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LERVPHHRRKANRMSDSSDRAGREAVVVGGASGIGWATATALAAEGCRVTIADLNVEGARERAAGLGAEH AAAHVDVTDEDSVQRLFEDAGPIDIAVNCAGFSNVGLITDMTAADFRAVIDVCLTGAFIVTKHAGRHLRE GGSLVQISSLNGRQPAAGMSAYCAAKAGLSMLTQVAALELGPRGIRVNAVAPGFVHTPLTAAAASVPGVV EDYVDNTVLGRAGTAEDIANAVVYLCAPGSSWLTGEVLDINGGAHLKRYPDVMGHVMRLVEQSS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4643 | - | - | 100% (274) | short-chain dehydrogenase/reductase SDR |
| M. vanbaalenii PYR-1 | Mvan_5189 | - | 1e-36 | 37.80% (254) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_1975 | fabG | 3e-36 | 37.45% (243) | 3-ketoacyl-(acyl-carrier-protein) reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1385 | fabG | 1e-35 | 38.08% (239) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. gilvum PYR-GCK | Mflv_2071 | - | 1e-124 | 85.06% (261) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv1350 | fabG | 1e-35 | 38.08% (239) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. leprae Br4923 | MLBr_01807 | fabG1 | 1e-29 | 35.44% (237) | 3-oxoacyl- |
| M. abscessus ATCC 19977 | MAB_4680c | - | 4e-34 | 37.82% (238) | putative short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_4765 | - | 3e-36 | 38.74% (253) | short chain dehydrogenase |
| M. avium 104 | MAV_5088 | fabG | 4e-38 | 40.57% (244) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. smegmatis MC2 155 | MSMEG_5234 | - | 1e-109 | 75.40% (252) | short-chain dehydrogenase/reductase SDR |
| M. thermoresistible (build 8) | TH_3206 | - | 9e-88 | 80.63% (191) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_3898 | fabG | 2e-35 | 37.45% (243) | 3-ketoacyl-(acyl-carrier-protein) reductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_4643|M.vanbaalenii_PYR-1 MERVPHHRRKANRMSDSSDRAGREAVVVGGASGIGWATATALAAEGCRVT
Mflv_2071|M.gilvum_PYR-GCK -------------MSNSSE---RVAVIVGGASGIGWATAQALAAEGCRVT
TH_3206|M.thermoresistible__bu --------------------------------------------------
MSMEG_5234|M.smegmatis_MC2_155 -------------MS------QRVAIVIGGASGIGWAGAKALAADGCRIV
Mb1385|M.bovis_AF2122/97 ------------MASLLNAR---TAVITGGAQGLGLAIGQRFVAEGARVV
Rv1350|M.tuberculosis_H37Rv ------------MASLLNAR---TAVITGGAQGLGLAIGQRFVAEGARVV
MUL_3898|M.ulcerans_Agy99 ------------MCGAHRDRGYVYPVVTGGAQGLGLAIAERFVSEGARVV
MAV_5088|M.avium_104 ------------MAESLLLG--KVAVVTGAGQGIGREIARALHRHGARVV
