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MTATASSPPRTGALLIGTERITAASGGSHQHRYPGTGVPNATIPLAGHSEVDRAVHSAREAQREWISYPV DRRRDLLFGLADLLRDHFAELTELNVHDYGVPISVAGNSVLTERFVRYYAGYPDKLTGASTPVSGAFDVN IVEREPYGVVAVIAPWNGPLVVAGAAVAPALAAGNAVIFKPSELASLAPLRFGELCLEAGLPPGLVNVLP AGPEGGEALVRHPGVGKVHFTGGHATAQQVLRAASDNVTPVTAELGGKSAYLVFADADLDTAAVIAAHQG PLTQAGQSCACASRILVEASVYVSFVEKLVAQVQAATIGDPLRPDVMLGPVITEAAADRILGVIERAVAE KAGDLVTGGRRLGGELASGYFIEPTIFSNVDNRSSLAQTETFGPVASVMPFADEAQAVSLANDSRYGLNA FVATANLERAHRVARRLQAGSVWVNRHSDIEPQGPYGGYKQSGFGRTGGVEGLHEFLQVKNIRIGMS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_3553 | - | - | 100% (487) | aldehyde dehydrogenase |
| M. avium 104 | MAV_1922 | - | 6e-96 | 44.77% (411) | aldehyde dehydrogenase |
| M. avium 104 | MAV_1897 | - | 2e-89 | 40.92% (479) | betaine-aldehyde dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2883c | aldC | 2e-81 | 40.00% (455) | aldehyde dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1907 | - | 0.0 | 66.88% (474) | aldehyde dehydrogenase |
| M. tuberculosis H37Rv | Rv2858c | aldC | 2e-81 | 40.00% (455) | aldehyde dehydrogenase |
| M. leprae Br4923 | MLBr_02573 | gabD1 | 4e-52 | 30.11% (455) | succinic semialdehyde dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3328 | - | 2e-76 | 38.51% (470) | gamma-aminobutyraldehyde dehydrogenase |
| M. marinum M | MMAR_3556 | - | 8e-77 | 38.49% (465) | aldehyde dehydrogenase NAD dependent |
| M. smegmatis MC2 155 | MSMEG_5815 | - | 0.0 | 66.81% (473) | betaine aldehyde dehydrogenase |
| M. thermoresistible (build 8) | TH_3419 | - | 1e-116 | 46.62% (474) | PUTATIVE putative aldehyde dehydrogenase |
| M. ulcerans Agy99 | MUL_2789 | - | 8e-75 | 37.85% (465) | gamma-aminobutyraldehyde dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0240 | - | 3e-81 | 36.21% (486) | betaine-aldehyde dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2883c|M.bovis_AF2122/97 -------------------------MSTTQLINPATEEVLASVDHTDANA
Rv2858c|M.tuberculosis_H37Rv -------------------------MSTTQLINPATEEVLASVDHTDANA
Mflv_1907|M.gilvum_PYR-GCK ---MVADPVTPIGLLIGTDRLTRTSLAPHPHIYPATGAPNATVALAGADE
MSMEG_5815|M.smegmatis_MC2_155 -MTSVVLPGDPIGSLIGDRRVTASSGGLHAHVYPATGLPNATVALAGAAE
MAV_3553|M.avium_104 MTATASSPPRTGALLIGTERITAASGGSHQHRYPGTGVPNATIPLAGHSE
