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SYLLAEPELLASVATEIDGIGSAISTAGTAAAGPTSSLLAAAGDEVSGAIANLFSVYGRECQAVLAQVEA FRSEFAQTLAAAGVAYAQTEAASLAALRGALGIPSAAPAVSSASTIPPFTANLTSLFLGPTGVPIPDESY VQAANNLFVRSSDILRPLYTPEELYPLTGVKSLTLNASVEEGLTILDNAIMAQLSIPGNSVTVFGYSQSA IIASLEMQKLAALGPSAPTASQLNFVLVGNEMNPNGGMLARFPDLSLPSLGLTFYGATPSDTIYPTAIYT LEYDGFADFPRYPLNFIADLNAVMGIPFVHVKYLDLTAAQVDSAIELPTSPGYSGVTSYYVIPTENLPLL EPLRAIPVIGNPLANLIQPDLKVIVNLGYGDPNYGYSTSYADVRTPFGLFPDVSPGTIVDALAAGTQEGI QDFTADLQAMFGQPIPTPDIVPPTPADILGKLSELPSPAQVVNTLTAVVANDYAVLLPTADIGLAVVTTL PLYSTQLFFDQLLQGNLIDAFGYPIAATVGLLTIGGAVEFLTIAAAAQTTVQDIGSLIP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_0370 | - | - | 100% (550) | PE family protein |
| M. marinum M | MMAR_3427 | - | 0.0 | 68.55% (550) | PE family protein |
| M. marinum M | MMAR_0372 | - | e-153 | 53.32% (557) | PE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0157c | PE2 | 1e-179 | 68.93% (457) | PE family protein |
| M. gilvum PYR-GCK | Mflv_1918 | - | 3e-33 | 37.15% (253) | hypothetical protein Mflv_1918 |
| M. tuberculosis H37Rv | Rv0152c | PE2 | 1e-179 | 68.93% (457) | PE family protein |
| M. leprae Br4923 | MLBr_01183 | - | 6e-10 | 34.78% (92) | hypothetical protein MLBr_01183 |
| M. abscessus ATCC 19977 | MAB_4141 | - | 1e-26 | 28.16% (316) | PE/PPE family protein |
| M. avium 104 | MAV_1346 | - | 9e-16 | 41.04% (134) | PE family protein |
| M. smegmatis MC2 155 | MSMEG_5455 | - | 1e-33 | 31.87% (342) | PE family protein |
| M. thermoresistible (build 8) | TH_3724 | - | 1e-43 | 38.36% (318) | PUTATIVE putative PE-PPE, C-terminal domain protein |
| M. ulcerans Agy99 | MUL_0967 | - | 1e-126 | 48.71% (542) | PE family protein |
| M. vanbaalenii PYR-1 | Mvan_4726 | - | 2e-36 | 32.99% (288) | hypothetical protein Mvan_4726 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0157c|M.bovis_AF2122/97 -----MRCRPP-------------SRNRSAHTARNTRPCSLKSRR-----
Rv0152c|M.tuberculosis_H37Rv -----MRCRPP-------------SRNRSAHTARNTRPCSLKSRR-----
MMAR_0370|M.marinum_M --MSYLLAEPELLASVATEIDGIGSAISTAGTAAAGPTSSLLAAAGDEVS
MUL_0967|M.ulcerans_Agy99 MAVIDLLASPQAMTATATEVAEIGLAINQADLAVAGPTTGLAAAAAAEVS
Mflv_1918|M.gilvum_PYR-GCK --MGKGD-----------------FGLKASEFTGRSSTRFADSVRR----
MSMEG_5455|M.smegmatis_MC2_155 --MGRLL-----------------HSLSTAFLVFVAVVVLCVSTS-----
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 --------------------------------------------------
TH_3724|M.thermoresistible__bu -------------------------VVAVGALTWGGXGVASPAGQ-----
Mvan_4726|M.vanbaalenii_PYR-1 ----------------------MRRRLRSAAWGLLSLVIAVLFAWG----
