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MDSVVAPVRRRPKDRKQQILEQAVGLFIDRGFHSVKLEDIAEAAGVTARALYRHYDNKQALLAEAIRTGQ DQYQSARRLTEGEQEPTPRPLSVDLPDLIAAAVASRSLTVLSQREARYLNDADRIEVRRRINAIVAGMRE SVLLEVPGLSPAHSELRAWAVSSTLTSLGRHSLTLPAEELKERLYQACMAAARTPPVCELEPLGTAAGGR DGQDVLFSRYETLLATGARLFRAQGYPAVSTSEIGKGAGIAGPGLYRSFSSKQAILDALIRRLDEWRSLE CIRALRANRQAAQRLRGLVEGHVRISLDAPDLVAVCATELNHASGDVRDGYLRNQADRDTLWIDLIGELV PQTSSVEARLLVAAAISFIEDVARTWHLTRYAAVADEITEIALSILTSRS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_2880 | mce3R | - | 100% (400) | TetR family transcriptional regulator |
| M. ulcerans Agy99 | MUL_3597 | - | 1e-33 | 30.56% (373) | putative regulatory protein |
| M. ulcerans Agy99 | MUL_3785 | - | 1e-15 | 30.72% (166) | putative regulatory protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1998c | - | 0.0 | 85.68% (398) | transcriptional regulatory protein |
| M. gilvum PYR-GCK | Mflv_0186 | - | 4e-37 | 30.53% (380) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv1963c | mce3R | 0.0 | 85.68% (398) | transcriptional repressor (probably TETR-family) MCE3R |
| M. leprae Br4923 | MLBr_00717 | - | 2e-06 | 28.17% (71) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_2061c | - | 2e-12 | 34.43% (183) | TetR family transcriptional regulator |
| M. marinum M | MMAR_2873 | mce3R | 0.0 | 99.25% (400) | TetR family transcriptional regulator |
| M. avium 104 | MAV_0110 | - | 2e-27 | 27.89% (380) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_0815 | - | 9e-36 | 31.12% (376) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_2795 | - | 8e-22 | 25.53% (380) | PUTATIVE transcriptional regulator, TetR family protein |
| M. vanbaalenii PYR-1 | Mvan_3994 | - | 1e-155 | 73.21% (392) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_2880|M.ulcerans_Agy99 --------------------------------------------------
MMAR_2873|M.marinum_M --------------------------------------------------
Mb1998c|M.bovis_AF2122/97 --------------------------------------------------
Rv1963c|M.tuberculosis_H37Rv --------------------------------------------------
Mvan_3994|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_0110|M.avium_104 --------------------------------------------------
TH_2795|M.thermoresistible__bu --------------------------------------------------
Mflv_0186|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0815|M.smegmatis_MC2_155 MHAPENSSTGQGAMALRNDTTASRLSMLRGWSMCVLDQMTPTYVNDRSPW
MAB_2061c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00717|M.leprae_Br4923 --------------------------------------------------
