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MVADPVTPIGLLIGTDRLTRTSLAPHPHIYPATGAPNATVALAGADEVGMAVSAAREAQREWITLGVDQR RDKLIDLADVVREHLGELAELNTLDYGVPISYAGNAVMLDQFLRHFAGYVDKPHGSSTPVSGSSDVNLIE REPFGAVGVIAPWNGSLVVAASCVAPALAAGNAVVFKPSELAPLAALRFGELCLEAGLPPGLVNILPAAA EGGDALVRHAGIAKIHFTGGGHTARAILRAAADNLTPVVTELGGKSANIIFDDADLDIAAVRSAHQGPLM QSGQSCACASRILVHEAVYEAFTERFIDVVESARIGDPLDPATVFGPVISAAALDRIVGVVGEAVDSGSG DLLAGGRRLTEDSLAAGYYLEPTVLGNVDNTSPLAQTETFGPVVSLIPFADDDGAVRIANDTPYGLNAFV HTRDLTRAHTVARRLQSGSVWINQGSRISPQGPYGGYKQSGSGRTGGLEGLREFQQVKNIRIGIG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1907 | - | - | 100% (485) | aldehyde dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0428 | - | 1e-77 | 38.31% (462) | betaine-aldehyde dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4389 | - | 4e-75 | 38.73% (457) | aldehyde dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2883c | aldC | 5e-80 | 40.31% (459) | aldehyde dehydrogenase |
| M. tuberculosis H37Rv | Rv2858c | aldC | 5e-80 | 40.31% (459) | aldehyde dehydrogenase |
| M. leprae Br4923 | MLBr_02573 | gabD1 | 6e-53 | 30.65% (460) | succinic semialdehyde dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3328 | - | 3e-72 | 37.55% (458) | gamma-aminobutyraldehyde dehydrogenase |
| M. marinum M | MMAR_3556 | - | 2e-74 | 38.43% (458) | aldehyde dehydrogenase NAD dependent |
| M. avium 104 | MAV_3553 | - | 0.0 | 66.88% (474) | aldehyde dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_5815 | - | 0.0 | 75.26% (481) | betaine aldehyde dehydrogenase |
| M. thermoresistible (build 8) | TH_3419 | - | 1e-118 | 46.95% (475) | PUTATIVE putative aldehyde dehydrogenase |
| M. ulcerans Agy99 | MUL_2789 | - | 6e-73 | 37.77% (458) | gamma-aminobutyraldehyde dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0014 | - | 3e-77 | 38.26% (460) | betaine-aldehyde dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1907|M.gilvum_PYR-GCK ---MVADPVTPIGLLIGTDRLTRTSLAPHPHIYPATGAPNATVALAGADE
MSMEG_5815|M.smegmatis_MC2_155 -MTSVVLPGDPIGSLIGDRRVTASSGGLHAHVYPATGLPNATVALAGAAE
MAV_3553|M.avium_104 MTATASSPPRTGALLIGTERITAASGGSHQHRYPGTGVPNATIPLAGHSE
TH_3419|M.thermoresistible__bu VQRTLPDKLPAPRLVIGGGDVISTSGGVYEHHYAATGGVQAEVPLAGPAE
Mb2883c|M.bovis_AF2122/97 -------------------------MSTTQLINPATEEVLASVDHTDANA
Rv2858c|M.tuberculosis_H37Rv -------------------------MSTTQLINPATEEVLASVDHTDANA
Mvan_0014|M.vanbaalenii_PYR-1 -----MSDIPHYRMYIDG--AWRDAADTIEVRSPATGELVATVAYGGVTT
MMAR_3556|M.marinum_M ----MTTTVSVAGSWING-AAHSTGGRQHAVINPATQETIAELALATPAD
MUL_2789|M.ulcerans_Agy99 ----MTTTVSVAGSWING-AAHSTGGRQHAVINPATQETIAELALATPAD
MAB_3328|M.abscessus_ATCC_1997 --------MSVPSSWING-RPVATHGDTHRVINPATGEAVADLKLATTAD
MLBr_02573|M.leprae_Br4923 --------------------------MSIATINPATGETVKTFTPTTQDE
..* .