MAB_4141|M.abscessus_ATCC_1997 -----------------------MAGQYSVPGKRHSLRRYVATIT-----
Mb0157c|M.bovis_AF2122/97 -----------------------FTVRFHQTLAAAANSYADAEAAIASTR
Rv0152c|M.tuberculosis_H37Rv -----------------------FTVRFHQTLAAAANSYADAEAAIASTR
MMAR_0370|M.marinum_M GAIANLFSVYGRECQAVLAQVEAFRSEFAQTLAAAGVAYAQTEAASLAAL
MUL_0967|M.ulcerans_Agy99 EAIATLFDNYAQGYQAVSRQTAAFHDAFAQTLFAASDSYVRAEAAAVKAL
Mflv_1918|M.gilvum_PYR-GCK -------------------RPGGATYGLYRHDGLGVGTWAWVFARSSRSF
MSMEG_5455|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 --------------------------------------------------
TH_3724|M.thermoresistible__bu --------------------------------------------------
Mvan_4726|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4141|M.abscessus_ATCC_1997 --------------------------------------------------
Mb0157c|M.bovis_AF2122/97 Q-------NQLAVPAAAP---TPAAAAMIP--PFPANLTTLFFGPTGIPL
Rv0152c|M.tuberculosis_H37Rv Q-------NQLAVPAAAP---TPAAAAMIP--PFPANLTTLFFGPTGIPL
MMAR_0370|M.marinum_M R-------GALGIPSAAP---AVSSASTIP--PFTANLTSLFLGPTGVPI
MUL_0967|M.ulcerans_Agy99 AGLTEPVANLFAPVLSGPESVAASATALLSGAPLKPVEAALILSESGVPT
Mflv_1918|M.gilvum_PYR-GCK PRSRRCWRYPRGVPTPVAVLVANTTALVMG--GTFHPLTGPRDSPEFVTA
MSMEG_5455|M.smegmatis_MC2_155 ------------MPTAAHLLLNHPHALVIG--GTGTPVP----PPEYVNG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 --------------------------------------------------
TH_3724|M.thermoresistible__bu ------------PERAAALRLTATADAIIMPGTKIGYIPSQDEFTAYATA
Mvan_4726|M.vanbaalenii_PYR-1 -------------SVVTSTSAGAGTALVMG--GNGHPLSVPQDTPDYINK
MAB_4141|M.abscessus_ATCC_1997 -----------AVAATCTVLAPLAMESRTIASTLASYVIGIGGNNDGASA
Mb0157c|M.bovis_AF2122/97 PPPSMLTPP--IRCR---SVRRALQAVFTPEELYPLTGVRSLVLNTSVEE
Rv0152c|M.tuberculosis_H37Rv PPPSMLTPP--IRCR---SVRRALQAVFTPEELYPLTGVRSLVLNTSVEE
MMAR_0370|M.marinum_M PDESYVQAANNLFVR---SSD-ILRPLYTPEELYPLTGVKSLTLNASVEE
MUL_0967|M.ulcerans_Agy99 PSASYISDVYTKYVEPNFPSATAPQGVSTPNGLYPFTGIKDLSLDISLAR
Mflv_1918|M.gilvum_PYR-GCK YLDNAVDNQISAAYG---YAVTNAVAVYTPEEFFPLGG---LTFDDSVAE
MSMEG_5455|M.smegmatis_MC2_155 QTDNYIGAEFPGEYR---YAVH------TPQNFWPVYGS--MSFDESTVA
MLBr_01183|M.leprae_Br4923 ------------------------------MPLFLNAEPQALTAAANTLE
MAV_1346|M.avium_104 ------------------------------MS-FVTTRPEALLAVASMLE
TH_3724|M.thermoresistible__bu VIGATAGAPGAVDYLG------------VPGEFWPATGLDSLTFDASVAX
Mvan_4726|M.vanbaalenii_PYR-1 YVTAADDAFIAPSGLCG--PQCSLVATYTPAQIRFVNGIFDMTYDESVAV
MAB_4141|M.abscessus_ATCC_1997 NIPRKLGGAYSVDYHP----------VSYPGAIWPVSGLTAPTFKTSVAQ
.
