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AVRKKPTRARGAGRSVRVCRMAASVGVRDARRRPKDRKQQIARASAEAFSELGYHAVSMEDIASRVGVTA ASLYRHYSGKYDLFRAAVLNLGEQLVSATAFADDESGDSPEELWERIVAALADAAIKTRASGGLYRWEAR FLQESDQAISNEQIRLVNRRLQRPLSALRPELDSRQRWTVTASVLSAIGSICDHRAKLPVNDMRRLLVSL ARRLRDADLPPVSAREKPGRRAAPSVGPAGEYEAILAAALRLFHEHGFRETGMDDIASAIGLPASTIYRY FSGKSAVLSTIYRRAADRVSGDMGAILAMAPDERTAVGQLIDAYVWRTFAEPELAYVYYAEQLNVPAEDR AALHNIQRSIVEGWARQVVAARPDLSVREARFAVHAGLGLVVDIGRLERFADTESSRRLIGRLLRVLLLP EHA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0013 | - | - | 100% (424) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_0186 | - | e-113 | 52.82% (390) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_1640 | - | 8e-34 | 30.03% (373) | TetR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1998c | - | 7e-35 | 29.21% (380) | transcriptional regulatory protein |
| M. tuberculosis H37Rv | Rv1963c | mce3R | 7e-35 | 29.21% (380) | transcriptional repressor (probably TETR-family) MCE3R |
| M. leprae Br4923 | MLBr_00717 | - | 1e-10 | 28.64% (199) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_4541 | - | 1e-12 | 27.11% (166) | TetR family transcriptional regulator |
| M. marinum M | MMAR_5559 | - | 7e-98 | 46.47% (411) | putative regulatory protein |
| M. avium 104 | MAV_0110 | - | 1e-113 | 53.85% (390) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_0815 | - | 1e-112 | 52.53% (396) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_2795 | - | 1e-104 | 49.88% (405) | PUTATIVE transcriptional regulator, TetR family protein |
| M. ulcerans Agy99 | MUL_3597 | - | 1e-97 | 46.47% (411) | putative regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_0719 | - | 1e-113 | 52.13% (399) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1998c|M.bovis_AF2122/97 --------------------------------------------------
Rv1963c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_0110|M.avium_104 --------------------------------------------------
TH_2795|M.thermoresistible__bu --------------------------------------------------
Mflv_0013|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0815|M.smegmatis_MC2_155 MHAPENSSTGQGAMALRNDTTASRLSMLRGWSMCVLDQMTPTYVNDRSPW
Mvan_0719|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_5559|M.marinum_M --------------------------------------------------
MUL_3597|M.ulcerans_Agy99 --------------------------------------------------
MAB_4541|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00717|M.leprae_Br4923 --------------------------------------------------
Mb1998c|M.bovis_AF2122/97 -----------------------MASVAQPVRRRPKDRKKQILDQAVGLF
Rv1963c|M.tuberculosis_H37Rv -----------------------MASVAQPVRRRPKDRKKQILDQAVGLF