Mflv_1907|M.gilvum_PYR-GCK VGMAVSAAREAQRE--WITLGVDQRRDKLIDLADVVREHLGELAELNTLD
MSMEG_5815|M.smegmatis_MC2_155 VDAAVSAAWEAHRE--WVAHPADRRRDMLVGLADVVHEHLDELAGLNVHD
MAV_3553|M.avium_104 VDRAVHSAREAQRE--WISYPVDRRRDLLFGLADLLRDHFAELTELNVHD
TH_3419|M.thermoresistible__bu VDAAVAAARAAFPA--WRDLDLNRRRDILQELARRLVADGERLGAIATLE
Mb2883c|M.bovis_AF2122/97 VDDAVQRARAAQRR--WARLAPAQRAAGLRAFAAAVQAHLDELAALEVAN
Rv2858c|M.tuberculosis_H37Rv VDDAVQRARAAQRR--WARLAPAQRAAGLRAFAAAVQAHLDELAALEVAN
Mvan_0014|M.vanbaalenii_PYR-1 VDDAVAAAKAADEAGVWRNTSAQQRADVLDAIADNLAARTDELTALQVAE
MMAR_3556|M.marinum_M VDRAVVAARRALPQ--WAGVTPAERSAVLAKLADLLEQRAPELIAEEVCQ
MUL_2789|M.ulcerans_Agy99 VDHAVVAARRALPQ--WAGVTTAERSAVLAELADLLEQRAPELIAEEVCQ
MAB_3328|M.abscessus_ATCC_1997 VDAAVAAARAAGPA--WASSTPVDRSSVLAKLAAVLSANADTLVADEVAQ
MLBr_02573|M.leprae_Br4923 VEDAIARAYARFDN--YRHTTFTQRAKWANATADLLEAEANQSAALMTLE
* *: * : * * : . :
Mflv_1907|M.gilvum_PYR-GCK YGVP-ISYAGNAV-MLDQFLRHFAGYVD----KPHGSSTPVSGSSDVNLI
MSMEG_5815|M.smegmatis_MC2_155 YAVP-ISNAGTAL-LLERFLRHFAGYAD----KPHGTSSPVSGSFDVNII
MAV_3553|M.avium_104 YGVP-ISVAGNSV-LTERFVRYYAGYPD----KLTGASTPVSGAFDVNIV
TH_3419|M.thermoresistible__bu VGTPNLLASSSSA-MAADWFTYYAGWIG----RSAGEVVPVPAGGALDYV
Mb2883c|M.bovis_AF2122/97 SGHPIVSA-EWEAGHVRDVLAFYAASPE----RLSGRQIPVAG--GVDVT
Rv2858c|M.tuberculosis_H37Rv SGHPIVSA-EWEAGHVRDVLAFYAASPE----RLSGRQIPVAG--GVDVT
Mvan_0014|M.vanbaalenii_PYR-1 NGATVRAAGAFLIGYAIAHLRYFAGLARTYAFQSSGPLMEAPTL-AAGMI
MMAR_3556|M.marinum_M TGKPLRLAEEFDVPGSVDNIRFFAGAAR----RLPGQATAEYSADHTSSI
MUL_2789|M.ulcerans_Agy99 TGKPLRLAEEFDVPGSVDNIRFFAGAAR----RLPGQATAEYSADHTSSI
MAB_3328|M.abscessus_ATCC_1997 TGKPVRLASEFDVPGSIDNVEFFAGAAR----HLEGKATAEYSADHTSSI
MLBr_02573|M.leprae_Br4923 MGKTLQSAKDEAMKCAKG-FRYYAEKAET--LLADEPAEAAAVGASKALA
. . . .:*
Mflv_1907|M.gilvum_PYR-GCK EREPFGAVGVIAPWNGSLVVAASCVAPALAAGNAVVFKPSELAPLAALRF
MSMEG_5815|M.smegmatis_MC2_155 EREPYGVVGVIAPWNGALAVAASCVAPALAAGNAVVFKPSELAPLAALRF
MAV_3553|M.avium_104 EREPYGVVAVIAPWNGPLVVAGAAVAPALAAGNAVIFKPSELASLAPLRF
TH_3419|M.thermoresistible__bu LDEPLGVIAAIIPWNGPLISIGMKVAPALAAGNCVVLKPPENAPFSALRF
Mb2883c|M.bovis_AF2122/97 FNEPMGVVGVITPWNFPMVIASWAIAPALAAGNAVLVKPAELTPLTTMRL