MMAR_4765|M.marinum_M ------------MVDELAGK---IAIVTGGASGIGRATVARFIAEGARVV
MAB_4680c|M.abscessus_ATCC_199 ------------MNGNSALLQGKNVIVTGGARGLGAAFSRHIVSQGGRVV
MLBr_01807|M.leprae_Br4923 -MTDAAAKVSAAPGRGKPAFVSRSILVTGGNRGIGLAVARRLVADGHRVA
Mvan_4643|M.vanbaalenii_PYR-1 IADLNVEGARERAAGLG---AEHAAAHVDVTDEDSVQRLFEDA----GPI
Mflv_2071|M.gilvum_PYR-GCK IADRNADGARERASELG---SGHRAEAVDVTDEDSVARLFDAI----GPL
TH_3206|M.thermoresistible__bu -----------------------------------VARLFDSV----GEL
MSMEG_5234|M.smegmatis_MC2_155 VADRDADAAAARAAELG---APHTSGHVDVTDEESVERLFAEVST-AGPI
Mb1385|M.bovis_AF2122/97 LGDVNLEATEVAAKRLG-GDDVALAVRCDVTQADDVDILIRTAVERFGGL
Rv1350|M.tuberculosis_H37Rv LGDVNLEATEVAAKRLG-GDDVALAVRCDVTQADDVDILIRTAVERFGGL
MUL_3898|M.ulcerans_Agy99 LGDVNLEATEAAAKQLG-GGEVAVAVRCDVTKADEVETLLQAALERFGGL
MAV_5088|M.avium_104 LADLDGSAARSAAAQIDDSGANCTGLACDVTSEEQVGALVAGTVREHGGL
MMAR_4765|M.marinum_M IADVEEERGESLAAALG---ADAMFCRTDVSQPEQVAAVVAAAVENFGGL
MAB_4680c|M.abscessus_ATCC_199 IADVLDGDGRQLAAELG---DAARFTHLDVTDAEQWRELIDTTLAGFGTI
MLBr_01807|M.leprae_Br4923 VTHRASVVPDWFF---G--------VECDVTDNDAIGAAFKAVEEHQGPV
. * :
Mvan_4643|M.vanbaalenii_PYR-1 DIAVNCAGFSNVGLITDMT--AADFRAVIDVCLTGAFIVTKHAGRHLRE-
Mflv_2071|M.gilvum_PYR-GCK DIAVNCAGFSNVGLITDMA--AEDFRAVIDVCLNGAFIVTKHAGRHLRR-
TH_3206|M.thermoresistible__bu DVAVNCAGFSNVGLITDMP--VDQFRSVIDVCLTGAFIVTKHAGRQLRE-
MSMEG_5234|M.smegmatis_MC2_155 DIVINCAGFSNVGLITDMP--AEDFRSVIDVCLTGGFIVAKHAGRHLPR-
Mb1385|M.bovis_AF2122/97 DVMVNNAGITRDATMRTMT--EEQFDQVIAVHLKGTWNGTRLAAAIMRER
Rv1350|M.tuberculosis_H37Rv DVMVNNAGITRDATMRTMT--EEQFDQVIAVHLKGTWNGTRLAAAIMRER
MUL_3898|M.ulcerans_Agy99 DIMVNNAGITRDATMRKMT--EEQFDQVIDVHLKGTWNGIRLAAAIMREN
MAV_5088|M.avium_104 DVFVNNAGITRDASLKRMT--VADFDAVIAVHLRGTWLGVREAAAVMRER
MMAR_4765|M.marinum_M HVMVNNAGVSGVMHRRFLDDDLADFHRVMAVNVLGVMAGTRDAARHMAAH
MAB_4680c|M.abscessus_ATCC_199 TGLVNNAGISSAAMVADEP--LEHFRKVIEINLVGVFIGMQAVIPAMRAH
MLBr_01807|M.leprae_Br4923 EVLVANAGITSDMLIMRMS--EEQFQKVIDVNLTGVFRVAKLASRNMIKQ
: **.: .* *: : : * : . :
Mvan_4643|M.vanbaalenii_PYR-1 -GGSLVQISSLNGRQPAAGMSAYCAAKAGLSMLTQVAALELGPRGIRVNA
Mflv_2071|M.gilvum_PYR-GCK -GGSLVQISSLNGRQPAAGMSAYCAAKAGLSMLTQVAALEMGPRGIRVNA
TH_3206|M.thermoresistible__bu -GGSLVSISSLNARQAAAGMSAYCAAKAGLSMLTQVAALELAPRGVRVNA
MSMEG_5234|M.smegmatis_MC2_155 -GGVLVSISSLNARQPAAGMSAYCAAKAGLSMLTQVAALEMGEAGIRVNA
