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RKTGVVCGTVFASAALALSSSSLGQAANTALVIGGISTPSMADALMSPLLGGKFKDQQRVSVKWPAQAGP MTGKGDLTLGASIAQGATNLNAQIDAALAQLKSGEKVTVVGLSAGSLVVNEILRELDESADAPGKDKITF VVVADSSRQKVISRTRYNANLDYTYQTAPETKYDIIVVTGEYDGMADFPDRLNLLAIVNAVAGGIFVHIP VMYADLSKVPARNISVEMNSEGGTTTHYLVPAEKLPLVRLFPSLANREAELKAKIDAAYSRNDVVAVSAP KAAVFAAAPAPAAPTAVVQTPSAAQVPGSVAASLRTAKADAAVEDAVVSEDAAVEDAVVSEEAAVSEEVD VKGADSADADIEETDTADQADIDSGAEKEAAQEDSDAGAQSGDDADKDGSVSSDSGASTDRSPSKPSATS DS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4518 | - | - | 100% (423) | hypothetical protein Mflv_4518 |
| M. gilvum PYR-GCK | Mflv_3371 | - | 3e-93 | 45.85% (434) | hypothetical protein Mflv_3371 |
| M. gilvum PYR-GCK | Mflv_3864 | - | 5e-91 | 46.28% (443) | hypothetical protein Mflv_3864 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3852 | - | 1e-28 | 29.75% (353) | hypothetical protein Mb3852 |
| M. tuberculosis H37Rv | Rv3822 | - | 5e-29 | 29.75% (353) | hypothetical protein Rv3822 |
| M. leprae Br4923 | MLBr_01232 | - | 7e-26 | 33.47% (248) | hypothetical protein MLBr_01232 |
| M. abscessus ATCC 19977 | MAB_0936c | - | 2e-26 | 34.26% (251) | hypothetical protein MAB_0936c |
| M. marinum M | MMAR_2235 | - | 5e-21 | 29.75% (326) | PE-PGRS family protein, PE16 |
| M. avium 104 | MAV_1760 | - | 8e-22 | 27.30% (381) | hypothetical protein MAV_1760 |
| M. smegmatis MC2 155 | MSMEG_6144 | - | 1e-31 | 31.96% (413) | PE family protein |
| M. thermoresistible (build 8) | TH_3724 | - | 9e-17 | 29.02% (286) | PUTATIVE putative PE-PPE, C-terminal domain protein |
| M. ulcerans Agy99 | MUL_0967 | - | 1e-20 | 31.70% (265) | PE family protein |
| M. vanbaalenii PYR-1 | Mvan_1838 | - | 1e-113 | 54.40% (432) | hypothetical protein Mvan_1838 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3852|M.bovis_AF2122/97 MKCPGVSDCVATVRHDNVFAIAAGLRWSAAVPPLHKGDAVTKLLVGAIAG
Rv3822|M.tuberculosis_H37Rv MKCPGVSDCVATVRHDNVFAIAAGLRWSAAVPPLHKGDAVTKLLVGAIAG
MAB_0936c|M.abscessus_ATCC_199 -----MRNLLAGTAVLVVACVTGCFGIPSAVA--DDPQVPGPPIPGIAPD
MAV_1760|M.avium_104 -----MKQLLAGVTALLSVSTAGYFGIGTAAA--DGGPIGGPPTPG-APG
MLBr_01232|M.leprae_Br4923 -----MKRLLATTLAALTVGTVSGFGSTVASS--EPGEPWLPPSPVPVRE
Mflv_4518|M.gilvum_PYR-GCK -----MRKTGVVCGTVFASAALALSSSSLGQA------------------
Mvan_1838|M.vanbaalenii_PYR-1 -MKIGVRKAGLACGAAFASAVLAASTATSAWG------------------
MMAR_2235|M.marinum_M --MSFVVTAPETVVAAASQLTGIGSAIEAANAAAAALTTRLLPAAADEVS
MUL_0967|M.ulcerans_Agy99 MAVIDLLASPQAMTATATEVAEIGLAINQADLAVAGPTTGLAAAAAAEVS
TH_3724|M.thermoresistible__bu ---------VVAVGALTWGGXGVASPAGQPER------------------
MSMEG_6144|M.smegmatis_MC2_155 --------MIAAVAAVVTAALVTTVP------------------------
