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SNSSERVAVIVGGASGIGWATAQALAAEGCRVTIADRNADGARERASELGSGHRAEAVDVTDEDSVARLF DAIGPLDIAVNCAGFSNVGLITDMAAEDFRAVIDVCLNGAFIVTKHAGRHLRRGGSLVQISSLNGRQPAA GMSAYCAAKAGLSMLTQVAALEMGPRGIRVNAVAPGFVHTPLTAAAASVPGVVEDYVDNTALGRAGTPED IAAAVVFLCSPGTSWMTGEVLDINGGAHLKRYPDVMGHVMKLMEPAS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2071 | - | - | 100% (258) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_1569 | - | 2e-41 | 39.25% (265) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4369 | fabG | 2e-37 | 38.43% (242) | 3-ketoacyl-(acyl-carrier-protein) reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3515c | - | 4e-37 | 36.25% (251) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv3485c | - | 4e-37 | 36.25% (251) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_01807 | fabG1 | 4e-31 | 36.29% (237) | 3-oxoacyl- |
| M. abscessus ATCC 19977 | MAB_4680c | - | 3e-33 | 37.61% (234) | putative short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_4968 | - | 1e-38 | 38.34% (253) | short-chain type dehydrogenase/reductase |
| M. avium 104 | MAV_5088 | fabG | 7e-38 | 39.09% (243) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. smegmatis MC2 155 | MSMEG_5234 | - | 1e-112 | 76.77% (254) | short-chain dehydrogenase/reductase SDR |
| M. thermoresistible (build 8) | TH_3206 | - | 7e-90 | 82.54% (189) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_4042 | - | 2e-39 | 38.74% (253) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_4643 | - | 1e-124 | 85.06% (261) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2071|M.gilvum_PYR-GCK ------------------------------------MSNSSE---RVAVI
Mvan_4643|M.vanbaalenii_PYR-1 -----------------------MERVPHHRRKANRMSDSSDRAGREAVV
TH_3206|M.thermoresistible__bu --------------------------------------------------
MSMEG_5234|M.smegmatis_MC2_155 ------------------------------------MS------QRVAIV
MAB_4680c|M.abscessus_ATCC_199 -----------------------------------MNGNSALLQGKNVIV
MAV_5088|M.avium_104 -------------------------------------MAESLLLGKVAVV
MLBr_01807|M.leprae_Br4923 ------------------------MTDAAAKVSAAPGRGKPAFVSRSILV
Mb3515c|M.bovis_AF2122/97 MNSRAPRNLAVSSPSAQVTGRMVQNGENLFQFRREGPQVQLSFQDRTYLV
Rv3485c|M.tuberculosis_H37Rv MNSRAPRNLAVSSPSAQVTGRMVQNGENLFQFRREGPQVQLSFQDRTYLV
MMAR_4968|M.marinum_M --------------------------------------MQLSFQDRTYLV
MUL_4042|M.ulcerans_Agy99 --------------------------------------MQLSFQDRTYLV
Mflv_2071|M.gilvum_PYR-GCK VGGASGIGWATAQALAAEGCRVTIADRNA---DGARERASELG---SGHR
