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RITKRGARSAGMACGTVAASAALAVSTATSGWGVSTAIVIGGIGTPSMHEVVTNQLLGGALQDYDQRISV NWPAEARPYTGEDDMTLGQSIEIGRANLNAQIDTALAQLERDADGNLLDSEQVTVVGLSAGSLVVTETLR GWQSDDKEDPDAEEINFVVVADSSRQEIIDDTEQYNPTYDYTYRKAPETVYDTVEVTGEYDGMADFPDRF NLTAISNAMAGSVLRHVQTMFSDLSDVPKQNTTVTENALGGTTVRYLVPAETLPLVQSNPSLAPREAELR AQVDRGYSRNDPANVAARLAGPDVPERIRDIVTPEAAAQDTEDVDLGIAAAVQQDEESGAGAIPEIDGQR SLGEQLEAAQNAEDGADTSPAPTSRTIGAAVEAISERSTAADDDTGATPLTPDAGDTESSTSDGASESAG SDVGDSTTRTSTKPSSDGAARSSSSAE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3864 | - | - | 100% (448) | hypothetical protein Mflv_3864 |
| M. gilvum PYR-GCK | Mflv_4518 | - | 6e-91 | 46.28% (443) | hypothetical protein Mflv_4518 |
| M. gilvum PYR-GCK | Mflv_3371 | - | 1e-85 | 43.25% (437) | hypothetical protein Mflv_3371 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1216c | - | 3e-21 | 30.13% (239) | hypothetical protein Mb1216c |
| M. tuberculosis H37Rv | Rv1184c | - | 3e-21 | 30.13% (239) | hypothetical protein Rv1184c |
| M. leprae Br4923 | MLBr_01232 | - | 3e-21 | 30.67% (225) | hypothetical protein MLBr_01232 |
| M. abscessus ATCC 19977 | MAB_0936c | - | 3e-20 | 29.88% (241) | hypothetical protein MAB_0936c |
| M. marinum M | MMAR_3427 | - | 6e-18 | 26.46% (325) | PE family protein |
| M. avium 104 | MAV_1760 | - | 2e-19 | 29.27% (328) | hypothetical protein MAV_1760 |
| M. smegmatis MC2 155 | MSMEG_6144 | - | 7e-29 | 28.74% (435) | PE family protein |
| M. thermoresistible (build 8) | TH_3724 | - | 9e-15 | 25.43% (346) | PUTATIVE putative PE-PPE, C-terminal domain protein |
| M. ulcerans Agy99 | MUL_0967 | - | 8e-11 | 25.32% (391) | PE family protein |
| M. vanbaalenii PYR-1 | Mvan_2535 | - | 1e-134 | 58.25% (424) | hypothetical protein Mvan_2535 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1216c|M.bovis_AF2122/97 -----------------------------MKRVIAGAFAVWLVGWAGGFG
Rv1184c|M.tuberculosis_H37Rv -----------------------------MKRVIAGAFAVWLVGWAGGFG
MLBr_01232|M.leprae_Br4923 -----------------------------MKRLLATTLAALTVGTVSGFG
MAB_0936c|M.abscessus_ATCC_199 -----------------------------MRNLLAGTAVLVVACVTGCFG
MAV_1760|M.avium_104 -----------------------------MKQLLAGVTALLSVSTAGYFG
Mflv_3864|M.gilvum_PYR-GCK -----------------------------MRITKRGARSAGMACGTVAAS
Mvan_2535|M.vanbaalenii_PYR-1 -----------------------------MRRTTGKVRRSAVTCAAAAVT
MMAR_3427|M.marinum_M --MAFLVAEPQVMATVAGQVEEIGSAIGVANEFAAGSISGVAAAAGDEVS
MUL_0967|M.ulcerans_Agy99 MAVIDLLASPQAMTATATEVAEIGLAINQADLAVAGPTTGLAAAAAAEVS
TH_3724|M.thermoresistible__bu ---------------------------------------VVAVGALTWGG
MSMEG_6144|M.smegmatis_MC2_155 ----------------------------------------MIAAVAAVVT
.
