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TQIVDTAGVFVGGEFRRTDRTVPVFEAATGEILGEGPSAAAADIDDAVAAARGEGAAKWRAATVDERADG LKRFATALRGRAKHTSTLVSRENGMPITLSRAVNGAFPSVLVNYYAKLIRSWTAEEVRPALIGHTVVRRE PIGVVGAITPWNYPQALAVMKIAPALAAGCSVVLKASPETSLDALVFAEAAAEAGLPPGVLNVVPGDAAA GAHLVTHPGVDKVAFTGSTNAGRVIGAECGRLIRPVTLELGGKSAAVILDDADLDTTVNGLRTASFVNNG QTCHLSSRILVPAKRYAEFVSAIAELADSLTVGDPLDEKTEIGPLVSERQRERVLDYVQVGRDSGARLVA GGSVPTGLERGWYVAPTVFADVDNSDRLAQEEIFGPVITITAYADDADAVRLANDTEFGLAGTVWSQDSA RATEIARAMHTGSVGVNHYQLDIQSPFGGIKSSGLGRELGPEGLDAYLVTKSIYQADPFPE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4389 | - | - | 100% (482) | aldehyde dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0428 | - | e-111 | 45.09% (468) | betaine-aldehyde dehydrogenase |
| M. gilvum PYR-GCK | Mflv_2502 | - | 7e-90 | 42.11% (475) | aldehyde dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0791 | aldA | 5e-83 | 39.91% (466) | aldehyde dehydrogenase NAD dependant AldA |
| M. tuberculosis H37Rv | Rv0223c | - | 1e-110 | 45.09% (468) | aldehyde dehydrogenase |
| M. leprae Br4923 | MLBr_02573 | gabD1 | 1e-59 | 32.10% (461) | succinic semialdehyde dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4484 | - | 1e-106 | 43.80% (468) | aldehyde dehydrogenase |
| M. marinum M | MMAR_3965 | - | 1e-118 | 45.89% (475) | NAD-dependent aldehyde dehydrogenase |
| M. avium 104 | MAV_3969 | - | 1e-126 | 49.89% (471) | aldehyde dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_0309 | - | 1e-112 | 44.87% (468) | aldehyde dehydrogenase family protein |
| M. thermoresistible (build 8) | TH_3068 | - | 1e-138 | 52.60% (462) | PUTATIVE aldehyde dehydrogenase |
| M. ulcerans Agy99 | MUL_1122 | - | 1e-107 | 44.35% (469) | aldehyde dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0240 | - | 1e-112 | 46.15% (468) | betaine-aldehyde dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4389|M.gilvum_PYR-GCK --------MTQIVDTAG---VFVGGEFRR--TDRTVPVFEAATGEILGEG
TH_3068|M.thermoresistible__bu -------VTMTETEPKG---FWIDGGWAAPATSERIQLIEASTGDPITTV
MMAR_3965|M.marinum_M --------MTADSTHRSFHELFIGGRWCKPTIAEPITVISPHSEEPIGRA
MAV_3969|M.avium_104 --------MDHDAAVR------TDGHGRR---ADVIRVISPHTERPVAEV
Rv0223c|M.tuberculosis_H37Rv ----------MSDSATEYDKLFIGGKWTKPSTSDVIEVRCPATGEYVGKV
MUL_1122|M.ulcerans_Agy99 -----------MGEKTEYDKLFIGGRWTEPSTSEVIEVHCPATGEYVGKV
MAB_4484|M.abscessus_ATCC_1997 --------------MTNYDKLFIGGVWTEPATDQVIEVISPATGQKVGQC
MSMEG_0309|M.smegmatis_MC2_155 MTAMTQTAPAATAATTNWDKLFIGGQWVEPSSSEIIEVFSPATGEKVGQA
Mvan_0240|M.vanbaalenii_PYR-1 ---MTQS----TTFRTEWDKLFIGGKWVEPATSDVIEVHSPATGELVGKV
Mb0791|M.bovis_AF2122/97 ----------MALWGDGISALLIDGKLSD-GRAGTFPTVNPATEEVLGVA