Mvan_4643|M.vanbaalenii_PYR-1 VGGASGIGWATATALAAEGCRVTIADLNV---EGARERAAGLG---AEHA
TH_3206|M.thermoresistible__bu --------------------------------------------------
MSMEG_5234|M.smegmatis_MC2_155 IGGASGIGWAGAKALAADGCRIVVADRDA---DAAAARAAELG---APHT
MAB_4680c|M.abscessus_ATCC_199 TGGARGLGAAFSRHIVSQGGRVVIADVLD---GDGRQLAAELGD-AARFT
MAV_5088|M.avium_104 TGAGQGIGREIARALHRHGARVVLADLDG---SAARSAAAQIDDSGANCT
MLBr_01807|M.leprae_Br4923 TGGNRGIGLAVARRLVADGHRVAVTHRAS---VVP-----------DWFF
Mb3515c|M.bovis_AF2122/97 TGGGSGIGKGVAAGLVAAGAAVMIVGRNPDKLAAAVKDIEALKT--GAIG
Rv3485c|M.tuberculosis_H37Rv TGGGSGIGKGVAAGLVAAGAAVMIVGRNPDKLAAAVKDIEALKT--GAIG
MMAR_4968|M.marinum_M TGGGSGIGKGVAAGLVAAGASVMIVGRNPDKLAGAVQELEALGANGGAIR
MUL_4042|M.ulcerans_Agy99 TGGGSGIGKGVAAGLVAAGASVMIVGRNPDKLAGAVQELEALGANGGAIR
Mflv_2071|M.gilvum_PYR-GCK AEAVDVTDEDSVARLFDAI----GPLDIAVNCAG-FSNVGLITDMAAEDF
Mvan_4643|M.vanbaalenii_PYR-1 AAHVDVTDEDSVQRLFEDA----GPIDIAVNCAG-FSNVGLITDMTAADF
TH_3206|M.thermoresistible__bu -----------VARLFDSV----GELDVAVNCAG-FSNVGLITDMPVDQF
MSMEG_5234|M.smegmatis_MC2_155 SGHVDVTDEESVERLFAEVST-AGPIDIVINCAG-FSNVGLITDMPAEDF
MAB_4680c|M.abscessus_ATCC_199 --HLDVTDAEQWRELIDTTLAGFGTITGLVNNAG-ISSAAMVADEPLEHF
MAV_5088|M.avium_104 GLACDVTSEEQVGALVAGTVREHGGLDVFVNNAG-ITRDASLKRMTVADF
MLBr_01807|M.leprae_Br4923 GVECDVTDNDAIGAAFKAVEEHQGPVEVLVANAG-ITSDMLIMRMSEEQF
Mb3515c|M.bovis_AF2122/97 YEPADITDEEQTLRVVDAATAWHGRLHGVVHCAGGSQTIGPITQIDSQAW
Rv3485c|M.tuberculosis_H37Rv YEPADITDEEQTLRVVDAATAWHGRLHGVVHCAGGSQTIGPITQIDSQAW
MMAR_4968|M.marinum_M YEPTDITNEDETARAVDAVTAWHGRLHGVVHCAGGSETIGPITQVDSEAW
MUL_4042|M.ulcerans_Agy99 YEPTDITNEDETARAVDAVTAWHGRLHGVVHCAGGSENIGPITQVDSEAW
. * : : ** : :
Mflv_2071|M.gilvum_PYR-GCK RAVIDVCLNGAFIVTKHAGRHLRRG--GSLVQISSLNGRQPAAGMSAYCA
Mvan_4643|M.vanbaalenii_PYR-1 RAVIDVCLTGAFIVTKHAGRHLREG--GSLVQISSLNGRQPAAGMSAYCA
TH_3206|M.thermoresistible__bu RSVIDVCLTGAFIVTKHAGRQLREG--GSLVSISSLNARQAAAGMSAYCA
MSMEG_5234|M.smegmatis_MC2_155 RSVIDVCLTGGFIVAKHAGRHLPRG--GVLVSISSLNARQPAAGMSAYCA
MAB_4680c|M.abscessus_ATCC_199 RKVIEINLVGVFIGMQAVIPAMRAHGCGSIVNISSAAGLVGLALTSGYGA
MAV_5088|M.avium_104 DAVIAVHLRGTWLGVREAAAVMRERKTGSIVNMSSLSGKAGNPGQTNYSA
MLBr_01807|M.leprae_Br4923 QKVIDVNLTGVFRVAKLASRNMIKQRFGRYIFMGSVVGLSGVPGQANYAA
Mb3515c|M.bovis_AF2122/97 RRTVDLNVNGTMYVLKHAARELVRGGGGSFVGISSIAASNTHRWFGAYGV
Rv3485c|M.tuberculosis_H37Rv RRTVDLNVNGTMYVLKHAARELVRGGGGSFVGISSIAASNTHRWFGAYGV
MMAR_4968|M.marinum_M RRTVDLNVNGTMYVLKHAAREMVRGGGGSFVGISSIAASNTHRWFGAYGV
MUL_4042|M.ulcerans_Agy99 RRTVDLNVNGTMYVLKHAAREMVRGGGGSFVGISSIAASNTHRWFGAYGV
.: : : * : . : * : :.* . * .