Mb1216c|M.bovis_AF2122/97 TAIAASEPAYPWAPGPPPSPSPVGD---------------ASTAKVVYAL
Rv1184c|M.tuberculosis_H37Rv TAIAASEPAYPWAPGPPPSPSPVGD---------------ASTAKVVYAL
MLBr_01232|M.leprae_Br4923 STVASSEPGEPWLP---PSPVPVRE---------------NSPAKIVYAL
MAB_0936c|M.abscessus_ATCC_199 IPSAVADDPQVPGP-PIPGIAPDGTVKAAP----------SAPDRTAYAL
MAV_1760|M.avium_104 IGTAAADGGPIGGP-PTPG-APG--------------------DQTAYAL
Mflv_3864|M.gilvum_PYR-GCK AALAVSTATSGWGV------------------------------STAIVI
Mvan_2535|M.vanbaalenii_PYR-1 AGLAMATATPGWGV------------------------------STALVI
MMAR_3427|M.marinum_M AAIASFFAAHGQAYQAVAGQVEAFHTEFQQALAQAGNAYVQAEAAGAAAL
MUL_0967|M.ulcerans_Agy99 EAIATLFDNYAQGYQAVSRQTAAFHDAFAQTLFAASDSYVRAEAAAVKAL
TH_3724|M.thermoresistible__bu XGVASPAGQPER--------------------------------AAALRL
MSMEG_6144|M.smegmatis_MC2_155 AALVTTVPALG---------------------------------ATAFTI
. . :
Mb1216c|M.bovis_AF2122/97 GG------------ARMPGIPWYEYTNQAGSQYFPNAKHDLIDYPAGAAF
Rv1184c|M.tuberculosis_H37Rv GG------------ARMPGIPWYEYTNQAGSQYFPNAKHDLIDYPAGAAF
MLBr_01232|M.leprae_Br4923 GG------------ARPPTFDWDYYTIRAGDEFFPDVNRKLIDYPARAPF
MAB_0936c|M.abscessus_ATCC_199 GG------------AHVLGIPYDEYIRMTGKDWFPNMKRENVWYPAGQVQ
MAV_1760|M.avium_104 GG------------AHVLGIPYDQYIRMEGADWFPGQQRQIVRYPAGQVQ
Mflv_3864|M.gilvum_PYR-GCK GG------------IGTPSMHEVVTNQLLGGALQDYDQRISVNWPAEARP
Mvan_2535|M.vanbaalenii_PYR-1 GG------------IGTPTLHDVVMSELLGGALRDYDQRRAVSWPAQARP
MMAR_3427|M.marinum_M AG-----------ALGVPATSAAAPAATIP--PFPANLTTLVMGGTGIPI
MUL_0967|M.ulcerans_Agy99 AGLTEPVANLFAPVLSGPESVAASATALLSGAPLKPVEAALILSESGVPT
TH_3724|M.thermoresistible__bu TAT-----------ADAIIMPGTKIGYIPSQDEFTAYATAVIGATAGAPG
MSMEG_6144|M.smegmatis_MC2_155 SG--------------TRILHDPPYPEQLVPGEFAGYDVEHIKYPASVFG
. : :
Mb1216c|M.bovis_AF2122/97 SWW---------------PTMLLPPGSHQDNM----------TVGVAVKD
Rv1184c|M.tuberculosis_H37Rv SWW---------------PTMLLPPGSHQDNM----------TVGVAVKD
MLBr_01232|M.leprae_Br4923 RYV---------------PTFLVP--GPRDEV----------TIGEAIAV
MAB_0936c|M.abscessus_ATCC_199 GHT---------------LERFFPGIGPIGEKILPGLGLDGPSIGESIDI
MAV_1760|M.avium_104 GHV---------------LERLFPGIGKLDES-FPGLGMDGPSVGESVAE
Mflv_3864|M.gilvum_PYR-GCK YTG---------------EDDMTLGQSIEIGR---------ANLNAQIDT
Mvan_2535|M.vanbaalenii_PYR-1 YTG---------------AADMTLGDSIEIGT---------ANLNADIDA
MMAR_3427|M.marinum_M PGPGFINLANELYVR----SANALLGLNTPEELYPLTGTKSLTLDASVSE
MUL_0967|M.ulcerans_Agy99 PSASYISDVYTKYVEPNFPSATAPQGVSTPNGLYPFTGIKDLSLDISLAR
TH_3724|M.thermoresistible__bu AVD----------------YLGVPGEFWPATG------LDSLTFDASVAX