Mb3852|M.bovis_AF2122/97 GMLAYAAILGDGIASADTALIVPGTAPSPYGPLRSLYHFNPAMQPQIGAN
Rv3822|M.tuberculosis_H37Rv GMLACAAILGDGIASADTALIVPGTAPSPYGPLRSLYHFNPAMQPQIGAN
MAB_0936c|M.abscessus_ATCC_199 GTVKAAPSAPDRTAYALGGAHVLGIPYDEYIRMTGKDWFPNMKRENVWYP
MAV_1760|M.avium_104 ----------DQTAYALGGAHVLGIPYDQYIRMEGADWFPGQQRQIVRYP
MLBr_01232|M.leprae_Br4923 -------NSPAKIVYALGGARPPTFDWDYYTIRAGDEFFPDVNRKLIDYP
Mflv_4518|M.gilvum_PYR-GCK ----------ANTALVIGGISTPSMADALMSPLLGG-KFKDQQRVSVKWP
Mvan_1838|M.vanbaalenii_PYR-1 ----------SSSALVIGGIATSSMHDVVMGQVLGG-ALKNQQRVSVNWP
MMAR_2235|M.marinum_M AGIAALMSTHAQEYQLLGGQLATYHDQLVQALDRTAGWYADAETGNAALL
MUL_0967|M.ulcerans_Agy99 EAIATLFDNYAQGYQAVSRQTAAFHDAFAQTLFAASDSYVRAEAAAVKAL
TH_3724|M.thermoresistible__bu ----------AAALRLTATADAIIMPGTKIGYIPSQDEFTAYATAVIGAT
MSMEG_6144|M.smegmatis_MC2_155 ----------ALGATAFTISGTRILHDPPYPEQLVPGEFAGYDVEHIKYP
Mb3852|M.bovis_AF2122/97 YYTPTATRHVVSYPGS----------------------------------
Rv3822|M.tuberculosis_H37Rv YYNPTATRHVVSYPGS----------------------------------
MAB_0936c|M.abscessus_ATCC_199 AGQVQGHTLERFFPGIGPIG------------------------------
MAV_1760|M.avium_104 AGQVQGHVLERLFPGIGKLD------------------------------
MLBr_01232|M.leprae_Br4923 ARAPFRYVPTFLVPGP----------------------------------
Mflv_4518|M.gilvum_PYR-GCK AQAGPMTGKGDLTLGAS---------------------------------
Mvan_1838|M.vanbaalenii_PYR-1 AEAAPWTGKDDLTLGAS---------------------------------
MMAR_2235|M.marinum_M RNVQQELLTGLTAPGRAWSGAGAASAGASGVDALMSSALLSGGRSVLVVG
MUL_0967|M.ulcerans_Agy99 AGLTEPVAN-LFAP--VLSGPESVAASAT---ALLSGAPLKPVEAALILS
TH_3724|M.thermoresistible__bu AGAPGAVDYLGVPG------------------------------------
MSMEG_6144|M.smegmatis_MC2_155 ASVFGMDRGIWEAAG-----------------------------------
Mb3852|M.bovis_AF2122/97 --------------------------------------FWPVTGLNSPTV
Rv3822|M.tuberculosis_H37Rv --------------------------------------FWPVTGLNSPTV
MAB_0936c|M.abscessus_ATCC_199 ------------------------------------EKILPGLGLDGPSI
MAV_1760|M.avium_104 ------------------------------------ES-FPGLGMDGPSV
MLBr_01232|M.leprae_Br4923 --------------------------------------------RDEVTI
Mflv_4518|M.gilvum_PYR-GCK ------------------------------------------IAQGATNL
Mvan_1838|M.vanbaalenii_PYR-1 ------------------------------------------IDIGITNL
MMAR_2235|M.marinum_M STGTPRPSYRFMREVYDLFVAPHY-FGDSLFGVQTPAQFQPFTGIPNLTF
MUL_0967|M.ulcerans_Agy99 ESGVPTPSASYISDVYTKYVEPNFPSATAPQGVSTPNGLYPFTGIKDLSL
TH_3724|M.thermoresistible__bu -------------------------------------EFWPATGLDSLTF
MSMEG_6144|M.smegmatis_MC2_155 ----------------------------------------------AVAA
