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ARDRLLDAAETCLQGKGLSGTTMEDIARHAGVSRATVYRYFASRESVVSGVIVRAAERYLHRTSGRILAH TDLGSAILDFVAVTVRAARREPIIGMLFASDDELAGVGLAEGTSVALFELVAEFLRPVFAAHWHQLEAGV SVDDAAEWILRIILSLLAVRGPRHRSPEGIDAFLRRFLLPALLADTHSCIAATTAE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4624 | - | - | 100% (197) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_3024 | - | 2e-97 | 90.86% (197) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_0366 | - | 2e-17 | 27.96% (186) | TetR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3277c | - | 2e-08 | 24.87% (193) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv1255c | - | 7e-14 | 29.28% (181) | transcriptional regulatory protein |
| M. leprae Br4923 | MLBr_00316 | - | 8e-05 | 41.18% (51) | putative TetR/AcrR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_2043 | - | 4e-64 | 72.29% (166) | putative transcriptional regulator, TetR |
| M. marinum M | MMAR_3161 | - | 1e-72 | 72.19% (187) | transcriptional regulatory protein |
| M. avium 104 | MAV_4189 | - | 1e-17 | 29.84% (191) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_4953 | - | 3e-18 | 30.21% (192) | putative transcriptional regulator |
| M. thermoresistible (build 8) | TH_4364 | - | 3e-22 | 34.95% (186) | PUTATIVE transcriptional regulator, TetR family protein |
| M. ulcerans Agy99 | MUL_4487 | - | 8e-16 | 32.79% (183) | transcriptional regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_3399 | - | 9e-18 | 29.57% (186) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1255c|M.tuberculosis_H37Rv ---------MAGTDWLSARRTELAA--DRILDAAERLFTQRDPASIGMNE
MUL_4487|M.ulcerans_Agy99 ---------MGRTDWLAAHRSEVAA--DRILDAAERLYTEHDPASIGMNE
MAB_2043|M.abscessus_ATCC_1997 -----------------------------------------------MED
MMAR_3161|M.marinum_M ----------MRWGAAAPSDRDSAR--DRLLDAAERCLESCGVVGTTMED
Mflv_4624|M.gilvum_PYR-GCK ----------------------MAR--DRLLDAAETCLQGKGLSGTTMED
MAV_4189|M.avium_104 -------MRTHGWQGEPPRSDEDAV--ARIVAAADRCVRRRGGQ-TTIAD
TH_4364|M.thermoresistible__bu -------MRTHGWRGTPPRSDDEAV--ERILAATHRCVAERGGQ-TTIAH
MSMEG_4953|M.smegmatis_MC2_155 --------------MTNATAPRSVR--DRLIDAAETCLRAKGIRATTVSE
Mvan_3399|M.vanbaalenii_PYR-1 --MPTSRARRNWGDDRALLNDEEAR--DRLLDAAERCVARRGDTQIRMSE
Mb3277c|M.bovis_AF2122/97 MSTPSATVAPVKRIPYAEASRALLR--DSVLDAMRDLLLTRDWSAITLSD
MLBr_00316|M.leprae_Br4923 MSVPRSGLSVQMAQPARPLRADAARNRARILGVAYEAFATEGLS-VPIDE
: .
Rv1255c|M.tuberculosis_H37Rv IAKAAGCSRATLYRYFDSREALRTAYVHRETRRLGREIMVKIAD-VVEPA
MUL_4487|M.ulcerans_Agy99 IARAAGCSRATLYRYFESREALRTAYVHRETLRLGREIMQQIGD-IDDPR
MAB_2043|M.abscessus_ATCC_1997 IGRTAGVSRATVYRYFPSREAVMSGVIIRAAERYLDRISPRIAA-HADLG
MMAR_3161|M.marinum_M IGRTAGVSRATVYRYFPNREAVMSGVIIRAAERYLDRINPRIAE-HTDLG
Mflv_4624|M.gilvum_PYR-GCK IARHAGVSRATVYRYFASRESVVSGVIVRAAERYLHRTSGRILA-HTDLG
MAV_4189|M.avium_104 VAAELGVSRKTVYRYFPSTTALLRAVATEGTRKFLEAMAERLSA-IDDIA