Mflv_2071|M.gilvum_PYR-GCK AKAGLSMLTQVAALEMGPRGIRVNAVAPGFVHTPLTAAAAS-VPGVVEDY
Mvan_4643|M.vanbaalenii_PYR-1 AKAGLSMLTQVAALELGPRGIRVNAVAPGFVHTPLTAAAAS-VPGVVEDY
TH_3206|M.thermoresistible__bu AKAGLSMLTQVAALELAPRGVRVNAVAPGFVHTPLTAPAAA-VPGVVEEY
MSMEG_5234|M.smegmatis_MC2_155 AKAGLSMLTQVAALEMGEAGIRVNAIAPGFVHTPLTAPAAM-IPGVVEEY
MAB_4680c|M.abscessus_ATCC_199 SKWGVRGLSKVAAIELGRERIRVNSVHPGVIYTPMTAKEG---FREGEGN
MAV_5088|M.avium_104 AKAGIVGLTKAAAKELAHHNVRVNAIQPGLIRTPMTAAMPPDVFAEREAA
MLBr_01807|M.leprae_Br4923 SKSGLIGMARSLARELGSRSITANVVAPGFIDTEMTRAMDSKYQEAALQA
Mb3515c|M.bovis_AF2122/97 TKSAVDHMMKLAADELGPSWVRVNSIRPGLIRTDLVVPVTE-SPELSADY
Rv3485c|M.tuberculosis_H37Rv TKSAVDHMMKLAADELGPSWVRVNSIRPGLIRTDLVVPVTE-SPELSADY
MMAR_4968|M.marinum_M TKSAVDHLMQLAADELGASWVRVNSIRPGLIRTDLVAAITE-SAELSSDY
MUL_4042|M.ulcerans_Agy99 TKSAVDHLMQLAADELGASWVRVNSIRPGLIRTDLVAAITE-SAELSSDY
:* .: : : * *:. : .* : **.: * :.
Mflv_2071|M.gilvum_PYR-GCK VDNTALGRAGTPEDIAAAVVFLCSPGTSWMTGEVLDINGGAHLKRYPDVM
Mvan_4643|M.vanbaalenii_PYR-1 VDNTVLGRAGTAEDIANAVVYLCAPGSSWLTGEVLDINGGAHLKRYPDVM
TH_3206|M.thermoresistible__bu LENTPLGRAGQPEDVAAAVVFLCSPAASWLTGEVLDLNGGAHLKRYPDIL
MSMEG_5234|M.smegmatis_MC2_155 VENTALGRAGTPEDIAAAVVFVCSPQASWLTGEVLDLNGGAHLRRYPDVL
MAB_4680c|M.abscessus_ATCC_199 MPIAAMGRVGNADEVAGAVAYLLSDAASYVTGAELAVDGGWTAGPTLTTI
MAV_5088|M.avium_104 VP---MKRAGEPEEVAGAVVFLASELSSYITGTVLGVGGGRYM-------
MLBr_01807|M.leprae_Br4923 IP---LGRIGAVEEIAGAVSFLASEDAGYISGAVIPVDGGLGMGH-----
Mb3515c|M.bovis_AF2122/97 RVCTPLPRVGEVEDVANLAMFLLSDAASWITGQVINVDGGHMLRRGPDFS
Rv3485c|M.tuberculosis_H37Rv RVCTPLPRVGEVEDVANLAMFLLSDAASWITGQVINVDGGHMLRRGPDFS
MMAR_4968|M.marinum_M AMCTPLPRQGEVEDVANMAMFLLSDAASFVTGQVINVDGGQMLRRGPDFS
MUL_4042|M.ulcerans_Agy99 AMCTPLPRQGEVEDVANMAMFLLSDAASFVTGQVINVDGGQMLRRGPDFS
: * * :::* . :: : :.:::* : :.**
Mflv_2071|M.gilvum_PYR-GCK GHVMKLMEPAS------
Mvan_4643|M.vanbaalenii_PYR-1 GHVMRLVEQSS------
TH_3206|M.thermoresistible__bu GHVMKLAEQS-------
MSMEG_5234|M.smegmatis_MC2_155 GHVMRLAQG--------
MAB_4680c|M.abscessus_ATCC_199 TGQ--------------
MAV_5088|M.avium_104 -----------------
MLBr_01807|M.leprae_Br4923 -----------------
Mb3515c|M.bovis_AF2122/97 PMLEPVFGADGLRGVVG
Rv3485c|M.tuberculosis_H37Rv PMLEPVFGADGLRGVVG
MMAR_4968|M.marinum_M AMLEPVFGRDALRGLV-
MUL_4042|M.ulcerans_Agy99 AMLEPVFGRDALRGLV-