MAV_0110|M.avium_104 ------------------------------MKRRPKDRKVQIARAATDAF
TH_2795|M.thermoresistible__bu -------------------MSAAGSDAHRNGRHRPKNRKALIARASADAF
Mflv_0013|M.gilvum_PYR-GCK MAVRKKPTRARGAGRSVRVCRMAASVGVRDARRRPKDRKQQIARASAEAF
MSMEG_0815|M.smegmatis_MC2_155 VRAFDRIGGPVYRDHMARTPLGPTTSGSVAVRRRPKDRKAQIARASAEAF
Mvan_0719|M.vanbaalenii_PYR-1 ---------------MA------STADDHGIRRRPKDRKAQIARASAEAF
MMAR_5559|M.marinum_M -----MAGTDSGYGEVMSAASVSPGAAADGIRRRPKDRKAQIARAAAESF
MUL_3597|M.ulcerans_Agy99 -----MAGTDSGYGEVMSAASVSPGAAADGIRRRPKDRKAQIARAAAESF
MAB_4541|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00717|M.leprae_Br4923 -------------------------MTTARRRLSPEDRRAELLALGAEVF
Mb1998c|M.bovis_AF2122/97 IERGFHSVKLEDIAEAAGVTARALYRHYDNKQALLAEAIRTGQDQYQSAR
Rv1963c|M.tuberculosis_H37Rv IERGFHSVKLEDIAEAAGVTARALYRHYDNKQALLAEAIRTGQDQYQSAR
MAV_0110|M.avium_104 SELGYHAVSMENIAARVGISAAALYRHSQGKYDLFREVFLALGQQLVDAT
TH_2795|M.thermoresistible__bu GAQGYHAVSMEEIAARVGISPAALYRHSQGKYDLFRDSVLGLGQLLVDAT
Mflv_0013|M.gilvum_PYR-GCK SELGYHAVSMEDIASRVGVTAASLYRHYSGKYDLFRAAVLNLGEQLVSAT
MSMEG_0815|M.smegmatis_MC2_155 SALGYHGVSMEAIASRVGISAAALYRHYSSKYELFRDAVLNLGQQLVDCT
Mvan_0719|M.vanbaalenii_PYR-1 SALGYYGVSMEMIASRVGISAAALYRHYSSKYELFRDAVLNLGQQLVDGT
MMAR_5559|M.marinum_M SAQGYHAVSMETIAAKVGVSAPALYRHYAGKYELFRGAVLALSQQLVDCT
MUL_3597|M.ulcerans_Agy99 SAQGYHAVSMETIAAKVGVSAPALYRHYAGKYELFRGAVLALSQQLVDCT
MAB_4541|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00717|M.leprae_Br4923 GKRPYDEVRIDEIAERAGVSRALMYHYFPDKRAFFAAVVKDEADRLYAAT
Mb1998c|M.bovis_AF2122/97 RLTEG-----ETEPTPRPLNADLEDLIAAAVASRALTVLWQREARYLNED
Rv1963c|M.tuberculosis_H37Rv RLTEG-----ETEPTPRPLNADLEDLIAAAVASRALTVLWQREARYLNED
MAV_0110|M.avium_104 AFADDLP---ADADPGETLSALTTALIDTTIVNRTAGGLYRWEGRYLRGD
TH_2795|M.thermoresistible__bu DFGDDVD---PAEDPHGLLAALVDALINVTIANRTAGGLYRWEGRYLREP
Mflv_0013|M.gilvum_PYR-GCK AFADDES---GDS-PEELWERIVAALADAAIKTRASGGLYRWEARFLQES
MSMEG_0815|M.smegmatis_MC2_155 AFADTADAPENSEDAREQLRLLAAALTDTSLANRESGGLYRWEARYLNED
Mvan_0719|M.vanbaalenii_PYR-1 AGIE-------GDDPQVVLDRLVSALTDTALANRGSGGLYRWEGRYLRGD
MMAR_5559|M.marinum_M QLDD-------SDDPAQLLDGLIASLIEVTLDNRLSGGLYRWQSRYLRAE
MUL_3597|M.ulcerans_Agy99 QLDD-------SDDPAQLLARLIASLIEVTLDNRLSGGLYRWQSRYLRAE
MAB_4541|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00717|M.leprae_Br4923 NIPP----------------------------------------------
Mb1998c|M.bovis_AF2122/97 DRTAVRRRINAIVAGMRDSVLLEVPDLSPQHSELRAWAVSSTLTSLGRHS
Rv1963c|M.tuberculosis_H37Rv DRTAVRRRINAIVAGMRDSVLLEVPDLSPQHSELRAWAVSSTLTSLGRHS
MAV_0110|M.avium_104 DQRKLAEQIKVINRRLQRPLIKLRPKLTSRQRWILSAATLSVIGSITDHR
TH_2795|M.thermoresistible__bu DRDILERQIQLVNRRLQRPLRVMRPELGSRQRWTLTASALSAIGSIADHS