MSMEG_6144|M.smegmatis_MC2_155 MDR----------------------GIWEAAG----------AVAAGVDR
. :
Mb1216c|M.bovis_AF2122/97 GTNSLDNAIH------HGTDPAAAVGLSQGSLVLDQEQARLANDP--TAP
Rv1184c|M.tuberculosis_H37Rv GTNSLDNAIH------HGTDPAAAVGLSQGSLVLDQEQARLANDP--TAP
MLBr_01232|M.leprae_Br4923 ATKNLNQAIH------RGTEPAAVVGLSQGSLALDTEQEQLATDP--TAP
MAB_0936c|M.abscessus_ATCC_199 GEPNLENAIR------SGG-PGTAMGLSEGALVLNAVKNALATDP--TAP
MAV_1760|M.avium_104 GIDNLDAAIR------TTGRPGTAIGLSEGAFVVDGEQARLANDP--TAP
Mflv_3864|M.gilvum_PYR-GCK ALAQLERDADG---NLLDSEQVTVVGLSAGSLVVTETLRGWQSDDK-EDP
Mvan_2535|M.vanbaalenii_PYR-1 ALGRLERDADG---NLLEGERVTVVGLSAGSLVVTEVLREWQSDGE-ENP
MMAR_3427|M.marinum_M GLTILDNAIMEQLAIP--GNTVTVFGVSQSAVIASLEMQKLAALGP-AAP
MUL_0967|M.ulcerans_Agy99 GATILNDAILQQLAALPAGSSVAVLGYSQSAVLSSRVMPKLLAEG----V
TH_3724|M.thermoresistible__bu GQAMLTPMVDG---AIESDTPIVVFGHSQSAVIATKEKQRLLAEYP-DPD
MSMEG_6144|M.smegmatis_MC2_155 FVGVDDEGNP-------ITEKIIVAGFSQGAIVIAYEKKRLMKLDEDERP
. * * .:.
Mb1216c|M.bovis_AF2122/97 APDKLQFTTFGDPTGRHAFGASFLARIFPPGSHIPIPFIEYTMPQQVDSQ
Rv1184c|M.tuberculosis_H37Rv APDKLQFTTFGDPTGRHAFGASFLARIFPPGSHIPIPFIEYTMPQQVDSQ
MLBr_01232|M.leprae_Br4923 PPDQLTFNTFGDPSGYHGFGKSVLASIFRPGDYIPL--IDYTMPQRMDSQ
MAB_0936c|M.abscessus_ATCC_199 EPESLTFATFGDPIAKSPFSESFLTQNFAPGSVVPF--MDYPVPARVDSQ
MAV_1760|M.avium_104 PPNTLNFATFGDPIGRHAFGQSFLTAMFGVGSVVPA--LDYTMPPPYESQ
Mflv_3864|M.gilvum_PYR-GCK DAEEINFVVVADSSRQEIIDD---TEQYNP-------TYDYTYRKAPETV
Mvan_2535|M.vanbaalenii_PYR-1 EADEINFVVVADSSRQQIIDD---TERYNP-------VYDYTYRRAPQTP
MMAR_3427|M.marinum_M TASQLNFVLLGNEMNPNGGLLARFPDLSIPSLG-----LTFYGGTPSDTI
MUL_0967|M.ulcerans_Agy99 TSSQVNFVLLGNPMNPNGGVLARFPDLTLPSLG-----FTFYGATP-DNA
TH_3724|M.thermoresistible__bu TAPDVTFVMVANPNRPNGGLLARFPGLYIPILG---VTFNGATPAPADGP
MSMEG_6144|M.smegmatis_MC2_155 TVDQLKFVTIGDPTGPNGILRWIPFRIPIIG---------LTPVRPPDTP
: * ..: :
Mb1216c|M.bovis_AF2122/97 YDTNHVVTAYDGFSDFPDRPDNLLAVANAAIGAAIAHTPIGFTGP----G
Rv1184c|M.tuberculosis_H37Rv YDTNHVVTAYDGFSDFPDRPDNLLAVANAAIGAAIAHTPIGFTGP----G
MLBr_01232|M.leprae_Br4923 YDSNRVVAAYDGLSEFPDRADNLLAQLNCFAGGAISHTPSGFFNP----E
MAB_0936c|M.abscessus_ATCC_199 YHTDQFISAYDSIADWPDRPDNLFALANAIAGLATGHTAVAFTNP----K
MAV_1760|M.avium_104 YDTNRFVAAYDSIADFPDRPDNMFALANTLMGLATGHTAVAFTNP----S
Mflv_3864|M.gilvum_PYR-GCK YDTVEVTGEYDGMADFPDR-FNLTAISNAMAGSVLRHVQTMFSDL----S
Mvan_2535|M.vanbaalenii_PYR-1 YDTVEVTGEYDGLADFPDRWWNLTAVANALAGAAVRHILAMFADL----S
MMAR_3427|M.marinum_M YPTANYTLEYDGFADFPRYPLNFISDLNAVMGIVYVHPTYLDLTQ----A