Mb0157c|M.bovis_AF2122/97 GLTILHDAIMVELATT------------------GNAVTVFGWSQSAIIA
Rv0152c|M.tuberculosis_H37Rv GLTILHDAIMVELATT------------------GNAVTVFGWSQSAIIA
MMAR_0370|M.marinum_M GLTILDNAIMAQLSIP------------------GNSVTVFGYSQSAIIA
MUL_0967|M.ulcerans_Agy99 GATILNDAILQQLAALP----------------AGSSVAVLGYSQSAVLS
Mflv_1918|M.gilvum_PYR-GCK GLANLGRCLRAEPGCVFNADPAVAARVGTVAPRHDDTFVVFGYSQSAAVA
MSMEG_5455|M.smegmatis_MC2_155 GLAALQAEMAKEG-------------------HFGSPLVILGYSSSTRIL
MLBr_01183|M.leprae_Br4923 GLS---------------------------------AATVASNAAAAQLT
MAV_1346|M.avium_104 GLG---------------------------------SSMDAQNAAAAAPT
TH_3724|M.thermoresistible__bu GQAMLTPMVDGAIES-------------------DTPIVVFGHSQSAVIA
Mvan_4726|M.vanbaalenii_PYR-1 GQANLNDCIQGSDCTATLAPYSETG----PHTVADSTYVIYAYSQSATVA
MAB_4141|M.abscessus_ATCC_1997 GRTNLNDEIVTAG---------------------NQPITIVGYSLGAVVV
* . : .:
Mb0157c|M.bovis_AF2122/97 SLEMQRFTAMGGAAPSASDLNFVLVGNEMNPNGGMLARFPDLTLPTLDLT
Rv0152c|M.tuberculosis_H37Rv SLEMQRFTAMGGAAPSASDLNFVLVGNEMNPNGGMLARFPDLTLPTLDLT
MMAR_0370|M.marinum_M SLEMQKLAALGPSAPTASQLNFVLVGNEMNPNGGMLARFPDLSLPSLGLT
MUL_0967|M.ulcerans_Agy99 SRVMPKLLAEG---VTSSQVNFVLLGNPMNPNGGVLARFPDLTLPSLGFT
Mflv_1918|M.gilvum_PYR-GCK SLLKRQLIDAP--GPEPAATTFMLAANPMRPNGGVLGRFPALTIPILGIT
MSMEG_5455|M.smegmatis_MC2_155 TADKNRRIAD---GDYAVDINYVLVSDVAKGNGGVMARFPGWHIPILGVT
MLBr_01183|M.leprae_Br4923 TEIAP----------PAADDVSILLAHFFSGHGRQYQAHASQGATNHQDL
MAV_1346|M.avium_104 TSIAP----------AAADEVSALQAAQFSAYGTWYQQVSAQAKAIHQTL
TH_3724|M.thermoresistible__bu TKEKQRLLAEYPDPDTAPDVTFVMVANPNRPNGGLLARFPGLYIPILGVT
Mvan_4726|M.vanbaalenii_PYR-1 ANQKLQLIAHP----VASTVSFLLVANPNRPDGGILERFVGAYIPLLGIT
MAB_4141|M.abscessus_ATCC_1997 SKSHSDLLQRYP--GGNPNIQFVLMGSANTPNGGIFARFPWLKIPLADIE
: : . * .
Mb0157c|M.bovis_AF2122/97 FYGATPS----DTIYPTAIYTLEYDGFA-DFSRYPLNFISDLNAVAGITF
Rv0152c|M.tuberculosis_H37Rv FYGATPS----DTIYPTAIYTLEYDGFA-DFSRYPLNFISDLNAVAGITF
MMAR_0370|M.marinum_M FYGATPS----DTIYPTAIYTLEYDGFA-DFPRYPLNFIADLNAVMGIPF
MUL_0967|M.ulcerans_Agy99 FYGATP-----DNAFPTVSYTLEYDGFA-DFPRYPINLLADINAVMGIPF
Mflv_1918|M.gilvum_PYR-GCK FHGATPTAG-VDGAYRTVDVVRQYDGLGGDFPVRPLNLLATVNALLGYGI
MSMEG_5455|M.smegmatis_MC2_155 FDGATRTDS-DGYAFDTKSISFVHDGWS-DFPVYPLNVLALANAVAGIAV
MLBr_01183|M.leprae_Br4923 IQSLLTS----SSAYAGTETAN----------------------------
MAV_1346|M.avium_104 VQNLDTN----ADSYGATEAANRVNTSAAALQGLAPNVIPNAAPAADPPP
TH_3724|M.thermoresistible__bu FNGATPAP--ADGPFDSYDVAREFDGWA-DFPRYPLNLVATANAILGIYY
Mvan_4726|M.vanbaalenii_PYR-1 FNGSTPTFSPQPRPLTTVDVARQYDGWA-DFPTNPLNLLADLNAIMGTIL
MAB_4141|M.abscessus_ATCC_1997 SNGAWEP-----DQFKTKVINTEYDTYG-DFPAYFNPLALANSIAAIQYA
.