TH_3419|M.thermoresistible__bu VQRTLPDKLPAPRLVIGGGDVISTSGGVYEHHYAATGGVQAEVPLAGPAE
Mvan_0240|M.vanbaalenii_PYR-1 MTQSTTFRTEWDKLFIGGKWVEPATSDVIEVHSPATGELVGKVPLASAAD
MMAR_3556|M.marinum_M ----MTTTVSVAGSWINGA-AHSTGGRQHAVINPATQETIAELALATPAD
MUL_2789|M.ulcerans_Agy99 ----MTTTVSVAGSWINGA-AHSTGGRQHAVINPATQETIAELALATPAD
MAB_3328|M.abscessus_ATCC_1997 --------MSVPSSWINGR-PVATHGDTHRVINPATGEAVADLKLATTAD
MLBr_02573|M.leprae_Br4923 --------------------------MSIATINPATGETVKTFTPTTQDE
..* . :
Mb2883c|M.bovis_AF2122/97 VDDAVQRARAAQR--RWARLAPAQRAAGLRAFAAAVQAHLDELAALEVAN
Rv2858c|M.tuberculosis_H37Rv VDDAVQRARAAQR--RWARLAPAQRAAGLRAFAAAVQAHLDELAALEVAN
Mflv_1907|M.gilvum_PYR-GCK VGMAVSAAREAQR--EWITLGVDQRRDKLIDLADVVREHLGELAELNTLD
MSMEG_5815|M.smegmatis_MC2_155 VDAAVSAAWEAHR--EWVAHPADRRRDMLVGLADVVHEHLDELAGLNVHD
MAV_3553|M.avium_104 VDRAVHSAREAQR--EWISYPVDRRRDLLFGLADLLRDHFAELTELNVHD
TH_3419|M.thermoresistible__bu VDAAVAAARAAFP--AWRDLDLNRRRDILQELARRLVADGERLGAIATLE
Mvan_0240|M.vanbaalenii_PYR-1 VDAACAAAREAFDNGPWPHMSPAERGEILGRAVKIMEERADELKFLLAAE
MMAR_3556|M.marinum_M VDRAVVAARRALP--QWAGVTPAERSAVLAKLADLLEQRAPELIAEEVCQ
MUL_2789|M.ulcerans_Agy99 VDHAVVAARRALP--QWAGVTTAERSAVLAELADLLEQRAPELIAEEVCQ
MAB_3328|M.abscessus_ATCC_1997 VDAAVAAARAAGP--AWASSTPVDRSSVLAKLAAVLSANADTLVADEVAQ
MLBr_02573|M.leprae_Br4923 VEDAIARAYARFD--NYRHTTFTQRAKWANATADLLEAEANQSAALMTLE
* * * : * . : . :
Mb2883c|M.bovis_AF2122/97 SGHP-IVSAEWEAGHVRDVLAFYAASPERLSGRQIPVAGGVDVTFN----
Rv2858c|M.tuberculosis_H37Rv SGHP-IVSAEWEAGHVRDVLAFYAASPERLSGRQIPVAGGVDVTFN----
Mflv_1907|M.gilvum_PYR-GCK YGVP--ISYAGNAVMLDQFLRHFAGYVDKPHGSSTPVSGSSDVNLIER--
MSMEG_5815|M.smegmatis_MC2_155 YAVP--ISNAGTALLLERFLRHFAGYADKPHGTSSPVSGSFDVNIIER--
MAV_3553|M.avium_104 YGVP--ISVAGNSVLTERFVRYYAGYPDKLTGASTPVSGAFDVNIVER--
TH_3419|M.thermoresistible__bu VGTPN-LLASSSSAMAADWFTYYAGWIGRSAGEVVPVPAGGALDYVLD--
Mvan_0240|M.vanbaalenii_PYR-1 TGQPPTIVDMMQYGAAMSSFQFYAGAADKFTWQDIR-DGVYGQTLVVR--
MMAR_3556|M.marinum_M TGKPLRLAEEFDVPGSVDNIRFFAGAARRLPGQATAEYSADHTSSIRR--
MUL_2789|M.ulcerans_Agy99 TGKPLRLAEEFDVPGSVDNIRFFAGAARRLPGQATAEYSADHTSSIRR--
MAB_3328|M.abscessus_ATCC_1997 TGKPVRLASEFDVPGSIDNVEFFAGAARHLEGKATAEYSADHTSSIRR--
MLBr_02573|M.leprae_Br4923 MGKT-LQSAKDEAMKCAKGFRYYAEKAETLLADEPAEAAAVGASKALARY
. . . .:* .