MUL_0967|M.ulcerans_Agy99 FPTVSYTLEYDGFADFPRYPINLLADINAVMGIPFVHADYQDLTQ----A
TH_3724|M.thermoresistible__bu FDSYDVAREFDGWADFPRYPLNLVATANAILGIYYLHGGYYELLT----E
MSMEG_6144|M.smegmatis_MC2_155 YETTIINGEYDGWADFPDRPWNLIATANALLGIIYVHGRYEDKVDGWDLS
: : :*. :::* *: : * * *
Mb1216c|M.bovis_AF2122/97 DVPPQN-IRTTVNSRGATTTTYLVPVNHLPLTLPLRYLG-----------
Rv1184c|M.tuberculosis_H37Rv DVPPQN-IRTTVNSRGATTTTYLVPVNHLPLTLPLRYLG-----------
MLBr_01232|M.leprae_Br4923 DVPPQN-IRTTVNSRGAKTTTYLIPVNHLPLTLPLRYLG-----------
MAB_0936c|M.abscessus_ATCC_199 MVPARN-IVTETNSRGGTTTTYFIPEQHLPLVMGFKYLG-----------
MAV_1760|M.avium_104 MVPPQN-IRTTINSRGAKDTTIMIPEKHLPLVMPLKYIG-----------
Mflv_3864|M.gilvum_PYR-GCK DVPKQN-TTVTENALGGTTVRYLVPAETLPLVQSNPSLAPREAELRAQVD
Mvan_2535|M.vanbaalenii_PYR-1 QVPDEN-VTVTQNLLGGTTTRYLVPAQRLPLVLLNPSLAPREAELKATVD
MMAR_3427|M.marinum_M QVDNAI-PLATSPGYSGVTSYYILPTENLPLLEPLRAIPVIGNPLANLIQ
MUL_0967|M.ulcerans_Agy99 QLDSAV-QLPTEG--PTQSTYYMIPTEHLPLLAPLRFIPYVGDPLAELLE
TH_3724|M.thermoresistible__bu NPDILDDPERTIVQQYGDTTYYLIRTEQLPLLRPLRDLG-VPEEFVDALE
MSMEG_6144|M.smegmatis_MC2_155 TVPEKN-IVETVNKAGGKTTTYLIPTEKLPLLQPLRDLGFPESFVAALEA
:: : *** :
Mb1216c|M.bovis_AF2122/97 ----------------------MSDAEVDQIDSVLQP-------------
Rv1184c|M.tuberculosis_H37Rv ----------------------MSDAEVDQIDSVLQP-------------
MLBr_01232|M.leprae_Br4923 ----------------------WSDALVDQIDAVLQP-------------
MAB_0936c|M.abscessus_ATCC_199 ----------------------VPEETLNRLDAILQP-------------
MAV_1760|M.avium_104 ----------------------IDENTLNKLDAILTP-------------
Mflv_3864|M.gilvum_PYR-GCK RGYSRNDPANV-------AARLAGPDVPERIRDIVTPEAAAQDTEDVDLG
Mvan_2535|M.vanbaalenii_PYR-1 RGYSRNDPVRT-------ALRTLTNEVPDDVEDTVTP----QDTQD----
MMAR_3427|M.marinum_M PDLKVLVNLGYGDPA--YGYSTSPADITTPFGLFPDVPPHVIADALVAGT
MUL_0967|M.ulcerans_Agy99 PNLRVLVNFGYGDPA--YGYDTGPANVPTPFGLFPPVSPLTVAEHLAAGT
TH_3724|M.thermoresistible__bu PYVRRIVDLGYDRNT--PYGEPAPVRVLPPLTPAPGPATQHNAGQG----
MSMEG_6144|M.smegmatis_MC2_155 PLRKIIDAAYKRNDPGRVTVTTTEETVVEDESEITQTAVTEIDETPSTDG
Mb1216c|M.bovis_AF2122/97 ---------------------------QIDAAYARNDNWFTRPVSVDPVR
Rv1184c|M.tuberculosis_H37Rv ---------------------------QIDAAYARNDNWFTRPVSVDPVR
MLBr_01232|M.leprae_Br4923 ---------------------------KIDAAYAYNDNPLNKPISVDPVN
MAB_0936c|M.abscessus_ATCC_199 ---------------------------RVDAGYSRNDDPATAPIAVDPRR
MAV_1760|M.avium_104 ---------------------------RVNAGYSRNDDPATAPVQVDPVH
Mflv_3864|M.gilvum_PYR-GCK IAAAVQQDEESGAGAIPEIDGQRSLGEQLEAAQNAEDGADTSPAPTSRTI
Mvan_2535|M.vanbaalenii_PYR-1 ---EVEASE--GDGAAPTGTSADHAEVSEATAEDRDVTADDAEAPGDETR
