For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
ATSSRRVGAETSKTRDTLLDCVETMMLEEGYASVTYRALAAKAGVTPSLVQYYFPTLDDVFIAAIRRYSE RNLAHLNKVMEKRAEDPLRALWEYSWDEATGTLMTEFMALGNHRKSIRTEIAAVTESVRTLQLDALTAKF GADARPWGDLSLPALQLLISSLPKFLNLEKGVGVETAHAELIEAFEGYLNSIEPTPKRKPVPRKRSR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1270 | - | - | 100% (208) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_2518 | - | 3e-30 | 36.98% (192) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_1588 | - | 2e-27 | 38.32% (167) | TetR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1711c | - | 3e-06 | 41.54% (65) | hypothetical protein Mb1711c |
| M. tuberculosis H37Rv | Rv1685c | - | 3e-06 | 41.54% (65) | hypothetical protein Rv1685c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2952c | - | 6e-08 | 29.73% (111) | TetR family transcriptional regulator |
| M. marinum M | MMAR_4693 | - | 2e-36 | 41.92% (198) | transcriptional regulator |
| M. avium 104 | MAV_1394 | - | 6e-53 | 63.29% (158) | hypothetical protein MAV_1394 |
| M. smegmatis MC2 155 | MSMEG_6628 | - | 7e-83 | 77.00% (200) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_1623 | - | 3e-85 | 78.28% (198) | transcriptional regulator, TetR family protein |
| M. ulcerans Agy99 | MUL_1664 | - | 4e-06 | 38.81% (67) | hypothetical protein MUL_1664 |
| M. vanbaalenii PYR-1 | Mvan_4140 | - | 6e-31 | 36.92% (195) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_6628|M.smegmatis_MC2_155 ---------------------MAASARRVG--AETSKTRDTLLDHVEQMM
TH_1623|M.thermoresistible__bu ------------VRSRSNEETMASSTRRVG--AETSKTRDTLLNCVEQMM
Mflv_1270|M.gilvum_PYR-GCK ---------------------MATSSRRVG--AETSKTRDTLLDCVETMM
MAV_1394|M.avium_104 --------------------------------------------------
MMAR_4693|M.marinum_M ----------------------MTSARRIG--APDAKNRGVLLDTAEELM
Mvan_4140|M.vanbaalenii_PYR-1 ----------------------MTSPRRIG--APDAKNRVVLLDAAEQLL
Mb1711c|M.bovis_AF2122/97 ------------------MAAPDNSRRRPGRPAGSSDTRERILSSARELF
Rv1685c|M.tuberculosis_H37Rv ------------------MAAPDNSRRRPGRPAGSSDTRERILSSARELF
MUL_1664|M.ulcerans_Agy99 ------------------METTNTGRRRPGRPTGTSNTREHILTCARELF
MAB_2952c|M.abscessus_ATCC_199 MYARKNAKVIALGGWSVVVANLEGRASRRTQAQRSAEMRTRLLDATVECL
MSMEG_6628|M.smegmatis_MC2_155 LGEGYASVSYRALASAAGVTPSLVQYYFPTLDDIFLAAIRRYSERNLAQL
TH_1623|M.thermoresistible__bu LAEGYASVTYRALAAKAGVTPSLVQYYFPTLDDIFIAAIRRYSERNIAQL
Mflv_1270|M.gilvum_PYR-GCK LEEGYASVTYRALAAKAGVTPSLVQYYFPTLDDVFIAAIRRYSERNLAHL
MAV_1394|M.avium_104 -----------------------MQYYFPSLDDIFVAAIRRYSERNMEWL
MMAR_4693|M.marinum_M IEEGYAAVTSRRVASEAGLKPQLVHYYFRTMEELFLELFRRRAEEGLRAQ
Mvan_4140|M.vanbaalenii_PYR-1 IEEGYAAVTSRRVADRAGLKPQLVHYYFRTMEDLFLAVFHRRAEEGLAVL
Mb1711c|M.bovis_AF2122/97 AHNGIDRTSIRAVAAKAGVDAALVHHYFGTKQQLFAAAIHIPIDP-MVII
Rv1685c|M.tuberculosis_H37Rv AHNGIDRTSIRAVAAKAGVDAALVHHYFGTKQQLFAAAIHIPIDP-MVII