Rv2858c|M.tuberculosis_H37Rv FNEPMGVVGVITPWNFPMVIASWAIAPALAAGNAVLVKPAELTPLTTMRL
Mvan_0014|M.vanbaalenii_PYR-1 VRDPVGVCAGMIPWNFPLLLAVWKLGPALAAGNTVVLKPDDQTPLTLLEL
MMAR_3556|M.marinum_M RREAIGVVATITPWNYPLQMAVWKVMPALAAGCTVVIKPSELTPLTTLTL
MUL_2789|M.ulcerans_Agy99 RREAIGVVATITPWNYPLQMAVWKVMPALAAGCTVVIKPSELTPLTTLTL
MAB_3328|M.abscessus_ATCC_1997 RREAAGVVATITPWNYPLQMAVWKVLPALAAGCTVVIKPSELTPLTTLTL
MLBr_02573|M.leprae_Br4923 RYQPLGVVLAVMPWNFPLWQTVRFAAPALMAGNVGLLKHASNVPQCALYL
:. *. : *** .: *** ** :.* . .. : :
Mflv_1907|M.gilvum_PYR-GCK GELCLEAGLPPGLVNILP-AAAEGGDALVRHAGIAKIHFTGGGHTARAIL
MSMEG_5815|M.smegmatis_MC2_155 GELCLVAGLPPGLVNILP-AASDGGDALVRHPGIRKIHFTGGGTTARAVL
MAV_3553|M.avium_104 GELCLEAGLPPGLVNVLP-AGPEGGEALVRHPGVGKVHFTGGHATAQQVL
TH_3419|M.thermoresistible__bu AELAAEAGLPPGVLNVIP-GGAEAGSALCSHPGVDKITFTGGGETARKVF
Mb2883c|M.bovis_AF2122/97 GELAVEAGLDEDLLQVLPGKGTVVGERFVTHPDIRKIVFTGSTEVGKRVM
Rv2858c|M.tuberculosis_H37Rv GELAVEAGLDEDLLQVLPGKGTVVGERFVTHPDIRKIVFTGSTEVGKRVM
Mvan_0014|M.vanbaalenii_PYR-1 ARAADEVGLPAGVLNVVTGAGPTVGARLAEHPDVRKVAFTGSTEVGKSVM
MMAR_3556|M.marinum_M ARLAAEAGLPDGVLNVVTGLGADVGAALAAHPGVDLVTFTGSTAVGRKVM
MUL_2789|M.ulcerans_Agy99 ARLAAEAGLPDGVLNVVTGLGADVGAALAAHPGVDLVTFTGSTAVGRKVM
MAB_3328|M.abscessus_ATCC_1997 ARLAAEAGLPEGVLNVVTGRGDDVGYALASHPDVDLVTFTGSTAVGRKVM
MLBr_02573|M.leprae_Br4923 ADVIARGGFPEDCFQTLLISANG-VEAILRDPRVAAATLTGSEPAGQAVG
. *: . .: : . : .. : :**. ..: :
Mflv_1907|M.gilvum_PYR-GCK RAAADNLTPVVTELGGKSANIIFDDADLDIAAVRSAHQGPLMQSGQSCAC
MSMEG_5815|M.smegmatis_MC2_155 RAATDNLTPVVTELGGKSANIIFPDADLGRAAALAAHQGPLMQSGQSCAC
MAV_3553|M.avium_104 RAASDNVTPVTAELGGKSAYLVFADADLDTAAVIAAHQGPLTQAGQSCAC
TH_3419|M.thermoresistible__bu AAAAQALTPVVLELGGKSANIVFPDADLDAAATMAVSAGLMMLSGQGCIL
Mb2883c|M.bovis_AF2122/97 AGAAAQVKRVTLELGGKSANIVFHDCDLERAATTAPAG-VFDNAGQDCCA
Rv2858c|M.tuberculosis_H37Rv AGAAAQVKRVTLELGGKSANIVFHDCDLERAATTAPAG-VFDNAGQDCCA
Mvan_0014|M.vanbaalenii_PYR-1 RAAADTVKKVTLELGGKGASIVLDDADLDLAVDGSLFA-FLLMSGQACES
MMAR_3556|M.marinum_M AAAATHGRRTQLELGGKAPFVVFDDADLDAAIQGAVAG-ALINSGQDCTA
MUL_2789|M.ulcerans_Agy99 AAAATHGRRTQLELGGKAPFVVFDDADLDAAIQGAVAG-AVINSGQDCTA
