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AESLLLGKVAVVTGAGQGIGREIARALHRHGARVVLADLDGSAARSAAAQIDDSGANCTGLACDVTSEEQ VGALVAGTVREHGGLDVFVNNAGITRDASLKRMTVADFDAVIAVHLRGTWLGVREAAAVMRERKTGSIVN MSSLSGKAGNPGQTNYSAAKAGIVGLTKAAAKELAHHNVRVNAIQPGLIRTPMTAAMPPDVFAEREAAVP MKRAGEPEEVAGAVVFLASELSSYITGTVLGVGGGRYM*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_5088 | fabG | - | 100% (249) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. avium 104 | MAV_1572 | - | 2e-74 | 58.47% (248) | short chain dehydrogenase |
| M. avium 104 | MAV_0886 | - | 2e-45 | 42.58% (256) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1385 | fabG | 1e-74 | 60.08% (248) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. gilvum PYR-GCK | Mflv_4369 | fabG | 5e-76 | 60.73% (247) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. tuberculosis H37Rv | Rv1350 | fabG | 1e-74 | 60.08% (248) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. leprae Br4923 | MLBr_01807 | fabG1 | 6e-38 | 37.87% (235) | 3-oxoacyl- |
| M. abscessus ATCC 19977 | MAB_4443 | fabG | 7e-43 | 41.13% (248) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. marinum M | MMAR_4033 | fabG | 8e-76 | 59.04% (249) | 3-oxoacyl- |
| M. smegmatis MC2 155 | MSMEG_2206 | fabG | 3e-77 | 61.22% (245) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. thermoresistible (build 8) | TH_3954 | - | 1e-108 | 79.12% (249) | PUTATIVE 3-oxoacyl-[acyl-carrier-protein] reductase |
| M. ulcerans Agy99 | MUL_3898 | fabG | 4e-73 | 59.24% (238) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. vanbaalenii PYR-1 | Mvan_1975 | fabG | 5e-76 | 60.16% (246) | 3-ketoacyl-(acyl-carrier-protein) reductase |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_5088|M.avium_104 --------------------------------------------------
TH_3954|M.thermoresistible__bu --------------------------------------------------
Mflv_4369|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1975|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2206|M.smegmatis_MC2_155 --------------------------------------------------
Mb1385|M.bovis_AF2122/97 --------------------------------------------------
Rv1350|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4033|M.marinum_M --------------------------------------------------
MUL_3898|M.ulcerans_Agy99 --------------------------------------------------
MAB_4443|M.abscessus_ATCC_1997 MSPKLTDDLYALLVNSGPGNLLAGRLGIPQPEKLRRYKKGQPALAGPVLI
MLBr_01807|M.leprae_Br4923 --------------------------------------------------
MAV_5088|M.avium_104 --------------------------------------------------
TH_3954|M.thermoresistible__bu --------------------------------------------------
Mflv_4369|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1975|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2206|M.smegmatis_MC2_155 --------------------------------------------------
Mb1385|M.bovis_AF2122/97 --------------------------------------------------
Rv1350|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4033|M.marinum_M --------------------------------------------------
MUL_3898|M.ulcerans_Agy99 --------------------------------------------------
MAB_4443|M.abscessus_ATCC_1997 GGEGRLAEPLRAALADDYEVVSNNLGGRWADKFGALVFDATGITTPVELK
MLBr_01807|M.leprae_Br4923 --------------------------------------------------