MUL_1664|M.ulcerans_Agy99 ALNGLDRTSVRSVAAAAGVDASLVHHYYGTKQQLFAAAIQIPIDP-TVVL
MAB_2952c|M.abscessus_ATCC_199 VAHGYAGTTTPRIAEMAGVTRGAQAYHFQSKEDLVVAAIEHLAQQRTQAA
::: : :::. :. :
MSMEG_6628|M.smegmatis_MC2_155 QKALAARI--DDPLRALWEYSRSEATG---ALMTEFMALGNHRKSIRAEI
TH_1623|M.thermoresistible__bu NKVLAERA--DDPLRALWEYSWDEATG---ALMTEFMALGNHRKNIRSEI
Mflv_1270|M.gilvum_PYR-GCK NKVMEKRA--EDPLRALWEYSWDEATG---TLMTEFMALGNHRKSIRTEI
MAV_1394|M.avium_104 TEELQRRA--DDPLHALWESSWHESTS---ALMTEFMALGNHRKSIRSEI
MMAR_4693|M.marinum_M AQALQS----PKPLWALWRLGSDPAFA---RISMEFMALANHRKALRAEI
Mvan_4140|M.vanbaalenii_PYR-1 STALAS----PQPLWALWRFSTAPEAT---RLTMEFMGLANHRKALRAEI
Mb1711c|M.bovis_AF2122/97 GPIREAPV--EELGYKLPSLLLPIWDS---ELGAGLIAT--LRSLISGSD
Rv1685c|M.tuberculosis_H37Rv GPIREAPV--EELGYKLPSLLLPIWDS---ELGAGLIAT--LRSLISGSD
MUL_1664|M.ulcerans_Agy99 EQIVETPV--DELGLKIPSVPLPLWDS---ELSTGLVAT--LRALMAGTE
MAB_2952c|M.abscessus_ATCC_199 IREIARLQGNPDPVSAVLDFMWEIHQGPIFVATMELWIASRTDKVLAQQI
. : : :
MSMEG_6628|M.smegmatis_MC2_155 AEVTERGRKIQLDALVAKFGKDARPGGHF--SLPALLLLISGLPKFLSLE
TH_1623|M.thermoresistible__bu ASATRKVRKIQLDALSAKFGKDARLGAEFDLSLPALQLLLSGLPKLLNLE
Mflv_1270|M.gilvum_PYR-GCK AAVTESVRTLQLDALTAKFGADARPWGDL--SLPALQLLISSLPKFLNLE
MAV_1394|M.avium_104 AAVTDSMRRVQVEALVAKFGNDARLLADL--SFDAVVLLINGVPKLLGLE
MMAR_4693|M.marinum_M AHYAERFRDEQRRVITAALQRYGVDSQDVP--PVVWTVLMASLSRFLVLE
Mvan_4140|M.vanbaalenii_PYR-1 VYYAERFRQEQNRAIADALQRYGTDFTDVP--PVVWTVFATSVSQALVME
Mb1711c|M.bovis_AF2122/97 VGLARSFLEEVVTVELGSRVDNPPGTGKIRTQFVASQLMGVVMARYIVRI
Rv1685c|M.tuberculosis_H37Rv VGLARSFLEEVVTVELGSRVDNPPGTGKIRTQFVASQLMGVVMARYIVRI
MUL_1664|M.ulcerans_Agy99 SNLARSFLQEVVTSEVGSRVDSPTGTGRIRAQFVTSQLLGVVMARHIVKI
MAB_2952c|M.abscessus_ATCC_199 QRMEPFVNSALAAAIVQLLPEHPAPAELAKIVYTAMDTLRGILIASFVDG
. : : :
MSMEG_6628|M.smegmatis_MC2_155 EGIGVKTAHKEVTAAFEKYLDEIEP-------------TPRRK----RSR
TH_1623|M.thermoresistible__bu AGVGVKTAHHEMAAAFERYMDALQPTAGTAETKTGAKSTPQRKSAAHRPK
Mflv_1270|M.gilvum_PYR-GCK KGVGVETAHAELIEAFEGYLNSIEP-------------TPKRKPVP-RKR
MAV_1394|M.avium_104 ESVGVDTAHAELIAACERFLDAVEP-----------RAKPRRRSKKAPTR
MMAR_4693|M.marinum_M KALGMSGGHAETIELVESYLRRLEG-------------EP----------
Mvan_4140|M.vanbaalenii_PYR-1 RALGMDTGHAETFAFCEEWIRRLEG-------------DPLPPLDQRA--
Mb1711c|M.bovis_AF2122/97 EPFASLPAEQIVQTIAPNLQRYLTG------------ELPDDLAP-----
Rv1685c|M.tuberculosis_H37Rv EPFASLPAEQIVQTIAPNLQRYLTG------------ELPDDLAP-----
MUL_1664|M.ulcerans_Agy99 EPFASLPADQVAQAIAPTLQRYLNR-------------------------
MAB_2952c|M.abscessus_ATCC_199 DVERARRRWARASAHLRAVAVAAFP--------------SLG--------
MSMEG_6628|M.smegmatis_MC2_155 ----
TH_1623|M.thermoresistible__bu SPGH
Mflv_1270|M.gilvum_PYR-GCK SR--
MAV_1394|M.avium_104 RR--
MMAR_4693|M.marinum_M ----
Mvan_4140|M.vanbaalenii_PYR-1 ----
Mb1711c|M.bovis_AF2122/97 ----
Rv1685c|M.tuberculosis_H37Rv ----
MUL_1664|M.ulcerans_Agy99 ----
MAB_2952c|M.abscessus_ATCC_199 ----