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MSAVDVHVIESGLPDGPAVVLSNSLGATHRMWDAQLDALERRFRVLRYDTRGHGASPVPDGPYSIDDLAD DVVGILDRRGIDTAHLVGLSLGGMTAMRVAARNPDRVNRMVLLCTAAELAPAQAWTDRAAAVRAGGAESV APAVIARWFTLSHLETHPAERAEWVDMIAATPAEGYASCCEAIAELDLREQLPTITAPTLAIAGADDPAT PPAKLEQIVSAIPGARLLVVDGAAHLANAEQPEQITPAIIEHLEQR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1348 | - | - | 100% (256) | 3-oxoadipate enol-lactonase |
| M. gilvum PYR-GCK | Mflv_0527 | - | 2e-40 | 36.51% (241) | 4-carboxymuconolactone decarboxylase |
| M. gilvum PYR-GCK | Mflv_3121 | - | 3e-22 | 31.89% (254) | transcriptional regulator, CadC |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0569 | bpoC | 6e-17 | 25.71% (245) | peroxidase BpoC |
| M. tuberculosis H37Rv | Rv0554 | bpoC | 6e-17 | 25.71% (245) | peroxidase BpoC |
| M. leprae Br4923 | MLBr_02269 | - | 1e-15 | 26.32% (247) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_0349c | - | 1e-23 | 31.60% (250) | putative hydrolase, alpha/beta fold |
| M. marinum M | MMAR_2050 | - | 9e-17 | 27.24% (279) | hypothetical protein MMAR_2050 |
| M. avium 104 | MAV_1905 | - | 2e-17 | 26.30% (270) | 2-hydroxy-6-ketonona-2,4-dienedoic acid hydrolase |
| M. smegmatis MC2 155 | MSMEG_1897 | pcaD | 8e-95 | 66.01% (253) | 3-oxoadipate enol-lactonase |
| M. thermoresistible (build 8) | TH_2963 | - | 2e-29 | 32.23% (242) | PUTATIVE putative 3-oxoadipate enol-lactonase |
| M. ulcerans Agy99 | MUL_0735 | lipG2 | 3e-16 | 27.40% (281) | lipase/esterase LipG2 |
| M. vanbaalenii PYR-1 | Mvan_0563 | - | 3e-40 | 36.93% (241) | 4-carboxymuconolactone decarboxylase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0569|M.bovis_AF2122/97 --------------------------------------------------
Rv0554|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_02269|M.leprae_Br4923 --------------------------------------------------
Mflv_1348|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_1897|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0563|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_0349c|M.abscessus_ATCC_199 ------------------------------------------MGSAALQD
TH_2963|M.thermoresistible__bu --------------------------------------------MPRFSR
MMAR_2050|M.marinum_M MRPTLAAAALAGASGLVGWGGARALARRIERNPDPFPRERLLAEPQGERV
MUL_0735|M.ulcerans_Agy99 --------------------------------------------MRAARR
MAV_1905|M.avium_104 ---------MTGSQPPETDAEAITRLDTDNYRSLWMYLKELEFRQGFVDI
Mb0569|M.bovis_AF2122/97 -----MINLAYDDNGTGDPVVFIAGRGGAGRTWHPHQVPAFLAAGYRCIT