MAB_3328|M.abscessus_ATCC_1997 AAAAVHGHRTQLELGGKAPFVVFDDADMDAAIAGAVAG-AIINSGQDCTA
MLBr_02573|M.leprae_Br4923 AIAGNEIKPTVLELGGSDPFIVMPSADLDAAVATAVTG-RVQNNGQSCIA
* . ****. . ::: ..*: * : . ** *
Mflv_1907|M.gilvum_PYR-GCK ASRILVHEAVYEAFTERFIDVVESARIGDPLDPATVFGPVISAAALDRIV
MSMEG_5815|M.smegmatis_MC2_155 ASRILVHESVYDAFTEQFLAVIGAARVGDPFDPEVNFGPVISAGSLDRLL
MAV_3553|M.avium_104 ASRILVEASVYVSFVEKLVAQVQAATIGDPLRPDVMLGPVITEAAADRIL
TH_3419|M.thermoresistible__bu PTRLLVHDDVYDEMVTRVVAGADALTVGDPWQPTTMMGPLATAAQLERVT
Mb2883c|M.bovis_AF2122/97 RSRILVQRSVYDRFMELLEPAVHSIVVGDPGSRATEMGPLVSRAHRDKVA
Rv2858c|M.tuberculosis_H37Rv RSRILVQRSVYDRFMELLEPAVHSIVVGDPGSRATEMGPLVSRAHRDKVA
Mvan_0014|M.vanbaalenii_PYR-1 GTRLLVHESIHDEFVRRMVARAETLVMGDPMSLASDLGPLVSAKQKARVE
MMAR_3556|M.marinum_M ATRAIVARELYHDFVAGVADVMSTVVIGDPMDPDTDIGPLISLAHRDRVA
MUL_2789|M.ulcerans_Agy99 ATRAIVARELCHDFVAGVADVMSTVVIGDPMDPDTDIGPLISLAHRDRVA
MAB_3328|M.abscessus_ATCC_1997 ATRALVARDLYDDFVAGVGEVMSKVVVGDPLDPDTDIGPLISAAHRAKVS
MLBr_02573|M.leprae_Br4923 AKRFIAHADIYDEFVEKFVARMETLRVGDPTDPDTDVGPLATESGRAQVE
.* :. : : . :*** .**: : ::
Mflv_1907|M.gilvum_PYR-GCK GVVGEAVDSGSGDLLAGGRRLTEDSLAAGYYLEPTVLGNVDNTSPLAQTE
MSMEG_5815|M.smegmatis_MC2_155 NVVHRAVEERAGELLVGGERLVDGALAGGFYMQPTVFGGVDNRSRLAQVE
MAV_3553|M.avium_104 GVIERAVAEKAGDLVTGGRRLG-GELASGYFIEPTIFSNVDNRSSLAQTE
TH_3419|M.thermoresistible__bu RAVDSALSDKAGKLLAGGRRPD--GLDAGYFYRPTVFGDVDPASDLAQTE
Mb2883c|M.bovis_AF2122/97 GYVP-----DDAPVAFRGTAPAG----RGFWFPPTVLTPKRGD-RTVTDE
Rv2858c|M.tuberculosis_H37Rv GYVP-----DDAPVAFRGTAPAG----RGFWFPPTVLTPKRGD-RTVTDE
Mvan_0014|M.vanbaalenii_PYR-1 KYIALGQ-EEGCKLAYQGTVPTDPALAQGHWVPPTILTGATNDMRIAREE
MMAR_3556|M.marinum_M DIVAKAP-AQGARIVVGGRIPD----LAGAFYLPTLLADVGEQSQAYREE
MUL_2789|M.ulcerans_Agy99 DILAKAP-AQGARIVVGGRIPD----LAGAFYLPTLLADVGEQSQAYREE
MAB_3328|M.abscessus_ATCC_1997 SIVDRAP-AQGGRIVTGATAPD----LPGSFYRPTLIADVAETSEVYRDE
MLBr_02573|M.leprae_Br4923 QQVDAAA-AAGAVIRCGGKRPD----RPGWFYPPTVITDITKDMALYTDE
: : . * : **:: *
Mflv_1907|M.gilvum_PYR-GCK TFGPVVSLIPFADDDGAVRIANDTPYGLNAFVHTRDLTRAHTVARRLQSG
MSMEG_5815|M.smegmatis_MC2_155 TFGPVVSLIRFVDDDEAVRLANDTPYGLNAFVHTADLTRAHTVSRQLEAG