MLBr_02573|M.leprae_Br4923 ---------------------------------MSIATINPATGETVKTF
. . : :
Mflv_4389|M.gilvum_PYR-GCK PSAAAADIDDAVAAARG--EGAAKWRAATVDERADGLKRFATALRGRAKH
TH_3068|M.thermoresistible__bu PAAGPADVDAAVGAARRAFDDPTGWAHWTAEQRRAAITSLADALTSRGEA
MMAR_3965|M.marinum_M PAAGPDEVEAAVAAARRAFDYGP-WPRLDPDERIRKVEELAAIYASHLDD
MAV_3969|M.avium_104 DAATPSDVDAAVAAARAAFDAGT-WSRGGPSHRIAAIRRLADIYDRRRAE
Rv0223c|M.tuberculosis_H37Rv PMAAAADVDAAVAAARAAFDNGP-WPSTPPHERAAVIAAAVKMLAERKDL
MUL_1122|M.ulcerans_Agy99 PLAAAADVDAAVAAARAAFDNGP-WPSTPPKERATVIANALKLLEERKDH
MAB_4484|M.abscessus_ATCC_1997 PLASPADVDAAVSAARRAFDNGP-WPRLTPHERQAVLQKAVSLLESRKDE
MSMEG_0309|M.smegmatis_MC2_155 PLATKADVDAACAAARKAFDEGP-WPRMTPQEREAVLAKATALIEESADE
Mvan_0240|M.vanbaalenii_PYR-1 PLASAADVDAACAAAREAFDNGP-WPHMSPAERGEILGRAVKIMEERADE
Mb0791|M.bovis_AF2122/97 ADADAEDMGRAIEAARRAFDSTD-WSRN-TELRVRCVRQLRDAMQQHVEE
MLBr_02573|M.leprae_Br4923 TPTTQDEVEDAIARAYARFDNYR---HTTFTQRAKWANATADLLEAEANQ
: :: * * : *
Mflv_4389|M.gilvum_PYR-GCK TSTLVSRENGMPITLSRAVNGAFPSVLVNYYAK-LIRSWTAE----EVRP
TH_3068|M.thermoresistible__bu IAKAVSTQNGMPISISSVTEAVMPAMLLNYYAE-LAEQQPVE----EKRT
MMAR_3965|M.marinum_M MADLITAEMGSPHSFSRLGQAAGAAGLMQLALA-AGRNFPWV----ERRQ
MAV_3969|M.avium_104 MAETITAEIGAPISFARRAQVGLPAFMIRAFCD-LAERHPWQ----ETRP
Rv0223c|M.tuberculosis_H37Rv FTKLLAAETGQPPTIIETMHWMGSMGAMNYFAG-AADKVTWT----ETRT
MUL_1122|M.ulcerans_Agy99 FAKLFADETGQPPMTVETMHWMGSIGALNFFAGPAVDQVRWK----EIRN
MAB_4484|M.abscessus_ATCC_1997 ICKAIADETGAPPMVIETLQWMGGFGAIQYYAN-AADAVKWK----ELRN
MSMEG_0309|M.smegmatis_MC2_155 FKTLLKLETGQPQTIVDMMQYGAAMSTLQFYAS-AADKFAWK----DIRD
Mvan_0240|M.vanbaalenii_PYR-1 LKFLLAAETGQPPTIVDMMQYGAAMSSFQFYAG-AADKFTWQ----DIRD
Mb0791|M.bovis_AF2122/97 LRELTISEVGAPRMLTASAQLEGPVGDLSFAAD-TAESYPWKQDLGEASP
MLBr_02573|M.leprae_Br4923 SAALMTLEMG-KTLQSAKDEAMKCAKGFRYYAEKAETLLADEP---AEAA
: * . .
Mflv_4389|M.gilvum_PYR-GCK ALIG-HTVVRREPIGVVGAITPWNYPQALAVMKIAPALAAGCSVVLKASP
TH_3068|M.thermoresistible__bu SFTGGTTLVRRTPVGVVAAIVPWNFPQTLTFFKLAPLLAAGCTAVIKPSP
MMAR_3965|M.marinum_M GIRG-QAHLRRAPVGVVGAIVPWNVPQFLIMPKLIPALIAGCTVIIKPAP
MAV_3969|M.avium_104 GFFGSDVYVRREPVGVVAAIVPWNMPQFLIVTKLIPALLAGCTVVLKPAP
Rv0223c|M.tuberculosis_H37Rv GSYG-QSIVSREPVGVVGAIVAWNVPLFLAVNKIAPALLAGCTIVLKPAA
MUL_1122|M.ulcerans_Agy99 GSYG-QTIVHREPIGVVGAIVAWNVPLFLAINKLGPAPLAGCTVVLKPAA
MAB_4484|M.abscessus_ATCC_1997 GAYG-QTLVTREPAGVVAAIAAWNVPLFLALNKIGPAFLAGCAVVLKPAA
MSMEG_0309|M.smegmatis_MC2_155 GIYG-QTLVLKEPVGVVGAVVAWNVPFFLAANKLGPALLAGCTIVLKPAA
Mvan_0240|M.vanbaalenii_PYR-1 GVYG-QTLVVREPVGVVGAVTAWNVPFFLAANKLGPALLAGCTVVLKPAA
Mb0791|M.bovis_AF2122/97 LGIATRRTLAREAVGVVGAITPWNFPHQINLAKLGPALAAGNTVVLKPAP
MLBr_02573|M.leprae_Br4923 AVGASKALARYQPLGVVLAVMPWNFPLWQTVRFAAPALMAGNVGLLKHAS
. . *** *: .** * * ** ::* :.