MUL_2880|M.ulcerans_Agy99 -----------------------MDSVVAPVRRRPKDRKQQILEQAVGLF
MMAR_2873|M.marinum_M -----------------------MDSVVAPVRRRPKDRKQQILEQAVGLF
Mb1998c|M.bovis_AF2122/97 -----------------------MASVAQPVRRRPKDRKKQILDQAVGLF
Rv1963c|M.tuberculosis_H37Rv -----------------------MASVAQPVRRRPKDRKKQILDQAVGLF
Mvan_3994|M.vanbaalenii_PYR-1 -----------------------------MVRRRPKDRKQQILDQAVRLF
MAV_0110|M.avium_104 ------------------------------MKRRPKDRKVQIARAATDAF
TH_2795|M.thermoresistible__bu ---------------MSAAG----SDAHRNGRHRPKNRKALIARASADAF
Mflv_0186|M.gilvum_PYR-GCK ---------------MAHS------AEDNGIRRRPKDRKAQIARASAEAF
MSMEG_0815|M.smegmatis_MC2_155 VRAFDRIGGPVYRDHMARTPLGPTTSGSVAVRRRPKDRKAQIARASAEAF
MAB_2061c|M.abscessus_ATCC_199 ---------------------------------MAGLRRKLLLEAAADLF
MLBr_00717|M.leprae_Br4923 -------------------------MTTARRRLSPEDRRAELLALGAEVF
. *: : .. *
MUL_2880|M.ulcerans_Agy99 IDRGFHSVKLEDIAEAAGVTARALYRHYDNKQALLAEAIRTGQDQYQSAR
MMAR_2873|M.marinum_M IDRGFHSVKLEDIAEAAGVTARALYRHYDNKQALLAEAIRTGQDQYQSAR
Mb1998c|M.bovis_AF2122/97 IERGFHSVKLEDIAEAAGVTARALYRHYDNKQALLAEAIRTGQDQYQSAR
Rv1963c|M.tuberculosis_H37Rv IERGFHSVKLEDIAEAAGVTARALYRHYDNKQALLAEAIRTGQDQYQSAR
Mvan_3994|M.vanbaalenii_PYR-1 IDRGFHSVKLEDIAEASGVTARALYRHYDNKQALLAAAIRAGQEQYQSAR
MAV_0110|M.avium_104 SELGYHAVSMENIAARVGISAAALYRHSQGKYDLFREVFLALGQQLVDAT
TH_2795|M.thermoresistible__bu GAQGYHAVSMEEIAARVGISPAALYRHSQGKYDLFRDSVLGLGQLLVDAT
Mflv_0186|M.gilvum_PYR-GCK SELGYHGVSMEMIASRVGISAAALYRHYAGKYELFRDAVLNLGQQLVDGT
MSMEG_0815|M.smegmatis_MC2_155 SALGYHGVSMEAIASRVGISAAALYRHYSSKYELFRDAVLNLGQQLVDCT
MAB_2061c|M.abscessus_ATCC_199 ARQGFHAVGIDDIGAAAGVSGPAVYRHFQNKDAILRELCDAAMTELLAGA
MLBr_00717|M.leprae_Br4923 GKRPYDEVRIDEIAERAGVSRALMYHYFPDKRAFFAAVVKDEADRLYAAT
:. * :: *. *:: :*:: .* ::
MUL_2880|M.ulcerans_Agy99 RLTEGEQEPTPR-----PLSVDLPDLIAAAVASRSLTVLSQREARYLNDA
MMAR_2873|M.marinum_M RLTEGEQEPTPR-----PLSVDLPDLIAAAVASRSLTVLWQREARYLNDA
Mb1998c|M.bovis_AF2122/97 RLTEGETEPTPR-----PLNADLEDLIAAAVASRALTVLWQREARYLNED
Rv1963c|M.tuberculosis_H37Rv RLTEGETEPTPR-----PLNADLEDLIAAAVASRALTVLWQREARYLNED
Mvan_3994|M.vanbaalenii_PYR-1 PPAGGEAESPHR-----ALSAELPDLVTAAVASRSLTVLWQREARYLDAA
MAV_0110|M.avium_104 AFADDLPADADP---GETLSALTTALIDTTIVNRTAGGLYRWEGRYLRGD
TH_2795|M.thermoresistible__bu DFGDDVDPAEDP---HGLLAALVDALINVTIANRTAGGLYRWEGRYLREP
Mflv_0186|M.gilvum_PYR-GCK AGID-GDDPE------VVLDRLVSALIDIALANRSSGGLYRWERRYLRGD
MSMEG_0815|M.smegmatis_MC2_155 AFADTADAPENSEDAREQLRLLAAALTDTSLANRESGGLYRWEARYLNED
MAB_2061c|M.abscessus_ATCC_199 RRATTAGTPTEV------LHALVDLHAAFGARRRGLLAVYAREHRSLSPL
MLBr_00717|M.leprae_Br4923 NIPPPAGLTMFEEVRVGVLAYMAYHKQNPEAAWAAYVGLGRSDPVLLGID
