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QLSFQDRTYLVTGGGSGIGKGVAAGLVAAGASVMIVGRNPDKLAGAVQELEALGANGGAIRYEPTDITNE DETARAVDAVTAWHGRLHGVVHCAGGSETIGPITQVDSEAWRRTVDLNVNGTMYVLKHAAREMVRGGGGS FVGISSIAASNTHRWFGAYGVTKSAVDHLMQLAADELGASWVRVNSIRPGLIRTDLVAAITESAELSSDY AMCTPLPRQGEVEDVANMAMFLLSDAASFVTGQVINVDGGQMLRRGPDFSAMLEPVFGRDALRGLV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4968 | - | - | 100% (277) | short-chain type dehydrogenase/reductase |
| M. marinum M | MMAR_4927 | - | 7e-31 | 31.37% (255) | dehydrogenase/reductase |
| M. marinum M | MMAR_4756 | - | 9e-31 | 35.51% (245) | oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3515c | - | 1e-136 | 85.20% (277) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1569 | - | 1e-113 | 71.38% (276) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv3485c | - | 1e-136 | 85.20% (277) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_01807 | fabG1 | 3e-23 | 29.88% (251) | 3-oxoacyl- |
| M. abscessus ATCC 19977 | MAB_1219 | - | 8e-30 | 30.59% (255) | short chain dehydrogenase |
| M. avium 104 | MAV_0671 | - | 1e-131 | 80.07% (281) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_5885 | - | 1e-118 | 72.56% (277) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_1273 | - | 2e-90 | 62.36% (271) | PROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE |
| M. ulcerans Agy99 | MUL_4042 | - | 1e-157 | 99.64% (277) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_5189 | - | 1e-118 | 73.38% (278) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4968|M.marinum_M --------------------------------------------------
MUL_4042|M.ulcerans_Agy99 --------------------------------------------------
Mb3515c|M.bovis_AF2122/97 --------------------------------------------------
Rv3485c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_0671|M.avium_104 --------------------------------------------------
Mflv_1569|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5189|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5885|M.smegmatis_MC2_155 --------------------------------------------------
TH_1273|M.thermoresistible__bu MGWSAVAKPDASEQVTYETLDDGRIARIWLNRPEAQNAQSRTLLVQLDEA
MAB_1219|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01807|M.leprae_Br4923 --------------------------------------------------
MMAR_4968|M.marinum_M --------------------------------------------------
MUL_4042|M.ulcerans_Agy99 --------------------------------------------------
Mb3515c|M.bovis_AF2122/97 --------------------------------------------------
Rv3485c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_0671|M.avium_104 --------------------------------------------------
Mflv_1569|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5189|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5885|M.smegmatis_MC2_155 --------------------------------------------------