MMAR_3427|M.marinum_M KQGISDFSADIQQMFSQPATLPSPPMLQAPDLMAALAAAPTPVEVVNTLT
MUL_0967|M.ulcerans_Agy99 QQGIVNSGAALQAQG--PPSIPLSDIAHTLTANPPWAGTPALPPSTSPAS
TH_3724|M.thermoresistible__bu -------------------ITVASATSTPDKRTPVVEAPVEEPPVQTGRS
MSMEG_6144|M.smegmatis_MC2_155 DIDETAVQSTTQRRTVANTAADRTAETAEVAEVTEDVDELAEQEEPVKEE
Mb1216c|M.bovis_AF2122/97 GLDP--LTAPG--SIVEG--------ARGLLGSPAFGG------------
Rv1184c|M.tuberculosis_H37Rv GLDP--LTAPG--SIVEG--------ARGLLGSPAFGG------------
MLBr_01232|M.leprae_Br4923 GMDP--IAGID--AELRDSILNVFAQLRSILPPPPG--------------
MAB_0936c|M.abscessus_ATCC_199 GFDPAEVTAPASQATFGGGSDPISQITSGALAVLGNGTRPTPPN------
MAV_1760|M.avium_104 GFDPAEVTAPANQATFGGGADPLSQIMAGAMSVLSHGAGEADH-------
Mflv_3864|M.gilvum_PYR-GCK GAAVEAISERSTAADDDTGATPLTPDAGDTESSTSDGASESAGSDVGDST
Mvan_2535|M.vanbaalenii_PYR-1 --STEDVDREATEPDSESDDTVTQNDAEPRESAADTAAEDSGPSD-----
MMAR_3427|M.marinum_M KIVSDDYATLLPLADIGTAFVITMPTYDATLFVDQLLQGNLINAFGYPIA
MUL_0967|M.ulcerans_Agy99 SIEDFILAVQAANSSISRGFVKTLSTAYATLLPTTDIASELVFTL-----
TH_3724|M.thermoresistible__bu TLKREKPVSARHLVRNSLRAVPGLRRGEPAATPTPDVTPDVTPDAPAGQP
MSMEG_6144|M.smegmatis_MC2_155 ATKDDEVTKVADEADKATPVKESTSVEKTDQAVKPDDTDKTVTTAEKVEK
Mb1216c|M.bovis_AF2122/97 --------------------------------------------------
Rv1184c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01232|M.leprae_Br4923 --------------------------------------------------
MAB_0936c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_1760|M.avium_104 --------------------------------------------------
Mflv_3864|M.gilvum_PYR-GCK TRTSTKPSSDGAARSSSSAE------------------------------
Mvan_2535|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_3427|M.marinum_M ADVGLTAISGGVVALVAIGTLQSNIKDLQSLFP-----------------
MUL_0967|M.ulcerans_Agy99 PSYNLNLFLDGVIQAING----QPIGD-----------------------
TH_3724|M.thermoresistible__bu EPAEPNESAAPPAAAEADDASE----------------------------
MSMEG_6144|M.smegmatis_MC2_155 ADEAEKVEKTKPNVRKVKRPQFNVFKPKKTRVTVPKAEPSTKAKPATKPD
Mb1216c|M.bovis_AF2122/97 -------------------
Rv1184c|M.tuberculosis_H37Rv -------------------
MLBr_01232|M.leprae_Br4923 -------------------
MAB_0936c|M.abscessus_ATCC_199 -------------------
MAV_1760|M.avium_104 -------------------
Mflv_3864|M.gilvum_PYR-GCK -------------------
Mvan_2535|M.vanbaalenii_PYR-1 -------------------
MMAR_3427|M.marinum_M -------------------
MUL_0967|M.ulcerans_Agy99 -------------------
TH_3724|M.thermoresistible__bu -------------------
MSMEG_6144|M.smegmatis_MC2_155 NDNDDTSDTTDKTAEKDAA