* : : *
MUL_2880|M.ulcerans_Agy99 DRIEVRRRINAIVAGMRESVLLEVPGLSPAHSELRAWAVSSTLTSLGRHS
MMAR_2873|M.marinum_M DRIEVRRRINAIVAGMRESVLLEVPGLSPAHSELRAWAVSSTLTSLGRHS
Mb1998c|M.bovis_AF2122/97 DRTAVRRRINAIVAGMRDSVLLEVPDLSPQHSELRAWAVSSTLTSLGRHS
Rv1963c|M.tuberculosis_H37Rv DRTAVRRRINAIVAGMRDSVLLEVPDLSPQHSELRAWAVSSTLTSLGRHS
Mvan_3994|M.vanbaalenii_PYR-1 ERAEVRRRIHAIVTGIEQSLRVEVPDLSPRHAELRAWAVSSVITSLGRHS
MAV_0110|M.avium_104 DQRKLAEQIKVINRRLQRPLIKLRPKLTSRQRWILSAATLSVIGSITDHR
TH_2795|M.thermoresistible__bu DRDILERQIQLVNRRLQRPLRVMRPELGSRQRWTLTASALSAIGSIADHS
Mflv_0186|M.gilvum_PYR-GCK DQAELLQQLRTVHHRLQTPVSILRPELTARQRSTLSTAVLSIVGSIVDHR
MSMEG_0815|M.smegmatis_MC2_155 DQAALNAQMRTVHHRIQRPLQQLRPELISRERWMLSTATLSVIGSVVDHR
MAB_2061c|M.abscessus_ATCC_199 ATRALRRRQHSYESFWVEALVRARGDLDRE--------------------
MLBr_00717|M.leprae_Br4923 DEAKNRQMEHIMSRIGDVVSVVPESKLHPDIER-----------------
. *
MUL_2880|M.ulcerans_Agy99 LTLPAEELKERL--YQACMAAARTPPVCELEPLGTAAGGRDGQDVLFSRY
MMAR_2873|M.marinum_M LTLPAEELKERL--YQACMAAARTPPVCELEPLGTAAGGRDGQDVLFSRY
Mb1998c|M.bovis_AF2122/97 LSLPGEELKKLL--YQACMAAARTPPVCELPPLPAGDAARDEADVLFSRY
Rv1963c|M.tuberculosis_H37Rv LSLPGEELKKLL--YQACMAAARTPPVCELPPLPAGDAARDEADVLFSRY
Mvan_3994|M.vanbaalenii_PYR-1 LTLAKDELHRLL--FGACMAVARTPPVGPLEPDVAPP---NDERALFSRH
MAV_0110|M.avium_104 SRLGNAEIRATLSDIAAAVLKAELPTQRGRGSEPARAPTLTSAAG---SY
TH_2795|M.thermoresistible__bu APLSVPGIRSFLASVVEDLLAADLPTPRRRRAPDPPPPRVTLAAG---IY
Mflv_0186|M.gilvum_PYR-GCK AKLPAAQIHRVLTQVARAILSTELPDAAPP-ATPAPAAERIRSAAESSKY
MSMEG_0815|M.smegmatis_MC2_155 GKLPAGQIREVLGEIVESVLAADLPELPELGAAAAPATTPVVSAA---KY
MAB_2061c|M.abscessus_ATCC_199 ------------------------------------------------RA
MLBr_00717|M.leprae_Br4923 -------------------------------------------------D
MUL_2880|M.ulcerans_Agy99 ETLLATGARLFRAQGYPAVSTSEIGKGAGIAGPGLYRSFSSKQAILDALI
MMAR_2873|M.marinum_M ETLLATGARLFRAQGYPAVSTSEIGKGAGIAGPGLYRSFSSKQAILDALI
Mb1998c|M.bovis_AF2122/97 ETLLAAGARLFRAQGYPAVNTSEIGKGAGIAGPGLYRSFSSKQAILDALI
Rv1963c|M.tuberculosis_H37Rv ETLLAAGARLFRAQGYPAVNTSEIGKGAGIAGPGLYRSFSSKQAILDALI
Mvan_3994|M.vanbaalenii_PYR-1 ETLLAAGARLFRAQGYPAVSTSEIGKGVGIAGPGLYRSFSSKQAILDALI
MAV_0110|M.avium_104 ELLLHESMRLFNERGYRETGMEDIAAAVGIPVASIYQYFPGKAAILAVYY
TH_2795|M.thermoresistible__bu ECVLHESIQMFHERGFRDTGMDDIAAAVGVPTTGIYRYFPGKADILAASL
Mflv_0186|M.gilvum_PYR-GCK EALLAESMRLFNLNGYRDTSMEEIASAVGMPASGIYKYFSGKNDILAAIF
MSMEG_0815|M.smegmatis_MC2_155 EALLNESMRLFNKNGYRDTTMEDIAAAVGMPASGIYRYFSGKADILAAGF
MAB_2061c|M.abscessus_ATCC_199 QGLVAAVLSLLNASAYMPASLDDATIEAMLAAAAVAALFS----------