Mb3852|M.bovis_AF2122/97 GSSVSAGTNNLDAAIR------STDGPIFVAGLSQGTLVLDREQARLAND
Rv3822|M.tuberculosis_H37Rv GSSVSAGTNNLDAAIR------STDGPIFVAGLSQGTLVLDREQARLAND
MAB_0936c|M.abscessus_ATCC_199 GESIDIGEPNLENAIR------SGG-PGTAMGLSEGALVLNAVKNALATD
MAV_1760|M.avium_104 GESVAEGIDNLDAAIR------TTGRPGTAIGLSEGAFVVDGEQARLAND
MLBr_01232|M.leprae_Br4923 GEAIAVATKNLNQAIH------RGTEPAAVVGLSQGSLALDTEQEQLATD
Mflv_4518|M.gilvum_PYR-GCK NAQIDAALAQLK-----------SGEKVTVVGLSAGSLVVNEILRELDES
Mvan_1838|M.vanbaalenii_PYR-1 NAQIDAALGRLGKDANG---NYVDGEKVTVVGLSAGSLVVNEVLRQLAAD
MMAR_2235|M.marinum_M DESAATGASYLHAAITQQLAD---GNRVVVAGFSQGASVATLEMRHLQSL
MUL_0967|M.ulcerans_Agy99 DISLARGATILNDAILQQLAALPAGSSVAVLGYSQSAVLSSRVMPKLLAE
TH_3724|M.thermoresistible__bu DASVAXGQAMLTPMVDG---AIESDTPIVVFGHSQSAVIATKEKQRLLAE
MSMEG_6144|M.smegmatis_MC2_155 GVDRFVGVDDEGNPIT---------EKIIVAGFSQGAIVIAYEKKRLMKL
. . . * * .: *
Mb3852|M.bovis_AF2122/97 PTAP--PPGQLTFIKAGDP-------NNLLWRAFRPGTHVPIIDYTVP--
Rv3822|M.tuberculosis_H37Rv PTAP--PPGQLTFIKAGDP-------NNLLWRAFRPGTHVPIIDYTVP--
MAB_0936c|M.abscessus_ATCC_199 PTAP--EPESLTFATFGDPIAKSPFSESFLTQNFAPGSVVPFMDYPVP--
MAV_1760|M.avium_104 PTAP--PPNTLNFATFGDPIGRHAFGQSFLTAMFGVGSVVPALDYTMP--
MLBr_01232|M.leprae_Br4923 PTAP--PPDQLTFNTFGDPSGYHGFGKSVLASIFRPGDYIPLIDYTMP--
Mflv_4518|M.gilvum_PYR-GCK ADAP--GKDKITFVVVADS---------SRQKVISRTRYNANLDYTYQ--
Mvan_1838|M.vanbaalenii_PYR-1 ADAP--DKDQITFIVVADS---------SRQKLINRTRYNSKFDYTYQ--
MMAR_2235|M.marinum_M PIDSRPSPEDLSFVLLGNPN-----NPNGGILARFPGLYIQSVGLTFNG-
MUL_0967|M.ulcerans_Agy99 GVTS----SQVNFVLLGNPM-----NPNGGVLARFPDLTLPSLGFTFYG-
TH_3724|M.thermoresistible__bu YPDPD-TAPDVTFVMVANPN-----RPNGGLLARFPGLYIPILGVTFNGA
MSMEG_6144|M.smegmatis_MC2_155 DEDERPTVDQLKFVTIGDPT-------GPNGILRWIPFRIPIIGLTPVR-
:.* .:. .. .
Mb3852|M.bovis_AF2122/97 --APVESQYDTINIVGQYDIFSDPPNRPGNLLADLNAIAAGGYYGHSATA
Rv3822|M.tuberculosis_H37Rv --APAESQYDTINIVGQYDIFSDPPNRPGNLLADLNAIAAGGYYGHSATA
MAB_0936c|M.abscessus_ATCC_199 --ARVDSQYHTDQFISAYDSIADWPDRPDNLFALANAIAG-LATGHTAVA
MAV_1760|M.avium_104 --PPYESQYDTNRFVAAYDSIADFPDRPDNMFALANTLMG-LATGHTAVA
MLBr_01232|M.leprae_Br4923 --QRMDSQYDSNRVVAAYDGLSEFPDRADNLLAQLNCFAG-GAISHTPSG
Mflv_4518|M.gilvum_PYR-GCK --TAPETKYDIIVVTGEYDGMADFPDR-LNLLAIVNAVAG-GIFVHIPVM
Mvan_1838|M.vanbaalenii_PYR-1 --PAPETEYDIVVVTGEYDGLADFPDRWWNALAVANAIAG-SIYVHVPVM
MMAR_2235|M.marinum_M --ATPVTEYPTTVYTTQYDGFADFPQYPLNVVADVNALLG-ISYSHSLYY
MUL_0967|M.ulcerans_Agy99 --ATPDNAFPTVSYTLEYDGFADFPRYPINLLADINAVMG-IPFVHADYQ
TH_3724|M.thermoresistible__bu TPAPADGPFDSYDVAREFDGWADFPRYPLNLVATANAILGIYYLHGGYYE
MSMEG_6144|M.smegmatis_MC2_155 ---PPDTPYETTIINGEYDGWADFPDRPWNLIATANALLGIIYVHGRYED
: :* :: * * .* * . .