Mb1385|M.bovis_AF2122/97 KRGAIVNMSSVSGKVGMVGQTNYSAAKAGIVGMTKAAAKELAHLGIRVNA
Rv1350|M.tuberculosis_H37Rv KRGAIVNMSSVSGKVGMVGQTNYSAAKAGIVGMTKAAAKELAHLGIRVNA
MUL_3898|M.ulcerans_Agy99 KRGAIVNMSSVSGKVGMVGQTNYSAAKAGIVGMTKAAAKELAHVGVRVNA
MAV_5088|M.avium_104 KTGSIVNMSSLSGKAGNPGQTNYSAAKAGIVGLTKAAAKELAHHNVRVNA
MMAR_4765|M.marinum_M GGGSIVNLTSIGGIQAGGGVMTYRASKAAVIQFTKSAAIELAHYEIRVNA
MAB_4680c|M.abscessus_ATCC_199 GCGSIVNISSAAGLVGLALTSGYGASKWGVRGLSKVAAIELGRERIRVNS
MLBr_01807|M.leprae_Br4923 RFGRYIFMGSVVGLSGVPGQANYAASKSGLIGMARSLARELGSRSITANV
* : : * . * *:* .: ::: * *:. : .*
Mvan_4643|M.vanbaalenii_PYR-1 VAPGFVHTPLTAAAASVP----------GVVEDYVDNTVLGRAGTAEDIA
Mflv_2071|M.gilvum_PYR-GCK VAPGFVHTPLTAAAASVP----------GVVEDYVDNTALGRAGTPEDIA
TH_3206|M.thermoresistible__bu VAPGFVHTPLTAPAAAVP----------GVVEEYLENTPLGRAGQPEDVA
MSMEG_5234|M.smegmatis_MC2_155 IAPGFVHTPLTAPAAMIP----------GVVEEYVENTALGRAGTPEDIA
Mb1385|M.bovis_AF2122/97 IAPGLIRSAMTEAMPQ------------RIWDQKLAEVPMGRAGEPSEVA
Rv1350|M.tuberculosis_H37Rv IAPGLIRSAMTEAMPQ------------RIWDQKLAEVPMGRAGEPSEVA
MUL_3898|M.ulcerans_Agy99 IAPGLIRSAMTEAMPQ------------RIWDQKLAEVPMGRAGEPSEVA
MAV_5088|M.avium_104 IQPGLIRTPMTAAMPP------------DVFAEREAAVPMKRAGEPEEVA
MMAR_4765|M.marinum_M IAPGNIPTPLLASSAAGMDQEQVERFTAQIRQTMREDRPLKREGTPEDIA
MAB_4680c|M.abscessus_ATCC_199 VHPGVIYTPMTAKEGF------------REGEGNMPIAAMGRVGNADEVA
MLBr_01807|M.leprae_Br4923 VAPGFIDTEMTRAMDS------------KYQEAALQAIPLGRIGAVEEIA
: ** : : : : * * .::*
Mvan_4643|M.vanbaalenii_PYR-1 NAVVYLCAPGSSWLTGEVLDINGGAHLKRYPDVMGHVMRLVEQSS
Mflv_2071|M.gilvum_PYR-GCK AAVVFLCSPGTSWMTGEVLDINGGAHLKRYPDVMGHVMKLMEPAS
TH_3206|M.thermoresistible__bu AAVVFLCSPAASWLTGEVLDLNGGAHLKRYPDILGHVMKLAEQS-
MSMEG_5234|M.smegmatis_MC2_155 AAVVFVCSPQASWLTGEVLDLNGGAHLRRYPDVLGHVMRLAQG--
Mb1385|M.bovis_AF2122/97 SVAVFLASDLSSYMTGTVLDVTG-----------GRFI-------
Rv1350|M.tuberculosis_H37Rv SVAVFLASDLSSYMTGTVLDVTG-----------GRFI-------
MUL_3898|M.ulcerans_Agy99 SVALFLACDLSSYMTGTVLDVTG-----------GRFI-------
MAV_5088|M.avium_104 GAVVFLASELSSYITGTVLGVGG-----------GRYM-------
MMAR_4765|M.marinum_M EAALYFAGERSRYVTGTVLPVDGGTVA-------GKVIRRSR---
MAB_4680c|M.abscessus_ATCC_199 GAVAYLLSDAASYVTGAELAVDGGWTA-------GPTLTTITGQ-
MLBr_01807|M.leprae_Br4923 GAVSFLASEDAGYISGAVIPVDG-----------GLGMGH-----
.. :. : :::* : : * * :