Mb0157c|M.bovis_AF2122/97 VHTKYLDLTPAQVEGATKLP-TSPGYTGVTDYYIIRTENRPLLQPL--RA
Rv0152c|M.tuberculosis_H37Rv VHTKYLDLTPAQVEGATKLP-TSPGYTGVTDYYIIRTENRPLLQPL--RA
MMAR_0370|M.marinum_M VHVKYLDLTAAQVDSAIELP-TSPGYSGVTSYYVIPTENLPLLEPL--RA
MUL_0967|M.ulcerans_Agy99 VHADYQDLTQAQLDSAVQLP-TEG--PTQSTYYMIPTEHLPLLAPL--RF
Mflv_1918|M.gilvum_PYR-GCK MHGETVDVPFAQARFQGRE--------GDTDYYLIGTDLLPLLQPL--LL
MSMEG_5455|M.smegmatis_MC2_155 LHPTYPELDRPDLVPVGST--------GDTEYFVIGTDIMPLLMPL--ET
MLBr_01183|M.leprae_Br4923 --HDSL--------------------------------------------
MAV_1346|M.avium_104 AGTTSLGTS-----------------IGWAQNVGAAASDFITLGEG--QF
TH_3724|M.thermoresistible__bu LHGGYYELLTENPDILDDPERTIVQQYGDTTYYLIRTEQLPLLRPL--RD
Mvan_4726|M.vanbaalenii_PYR-1 LHPNYSDAGTPQLQGQYQDS----------TYYLIPAPITPVLVPL--TW
MAB_4141|M.abscessus_ATCC_1997 HPDAYYDRIDPAALDDPDNPNVVKTVQGNTTYYLVRAEHLPLLQPLRDLT
Mb0157c|M.bovis_AF2122/97 VPVIGDPLADLIQPNLKVIVNLGYGDPNYGYSTSYADVRTPFGLW-PNVP
Rv0152c|M.tuberculosis_H37Rv VPVIGDPLADLIQPNLKVIVNLGYGDPNYGYSTSYADVRTPFGLW-PNVP
MMAR_0370|M.marinum_M IPVIGNPLANLIQPDLKVIVNLGYGDPNYGYSTSYADVRTPFGLF-PDVS
MUL_0967|M.ulcerans_Agy99 IPYVGDPLAELLEPNLRVLVNFGYGDPAYGYDTGPANVPTPFGLF-PPVS
Mflv_1918|M.gilvum_PYR-GCK F-VPRPILSALDAP-LRVLVEDAYDR------DAGPGDPTTARWW-PVKD
MSMEG_5455|M.smegmatis_MC2_155 IGVPRPILLAVDEP-LRVLVEAGYRR------DIAPGAPTPARLI-PIVN
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 APVPGAAGIPNFNPGLTAATTAGPPAPAAPAAAAGAPVLASMGRG-PSIG
TH_3724|M.thermoresistible__bu LGVP-EEFVDALEPYVRRIVDLGYDR------NTPYGEPAPVRVL-PPLT
Mvan_4726|M.vanbaalenii_PYR-1 VPIVGKPLAIALDPAVRVLVEMGYDR------TVNPGQPTPARYL-YVPN
MAB_4141|M.abscessus_ATCC_1997 NPIGASFVLDAIEPTLRVFIDMAYDR------DTGPGTTTQFSFFTPSKN
Mb0157c|M.bovis_AF2122/97 PQVIADALAAGTQEGILDFTADLQAL-----------SAQPLTLPQIQLP
Rv0152c|M.tuberculosis_H37Rv PQVIADALAAGTQEGILDFTADLQAL-----------SAQPLTLPQIQLP
MMAR_0370|M.marinum_M PGTIVDALAAGTQEGIQDFTADLQAM-----------FGQPIPTPDIVPP
MUL_0967|M.ulcerans_Agy99 PLTVAEHLAAGTQQGIVNSGAALQAQ-----------GPPSIPLSDIAHT
Mflv_1918|M.gilvum_PYR-GCK FAGTAAKLIASVPVAVDNLTEGFGLG-----------RVLGTPVPGVFGV
MSMEG_5455|M.smegmatis_MC2_155 PITLTRNFIAAIPVGVDDAMEELGHG-----------RPLGTQPSGVFGV
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 GLSVPPSWAPGGVAPAANATPAQLVG-----------AGFTSAAPDTAPV
TH_3724|M.thermoresistible__bu PAPGPATQHNAGQGITVASATSTPDK-----------RTPVVEAP-----
Mvan_4726|M.vanbaalenii_PYR-1 LIKAALNFAMAIPTGWDDAISYLTGDP--------DCRPFHTTVPASPFG
MAB_4141|M.abscessus_ATCC_1997 IVDAFNKLPTAIAEGAHNVENGLAGATPKQSASPEKPASPPVPQPGPTNP
Mb0157c|M.bovis_AF2122/97 QPADL-------------VAAVAAAPTPAEVVNTLARIISTNYAVLLPTV
Rv0152c|M.tuberculosis_H37Rv QPADL-------------VAAVAAAPTPAEVVNTLARIISTNYAVLLPTV
MMAR_0370|M.marinum_M TPADI-------------LGKLSELPSPAQVVNTLTAVVANDYAVLLPTA