Rv0554|M.tuberculosis_H37Rv -----MINLAYDDNGTGDPVVFIAGRGGAGRTWHPHQVPAFLAAGYRCIT
MLBr_02269|M.leprae_Br4923 -----MINLAYEDRGTGEPVVFIAGRGGAGRTWQPHQVPAFLAAGYRVIT
Mflv_1348|M.gilvum_PYR-GCK -MSAVDVHVIESGLPD-GPAVVLSNSLG-ATHRMWDAQLDALERRFRVLR
MSMEG_1897|M.smegmatis_MC2_155 -MSSVAVHHVVTGRSD-GPAVVFSNSLG-STHRMWDPQLAAFEERFRVVR
Mvan_0563|M.vanbaalenii_PYR-1 -MSNPPLTAIHLGGPDDGPLLLLGPSLGTTTATLWTGVAQRLVDHVRVVG
MAB_0349c|M.abscessus_ATCC_199 RYLQSCLGGLHVRIGGEGPVILFWPSLL-MTGSMWAAQAEYFADRYTVIL
TH_2963|M.thermoresistible__bu AGTTIDYTDTGAPAGRLEAPTILFGHGLLFSGWQFNLQIYALRRYYRCLA
MMAR_2050|M.marinum_M AITRPDGTVLHALVAGRGTPVILVHGYCASLTEWNFVWDELLARGLRVIA
MUL_0735|M.ulcerans_Agy99 LRATSKLFYEELGDPSGQPVLLIMGLGAQLPMWPDEFCARLVAAGYRVIR
MAV_1905|M.avium_104 AVNGTVVRTRYAEAGSPDKPHAILLHGTGGHWETFAPNLEALSEHLHCVA
: . :
Mb0569|M.bovis_AF2122/97 FDNRGIG-----------------------ATENAEGFTTQTMVADTAAL
Rv0554|M.tuberculosis_H37Rv FDNRGIG-----------------------ATENAEGFTTQTMVADTAAL
MLBr_02269|M.leprae_Br4923 FDNRGIG-----------------------ATENTEGFTTQTMVADTAVL
Mflv_1348|M.gilvum_PYR-GCK YDTRGHGA----------------------SPVPDGPYSIDDLADDVVGI
MSMEG_1897|M.smegmatis_MC2_155 YDTRGHGQ----------------------SPVPEGPYTIDDLADDVVAL
Mvan_0563|M.vanbaalenii_PYR-1 WDLPGHGR----------------------GRR-AHPFTIADLAAAVLVI
MAB_0349c|M.abscessus_ATCC_199 VDPPGHGD----------------------SQSLTRMFRFEDCAHAITQI
TH_2963|M.thermoresistible__bu IDWRGQGA----------------------SSGAARPYDMDTLTEDAAHL
MMAR_2050|M.marinum_M FDQRGHGR----------------------STLGAEGIGSEPMADDLAAV
MUL_0735|M.ulcerans_Agy99 FDHRDTGLSAKMRGMRAPGSVYRRIGRYLLGRPSPVPYTLLDMTEDVAAL
MAV_1905|M.avium_104 IDMVGNGF----------------------SDKPDYDYEIAVYVEHVLGV
* . * . . :
Mb0569|M.bovis_AF2122/97 IETLDIAPARVVGVSMGAFIAQELMVVA---PELVSSA-VLMATRG---R
Rv0554|M.tuberculosis_H37Rv IETLDIAPARVVGVSMGAFIAQELMVVA---PELVSSA-VLMATRG---R
MLBr_02269|M.leprae_Br4923 IESLGAVPARIVGVSMGSFIAQELMVAR---PELVRAA-VLMATRG---R
Mflv_1348|M.gilvum_PYR-GCK LDRRGIDTAHLVGLSLGGMTAMRVAARN---PDRVNRM-VLLCTAA---E
MSMEG_1897|M.smegmatis_MC2_155 LDTLGIERAHVVGLSLGGMTAMRLSARN---PQRVDRI-ALLCTAT---H
Mvan_0563|M.vanbaalenii_PYR-1 ADDLNVETFHYAGDSVGGCVGLQLLLDA---PQRVSSA-TLLCTGA---A
MAB_0349c|M.abscessus_ATCC_199 LDSLGIERAHVVGNSWGGMIGGTFTAMY---PHRAGAS-VLMNATA---S
TH_2963|M.thermoresistible__bu VRSLGVAPAHYVGLSMGGFVGIRLAARH---PELVRSL-VLMNTSAGPED
MMAR_2050|M.marinum_M LQHFDIRDGVLVGHSMGGFVSIRALLDHGALAQRLRAV-VLFATWAGRVL
MUL_0735|M.ulcerans_Agy99 LDHLSIARAHVVGASLGGMIAQILAADQ---PQRVASLGIIMSTTGKAFS
MAV_1905|M.avium_104 MDHFGMTSANFVAMSLGAFVASAVAVGH---PDRVDKV-ILMSPAG---R
. .. * *. . .. :: .
