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VPAVRRPGRPVGANSDQTRRTILCAARDVIAEHGYRAATFQQIALRAGVSRPTLHYYFATREQLYEVLLA DVRAEVARCAAEATLAGSLLRQLEVFIAEMHRLGGAEPALMGLVVTARVDHRGVLRHEAATAVVATVHAF FDAVVVDAVRRGELAFDTDAHAVADLLGALFWGLVFHAGFISGADGAPEIARQLLRMVGFGLLDTPEPAS VDA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2776 | - | - | 100% (213) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_0103 | - | 3e-18 | 33.33% (162) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_4272 | - | 2e-08 | 25.93% (189) | TetR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0149 | - | 1e-23 | 36.41% (184) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_3637 | - | 4e-65 | 60.18% (221) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv0144 | - | 1e-23 | 36.41% (184) | TetR family transcriptional regulator |
| M. leprae Br4923 | MLBr_00815 | - | 2e-08 | 44.44% (54) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_0647 | - | 1e-08 | 25.93% (162) | transcriptional regulator TetR |
| M. marinum M | MMAR_0355 | - | 1e-26 | 37.69% (199) | TetR family transcriptional regulator |
| M. avium 104 | MAV_5151 | - | 1e-21 | 33.52% (179) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_3177 | - | 2e-29 | 39.05% (210) | transcriptional regulatory protein, putative |
| M. thermoresistible (build 8) | TH_3831 | - | 4e-29 | 36.56% (186) | PUTATIVE putative transcriptional regulator, TetR family |
| M. ulcerans Agy99 | MUL_4765 | - | 9e-27 | 37.69% (199) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0149|M.bovis_AF2122/97 MPHSWTPTSVMTPPLVVAAFRPVGHYRLATDRAGGPCSPPATGAKLTSSV
Rv0144|M.tuberculosis_H37Rv MPHSWTPTSVMTPPLVVAAFRPVGHYRLATDRAGGPCSPPATGAKLTSSV
MMAR_0355|M.marinum_M --------------------------------------------------
MUL_4765|M.ulcerans_Agy99 --------------------------------------------------
MAV_5151|M.avium_104 --------------------------------------------------
TH_3831|M.thermoresistible__bu --------------------------------------------------
Mvan_2776|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3637|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_3177|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0647|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00815|M.leprae_Br4923 -------------------------------------------------M
Mb0149|M.bovis_AF2122/97 ASRPTVGTKPQWWHTLVMSMSLTAGRGPGRPPAAKADETRKRILHAARQV
Rv0144|M.tuberculosis_H37Rv ASRPTVGTKPQWWHTLVMSMSLTAGRGPGRPPAAKADETRKRILHAARQV
MMAR_0355|M.marinum_M -------------------MQLTASRGPGRPPAAKADDTRRRIVGAAREV
MUL_4765|M.ulcerans_Agy99 ------------------MMQLTASRGPGRPPAAKADDTRRRIVGAAREV
MAV_5151|M.avium_104 -------------------MLPRGNRRPGRPPAAKADETRQRIIQAARLV
TH_3831|M.thermoresistible__bu ----------------------------MRPARTASSDTRARILEAARRI
Mvan_2776|M.vanbaalenii_PYR-1 ---------------------MPAVRRPGRPVGANSDQTRRTILCAARDV
Mflv_3637|M.gilvum_PYR-GCK --------------MENETLSVSAGRKRGRPVAADSEQTRRTVLAAARDI
MSMEG_3177|M.smegmatis_MC2_155 --------------MTEAGQPRPLRRAPGRPVGADSAQTRMHILRVGCEL
MAB_0647|M.abscessus_ATCC_1997 ------------------------MDQPARPLRADAARNRARVLEVAYQT
MLBr_00815|M.leprae_Br4923 NNLAKAAQRRTVRPIDRGRLSDDIATPNQRSNRLSRDKRRGQLLIVASDV
*. * :: ..