TH_1273|M.thermoresistible__bu FLRAEADDQVRVVILAARGRNFSAGHDLGSEEALLERQPGPDQHPTFRSH
MAB_1219|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01807|M.leprae_Br4923 --------------------------------------------------
MMAR_4968|M.marinum_M --------------------------------------------------
MUL_4042|M.ulcerans_Agy99 --------------------------------------------------
Mb3515c|M.bovis_AF2122/97 --------------------------------------------------
Rv3485c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_0671|M.avium_104 --------------------------------------------------
Mflv_1569|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5189|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5885|M.smegmatis_MC2_155 --------------------------------------------------
TH_1273|M.thermoresistible__bu GATATGIAERTYRQEWHFYFENTCRWRDLRKITIAQVQGNAISAALMLIW
MAB_1219|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01807|M.leprae_Br4923 --------------------------------------------------
MMAR_4968|M.marinum_M --------------------------------------------------
MUL_4042|M.ulcerans_Agy99 --------------------------------------------------
Mb3515c|M.bovis_AF2122/97 ----------------------------------MNSRAPRNLAVSSPSA
Rv3485c|M.tuberculosis_H37Rv ----------------------------------MNSRAPRNLAVSSPSA
MAV_0671|M.avium_104 --------------------------------------------------
Mflv_1569|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5189|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5885|M.smegmatis_MC2_155 --------------------------------------------------
TH_1273|M.thermoresistible__bu ACDLIVAADDARFSDVVGVRMGMPGVEYYAHPWEFGPRKAKELLLTGDSI
MAB_1219|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01807|M.leprae_Br4923 --------------------------------------------------
MMAR_4968|M.marinum_M ----------------------MQLSFQDR--------TYLVTGGGSGIG
MUL_4042|M.ulcerans_Agy99 ----------------------MQLSFQDR--------TYLVTGGGSGIG
Mb3515c|M.bovis_AF2122/97 QVTGRMVQNGENLFQFRREGPQVQLSFQDR--------TYLVTGGGSGIG
Rv3485c|M.tuberculosis_H37Rv QVTGRMVQNGENLFQFRREGPQVQLSFQDR--------TYLVTGGGSGIG
MAV_0671|M.avium_104 ----------------------MQLSFQDR--------TYLITGGGSGIG
Mflv_1569|M.gilvum_PYR-GCK ----------------------MLLSLVDR--------TVLVTGGGSGIG
Mvan_5189|M.vanbaalenii_PYR-1 ----------------------MLLSLSER--------TYLVTGGGSGIG
MSMEG_5885|M.smegmatis_MC2_155 ----------------------MQLSLAER--------TYLVTGGGSGIG
TH_1273|M.thermoresistible__bu DADEAYRMGMVSKVFPRAELEEKTLEFARRIAERPTMAALLIKDSGNAAS
MAB_1219|M.abscessus_ATCC_1997 -----------------------MGEFDNK--------VAIVTGAAQGIG
MLBr_01807|M.leprae_Br4923 --------MTDAAAKVSAAPGRGKPAFVSR--------SILVTGGNRGIG
: : ::... . .
MMAR_4968|M.marinum_M KGVAAG---LVAAGA------SVMIVG---RNPDKLAGAVQELEALGANG