MAV_5088|M.avium_104 --------------------------------------------------
TH_3954|M.thermoresistible__bu --------------------------------------------------
Mflv_4369|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1975|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2206|M.smegmatis_MC2_155 --------------------------------------------------
Mb1385|M.bovis_AF2122/97 --------------------------------------------------
Rv1350|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4033|M.marinum_M --------------------------------------------------
MUL_3898|M.ulcerans_Agy99 --------------------------------------------------
MAB_4443|M.abscessus_ATCC_1997 ALHEFFTPLLRNVGKSGRLLVIGTTPDKAATTDERIAQRALEGFTRSLAK
MLBr_01807|M.leprae_Br4923 --------------------------------------------------
MAV_5088|M.avium_104 ---------------------------------MAESLLLGK--------
TH_3954|M.thermoresistible__bu ---------------------------------MPSALLAEK--------
Mflv_4369|M.gilvum_PYR-GCK -----------------------------------MSLLTGQ--------
Mvan_1975|M.vanbaalenii_PYR-1 -----------------------------MRMGEQVSLLTGQ--------
MSMEG_2206|M.smegmatis_MC2_155 -------------------------------------MLTGQ--------
Mb1385|M.bovis_AF2122/97 ----------------------------------MASLLNAR--------
Rv1350|M.tuberculosis_H37Rv ----------------------------------MASLLNAR--------
MMAR_4033|M.marinum_M ----------------------------------MSVSLLNG--------
MUL_3898|M.ulcerans_Agy99 ----------------------------------MCGAHRDRGY------
MAB_4443|M.abscessus_ATCC_1997 EFSNGATVQLVYLHPDAKTGATGLESTVRFILSAKSTYVDGQVFYVGADD
MLBr_01807|M.leprae_Br4923 --------------------MTDAAAKVSAAPGRGKPAFVSR--------
MAV_5088|M.avium_104 --------------VAVVTGAGQGIGREIARALHRHGARVVLADLDGSAA
TH_3954|M.thermoresistible__bu --------------VAVVTGAGRGIGREIARVLHAHGAEVVLADLDADAA
Mflv_4369|M.gilvum_PYR-GCK --------------TAVITGGAQGLGFAIAQRFVDEGARVVLGDVNLEAT
Mvan_1975|M.vanbaalenii_PYR-1 --------------TAVITGGAQGLGFAIAQRFVEEGARVVLGDVNLDAT
MSMEG_2206|M.smegmatis_MC2_155 --------------TAVVTGGAQGLGLAIAKRFISEGARVVLGDLNSEAT
Mb1385|M.bovis_AF2122/97 --------------TAVITGGAQGLGLAIGQRFVAEGARVVLGDVNLEAT
Rv1350|M.tuberculosis_H37Rv --------------TAVITGGAQGLGLAIGQRFVAEGARVVLGDVNLEAT
MMAR_4033|M.marinum_M -------------QIAVVTGGAQGLGLAIAERFVSEGARVVLGDVNLEAT
MUL_3898|M.ulcerans_Agy99 -------------VYPVVTGGAQGLGLAIAERFVSEGARVVLGDVNLEAT
MAB_4443|M.abscessus_ATCC_1997 STAPADWDKPLAGKVAIVTGAARGIGETIAEVFARDGAAVVAIDMPSEEL
MLBr_01807|M.leprae_Br4923 --------------SILVTGGNRGIGLAVARRLVADGHRVAVTHR----A
::**. :*:* :.. : .* *. .
MAV_5088|M.avium_104 RSAAAQIDDSGANCTGLACDVTSEEQVGALVAGTVREHG-GLDVFVNNAG
TH_3954|M.thermoresistible__bu AQAAAEVDG-----TGVGCDVTAEDQMKRLVADTVAKHG-RLDLFVNNAG
Mflv_4369|M.gilvum_PYR-GCK QEAAEKLGG-ADVAHAVRCDVTSSAEVDALVAAAVDTFG-ALDIMVNNAG
Mvan_1975|M.vanbaalenii_PYR-1 VAAAEKLGG-EDVARAVRCDVTDSAEVDALIAAAVDGFG-SLDIMVNNAG
MSMEG_2206|M.smegmatis_MC2_155 EAAVEELGG-SEVAAAVRCDVTSSADVDALVQAAVERFG-GLDIMVNNAG
Mb1385|M.bovis_AF2122/97 EVAAKRLGG-DDVALAVRCDVTQADDVDILIRTAVERFG-GLDVMVNNAG
Rv1350|M.tuberculosis_H37Rv EVAAKRLGG-DDVALAVRCDVTQADDVDILIRTAVERFG-GLDVMVNNAG
MMAR_4033|M.marinum_M EAAAKQLGG-GEVAVAVRCDVTKADEVETLLQTALERFG-GLDIMVNNAG
MUL_3898|M.ulcerans_Agy99 EAAAKQLGG-GEVAVAVRCDVTKADEVETLLQAALERFG-GLDIMVNNAG