MLBr_00717|M.leprae_Br4923 LRVIVHGWLAFTFEVCRQRIMDPSTDADRLADSCAHALLDAIAR------
:: : . :. . :
MUL_2880|M.ulcerans_Agy99 RRLDEWRSLECIRALRANRQAAQRLRGLVEGHVRISLDAPDLVAVCATEL
MMAR_2873|M.marinum_M RRLDEWRSLECIRALRANRQAAQRLRGLVEGHVRISLDAPDLVAVCVTEL
Mb1998c|M.bovis_AF2122/97 RRLDEWRCLECIRALRANQQAAQRLRGLVQGHVRISLDAPDLVAVSVTEL
Rv1963c|M.tuberculosis_H37Rv RRLDEWRCLECIRALRANQQAAQRLRGLVQGHVRISLDAPDLVAVSVTEL
Mvan_3994|M.vanbaalenii_PYR-1 TRLDEWWSLACIRVLRTDTEAAECLRALVAGRVQISLDDPDLVAMSVTEL
MAV_0110|M.avium_104 RRAADQLSADLSSILATSSDPEQALARLIEAYVTRSFANPELACVYYTER
TH_2795|M.thermoresistible__bu RRAVDRTSQDLARITAATADPHTALTQLVRAYLDQFRERPALAYVQHTER
Mflv_0186|M.gilvum_PYR-GCK RRASDRVSAETAEIVSTVPDPQEALAAVIDAYVTRAFGQPEMESLYYSER
MSMEG_0815|M.smegmatis_MC2_155 RRAADRLSADMAEILAAGGEPEDVLAALIDDYVTRSFDRPELEHVYYTER
MAB_2061c|M.abscessus_ATCC_199 RAVTQQVDGAPHRI------------------------------------
MLBr_00717|M.leprae_Br4923 ---VPEISKELADAMAIARQPPQ---------------------------
MUL_2880|M.ulcerans_Agy99 NHASGDVRDGYLRNQADRDTLWIDLIGELVPQTSSVEARLLVAAAISFIE
MMAR_2873|M.marinum_M NHASGDVRDGYLRNQADRDTLWIDLIGELVPQTSSVEARLLVAAAISFIE
Mb1998c|M.bovis_AF2122/97 SHASVEVRDGYLRNQGDREAVWIDLIGKLVPATSVAQGRLLVAAAISFIE
Rv1963c|M.tuberculosis_H37Rv SHASVEVRDGYLRNQGDREAVWIDLIGKLVPATSVAQGRLLVAAAISFIE
Mvan_3994|M.vanbaalenii_PYR-1 SFASEEVRDRYMRNQADREAVWIELIGKLVPQTAPAEARLLVGAANSFID
MAV_0110|M.avium_104 HNLPETDAVLLYNIQRSTVESWARLAVAARPELTLGRARYAVHAAFALAV
TH_2795|M.thermoresistible__bu RNLPESEARVVERIEQSLVDSWARLVTEQRPELTVATARYAVYCAFALVT
Mflv_0186|M.gilvum_PYR-GCK LNMSPSDQRIVRDLQRSTVESWVELVAAVRPDWTPGEARFAVHAAMALVI
MSMEG_0815|M.smegmatis_MC2_155 LNMTPADQKILRDLQRSAVESWVNVVMPVRPHWSAGQARFAVHAAMALVI
MAB_2061c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00717|M.leprae_Br4923 --------------------------------------------------
MUL_2880|M.ulcerans_Agy99 DVARTWHLTRYAAVADEITEIALSILTSRS----------------
MMAR_2873|M.marinum_M DVARTWHLTRYAAVADEITAIALSILTSRS----------------
Mb1998c|M.bovis_AF2122/97 DVARTWHLTRYAGVADEISGLALAILTSGAGNLLRA----------
Rv1963c|M.tuberculosis_H37Rv DVARTWHLTRYAGVADEISGLALAILTSGAGNLLRA----------
Mvan_3994|M.vanbaalenii_PYR-1 DAVRTWHLTRYAGIADEITAITLSILTSRQ----------------
MAV_0110|M.avium_104 DIGRLVYPNTGAPASTTVRRLMEVTVLGRPAAASRDGLRGAGRQRR
TH_2795|M.thermoresistible__bu DLGRLTDSHASPSAQAAVQHLMEVVLLGG-----------------
Mflv_0186|M.gilvum_PYR-GCK DVGRLVHYAASDEARDTVEGLVDAALRGSYRLRATLPSM-------
MSMEG_0815|M.smegmatis_MC2_155 DLGRLMGYRNSEQARAVVSTMVDLVLLGRYRLRTALPAR-------
MAB_2061c|M.abscessus_ATCC_199 ----------------------------------------------
MLBr_00717|M.leprae_Br4923 ----------------------------------------------