Mb2883c|M.bovis_AF2122/97 EPMGVVGVITPWNFPMVIASWAIAPALAAGNAVLVKPAELTPLTTMRLGE
Rv2858c|M.tuberculosis_H37Rv EPMGVVGVITPWNFPMVIASWAIAPALAAGNAVLVKPAELTPLTTMRLGE
Mflv_1907|M.gilvum_PYR-GCK EPFGAVGVIAPWNGSLVVAASCVAPALAAGNAVVFKPSELAPLAALRFGE
MSMEG_5815|M.smegmatis_MC2_155 EPYGVVGVIAPWNGALAVAASCVAPALAAGNAVVFKPSELAPLAALRFGE
MAV_3553|M.avium_104 EPYGVVAVIAPWNGPLVVAGAAVAPALAAGNAVIFKPSELASLAPLRFGE
TH_3419|M.thermoresistible__bu EPLGVIAAIIPWNGPLISIGMKVAPALAAGNCVVLKPPENAPFSALRFAE
Mvan_0240|M.vanbaalenii_PYR-1 EPVGVVGAVTAWNVPFFLAANKLGPALLAGCTVVLKPAAETPLSVFAMAE
MMAR_3556|M.marinum_M EAIGVVATITPWNYPLQMAVWKVMPALAAGCTVVIKPSELTPLTTLTLAR
MUL_2789|M.ulcerans_Agy99 EAIGVVATITPWNYPLQMAVWKVMPALAAGCTVVIKPSELTPLTTLTLAR
MAB_3328|M.abscessus_ATCC_1997 EAAGVVATITPWNYPLQMAVWKVLPALAAGCTVVIKPSELTPLTTLTLAR
MLBr_02573|M.leprae_Br4923 QPLGVVLAVMPWNFPLWQTVRFAAPALMAGNVGLLKHASNVPQCALYLAD
:. *.: .: .** .: *** ** :.* . .. : :.
Mb2883c|M.bovis_AF2122/97 LAVEAGLDEDLLQVLPGKGTVVGERFVTHPDIRKIVFTGSTEVGKRVMAG
Rv2858c|M.tuberculosis_H37Rv LAVEAGLDEDLLQVLPGKGTVVGERFVTHPDIRKIVFTGSTEVGKRVMAG
Mflv_1907|M.gilvum_PYR-GCK LCLEAGLPPGLVNILPA-AAEGGDALVRHAGIAKIHFTGGGHTARAILRA
MSMEG_5815|M.smegmatis_MC2_155 LCLVAGLPPGLVNILPA-ASDGGDALVRHPGIRKIHFTGGGTTARAVLRA
MAV_3553|M.avium_104 LCLEAGLPPGLVNVLPA-GPEGGEALVRHPGVGKVHFTGGHATAQQVLRA
TH_3419|M.thermoresistible__bu LAAEAGLPPGVLNVIPG-GAEAGSALCSHPGVDKITFTGGGETARKVFAA
Mvan_0240|M.vanbaalenii_PYR-1 MFVEAGLPEGVLSIVPG-GPETGQALTANPNLDKYTFTGSSGVGKEIAKI
MMAR_3556|M.marinum_M LAAEAGLPDGVLNVVTGLGADVGAALAAHPGVDLVTFTGSTAVGRKVMAA
MUL_2789|M.ulcerans_Agy99 LAAEAGLPDGVLNVVTGLGADVGAALAAHPGVDLVTFTGSTAVGRKVMAA
MAB_3328|M.abscessus_ATCC_1997 LAAEAGLPEGVLNVVTGRGDDVGYALASHPDVDLVTFTGSTAVGRKVMAA
MLBr_02573|M.leprae_Br4923 VIARGGFPEDCFQTLLI-SANGVEAILRDPRVAAATLTGSEPAGQAVGAI
: .*: . .. : . : .. : :**. ..: :
Mb2883c|M.bovis_AF2122/97 AAAQVKRVTLELGGKSANIVFHDCDLERAAT-TAPAGVFDNAGQDCCARS
Rv2858c|M.tuberculosis_H37Rv AAAQVKRVTLELGGKSANIVFHDCDLERAAT-TAPAGVFDNAGQDCCARS
Mflv_1907|M.gilvum_PYR-GCK AADNLTPVVTELGGKSANIIFDDADLDIAAVRSAHQGPLMQSGQSCACAS
MSMEG_5815|M.smegmatis_MC2_155 ATDNLTPVVTELGGKSANIIFPDADLGRAAALAAHQGPLMQSGQSCACAS
MAV_3553|M.avium_104 ASDNVTPVTAELGGKSAYLVFADADLDTAAVIAAHQGPLTQAGQSCACAS
TH_3419|M.thermoresistible__bu AAQALTPVVLELGGKSANIVFPDADLDAAATMAVSAGLMMLSGQGCILPT
Mvan_0240|M.vanbaalenii_PYR-1 AADKLKPCTLELGGKSAAIILEDADLDSTLPMLVFSG-LMNSGQACVGQT
MMAR_3556|M.marinum_M AATHGRRTQLELGGKAPFVVFDDADLD-AAIQGAVAGALINSGQDCTAAT
MUL_2789|M.ulcerans_Agy99 AATHGRRTQLELGGKAPFVVFDDADLD-AAIQGAVAGAVINSGQDCTAAT
MAB_3328|M.abscessus_ATCC_1997 AAVHGHRTQLELGGKAPFVVFDDADMD-AAIAGAVAGAIINSGQDCTAAT
MLBr_02573|M.leprae_Br4923 AGNEIKPTVLELGGSDPFIVMPSADLD-AAVATAVTGRVQNNGQSCIAAK
* ****. . ::: ..*: : . * . ** * .