Mflv_4389|M.gilvum_PYR-GCK ETSLDALVFAEAAAE-AGLPPGVLNVVPGD-AAAGAHLVTHPGVDKVAFT
TH_3068|M.thermoresistible__bu ETVLDSYLLAEAIEE-SDIPAGVVNIVPGG-RETGAYLVEHPGVDKVAFT
MMAR_3965|M.marinum_M ETPLDALWLAEMIEQ-IELPEGVVSVLPGG-PSVGEALVRHPGVDKIAFT
MAV_3969|M.avium_104 ESPLDALLLAEMISE-ADLPPGAVSVLPGD-AALGAYLAGHRGVDKVSFT
Rv0223c|M.tuberculosis_H37Rv ETPLTANALAEVFAE-VGLPEGVLSVVPGG-IETGQALTSNPDIDMFTFT
MUL_1122|M.ulcerans_Agy99 ETPLTANALAEVFAE-AGLPEGVLSVVPGG-VETGQALTSNPGVDLFTFT
MAB_4484|M.abscessus_ATCC_1997 ETPLSSFILAEVFAE-AGVPEGVLSVVPGG-AETGRALTNNPDVDVFSFT
MSMEG_0309|M.smegmatis_MC2_155 ETPLTTNLMAQKFLE-AGLPEGVLSVVPGG-PETGRALTDNPALDKFTFT
Mvan_0240|M.vanbaalenii_PYR-1 ETPLSVFAMAEMFVE-AGLPEGVLSIVPGG-PETGQALTANPNLDKYTFT
Mb0791|M.bovis_AF2122/97 DTPWCAAALGEIIVEHTDFPPGVVNIVTSSSHALGALLAKDPRVDMISFT
MLBr_02573|M.leprae_Br4923 NVPQCALYLADVIAR-GGFPEDCFQTLLIS-ANGVEAILRDPRVAAATLT
: :.: . .* . .. : . : . : ::*
Mflv_4389|M.gilvum_PYR-GCK GSTNAGRVIGAECGRLIRPVTLELGGKSAAVILDDADLDTTVNGLRTASF
TH_3068|M.thermoresistible__bu GSTAAGRAIGEACGRLIRPVTLELGGKSASIILDDADLPALLEQFFAATL