MUL_4042|M.ulcerans_Agy99 KGVAAG---LVAAGA------SVMIVG---RNPDKLAGAVQELEALGANG
Mb3515c|M.bovis_AF2122/97 KGVAAG---LVAAGA------AVMIVG---RNPDKLAAAVKDIEALKT--
Rv3485c|M.tuberculosis_H37Rv KGVAAG---LVAAGA------AVMIVG---RNPDKLAAAVKDIEALKT--
MAV_0671|M.avium_104 KGVAAG---LVSAGA------SVMIVG---RNPDRLAGAVEEIAPLADRA
Mflv_1569|M.gilvum_PYR-GCK KGVAAA---VVASGG------NVVLAG---RNADKLAAAAEEITAQSGD-
Mvan_5189|M.vanbaalenii_PYR-1 KGVAAA---VVASGG------NAVLAG---RNADKLAAAAEEIKAQTGD-
MSMEG_5885|M.smegmatis_MC2_155 KGAAAA---IVAAGG------DVMLVG---RNADKLSAAADEIGAL----
TH_1273|M.thermoresistible__bu DAMGXXXQPPVPAGGRLDRLRDLVLIGDVGRMGAHLAARPGEFACGGGQP
MAB_1219|M.abscessus_ATCC_1997 EAYAHA---LAREGA------AVVVAD---INAEMGEGVAKQIVADG---
MLBr_01807|M.leprae_Br4923 LAVARR---LVADGHR--------------VAVTHRASVVPDWFFG----
. . . * . :
MMAR_4968|M.marinum_M --------------GAIRYEPTDITNEDE------------------TAR
MUL_4042|M.ulcerans_Agy99 --------------GAIRYEPTDITNEDE------------------TAR
Mb3515c|M.bovis_AF2122/97 --------------GAIGYEPADITDEEQ------------------TLR
Rv3485c|M.tuberculosis_H37Rv --------------GAIGYEPADITDEEQ------------------TLR
MAV_0671|M.avium_104 G-----------NGGAIRYEPTDVTNEDE------------------VVR
Mflv_1569|M.gilvum_PYR-GCK ------------GAGEVMYEPADVTDEDA------------------VTR
Mvan_5189|M.vanbaalenii_PYR-1 ------------GAGEVIYEPADVTDEDQ------------------AAR
MSMEG_5885|M.smegmatis_MC2_155 ------------GPGSVRYEPADVTDEDE------------------VHR
TH_1273|M.thermoresistible__bu VGIASDDQHLATGRGDRGGHPFADTASAAGHQIRPVGQRQLHGHPPFRSR
MAB_1219|M.abscessus_ATCC_1997 --------------GRAIFAGVDVSDPDS------------------AIA
MLBr_01807|M.leprae_Br4923 -------------------VECDVTDNDAIG---------------AAFK
:
MMAR_4968|M.marinum_M AVDAV--TAWHGRLHGVVHCAG--GSETIGPITQVDSEAWRRTVDLNVNG
MUL_4042|M.ulcerans_Agy99 AVDAV--TAWHGRLHGVVHCAG--GSENIGPITQVDSEAWRRTVDLNVNG
Mb3515c|M.bovis_AF2122/97 VVDAA--TAWHGRLHGVVHCAG--GSQTIGPITQIDSQAWRRTVDLNVNG
Rv3485c|M.tuberculosis_H37Rv VVDAA--TAWHGRLHGVVHCAG--GSQTIGPITQIDSQAWRRTVDLNVNG
MAV_0671|M.avium_104 AVDAA--TAWHGRLHGAVHCAG--GSLTVGPITHTDSEAWRNTVDLNVNG
Mflv_1569|M.gilvum_PYR-GCK LVQAA--TGWRGRLDAVVHSAG--GSETIGPLTQVDSAAWRNTVDLNVNG
Mvan_5189|M.vanbaalenii_PYR-1 LVEAA--TAWHGRLDGVVHSAG--GSETIGPITQIDSAAWRNTVDLNVNG
MSMEG_5885|M.smegmatis_MC2_155 AVDAA--TAWHGRLHGVVHSAG--GSQTIGPITQIDSELWRQTIDLNING
TH_1273|M.thermoresistible__bu DITAGGLXGWHARLHGVVHCAG--GSETIGPITQVDSEAWRRTVDLNVNG
MAB_1219|M.abscessus_ATCC_1997 MADKA--VSEFGGIDYLVNNAAIYGGMKLDLLLSVPWDYYKKFMSVNQDG
MLBr_01807|M.leprae_Br4923 AVEEH-----QGPVEVLVANAG---ITSDMLIMRMSEEQFQKVIDVNLTG
. :. * *. . : ::. :.:* *
MMAR_4968|M.marinum_M TMYVLKHAAREMVRGGGGSFVGISSIAASNTHRWFGAYGVTKSAVDHLMQ
MUL_4042|M.ulcerans_Agy99 TMYVLKHAAREMVRGGGGSFVGISSIAASNTHRWFGAYGVTKSAVDHLMQ
Mb3515c|M.bovis_AF2122/97 TMYVLKHAARELVRGGGGSFVGISSIAASNTHRWFGAYGVTKSAVDHMMK
Rv3485c|M.tuberculosis_H37Rv TMYVLKHAARELVRGGGGSFVGISSIAASNTHRWFGAYGVTKSAVDHMMK