Mb2883c|M.bovis_AF2122/97 RILVQRSVYDRFMELLEPAVHSIVVGDPGSRATEMGPLVSRAHRDKVAGY
Rv2858c|M.tuberculosis_H37Rv RILVQRSVYDRFMELLEPAVHSIVVGDPGSRATEMGPLVSRAHRDKVAGY
Mflv_1907|M.gilvum_PYR-GCK RILVHEAVYEAFTERFIDVVESARIGDPLDPATVFGPVISAAALDRIVGV
MSMEG_5815|M.smegmatis_MC2_155 RILVHESVYDAFTEQFLAVIGAARVGDPFDPEVNFGPVISAGSLDRLLNV
MAV_3553|M.avium_104 RILVEASVYVSFVEKLVAQVQAATIGDPLRPDVMLGPVITEAAADRILGV
TH_3419|M.thermoresistible__bu RLLVHDDVYDEMVTRVVAGADALTVGDPWQPTTMMGPLATAAQLERVTRA
Mvan_0240|M.vanbaalenii_PYR-1 RILAPRSRYDEVVEKLAAAAAGMAPGLPDNPAAMIGPLISEKQRDRVEGY
MMAR_3556|M.marinum_M RAIVARELYHDFVAGVADVMSTVVIGDPMDPDTDIGPLISLAHRDRVADI
MUL_2789|M.ulcerans_Agy99 RAIVARELCHDFVAGVADVMSTVVIGDPMDPDTDIGPLISLAHRDRVADI
MAB_3328|M.abscessus_ATCC_1997 RALVARDLYDDFVAGVGEVMSKVVVGDPLDPDTDIGPLISAAHRAKVSSI
MLBr_02573|M.leprae_Br4923 RFIAHADIYDEFVEKFVARMETLRVGDPTDPDTDVGPLATESGRAQVEQQ
* :. . . * * . .**: : ::
Mb2883c|M.bovis_AF2122/97 VPDDAPVAFRGTAPAG---------RGFWFPPTVLTPK-RGDRTVTDEIF
Rv2858c|M.tuberculosis_H37Rv VPDDAPVAFRGTAPAG---------RGFWFPPTVLTPK-RGDRTVTDEIF
Mflv_1907|M.gilvum_PYR-GCK VGEAVDSGSGDLLAGGRRLTEDSLAAGYYLEPTVLGNVDNTSPLAQTETF
MSMEG_5815|M.smegmatis_MC2_155 VHRAVEERAGELLVGGERLVDGALAGGFYMQPTVFGGVDNRSRLAQVETF
MAV_3553|M.avium_104 IERAVAEKAGDLVTGGRRLG-GELASGYFIEPTIFSNVDNRSSLAQTETF
TH_3419|M.thermoresistible__bu VDSALSDKAGKLLAGGRRPD--GLDAGYFYRPTVFGDVDPASDLAQTEIF
Mvan_0240|M.vanbaalenii_PYR-1 IKKGIEEGAR-VVTGGGRPE--GLDSGWYVQPTVFADVDNSMTIAQEEIF
MMAR_3556|M.marinum_M VAKAPAQGAR-IVVGGRIPD----LAGAFYLPTLLADVGEQSQAYREEIF
MUL_2789|M.ulcerans_Agy99 LAKAPAQGAR-IVVGGRIPD----LAGAFYLPTLLADVGEQSQAYREEIF
MAB_3328|M.abscessus_ATCC_1997 VDRAPAQGGR-IVTGATAPD----LPGSFYRPTLIADVAETSEVYRDEIF
MLBr_02573|M.leprae_Br4923 VDAAAAAGAVIRCGGKRPDR-----PGWFYPPTVITDITKDMALYTDEVF
: . * : **:: * *
Mb2883c|M.bovis_AF2122/97 GPVVVVLTFDDEADAISLANDTAYGLSGSIWTDDLSRALRVARAVESGNL
Rv2858c|M.tuberculosis_H37Rv GPVVVVLTFDDEADAISLANDTAYGLSGSIWTDDLSRALRVARAVESGNL
Mflv_1907|M.gilvum_PYR-GCK GPVVSLIPFADDDGAVRIANDTPYGLNAFVHTRDLTRAHTVARRLQSGSV