MMAR_3965|M.marinum_M GSSATGRRIAALCGEGLKRVSLELGGKSAAIILDDADIGKTVAGLKTAGL
MAV_3969|M.avium_104 GSTAAGRAVAAACAANLTKVSLELGGKSAALVLDDAPPDKVAAGVRAASL
Rv0223c|M.tuberculosis_H37Rv GSSAVGREVGRRAAEMLKPCTLELGGKSAAIILEDVDLAAAIPMMVFSGV
MUL_1122|M.ulcerans_Agy99 GSSAVGKEIGRRAAEMLKPCTLELGGKSAAILLEDVDLSTAVPMMVFSGI
MAB_4484|M.abscessus_ATCC_1997 GSTAVGKEIAEIAAKNLKKVTLELGGKSAAIVLEDADLAAALPMLVFSGL
MSMEG_0309|M.smegmatis_MC2_155 GSSAVGKEIGKIAAEKLKPCTLELGGKSAAIILEDADLDSTLPMLLFSGL
Mvan_0240|M.vanbaalenii_PYR-1 GSSGVGKEIAKIAADKLKPCTLELGGKSAAIILEDADLDSTLPMLVFSGL
Mb0791|M.bovis_AF2122/97 GSTATGRAVMADAAATIKKVFLELGGKSAFVVLDDADLAAASAVSAFSAC
MLBr_02573|M.leprae_Br4923 GSEPAGQAVGAIAGNEIKPTVLELGGSDPFIVMPSADLDAAVATAVTGRV
** .*: : .. : *****... ::: .. .
Mflv_4389|M.gilvum_PYR-GCK VNNGQTCHLSSRILVPAKRYAEFVSAIAELADSLTVGDPLDEKTEIGPLV
TH_3068|M.thermoresistible__bu MNNGQTCYLGTRVLAPRSRYAETVDILTDFARSLKVGNALDAATQIGPLA
MMAR_3965|M.marinum_M MNNGQACVAQTRILVSERRHDEVVDALADMMSALQVGDPADEKTDVGPLV
MAV_3969|M.avium_104 SNSGQICNALTRVLVPQARHDDYVDALAAHMGGLRVGDPADPDTDLGPLV
Rv0223c|M.tuberculosis_H37Rv MNAGQGCVNQTRILAPRSRYDEIVAAVTNFVTALPVGPPSDPAAQIGPLI
MUL_1122|M.ulcerans_Agy99 MNTGQACVGQTRILAPRSRYEEIVEAVSAFVQTLPVGPPSDPAAQIGSLI
MAB_4484|M.abscessus_ATCC_1997 MNAGQGCVNQTRVLAPRSRYDEVVDGIVGMVSLMGVGLPDDPATQVGPLI
MSMEG_0309|M.smegmatis_MC2_155 MNSGQACVGQTRILAPRSRYDEVVEKVAAGVAAMQVGVPDDPAAMVGPLI
Mvan_0240|M.vanbaalenii_PYR-1 MNSGQACVGQTRILAPRSRYDEVVEKLAAAAAGMAPGLPDNPAAMIGPLI
Mb0791|M.bovis_AF2122/97 MHAGQGCAITTRLVVPRARYEEAVAIAAATMSSIRPGDPNDPGTVCGPLI
MLBr_02573|M.leprae_Br4923 QNNGQSCIAAKRFIAHADIYDEFVEKFVARMETLRVGDPTDPDTDVGPLA
: ** * .*.:. : : * : * . : : *.*
Mflv_4389|M.gilvum_PYR-GCK SERQRERVLDYVQVGRDSGARLVAGG-SVPTGLERGWYVAPTVFADVDNS
TH_3068|M.thermoresistible__bu TENQQRRVQGYIEKGRAEGGRITTGG-GRPADLDRGWFVEPTVFADVANS
MMAR_3965|M.marinum_M AQRQQRRVRDYIRSGQQEGARIVLGGQDSPQ--DRGWYVRPTLFTDATND
MAV_3969|M.avium_104 SRRQQQRVRDYIRIGQQEGARLVVGGADMPDGLDRGWYVRPTLFAAAGNA
Rv0223c|M.tuberculosis_H37Rv SEKQRTRVEGYIAKGIEEGARLVCGG-GRPEGLDNGFFIQPTVFADVDNK
MUL_1122|M.ulcerans_Agy99 SEKQRARVEGYIAKGIEEGARLVSGG-GRPESLDNGFFVQPTVFADVDNK
MAB_4484|M.abscessus_ATCC_1997 TEKQRTRVEGYIAKGIAEGARLAYGG-KRPEGLDGGYFVQPTIFADVDNS
MSMEG_0309|M.smegmatis_MC2_155 SEKQRERVEGYIKKGIEEGARLVTGG-GRPEGLDSGWFVQPTVFADVDNS
Mvan_0240|M.vanbaalenii_PYR-1 SEKQRDRVEGYIKKGIEEGARVVTGG-GRPEGLDSGWYVQPTVFADVDNS
Mb0791|M.bovis_AF2122/97 SARQRDRVQGYLDLAVAEGGRFACGG-ARPADREVGFYIEPTVIAGLTND