Mflv_0013|M.gilvum_PYR-GCK DQAISNEQIRLVNRRLQRPLSALRPELDSRQRWTVTASVLSAIGSICDHR
MSMEG_0815|M.smegmatis_MC2_155 DQAALNAQMRTVHHRIQRPLQQLRPELISRERWMLSTATLSVIGSVVDHR
Mvan_0719|M.vanbaalenii_PYR-1 DQATLLQQIHTVHHRIHRPLSALRPELTARQRSTLSTAALSIVGSIVDHR
MMAR_5559|M.marinum_M DQAAVADVLKVVNRRIQKPLTVIRPSLRPAQRWMLSAGVLSVIGSIVDHP
MUL_3597|M.ulcerans_Agy99 DQAAVADVLKVVNRRIQKPLTVIRASLRPAQRWMLSAGVLSVIGSIVDHP
MAB_4541|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00717|M.leprae_Br4923 --------------------------------------------------
Mb1998c|M.bovis_AF2122/97 LSLPGEELKKLLYQACMAAARTPPVCELPPLPAGDAARDEADVLFSRYET
Rv1963c|M.tuberculosis_H37Rv LSLPGEELKKLLYQACMAAARTPPVCELPPLPAGDAARDEADVLFSRYET
MAV_0110|M.avium_104 SRLGNAEIRATLSDIAAAVL-KAELPTQRGRGSEPARAPTLTSAAGSYEL
TH_2795|M.thermoresistible__bu APLSVPGIRSFLASVVEDLL-AADLPTPRRRRAPDPPPPRVTLAAGIYEC
Mflv_0013|M.gilvum_PYR-GCK AKLPVNDMRRLLVSLARRLR-DADLPPVSAREKPGRRAAPSVGPAGEYEA
MSMEG_0815|M.smegmatis_MC2_155 GKLPAGQIREVLGEIVESVL-AADLPELPELGAAAAPATTPVVSAAKYEA
Mvan_0719|M.vanbaalenii_PYR-1 AKLPAAQVHALIAQISRAVL-GAELSADPPRYPPDVVPARPTAEPSKYEA
MMAR_5559|M.marinum_M ARLAADEIRALLGEAASAIV-CAELPEPGDVAVRKASWRIFAEDASVYET
MUL_3597|M.ulcerans_Agy99 ARLAADEIRALLGEAASAIV-CAELPEPGDVAVRKASWRIFAEDASVYET
MAB_4541|M.abscessus_ATCC_1997 ---------------MTNLIPESETPNKRERAKADRR-----------DQ
MLBr_00717|M.leprae_Br4923 --------------------------------------------------
Mb1998c|M.bovis_AF2122/97 LLAAGARLFRAQGYPAVNTSEIGKGAGIAGPGLYRSFSSKQAILDALIRR
Rv1963c|M.tuberculosis_H37Rv LLAAGARLFRAQGYPAVNTSEIGKGAGIAGPGLYRSFSSKQAILDALIRR
MAV_0110|M.avium_104 LLHESMRLFNERGYRETGMEDIAAAVGIPVASIYQYFPGKAAILAVYYRR
TH_2795|M.thermoresistible__bu VLHESIQMFHERGFRDTGMDDIAAAVGVPTTGIYRYFPGKADILAASLRR
Mflv_0013|M.gilvum_PYR-GCK ILAAALRLFHEHGFRETGMDDIASAIGLPASTIYRYFSGKSAVLSTIYRR
MSMEG_0815|M.smegmatis_MC2_155 LLNESMRLFNKNGYRDTTMEDIAAAVGMPASGIYRYFSGKADILAAGFRR
Mvan_0719|M.vanbaalenii_PYR-1 LLTASMQLFDRNGYRDTTMEDIASAVGMPTSGIYKYFSGKSDILATIFRR
MMAR_5559|M.marinum_M LLHASMVLFKDRGYAQTSMAQIASASGVPVSGIYRYFSGKCEILATGLRR
MUL_3597|M.ulcerans_Agy99 LLHASMVLFKDRGYAQTSMAQIASAAGVPVSGIYRYFSGKCEILATGLRR
MAB_4541|M.abscessus_ATCC_1997 LLRAAARLLAMRGYARVRLEDLGSAVGISGPAIYRHFPNKEALLVDLLTD
MLBr_00717|M.leprae_Br4923 --PAGLTMFEEVRVGVLAYMAYHKQNPEAAWAAYVGLGRSDPVLLGIDDE
. :: . * : . :*
Mb1998c|M.bovis_AF2122/97 LDEWRCLECIRALRANQQAAQRLRGLVQGHVRISLDAPDLVAVSVTELSH
Rv1963c|M.tuberculosis_H37Rv LDEWRCLECIRALRANQQAAQRLRGLVQGHVRISLDAPDLVAVSVTELSH
MAV_0110|M.avium_104 AADQLSADLSSILATSSDPEQALARLIEAYVTRSFANPELACVYYTERHN
TH_2795|M.thermoresistible__bu AVDRTSQDLARITAATADPHTALTQLVRAYLDQFRERPALAYVQHTERRN
Mflv_0013|M.gilvum_PYR-GCK AADRVSGDMGAILAMAPDERTAVGQLIDAYVWRTFAEPELAYVYYAEQLN