MSMEG_5815|M.smegmatis_MC2_155 GPVVSLIRFVDDDEAVRLANDTPYGLNAFVHTADLTRAHTVSRQLEAGSV
MAV_3553|M.avium_104 GPVASVMPFADEAQAVSLANDSRYGLNAFVATANLERAHRVARRLQAGSV
TH_3419|M.thermoresistible__bu GPVLAILRFRSEEEAVELANNTQYGLAAYIHTRDLRRAHVMAAALDAGGV
Mvan_0240|M.vanbaalenii_PYR-1 GPVLAVIPYEDEDDAVRIANDSVYGLAGSVYTTDNDRALKIARRIRTGTY
MMAR_3556|M.marinum_M GPVLTVRAHDGDDDALRQANDTDYGLAASAWTRDVYRAQRASREISAGCV
MUL_2789|M.ulcerans_Agy99 GPVLTVRAHDGDDDALRQANDTDYGLAASAWTRDVYRAQRASREISAGCV
MAB_3328|M.abscessus_ATCC_1997 GPVLTVRPFTDDDDALRQANDTAYGLAASAWTRDVYRAQRASREIRAGCV
MLBr_02573|M.leprae_Br4923 GPVASVYCATNIDDAIEIANATPFGLGSNAWTQNESEQRHFIDNIVAGQV
*** : . *: ** : :** . * : . : :*
Mb2883c|M.bovis_AF2122/97 SVNSHSSVRFNTPFGGFKQSGVGRELGPDAPLQFTETKNVFIAVGEEM--
Rv2858c|M.tuberculosis_H37Rv SVNSHSSVRFNTPFGGFKQSGVGRELGPDAPLQFTETKNVFIAVGEEM--
Mflv_1907|M.gilvum_PYR-GCK WINQGSRISPQGPYGGYKQSGSGRTGGLEGLREFQQVKNIRIGIG-----
MSMEG_5815|M.smegmatis_MC2_155 WVNQFSQISPQGPYGGYKQSGSGRTGGLDGLHEFQQIKNIRIGMG-----
MAV_3553|M.avium_104 WVNRHSDIEPQGPYGGYKQSGFGRTGGVEGLHEFLQVKNIRIGMS-----
TH_3419|M.thermoresistible__bu AVNGFPIVPSAAPFGGVKQSGFGREGGIWGLREFQRTKNVYIGLQ-----
Mvan_0240|M.vanbaalenii_PYR-1 AVN-MYAFDPCAPFGGFKNSGIGRENGWEGIEAYCEPKSILLPFGYTPAT
MMAR_3556|M.marinum_M WINDHIPIVSEMPHGGVAASGFGKDMSEYSFEEYLTIKHVMSDITGVAEK
MUL_2789|M.ulcerans_Agy99 WINDHIPIVSEMPHGGVAASGFGNDMSEYSFDEYLTIKHVMSDITGVAEK
MAB_3328|M.abscessus_ATCC_1997 WINDHIPIISEMPHGGFGASGFGKDMSDYSLEEYLTVKHVMSDITGTADK
MLBr_02573|M.leprae_Br4923 FINGMTVSYPELPFGGIKRSGYGRELSTHGIREFCNIKTVWIA-------
:* *.** ** *. . . : * :
Mb2883c|M.bovis_AF2122/97 -----------
Rv2858c|M.tuberculosis_H37Rv -----------
Mflv_1907|M.gilvum_PYR-GCK -----------
MSMEG_5815|M.smegmatis_MC2_155 -----------
MAV_3553|M.avium_104 -----------
TH_3419|M.thermoresistible__bu -----------
Mvan_0240|M.vanbaalenii_PYR-1 -----------
MMAR_3556|M.marinum_M PWHRTIFSTRI
MUL_2789|M.ulcerans_Agy99 PWHRTIFSTRI
MAB_3328|M.abscessus_ATCC_1997 DWHRTIFAKR-
MLBr_02573|M.leprae_Br4923 -----------