MAV_0671|M.avium_104 TMYVLKHVGRELVRGGGGSFIGISSIAASNTHRWFGPYGVTKSAIDHMMM
Mflv_1569|M.gilvum_PYR-GCK TMYVLKHAAREMVRGGGGAFIGISSIASSNTHRWFGAYGPSKAALDHLMM
Mvan_5189|M.vanbaalenii_PYR-1 TMYVLKHSAREMVRGGGGSFIGISSIASSNTHRWFGAYGPSKAALDHLMM
MSMEG_5885|M.smegmatis_MC2_155 TMYLLKHAGREMVRGGGGSFVGISSIASSNIHRWFGAYGVSKAALDHLLK
TH_1273|M.thermoresistible__bu TMYLIKHAAREMVRGGGGSFVGVSSIASSNTHRWFGAYGPSKAALDHLLM
MAB_1219|M.abscessus_ATCC_1997 ALVCTRAVYKHIAQRGGGAIVNQSSTAAWLYS---GFYGLAKVGINGLTQ
MLBr_01807|M.leprae_Br4923 VFRVAKLASRNMIKQRFGRYIFMGSVVGLSGVPGQANYAASKSGLIGMAR
.: : :.: : * : .* .. . *. :* .: :
MMAR_4968|M.marinum_M LAADELGASWVRVNSIRPGLIRTDLVAA-ITESAELSSDYAMCTPLPRQG
MUL_4042|M.ulcerans_Agy99 LAADELGASWVRVNSIRPGLIRTDLVAA-ITESAELSSDYAMCTPLPRQG
Mb3515c|M.bovis_AF2122/97 LAADELGPSWVRVNSIRPGLIRTDLVVP-VTESPELSADYRVCTPLPRVG
Rv3485c|M.tuberculosis_H37Rv LAADELGPSWVRVNSIRPGLIRTDLVVP-VTESPELSADYRVCTPLPRVG
MAV_0671|M.avium_104 LAADELGESWVRVNSIRPGLIRTDLVDASVIQSPEISADYAQCTPLPRVG
Mflv_1569|M.gilvum_PYR-GCK VAADELGPSSVRVNGIRPGLTKTDMVAP-ILDTPAVSDDYAACTPLPRVG
Mvan_5189|M.vanbaalenii_PYR-1 VAADELGPSSVRVNGIRPGLTRTDMVAP-IVDTPALSEDYAACTPLPRVG
MSMEG_5885|M.smegmatis_MC2_155 LAADELGPSWVRVNSIRPGLTRTEMVEP-ILGVPAVTDDYAACTPLPRFG
TH_1273|M.thermoresistible__bu VAADELGPSWVRVNGIRPGLTKTDLVAP-IMDTPAVVDDYRACTPLPRFG
MAB_1219|M.abscessus_ATCC_1997 QLSRELGGQKIRINAIAPGPTDTEATRG--TVPEQFRSELVKNIPLSRMG
MLBr_01807|M.leprae_Br4923 SLARELGSRSITANVVAPGFIDTEMTRA---MDSKYQEAALQAIPLGRIG
: *** : * : ** *: . ** * *
MMAR_4968|M.marinum_M EVEDVANMAMFLLSDAASFVTGQVINVDGGQMLRRGPDFSAMLEPVFGRD
MUL_4042|M.ulcerans_Agy99 EVEDVANMAMFLLSDAASFVTGQVINVDGGQMLRRGPDFSAMLEPVFGRD
Mb3515c|M.bovis_AF2122/97 EVEDVANLAMFLLSDAASWITGQVINVDGGHMLRRGPDFSPMLEPVFGAD
Rv3485c|M.tuberculosis_H37Rv EVEDVANLAMFLLSDAASWITGQVINVDGGHMLRRGPDFSPMLEPVFGAD
MAV_0671|M.avium_104 EVEDVANLAMFLLSDAAGWITGQCINVDGGHMLRRGPDYSSMMVQMFGQD
Mflv_1569|M.gilvum_PYR-GCK EVEDIANLAVFLLSDAASFITGQVINVDGGHGLRRGPDLSGMLEPLFGAD
Mvan_5189|M.vanbaalenii_PYR-1 EVEDIANLAVFLLSDAASFITGQVINVDGGHGLRRGPDLSAMLEPIFGAD
MSMEG_5885|M.smegmatis_MC2_155 EVEDIANLAVFLLSDAAGWITGQAINVDGGHGLRRGPDISGMLEPLFGAE
TH_1273|M.thermoresistible__bu EVSDIANLAVFLLSDAASWITGQIINVDGGHGLRRGPDMSGMLEPVFGAD
MAB_1219|M.abscessus_ATCC_1997 TVDDMVGMCLFLLSDKASWITGQVFNVDGGQIIRS---------------
MLBr_01807|M.leprae_Br4923 AVEEIAGAVSFLASEDAGYISGAVIPVDGGLGMGH---------------
*.::.. ** *: *.:::* : **** :
MMAR_4968|M.marinum_M ALRGLV---
MUL_4042|M.ulcerans_Agy99 ALRGLV---
Mb3515c|M.bovis_AF2122/97 GLRGVVG--
Rv3485c|M.tuberculosis_H37Rv GLRGVVG--
MAV_0671|M.avium_104 ALRGVV---
Mflv_1569|M.gilvum_PYR-GCK GLRGVVAE-
Mvan_5189|M.vanbaalenii_PYR-1 GLRGVVST-
MSMEG_5885|M.smegmatis_MC2_155 GLRGVVTDG
TH_1273|M.thermoresistible__bu GLRGVVEG-
MAB_1219|M.abscessus_ATCC_1997 ---------
MLBr_01807|M.leprae_Br4923 ---------