MAB_4443|M.abscessus_ATCC_1997 NELASRVGG-----TALALDVTSEDAVDTITAHLKEHHGGKADILVNNAG
MLBr_01807|M.leprae_Br4923 SVVPDWFFG-------VECDVTDNDAIGAAFKAVEEHQG-PVEVLVANAG
. . : *** : * :::* ***
MAV_5088|M.avium_104 ITRDASLKRMTVADFDAVIAVHLRGTWLGVREAAAVMRERKTGSIVNMSS
TH_3954|M.thermoresistible__bu ITRDASLKRMTVADFDAVVTVHLRGTWLGVREATAVMREQKSGSIVNISS
Mflv_4369|M.gilvum_PYR-GCK ITRDATMRKMTEDDFDKVIAVHLKGTWNGLRAAAAIMRENKRGVIVNMSS
Mvan_1975|M.vanbaalenii_PYR-1 ITRDATMRKMTEEQFDQVIAVHLKGTWNGLRAAAAVMREQKRGAIVNMSS
MSMEG_2206|M.smegmatis_MC2_155 ITRDATLRKMTEEQFDQVIAVHLKGTWNGTKAAAAIMRENKRGAIVNMSS
Mb1385|M.bovis_AF2122/97 ITRDATMRTMTEEQFDQVIAVHLKGTWNGTRLAAAIMRERKRGAIVNMSS
Rv1350|M.tuberculosis_H37Rv ITRDATMRTMTEEQFDQVIAVHLKGTWNGTRLAAAIMRERKRGAIVNMSS
MMAR_4033|M.marinum_M ITRDATMRKMTEEQFDQVIDVHLKGTWNGIRLAAAIMRENKRGAIVNMSS
MUL_3898|M.ulcerans_Agy99 ITRDATMRKMTEEQFDQVIDVHLKGTWNGIRLAAAIMRENKRGAIVNMSS
MAB_4443|M.abscessus_ATCC_1997 ITRDKLLKNMDDARWDSVIAVNLLAPQRLTEGLIGNGTIGEGGRVIGLAS
MLBr_01807|M.leprae_Br4923 ITSDMLIMRMSEEQFQKVIDVNLTGVFRVAKLASRNMIKQRFGRYIFMGS
** * : * :: *: *:* . . . * : :.*
MAV_5088|M.avium_104 LSGKAGNPGQTNYSAAKAGIVGLTKAAAKELAHHNVRVNAIQPGLIRTPM
TH_3954|M.thermoresistible__bu LSGKSGNPGQTNYSAAKAGIIGLTKAAAKEVAHHNVRVNAIQPGLIRTPM
Mflv_4369|M.gilvum_PYR-GCK ISGKVGMIGQTNYSAAKAGIVGMTKAASKELAYLGVRVNAIQPGLIRSAM
Mvan_1975|M.vanbaalenii_PYR-1 ISGKVGMVGQTNYSAAKAGIVGMTKAASKELAYLGVRVNAIQPGLIRSAM
MSMEG_2206|M.smegmatis_MC2_155 ISGKVGLIGQTNYSAAKAGIVGMTKAAAKELAYLGVRVNAIQPGLIRSAM
Mb1385|M.bovis_AF2122/97 VSGKVGMVGQTNYSAAKAGIVGMTKAAAKELAHLGIRVNAIAPGLIRSAM
Rv1350|M.tuberculosis_H37Rv VSGKVGMVGQTNYSAAKAGIVGMTKAAAKELAHLGIRVNAIAPGLIRSAM
MMAR_4033|M.marinum_M VSGKVGMVGQTNYSAAKAGIVGMTKAAAKELAHVGVRVNAIAPGLIRSAM
MUL_3898|M.ulcerans_Agy99 VSGKVGMVGQTNYSAAKAGIVGMTKAAAKELAHVGVRVNAIAPGLIRSAM
MAB_4443|M.abscessus_ATCC_1997 IAGIAGNRGQTNYGATKAGMIGITQALAPSLAEKGITINAVAPGFIETKM
MLBr_01807|M.leprae_Br4923 VVGLSGVPGQANYAASKSGLIGMARSLARELGSRSITANVVAPGFIDTEM
: * * **:**.*:*:*::*:::: : .:. .: *.: **:* : *
MAV_5088|M.avium_104 TAAMPPDVFAEREAAVPMKRAGEPEEVAGAVVFLASELSSYITGTVLGVG
TH_3954|M.thermoresistible__bu TETMPAEVFAEREAAVPMKRAGEPAEVAGAVVFLGSDLSSYITGSVIEVG
Mflv_4369|M.gilvum_PYR-GCK TEAMPQRIWDSKVAEVPLGRAGEPDEVAKVALFLASDLSSYMTGTVLEVT
Mvan_1975|M.vanbaalenii_PYR-1 TEAMPQRIWDSKVAEVPMGRAGEPEEVANVALFLASDLSSYMTGTVLEVT
MSMEG_2206|M.smegmatis_MC2_155 TEAMPQRIWDEKLAEIPMGRAGEPDEVAKVALFLASDLSSYMTGTVLEVT
Mb1385|M.bovis_AF2122/97 TEAMPQRIWDQKLAEVPMGRAGEPSEVASVAVFLASDLSSYMTGTVLDVT
Rv1350|M.tuberculosis_H37Rv TEAMPQRIWDQKLAEVPMGRAGEPSEVASVAVFLASDLSSYMTGTVLDVT
MMAR_4033|M.marinum_M TEAMPQRIWDQKLAEVPMGRAGEPSEVASVALFLACDLSSYMTGTVLDVT
MUL_3898|M.ulcerans_Agy99 TEAMPQRIWDQKLAEVPMGRAGEPSEVASVALFLACDLSSYMTGTVLDVT
MAB_4443|M.abscessus_ATCC_1997 TAAIPLANREVGRRINSLNQGGEPVDVAETIAYFASPASNAVTGNVVRVC
MLBr_01807|M.leprae_Br4923 TRAMDSKYQEAALQAIPLGRIGAVEEIAGAVSFLASEDAGYISGAVIPVD
* :: .: : * ::* . ::.. :. ::* *: *
MAV_5088|M.avium_104 GGRYM--
TH_3954|M.thermoresistible__bu GGRYM--
Mflv_4369|M.gilvum_PYR-GCK GGRHL--
Mvan_1975|M.vanbaalenii_PYR-1 GGRHL--
MSMEG_2206|M.smegmatis_MC2_155 GGRHV--
Mb1385|M.bovis_AF2122/97 GGRFI--
Rv1350|M.tuberculosis_H37Rv GGRFI--
MMAR_4033|M.marinum_M GGRFI--
MUL_3898|M.ulcerans_Agy99 GGRFI--
MAB_4443|M.abscessus_ATCC_1997 GQSWLGA
MLBr_01807|M.leprae_Br4923 GGLGMGH
* :