TH_4364|M.thermoresistible__bu VAAELGVSRATVYRYFPSTSALLQAAAVEGTRRFLHRMAERLGR-IDDVA
MSMEG_4953|M.smegmatis_MC2_155 VAEAAGVSRGWLYRHFPDKVSLLGAAIVRLNDAYWSDAHAFLAA-YDGLD
Mvan_3399|M.vanbaalenii_PYR-1 VADAANVVRSTVYRYYPSRDDLLLGLVLRRVDRACTRWIRELRR-PQDAA
Mb3277c|M.bovis_AF2122/97 VARAAGISRQTIYNEFGSRQGLAQGYALRLADRLVDNVHASLDANVGNFY
MLBr_00316|M.leprae_Br4923 IARRAGVGAGTVYRHFPTKEALCAAVIGDRMPHLVDDGYVLLKS--AGPG
:. . :*. : : . :
Rv1255c|M.tuberculosis_H37Rv ERLLVSITTTLRMVRDNPA-LAAWFTTTRPPIGGEMAG-RSEVIAALAAA
MUL_4487|M.ulcerans_Agy99 DQLITSITATLRMVRQRPA-LAAWFASTRPPIGGELAG-QSEVIAGLAAA
MAB_2043|M.abscessus_ATCC_1997 SALVDFVEYTVEAARREEI-IGLLFGSDEELAGVGLAAGTSTSLFEIVTE
MMAR_3161|M.marinum_M SALVDFVEYTVEAARREEI-IGLLFGSDEELAGVGLAAGTSTSLFELVTE
Mflv_4624|M.gilvum_PYR-GCK SAILDFVAVTVRAARREPI-IGMLFASDDELAGVGLAEGTSVALFELVAE
MAV_4189|M.avium_104 EAVVEGVVLTVTAVPDEPY-LQLLLE---EPSHALLRSITSETARRVGQQ
TH_4364|M.thermoresistible__bu DAIIEGVVQTVAAVPNEPY-LRLLLD---EPSHVLLRDVTSESAREIGKS
MSMEG_4953|M.smegmatis_MC2_155 EKIAAGIRYGRTAYDDPGA-LLMKLRLDEPEEFAACAGAGVQGLVPDLAA
Mvan_3399|M.vanbaalenii_PYR-1 ASIRELVLLPAASVDSGDP-VNLALYAGESTGLATVLEAGAQSVTEIVAG
Mb3277c|M.bovis_AF2122/97 EAFLQGFRSFFAESAADPL-VISLLTGVAKPDLLQLITTDSAPIITRASA
MLBr_00316|M.leprae_Br4923 EALFTYLRSLVLHWGATDRGLVDALAGAGGIDILGVAPDAEDAFLTILSD
. . : :
Rv1255c|M.tuberculosis_H37Rv FLNSLGPDDPTTVERRAR----------WVVRMLTSLLMFPG---RDEAD
MUL_4487|M.ulcerans_Agy99 FLQSLGPEAPAAVERRAR----------WTVRVIVSLLMFPG---QDEAD
MAB_2043|M.abscessus_ATCC_1997 FLRPIFTRHWSCVEPGVS----VDDAAEWVVRTILSLLTVRGPRERSRDG
MMAR_3161|M.marinum_M FLRPIFRRHWSYVEPGVS----VDDAAEWVLRTILSLLTVRGPRERSRDG
Mflv_4624|M.gilvum_PYR-GCK FLRPVFAAHWHQLEAGVS----VDDAAEWILRIILSLLAVRGPRHRSPEG
MAV_4189|M.avium_104 VLVEHTSVDWERTPMASR---TLDELVEWSLRAVHSFLANPSDPPRDADQ
TH_4364|M.thermoresistible__bu MLLESTSVDWARLRPAAEIVDELDELIEWSLRIVQSFLTDPGDPPRSPDA
MSMEG_4953|M.smegmatis_MC2_155 FWTRYLLAARDTGEIHPN--TDIAEAAEWVARVVISFATVPGEQLDASDT
Mvan_3399|M.vanbaalenii_PYR-1 NLKPLFKAWKDEGQIYPD--LDLNETVQWMS-ATSSFLLTPTWRHRSPAA
Mb3277c|M.bovis_AF2122/97 RLAPAFTDTWVATTDNDAN-----VLSRAIVRLCLSYVSMPPEADHDVAA
MLBr_00316|M.leprae_Br4923 LLYAAQYAGTARTDVGVR----------EVKSILVGCQAMEAYNSALAER
.
Rv1255c|M.tuberculosis_H37Rv --ERAMIAEFVVPIVTPASAAARKAGHPGPE-
MUL_4487|M.ulcerans_Agy99 --ERAMLEEFVAPVVTPFPTRR----------
MAB_2043|M.abscessus_ATCC_1997 --LRAFLSRFLLPAILAGDHARPM--------
MMAR_3161|M.marinum_M --LRTFLSRFLLPAILASDHCRPM--------
Mflv_4624|M.gilvum_PYR-GCK --IDAFLRRFLLPALLADTHSCIAATTAE---
MAV_4189|M.avium_104 --LRGYLRRWLAPAIRQWVQQAAAGTMV----
TH_4364|M.thermoresistible__bu --LRAHLHRWLGPAIREWVASVGIDAEQSPPE
MSMEG_4953|M.smegmatis_MC2_155 GAVLTHLRRYVMPGLRAEPAS-----------
Mvan_3399|M.vanbaalenii_PYR-1 --KRRFVDRYLLRALIR---------------
Mb3277c|M.bovis_AF2122/97 -----DLARLITPFAERHGVINVP--------
MLBr_00316|M.leprae_Br4923 ------VTDVVVDGLRAAR-------------
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