MSMEG_0815|M.smegmatis_MC2_155 AADRLSADMAEILAAGGEPEDVLAALIDDYVTRSFDRPELEHVYYTERLN
Mvan_0719|M.vanbaalenii_PYR-1 AADRVSAELASVVATMSDPEEALTAVIDGYVQRSFDQPELECVYYSERLN
MMAR_5559|M.marinum_M AADRVSGQLSPIVGALTEPRQALTLLIDAYVATSFANPELAAVYYTERAN
MUL_3597|M.ulcerans_Agy99 AADRVSGQLSPIVGALTEPRQALTLLIDAYVATSFANPELAAVYYTERAN
MAB_4541|M.abscessus_ATCC_1997 VSRRLLEGGMTVAAAASSPAEALDGLIDFHLDFALNESDLIRVQDRDLDS
MLBr_00717|M.leprae_Br4923 AKNRQMEHIMSRIGD--------------------------VVSVVPESK
*
Mb1998c|M.bovis_AF2122/97 ASVEVRDGYLRNQGDREAVWIDLIGKLVPATSVAQGRLLVAAAISFIEDV
Rv1963c|M.tuberculosis_H37Rv ASVEVRDGYLRNQGDREAVWIDLIGKLVPATSVAQGRLLVAAAISFIEDV
MAV_0110|M.avium_104 LPETDAVLLYNIQRSTVESWARLAVAARPELTLGRARYAVHAAFALAVDI
TH_2795|M.thermoresistible__bu LPESEARVVERIEQSLVDSWARLVTEQRPELTVATARYAVYCAFALVTDL
Mflv_0013|M.gilvum_PYR-GCK VPAEDRAALHNIQRSIVEGWARQVVAARPDLSVREARFAVHAGLGLVVDI
MSMEG_0815|M.smegmatis_MC2_155 MTPADQKILRDLQRSAVESWVNVVMPVRPHWSAGQARFAVHAAMALVIDL
Mvan_0719|M.vanbaalenii_PYR-1 MSAADQRIVRDLQRSTVESWVELVVAVRPEWSAAEARFAVHAAMALVVDL
MMAR_5559|M.marinum_M LTPADQMLLHNIQLSTIDSWVRLLTSVRPSLSATRARFLVHAAMALVVDL
MUL_3597|M.ulcerans_Agy99 LTPADQMLLHNIQLSTIDSWVRLLTSVRPSLSATRARFLVHAAMALVVDL
MAB_4541|M.abscessus_ATCC_1997 LPENARRQVRQYQRRYVEAWVQVLCRSQQGLDESDARIKAHAAFGLMNST
MLBr_00717|M.leprae_Br4923 LHPDIERDLRVIVHGWLAFTFEVCRQRIMDPSTDADRLADSCAHALLDAI
* .. .:
Mb1998c|M.bovis_AF2122/97 ARTWHLTRYAG----VADEISGLALAILTSGAGNLLRA------------
Rv1963c|M.tuberculosis_H37Rv ARTWHLTRYAG----VADEISGLALAILTSGAGNLLRA------------
MAV_0110|M.avium_104 GRLVYPNTGA----PASTTVRRLMEVTVLGRPAAASRDGLRGAGRQRR--
TH_2795|M.thermoresistible__bu GRLTDSHASP----SAQAAVQHLMEVVLLGG-------------------
Mflv_0013|M.gilvum_PYR-GCK GRLERFADTE----SSRRLIGRLLRVLLLPEHA-----------------
MSMEG_0815|M.smegmatis_MC2_155 GRLMGYRNSE----QARAVVSTMVDLVLLGRYRLRTALPAR---------
Mvan_0719|M.vanbaalenii_PYR-1 GRLMRYENSE----EARETVSGLVDMTLLGRYRLRATLPAK---------
MMAR_5559|M.marinum_M GRMVDPQDSAGQSAYVQACVRELMELTLFGPTPAQADAAPPPPPGRRRRG
MUL_3597|M.ulcerans_Agy99 GRMVDPQDSAGQSAYVQACVRELMELTLFGPTPAQADAAPPPPPGRRRRG
MAB_4541|M.abscessus_ATCC_1997 PYSAGRSAPS----QTRTVLRQMVVAALRS--------------------
MLBr_00717|M.leprae_Br4923 ARVP-------------EISKELADAMAIARQPPQ---------------
:
Mb1998c|M.bovis_AF2122/97 ----------
Rv1963c|M.tuberculosis_H37Rv ----------
MAV_0110|M.avium_104 ----------
TH_2795|M.thermoresistible__bu ----------
Mflv_0013|M.gilvum_PYR-GCK ----------
MSMEG_0815|M.smegmatis_MC2_155 ----------
Mvan_0719|M.vanbaalenii_PYR-1 ----------
MMAR_5559|M.marinum_M SSNPGHVARR
MUL_3597|M.ulcerans_Agy99 SSNPGHVARR
MAB_4541|M.abscessus_ATCC_1997 ----------
MLBr_00717|M.leprae_Br4923 ----------