MLBr_02573|M.leprae_Br4923 TESGRAQVEQQVDAAAAAGAVIRCGG---KRPDRPGWFYPPTVITDITKD
: : :* : . *. . ** *:: **::: :
Mflv_4389|M.gilvum_PYR-GCK DRLAQEEIFGPVITITAYADDADAVRLANDTEFGLAGTVWSQDSARATEI
TH_3068|M.thermoresistible__bu HTIAREEIFGPVLTVIPYTDVDEAVAIANDSEFGLGGSVWTSDPERGVQV
MMAR_3965|M.marinum_M MCIAREEIFGPVLTVLTYRDEQDAIRIANDSDYGLAGSVWTADTAHGLEI
MAV_3969|M.avium_104 MRIAREEIFGPVITVIPYRDDDEAVAIANDSDYGLAGSVWSDDTDRALAL
Rv0223c|M.tuberculosis_H37Rv MTIAQEEIFGPVLAIIPYDTEEDAIAIANDSVYGLAGSVWTTDVPKGIKI
MUL_1122|M.ulcerans_Agy99 MTIAQEEIFGPVLVVIPYDTKEDAIKIANDSVYGLAGSVWTSNVPKGIEI
MAB_4484|M.abscessus_ATCC_1997 MTIAQEEIFGPVLSIIAYDSVDEAVKIANDSNYGLAGSVWTTDVQKGLEV
MSMEG_0309|M.smegmatis_MC2_155 MTIAQEEIFGPVLVVIPFEDEDDAVRIANDSVYGLAGSVYTTDHAKGVEI
Mvan_0240|M.vanbaalenii_PYR-1 MTIAQEEIFGPVLAVIPYEDEDDAVRIANDSVYGLAGSVYTTDNDRALKI
Mb0791|M.bovis_AF2122/97 ARVAREEIFGPVLTVIAHDGDDDAVRIANDSPYGLSGTVYGADPQRAARI
MLBr_02573|M.leprae_Br4923 MALYTDEVFGPVASVYCATNIDDAIEIANATPFGLGSNAWTQNESEQRHF
: :*:**** : :*: :** : :**....: : . .
Mflv_4389|M.gilvum_PYR-GCK ARAMHTGSVGVNH-YQLDIQSPFGGIKSSGLGRELGPEGLDAYLVTKSIY
TH_3068|M.thermoresistible__bu ARRVQTGSIGVNN-YTLDFRSPFGGVKASGLGRELGPEGLAAYQQLTSIF
MMAR_3965|M.marinum_M AAAVRTGTYGINM-YTLDISAPFGGFKQSGIGREFGPEGLAEYVELQTVL
MAV_3969|M.avium_104 ATRIHTGTVGVNQGYTMDPFAPFGGVKASGYGRELGPEGLDGYLDTKSIA
Rv0223c|M.tuberculosis_H37Rv SQQIRTGTYGINW-YAFDPGSPFGGYKNSGIGRENGPEGVEHFTQQKSVL
MUL_1122|M.ulcerans_Agy99 SEKIRTGTYAINW-YAFDPCCPFGGYKNSGIGRENGPEGVEHFTQQKSVL
MAB_4484|M.abscessus_ATCC_1997 AAQIRTGTYGINW-YAFDPSCPFGGYKQSGIGRENGPEGIEEYCELKSVL
MSMEG_0309|M.smegmatis_MC2_155 ASKVRTGTYGINM-YAFDPGAPFGGYKNSGIGRECGPEGIAGYCESKSVL
Mvan_0240|M.vanbaalenii_PYR-1 ARRIRTGTYAVNM-YAFDPCAPFGGFKNSGIGRENGWEGIEAYCEPKSIL
Mb0791|M.bovis_AF2122/97 ASRLRVGTVNVNGGVWYCADAPFGGYKQSGIGREMGLLGFEEYLEAKLIA
MLBr_02573|M.leprae_Br4923 IDNIVAGQVFINGMTVSYPELPFGGIKRSGYGRELSTHGIREFCNIKTVW
: .* :* **** * ** *** . *. : :
Mflv_4389|M.gilvum_PYR-GCK QADPFPE---------
TH_3068|M.thermoresistible__bu LA--------------
MMAR_3965|M.marinum_M CSGKMPPLRGFEEPAG
MAV_3969|M.avium_104 VA-----------PSG
Rv0223c|M.tuberculosis_H37Rv LPMGYTVA--------
MUL_1122|M.ulcerans_Agy99 MPMGYTLES-------
MAB_4484|M.abscessus_ATCC_1997 LPMGYTLESI------
MSMEG_0309|M.smegmatis_MC2_155 LPFGYTPE--------
Mvan_0240|M.vanbaalenii_PYR-1 LPFGYTPAT-------
Mb0791|M.bovis_AF2122/97 TAAN------------
MLBr_02573|M.leprae_Br4923 IA--------------
.