MUL_0967|M.ulcerans_Agy99 LTAN---------------PPWAGTPALPPSTSPASSIEDFILAVQAANS
Mflv_1918|M.gilvum_PYR-GCK GG-----------------PDLPDVDEGGAVTSDIDEDAVAQRDSASSTE
MSMEG_5455|M.smegmatis_MC2_155 GGEDTELKGLPAGVISLAKPTLPVSSHTTVVEKTERKDLAKPAAEPEPVV
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 TAVPG---------------GVPSMATAGRGGYGLGAPRYGVKPTVMPKP
TH_3724|M.thermoresistible__bu ---------------------VEEPPVQTGRSTLKREKPVSARHLVRNSL
Mvan_4726|M.vanbaalenii_PYR-1 VGGPPVYTG-AIDPYGEPTPYLAPPVETHGEAAPGSGSPAAHPAGTEPPE
MAB_4141|M.abscessus_ATCC_1997 GSATTQIPAPEAPTPSVVSLSTAEPPAPPASAKAADPTAISVSTAGASTA
Mb0157c|M.bovis_AF2122/97 DIALALVTTLP-LYTTQLFVRQLAAGN-LINAIGYP------LAATVGLG
Rv0152c|M.tuberculosis_H37Rv DIALALVTTLP-LYTTQLFVRQLAAGN-LINAIGYP------LAATVGLG
MMAR_0370|M.marinum_M DIGLAVVTTLP-LYSTQLFFDQLLQGN-LIDAFGYP------IAATVGLL
MUL_0967|M.ulcerans_Agy99 SISRGFVKTLSTAYATLLPTTDIASEL-VFTLPSYN------LNLFLDG-
Mflv_1918|M.gilvum_PYR-GCK RSAPAEESRSAVGGADSDGRDDVVDPEPAAPEAETS------EAETVTET
MSMEG_5455|M.smegmatis_MC2_155 EDEPAVEDETPVADTKKASPKPLRPKVRGPISFDAP------KLPTIRKA
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 AI------------------------------------------------
TH_3724|M.thermoresistible__bu RAVPGLRRGEPAATPTPDVTPDVTPDAPAGQPEPAE------PNE-----
Mvan_4726|M.vanbaalenii_PYR-1 TVTFSPTTESTPSTLLPETPAESEDMPPDFVENDTP------DSDEVSPT
MAB_4141|M.abscessus_ATCC_1997 RDQDFQPDTKPDPKSTPPPTKDSVGEADKSKNTLKPTLRLPKLPVAQPGT
Mb0157c|M.bovis_AF2122/97 TIDSGRRGIAHPPRGGLGHRSKHRGPRHLTDSRRHRRPPTTVYRPRQ---
Rv0152c|M.tuberculosis_H37Rv TIDSGRRGIAHPPRGGLGHRSKHRGPRHLTDSRRHRRPPTTVYRPRQ---
MMAR_0370|M.marinum_M TIG-----------GAVEFLTIAAAAQTTVQDIGSLIP------------
MUL_0967|M.ulcerans_Agy99 -------------------VIQAINGQPIGD-------------------
Mflv_1918|M.gilvum_PYR-GCK EADD---------ADDADDGADADDEDIDADGADADGEDTAGNTAEAA--
MSMEG_5455|M.smegmatis_MC2_155 TGDRPLKRLLSALTPKRPKPASSHDAGPAAGNKDTDNADKPAARADDAA-
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 --------------------------------------------------
TH_3724|M.thermoresistible__bu --------------------SAAPPAAAEADDASE---------------
Mvan_4726|M.vanbaalenii_PYR-1 EDDALKDTETINESQDGPTESASGVSGEDAADADSRSADADSLSADAGDS
MAB_4141|M.abscessus_ATCC_1997 APKSPKFPSLKNHLKSVPGLSEKKNPAADASSKHSQPANAPAHTSDKTSD
Mb0157c|M.bovis_AF2122/97 ------------
Rv0152c|M.tuberculosis_H37Rv ------------
MMAR_0370|M.marinum_M ------------
MUL_0967|M.ulcerans_Agy99 ------------
Mflv_1918|M.gilvum_PYR-GCK ------------
MSMEG_5455|M.smegmatis_MC2_155 ------------
MLBr_01183|M.leprae_Br4923 ------------
MAV_1346|M.avium_104 ------------
TH_3724|M.thermoresistible__bu ------------
Mvan_4726|M.vanbaalenii_PYR-1 APADAAAADTAA
MAB_4141|M.abscessus_ATCC_1997 HASETGRGAA--