Mb3852|M.bovis_AF2122/97 FSD---PARVAPRDITTTTNSLGATTTTYFIRTDQLPLVRALVDMAGLPP
Rv3822|M.tuberculosis_H37Rv FSD---PARVAPRDITTTTNSLGATTTTYFIRTDQLPLVRALVDMAGLPP
MAB_0936c|M.abscessus_ATCC_199 FTN---PKMVPARNIVTETNSRGGTTTTYFIPEQHLPLVMGFKYLG-VPE
MAV_1760|M.avium_104 FTN---PSMVPPQNIRTTINSRGAKDTTIMIPEKHLPLVMPLKYIG-IDE
MLBr_01232|M.leprae_Br4923 FFN---PEDVPPQNIRTTVNSRGAKTTTYLIPVNHLPLTLPLRYLG-WSD
Mflv_4518|M.gilvum_PYR-GCK YAD---LSKVPARNISVEMNSEGGTTTHYLVPAEKLPLVRLFPSLANREA
Mvan_1838|M.vanbaalenii_PYR-1 FAD---LSKVPAENITVDVNSKGGTTTSYLVPTAKLPLVQLFPSLAAKEA
MMAR_2235|M.marinum_M GLT---PDQVAAG-VVLPVSSPDVNTTYILIPNEHLPLLQPLRGI--VPD
MUL_0967|M.ulcerans_Agy99 DLT---QAQLDSA-VQLPTEGP-TQSTYYMIPTEHLPLLAPLRFIPYVGD
TH_3724|M.thermoresistible__bu LLT---ENPDILDDPERTIVQQYGDTTYYLIRTEQLPLLRPLRDLG-VPE
MSMEG_6144|M.smegmatis_MC2_155 KVDGWDLSTVPEKNIVETVNKAGGKTTTYLIPTEKLPLLQPLRDLG-FPE
* :: :*** : :
Mb3852|M.bovis_AF2122/97 QAAGTVDAALRP-----------IIDRAYQPGPAPAVNPRDLVQGIRGIP
Rv3822|M.tuberculosis_H37Rv QAAGTVDAALRP-----------IIDRAYQPGPAPAVNPRDLVQGIRGIP
MAB_0936c|M.abscessus_ATCC_199 ETLNRLDAILQP-----------RVDAGYSRNDDPATAP----IAVDPRR
MAV_1760|M.avium_104 NTLNKLDAILTP-----------RVNAGYSRNDDPATAP----VQVDPVH
MLBr_01232|M.leprae_Br4923 ALVDQIDAVLQP-----------KIDAAYAYNDNPLNKP----ISVDPVN
Mflv_4518|M.gilvum_PYR-GCK ELKAKIDAAYSRNDVV-----AVSAPKAAVFAAAPAPAAPTAVVQTPSAA
Mvan_1838|M.vanbaalenii_PYR-1 ELKAKIDKAYSRNDAP-----PAGALSTLVAAAPAVVADQAAVVEESPAE
MMAR_2235|M.marinum_M SVLDGIEPGLRDVVELGYDR------TGYADVPTPASLFPANVNPNVVAG
MUL_0967|M.ulcerans_Agy99 PLAELLEPNLRVLVNFGYGDPAYGYDTGPANVPTPFGLFPP-VSPLTVAE
TH_3724|M.thermoresistible__bu EFVDALEPYVRRIVDLGYDRNTPYGEPAPVRVLPPLTPAPGPATQHNAGQ
MSMEG_6144|M.smegmatis_MC2_155 SFVAALEAPLRKIIDAAYKRNDPGRVTVTTTEETVVEDESEITQTAVTEI
::
Mb3852|M.bovis_AF2122/97 AIAPAIAIPIGSTTGASAATSTAAATAAATNALRGANVGPGANKALSMVR
Rv3822|M.tuberculosis_H37Rv AIAPAIAIPIGSTTGASAATSTAAATAAATNALRGANVGPGANKALSMVR
MAB_0936c|M.abscessus_ATCC_199 GFDPAEVTAPASQATFGGGSDPISQITSGALAVLGNGTRPTPPN------
MAV_1760|M.avium_104 GFDPAEVTAPANQATFGGGADPLSQIMAGAMSVLSHGAGEADH-------
MLBr_01232|M.leprae_Br4923 GMDPIAGIDAELR-------DSILNVFAQLRSILPPPPG-----------
Mflv_4518|M.gilvum_PYR-GCK QVPGSVAASLRTAKADAAVEDAVVSEDAAVEDAVVSEEAAVSEEVDVKGA
Mvan_1838|M.vanbaalenii_PYR-1 AVAEPVEQAVTEPVEQAVTEPVEQAVTEPVEQADTDGATPVLEEVVEEVV
MMAR_2235|M.marinum_M AFVEGAVRGIDNGLAGMGLPPLPDLPAAPLLPEIWSNAPPIPGWPASVPS
MUL_0967|M.ulcerans_Agy99 HLAAGTQQGIVNSGAALQAQGPPSIPLSDIAHTLTAN-PPWAGTPALPPS
TH_3724|M.thermoresistible__bu GITVASATSTPDKRTPVVEAPVEEPPVQTGRSTLKREKPVSARHLVRNSL