Mb0569|M.bovis_AF2122/97 LDRARQFFNKAEAELYDSGVQLPPTYDARARLLENFSRKTLNDDVAVGDW
Rv0554|M.tuberculosis_H37Rv LDRARQFFNKAEAELYDSGVQLPPTYDARARLLENFSRKTLNDDVAVGDW
MLBr_02269|M.leprae_Br4923 LDRTRQFFHAAEAEFHDSGIQLPSGYNAKVRLLENLSRKTLNDDVAVADW
Mflv_1348|M.gilvum_PYR-GCK LAPAQAWTDRAAAVRAGGAESVAPAVIARWFTLSHLETH-------PAER
MSMEG_1897|M.smegmatis_MC2_155 LPPSSAWTERAAAVRTHGSAAVAESVVGRWFTPGFLAAD-------PGRK
Mvan_0563|M.vanbaalenii_PYR-1 IGTPDGWLARAATVRAGGVDTMLAGAAERWFAPGFVDRE-------PGTA
MAB_0349c|M.abscessus_ATCC_199 RASMRQRVEFRLLTEIVRILGRFREPLTTRAVKAFVGPTIMRERPHVEQS
TH_2963|M.thermoresistible__bu PAKADRYRTMARIYRFTGIGPLRRAVLPLMFGPAFLADPDSED--VIDEW
MMAR_2050|M.marinum_M DGAPQNRLQIPLLERGILQRLLRSRTIAVLFGAAQCGARPSP--AMISVF
MUL_0735|M.ulcerans_Agy99 APPAWRVIKLAFGQPGPNASAEEKLAFEVRNVAVFNGPNFLPPQSDLRQR
MAV_1905|M.avium_104 EASASNMARIRAERTKAVNEPTWGSLHAVFAHLIADESNRLPDLIGLRQA
Mb0569|M.bovis_AF2122/97 IAMFSMWPIKSTPGLRCQLDCAPQTNRLP--AYRNIAAPVLVIGFADDVV
Rv0554|M.tuberculosis_H37Rv IAMFSMWPIKSTPGLRCQLDCAPQTNRLP--AYRNIAAPVLVIGFADDVV
MLBr_02269|M.leprae_Br4923 IAMFNMWPIKSTPGLRCQTDVAPQNNRLP--AYRSIAAPVLVIGFAEDVV
Mflv_1348|M.gilvum_PYR-GCK AEWVDMIAATPAEGYASCCEAIAELDLRE--QLPTITAPTLAIAGADDPA
MSMEG_1897|M.smegmatis_MC2_155 AAYQQMIAATPAEGYAGCCEAIAALDLRA--DLARITAPTLAIAGTDDPA
Mvan_0563|M.vanbaalenii_PYR-1 SALLDALSHTDAESYAQVCEALAVFDVTN--QLSEIVTPVLAVAGSVDVP
MAB_0349c|M.abscessus_ATCC_199 IRAELRDLRVDSVYWAVNSVVPARPDQRE--LLGRITTPILVIAGREDPT
TH_2963|M.thermoresistible__bu ERRLRRYPRSSVR--DAVLAVANRAGVED--ELAAIDVPTLVIGGAQDAA
MMAR_2050|M.marinum_M LEWFHQHLDRHGPHLPIVRAFS-REDRYP--RLAEISVPAVVMVGSSDRT
MUL_0735|M.ulcerans_Agy99 VRLLADRCNYPPGMLRQFDAVLGTGSLLG--YSKAITAPTVVLHGSADPM
MAV_1905|M.avium_104 IYRREDTRRTIDRLLILQDEKVRNRNLIPDEKWRGITAPVMIVASGKDHG
. * .* : : *
Mb0569|M.bovis_AF2122/97 TPPYLGREVADALPNGRYLQIPDAGHLGFFERPEAVNTAMLKFFASVKA-
Rv0554|M.tuberculosis_H37Rv TPPYLGREVADALPNGRYLQIPDAGHLGFFERPEAVNTAMLKFFASVKA-
MLBr_02269|M.leprae_Br4923 TPPSLGREVADVLPNGRYLQIPDAGHLGFFERPEAVNAAALQFFAGVKGE
Mflv_1348|M.gilvum_PYR-GCK TPPAKLEQIVSAIPGARLLVVDGAAHLANAEQPEQITPAIIEHL--EQR-
MSMEG_1897|M.smegmatis_MC2_155 TPPDRLAEITAAVRGARLVQVTPGAHLANVEQADAITPTLLEHLGTEQS-
Mvan_0563|M.vanbaalenii_PYR-1 TPPESLRRIASDVKDGDLVVLEGVGHLAPAEAPQRVAGLIAEIVGVPQPP
MAB_0349c|M.abscessus_ATCC_199 FPVAETELMAEAIPGAELVIMENTGHLAALERPEEVNALIDDFLKRHPIE
TH_2963|M.thermoresistible__bu TPPAHAQALAAGIRGARLEIIDDCGHSSPLERPDVVTELLRGFLLEHT--
MMAR_2050|M.marinum_M TPPSHSHRLAAGIPGARLVTVPGAGHLLNWEAVDELAEVVESFAAQR---
