 AMYEAKHDGGDQSRILHADDDSEGRYLWRSGA------------------
MSMEG_2774|M.smegmatis_MC2_155 AMNESRAAGGNQTISVNYPTPTPNQE------------------------
TH_3406|M.thermoresistible__bu TMYEARRAGGNQARYRKYPNPTAVTEAHYPEQAADDF-------------
MLBr_00397|M.leprae_Br4923 TALLVGLAAGMVNGIVFAYGKIPSFVSTLGMLQVCRGITLMISDSSAKPM
: .*
Mb1389c|M.bovis_AF2122/97 VDLRTGDIVGTEALVRWQHPTRGLLAPGCFIPVAESINLAGELDRWVLRR
Rv1354c|M.tuberculosis_H37Rv VDLRTGDIVGTEALVRWQHPTRGLLAPGCFIPVAESINLAGELDRWVLRR
Mflv_1914|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4819|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_1995|M.avium_104 --------------------------------------------------
MAB_3940c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_2774|M.smegmatis_MC2_155 --------------------------------------------------
TH_3406|M.thermoresistible__bu --------------------------------------------------
MLBr_00397|M.leprae_Br4923 PFHGILGAMGAMPWILIVCLFVTILAG--------ILFQFTMFGRWVKAI
Mb1389c|M.bovis_AF2122/97 ACNEFSEWQSAGLGHDALLRINVSAGQLVTGGFVDFVADTIGQHGLDASS
Rv1354c|M.tuberculosis_H37Rv ACNEFSEWQSAGLGHDALLRINVSAGQLVTGGFVDFVADTIGQHGLDASS
Mflv_1914|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4819|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_1995|M.avium_104 --------------------------------------------------
MAB_3940c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_2774|M.smegmatis_MC2_155 --------------------------------------------------
TH_3406|M.thermoresistible__bu --------------------------------------------------
MLBr_00397|M.leprae_Br4923 GGNERVATLAGVPTRGIKVAIFAICGLTAGLGGIVLASRLGAGTPTAATG
Mb1389c|M.bovis_AF2122/97 VCLEITENVVVQDLHTARATLARLKEVGVHIAIDDFGTGYSAISLLQTLP
Rv1354c|M.tuberculosis_H37Rv VCLEITENVVVQDLHTARATLARLKEVGVHIAIDDFGTGYSAISLLQTLP
Mflv_1914|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4819|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_1995|M.avium_104 --------------------------------------------------
MAB_3940c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_2774|M.smegmatis_MC2_155 --------------------------------------------------
TH_3406|M.thermoresistible__bu --------------------------------------------------
MLBr_00397|M.leprae_Br4923 FEIDVIAAVVIGGTPLTGGLGRLSGTLIGAIIISMLSNGMVFMGVGNAAS
Mb1389c|M.bovis_AF2122/97 IDTLKIDKTFVRQLGTNTSDLVIVRGIMTLAEGFQLDVVAEGVETEAAAR
Rv1354c|M.tuberculosis_H37Rv IDTLKIDKTFVRQLGTNTSDLVIVRGIMTLAEGFQLDVVAEGVETEAAAR
Mflv_1914|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4819|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_1995|M.avium_104 --------------------------------------------------
MAB_3940c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_2774|M.smegmatis_MC2_155 --------------------------------------------------
TH_3406|M.thermoresistible__bu --------------------------------------------------
MLBr_00397|M.leprae_Br4923 QIIKGIMLAAAVFVFLQRRKIGIIK-------------------------
Mb1389c|M.bovis_AF2122/97 ILLDQRCYRAQGFLFSRPVPGEAMRHMLSARRLPPTCIPATDPALS
Rv1354c|M.tuberculosis_H37Rv ILLDQRCYRAQGFLFSRPVPGEAMRHMLSARRLPPTCIPATDPALS
Mflv_1914|M.gilvum_PYR-GCK ----------------------------------------------
Mvan_4819|M.vanbaalenii_PYR-1 ----------------------------------------------
MAV_1995|M.avium_104 ----------------------------------------------
MAB_3940c|M.abscessus_ATCC_199 ----------------------------------------------
MSMEG_2774|M.smegmatis_MC2_155 ----------------------------------------------
TH_3406|M.thermoresistible__bu ----------------------------------------------
MLBr_00397|M.leprae_Br4923 ----------------------------------------------