MSMEG_6144|M.smegmatis_MC2_155 DETPSTDGDIDETAVQSTTQRRTVANTAADRTAETAEVAEVTEDVDELAE
Mb3852|M.bovis_AF2122/97 GLLPKGKKH-----------------------------------------
Rv3822|M.tuberculosis_H37Rv GLLPKGKKH-----------------------------------------
MAB_0936c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_1760|M.avium_104 --------------------------------------------------
MLBr_01232|M.leprae_Br4923 --------------------------------------------------
Mflv_4518|M.gilvum_PYR-GCK DSADADIEETD-----------------------------------TADQ
Mvan_1838|M.vanbaalenii_PYR-1 EEAPDDDTDVT-----------------------------------DADG
MMAR_2235|M.marinum_M AIAVPPQLGGAIAGPLDHLYRTLDSVINGQINPAITSGIYQYGADLSAEA
MUL_0967|M.ulcerans_Agy99 TSPAS----------------SIEDFI------------------LAVQA
TH_3724|M.thermoresistible__bu RAVPGLRRGEP------------------------------------AAT
MSMEG_6144|M.smegmatis_MC2_155 QEEPVKEEATKDDEVTKVADEADKATPVKESTSVEKTDQAVKPDDTDKTV
Mb3852|M.bovis_AF2122/97 --------------------------------------------------
Rv3822|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0936c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_1760|M.avium_104 --------------------------------------------------
MLBr_01232|M.leprae_Br4923 --------------------------------------------------
Mflv_4518|M.gilvum_PYR-GCK ADIDSGAEKEAAQEDSDAGAQSGDDADKDGSVSSDSGASTDRSPSKPSAT
Mvan_1838|M.vanbaalenii_PYR-1 EQTPAPEGADVPVVADDAVESAGADLTESTETESPSDYLSIDAESAGTPE
MMAR_2235|M.marinum_M ARHGASSELLNAIYVGRQVLPILIEGPGVILTADTYYSINAIKDLAAGNL
MUL_0967|M.ulcerans_Agy99 ANSSISRGFVKTLSTAYATLLPTTDIASELVFTLPSYNLNLFLDGVIQAI
TH_3724|M.thermoresistible__bu PTPDVTPDVTPDAPAGQPEPAEPNESAAPPAAAEADDASE----------
MSMEG_6144|M.smegmatis_MC2_155 TTAEKVEKADEAEKVEKTKPNVRKVKRPQFNVFKPKKTRVTVPKAEPSTK
Mb3852|M.bovis_AF2122/97 ---------------------------------------
Rv3822|M.tuberculosis_H37Rv ---------------------------------------
MAB_0936c|M.abscessus_ATCC_199 ---------------------------------------
MAV_1760|M.avium_104 ---------------------------------------
MLBr_01232|M.leprae_Br4923 ---------------------------------------
Mflv_4518|M.gilvum_PYR-GCK SDS------------------------------------
Mvan_1838|M.vanbaalenii_PYR-1 SE-------------------------------------
MMAR_2235|M.marinum_M SGFNQNLQLIPATNAMLLTFGATIPIAAGVSAYIGRDFP
MUL_0967|M.ulcerans_Agy99 NGQ---------------------PIGD-----------
TH_3724|M.thermoresistible__bu ---------------------------------------
MSMEG_6144|M.smegmatis_MC2_155 AKPATKPDNDNDDTSDTTDKTAEKDAA------------