MUL_0735|M.ulcerans_Agy99 VRLRNGRAVAAAIPDARFVVVDGMGHDLPQPVWRPILETLTENFSRAAPP
MAV_1905|M.avium_104 VYQDTARTIADLIPNSEVFEMPSVRHWPHFEDPESFNAAAVEFLTRR---
:. : .. : * .
Mb0569|M.bovis_AF2122/97 --------------------------------------------------
Rv0554|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_02269|M.leprae_Br4923 WP------------------------------------------------
Mflv_1348|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_1897|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0563|M.vanbaalenii_PYR-1 SKTLEDVHRAGMAVRREVLGEAHVDRAVAGTTDLTADFQHMITQYAWGTI
MAB_0349c|M.abscessus_ATCC_199 D-------------------------------------------------
TH_2963|M.thermoresistible__bu --------------------------------------------------
MMAR_2050|M.marinum_M --------------------------------------------------
MUL_0735|M.ulcerans_Agy99 HV------------------------------------------------
MAV_1905|M.avium_104 --------------------------------------------------
Mb0569|M.bovis_AF2122/97 --------------------------------------------------
Rv0554|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_02269|M.leprae_Br4923 --------------------------------------------------
Mflv_1348|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_1897|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0563|M.vanbaalenii_PYR-1 WTRPGLDLRSRSMITLTALVARGHHEELAMHLRAARRNGLSNDEIKELLM
MAB_0349c|M.abscessus_ATCC_199 --------------------------------------------------
TH_2963|M.thermoresistible__bu --------------------------------------------------
MMAR_2050|M.marinum_M --------------------------------------------------
MUL_0735|M.ulcerans_Agy99 --------------------------------------------------
MAV_1905|M.avium_104 --------------------------------------------------
Mb0569|M.bovis_AF2122/97 ---------------------------------
Rv0554|M.tuberculosis_H37Rv ---------------------------------
MLBr_02269|M.leprae_Br4923 ---------------------------------
Mflv_1348|M.gilvum_PYR-GCK ---------------------------------
MSMEG_1897|M.smegmatis_MC2_155 ---------------------------------
Mvan_0563|M.vanbaalenii_PYR-1 QTAIYCGVPDANSAFRIAAEVLPEFDEHPGAPS
MAB_0349c|M.abscessus_ATCC_199 ---------------------------------
TH_2963|M.thermoresistible__bu ---------------------------------
MMAR_2050|M.marinum_M ---------------------------------
MUL_0735|M.ulcerans_Agy99 ---------------------------------
MAV_1905|M.avium_104 ---------------------------------