Mb0149|M.bovis_AF2122/97 FSERGYDGATFQEIAVRADLTRPAINHYFANKRVLYQEVVEQTHELVIVA
Rv0144|M.tuberculosis_H37Rv FSERGYDGATFQEIAVRADLTRPAINHYFANKRVLYQEVVEQTHELVIVA
MMAR_0355|M.marinum_M FSERGYDGATFQAIAVSADLTRPAINHYFASKQALYREVVVQTNELVVAA
MUL_4765|M.ulcerans_Agy99 FSERGYDGATFQAIAVSADLTRPAINHYFASKQALYREVVVQTNELVVAA
MAV_5151|M.avium_104 FSERGYDGATFQAIAARADLTRPAINHYFSSKRALYQEVMDETNEFVIGV
TH_3831|M.thermoresistible__bu IVERGYPAATCQGIARAAGVSRPTLHYYFASREEIYDCLVEQSRNLLAEC
Mvan_2776|M.vanbaalenii_PYR-1 IAEHGYRAATFQQIALRAGVSRPTLHYYFATREQLYEVLLADVRAEVARC
Mflv_3637|M.gilvum_PYR-GCK IAERGYQATTFQQIAQRAGVSRPTLHYYFATREDLYDALLADVCERLGRC
MSMEG_3177|M.smegmatis_MC2_155 INERGFAALTFQGVAKRSGLSRPTLNYYFATRDELFHALVHEGNAIVQEC
MAB_0647|M.abscessus_ATCC_1997 FAEEGLG-VPIDEIARRAGVGAGTVYRHFPAKEDLYRAIAEDRMGSVIDK
MLBr_00815|M.leprae_Br4923 FVDHGYHAAGMDEIADRAGVSKPVLYQHFSSKLELYLAVLERHMNNLVSS
: :.* : :* :.: .: :*. : :: : :
Mb0149|M.bovis_AF2122/97 GIERARREPTLMGRLAVVVDFAMEADAQYPASTAFLATTVLESQRHP---
Rv0144|M.tuberculosis_H37Rv GIERARREPTLMGRLAVVVDFAMEADAQYPASTAFLATTVLESQRHP---
MMAR_0355|M.marinum_M GVERARSVQTLLGQLCTFVMVAKEADASHPATTAFLATAVLESQRHP---
MUL_4765|M.ulcerans_Agy99 GVERARSVQTLLGQLCTFVMVAKEADASHPATTAFLATAVLESQRHP---
MAV_5151|M.avium_104 GIKEADRETTLVGRLTAFISAAVKANAENPAGSAFIIGGVLESQRHP---
TH_3831|M.thermoresistible__bu -AERAMRYDTLVERLTEFGLRLREVDSRDRSTIAFLISARLEGMRNR---
Mvan_2776|M.vanbaalenii_PYR-1 AAEATLA-GSLLRQLEVFIAEMHRLGGAEPALMGLVVTARVDHRGVLR--
Mflv_3637|M.gilvum_PYR-GCK AAAAAGQ-DSLRGQLAAFMAEMNRLAVAEPAMMKLVVTARIDHHGARIGT
MSMEG_3177|M.smegmatis_MC2_155 IAAAKQQ-EDPLERVCALLDAMADAWSADPCLCQFLVNARLEAGRN----
MAB_0647|M.abscessus_ATCC_1997 GRELLAAVDPGE-ALFEFLRSMMDWGGTDQGLVDALSGAGID--------
MLBr_00815|M.leprae_Br4923 VQQALRTTTNNRQRLHAAVQAFFDFIEHDGQGYRLIFENDNITEPR----
: :
Mb0149|M.bovis_AF2122/97 -ELSRTENDAVRATREFLVWAVNDAIERGELAADVDVSSLAETLLVVLCG
Rv0144|M.tuberculosis_H37Rv -ELSRTENDAVRATREFLVWAVNDAIERGELAADVDVSSLAETLLVVLCG
MMAR_0355|M.marinum_M -ELRRSDHDAVAATREFLDTAVRDAIQRGELEAGVDASQLAEALLLLLCG
MUL_4765|M.ulcerans_Agy99 -ELRRSDHDAVAATREFLDTAVRDAIQRGELEAGVDASQLAEALLLLLCG
MAV_5151|M.avium_104 -EWNTAENDSVRIAREFLIRVVNDAIEHGEVAADIDASALVETLLVVMCG
TH_3831|M.thermoresistible__bu -ELG---EDPAMALREFFTELLADAVAAGELPSDIDIESAVEVMYTVLWG
Mvan_2776|M.vanbaalenii_PYR-1 ---HEAATAVVATVHAFFDAVVVDAVRRGELAFDTDAHAVADLLGALFWG
Mflv_3637|M.gilvum_PYR-GCK GEGRGAATDIVSTVHDFYDAVVLAAAARGELPAGHDPHAVADMLAAVFWG
MSMEG_3177|M.smegmatis_MC2_155 ---PALPNGIATAIRDFLDDVVGDAIAGGALSAHTDPAPVAQLLHAMVWG
MAB_0647|M.abscessus_ATCC_1997 ------VQALIPHIEESFYAVLGDLLRAAQQAGTVRSDVGVHEVKALLVG
MLBr_00815|M.leprae_Br4923 -----VAAQVRVATESCIDAVFALISADSRLDPHRARMVAVGLVGISVDC
. . . . : .
Mb0149|M.bovis_AF2122/97 VGFYIGFVG---SYQRMATITDSFQQLLAGTLWRPPT------
Rv0144|M.tuberculosis_H37Rv VGFYIGFVG---SYQRMATITDSFQQLLAGTLWRPPT------
MMAR_0355|M.marinum_M VGFYAGFVG---SYRDMENILDTLCKMMAGTLWKPRS------
MUL_4765|M.ulcerans_Agy99 VGFYAGFVG---SYRDMENILDTLCKMMAGTLWKPRS------
MAV_5151|M.avium_104 VGLYAGYVE---TYQEMLAVTGMLRQLLEGALWRPGS------
TH_3831|M.thermoresistible__bu LGFYTGFVE---RSTDMLVLAEQLENLFASA------------
Mvan_2776|M.vanbaalenii_PYR-1 LVFHAGFIS---GADGAPEIARQLLRMVGFGLLDTPEPASVDA
Mflv_3637|M.gilvum_PYR-GCK LGFHARMLTADIGVDGVPEVARQLLSVLDSGLLDGALRAPADA
MSMEG_3177|M.smegmatis_MC2_155 VGLCLGYGG----TSDPKLITKQLESAIAGGLLTESRQAS---
MAB_0647|M.abscessus_ATCC_1997 CQAMQSYNK---------DVSRQVTDVVFDGLRPRP-------
MLBr_00815|M.leprae_Br4923 ARYWLDTNR----PISKSDAVEGTVQFAWGGLSHVPLTRL---