MAV_3553|M.avium_104 TFGPVASVMPFADEAQAVSLANDSRYGLNAFVATANLERAHRVARRLQAG
TH_3419|M.thermoresistible__bu IFGPVLAILRFRSEEEAVELANNTQYGLAAYIHTRDLRRAHVMAAALDAG
Mb2883c|M.bovis_AF2122/97 IFGPVVVVLTFDDEADAISLANDTAYGLSGSIWTDDLSRALRVARAVESG
Rv2858c|M.tuberculosis_H37Rv IFGPVVVVLTFDDEADAISLANDTAYGLSGSIWTDDLSRALRVARAVESG
Mvan_0014|M.vanbaalenii_PYR-1 IFGPVLVVLTYGDDDEAVAIANDSEYGLSAGVWSADRERALGIARRLQSG
MMAR_3556|M.marinum_M IFGPVLTVRAHDGDDDALRQANDTDYGLAASAWTRDVYRAQRASREISAG
MUL_2789|M.ulcerans_Agy99 IFGPVLTVRAHDGDDDALRQANDTDYGLAASAWTRDVYRAQRASREISAG
MAB_3328|M.abscessus_ATCC_1997 IFGPVLTVRPFTDDDDALRQANDTAYGLAASAWTRDVYRAQRASREIRAG
MLBr_02573|M.leprae_Br4923 VFGPVASVYCATNIDDAIEIANATPFGLGSNAWTQNESEQRHFIDNIVAG
**** : . *: ** : :** . : : . : :*
Mflv_1907|M.gilvum_PYR-GCK SVWINQGSRISPQGPYGGYKQSGSGRTGGLEGLREFQQVKNIRIGIG---
MSMEG_5815|M.smegmatis_MC2_155 SVWVNQFSQISPQGPYGGYKQSGSGRTGGLDGLHEFQQIKNIRIGMG---
MAV_3553|M.avium_104 SVWVNRHSDIEPQGPYGGYKQSGFGRTGGVEGLHEFLQVKNIRIGMS---
TH_3419|M.thermoresistible__bu GVAVNGFPIVPSAAPFGGVKQSGFGREGGIWGLREFQRTKNVYIGLQ---
Mb2883c|M.bovis_AF2122/97 NLSVNSHSSVRFNTPFGGFKQSGVGRELGPDAPLQFTETKNVFIAVGEEM
Rv2858c|M.tuberculosis_H37Rv NLSVNSHSSVRFNTPFGGFKQSGVGRELGPDAPLQFTETKNVFIAVGEEM
Mvan_0014|M.vanbaalenii_PYR-1 TVWVNDWHMINAMYPFGGVKQSGLGRELGPDALDEYTEPKFIHVDMTDDR
MMAR_3556|M.marinum_M CVWINDHIPIVSEMPHGGVAASGFGKDMSEYSFEEYLTIKHVMSDITGVA
MUL_2789|M.ulcerans_Agy99 CVWINDHIPIVSEMPHGGVAASGFGNDMSEYSFDEYLTIKHVMSDITGVA
MAB_3328|M.abscessus_ATCC_1997 CVWINDHIPIISEMPHGGFGASGFGKDMSDYSLEEYLTVKHVMSDITGTA
MLBr_02573|M.leprae_Br4923 QVFINGMTVSYPELPFGGIKRSGYGRELSTHGIREFCNIKTVWIA-----
: :* *.** ** *. . . :: * :
Mflv_1907|M.gilvum_PYR-GCK ---------------
MSMEG_5815|M.smegmatis_MC2_155 ---------------
MAV_3553|M.avium_104 ---------------
TH_3419|M.thermoresistible__bu ---------------
Mb2883c|M.bovis_AF2122/97 ---------------
Rv2858c|M.tuberculosis_H37Rv ---------------
Mvan_0014|M.vanbaalenii_PYR-1 RKHVYPVVISAAAQG
MMAR_3556|M.marinum_M EKPWHRTIFSTRI--
MUL_2789|M.ulcerans_Agy99 EKPWHRTIFSTRI--
MAB_3328|M.abscessus_ATCC_1997 DKDWHRTIFAKR---
MLBr_02573|M.leprae_Br4923 ---------------