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VDKVFTYSGGGAAPAGLDRPATIGAGRGARGWVAVALATFAIAWGGNEFTPLLVMYRLDDGFSALTVDLL LFAYVLGIVPALLIGGPMSDRFGRRPLMLPAPLLAAIGSLILAVGADSAWLLGVGRVFSGLALGLAMAVG GSWIKELSSPPWDVGDAGARRAAMSLTAGFGLGAAVAGVLAQWGPAPTVLPYAINVAMAVAAAVLLLSAP ETRARSVSVRPAANSWWSDLAIPGASHRRFLLVVVPLAPWVFGAGASAYAVLPALMTEHVAAAPIAFSAL LCAVTLGVAFGVQHLGRSLLSGGALGVVVALGLVAAGMALAAWASASLTIWATVVAAAVLGAGYGMALVA GLQEIQRIATPDDLAGLTAVFYSLCYLGFGVPAAMVFLSDYASYPSMFGFGAVAAVGCLAVAVTGLRRTP AIS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1534 | - | - | 100% (423) | major facilitator transporter |
| M. gilvum PYR-GCK | Mflv_1450 | - | 2e-22 | 27.30% (381) | major facilitator transporter |
| M. gilvum PYR-GCK | Mflv_0301 | - | 1e-12 | 27.98% (436) | EmrB/QacA family drug resistance transporter |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0865 | - | 1e-08 | 26.58% (301) | integral membrane protein |
| M. tuberculosis H37Rv | Rv0842 | - | 2e-08 | 26.58% (301) | integral membrane protein |
| M. leprae Br4923 | MLBr_01562 | - | 1e-06 | 22.81% (377) | putative transmembrane efflux protein |
| M. abscessus ATCC 19977 | MAB_0069 | - | 1e-112 | 58.12% (382) | major facilitator transporter |
| M. marinum M | MMAR_4785 | - | 4e-10 | 26.94% (360) | integral membrane protein |
| M. avium 104 | MAV_0138 | - | 1e-43 | 33.25% (391) | transporter, major facilitator family protein |
| M. smegmatis MC2 155 | MSMEG_0534 | - | 2e-84 | 43.00% (393) | permease, major facilitator family protein |
| M. thermoresistible (build 8) | TH_0476 | - | 4e-25 | 26.08% (395) | major facilitator superfamily protein MFS_1 |
| M. ulcerans Agy99 | MUL_0354 | - | 1e-11 | 27.20% (364) | integral membrane protein |
| M. vanbaalenii PYR-1 | Mvan_5224 | - | 1e-174 | 76.21% (412) | major facilitator superfamily transporter |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1534|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5224|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_0069|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_0534|M.smegmatis_MC2_155 --------------------------------------------------
Mb0865|M.bovis_AF2122/97 --------------------------------------------------
Rv0842|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4785|M.marinum_M --------------------------------------------------
MUL_0354|M.ulcerans_Agy99 MLTSGSMTTTATIAAGEAMRVSSSSSPDLPDAGDTTKFLRPRNAALRSKA
MAV_0138|M.avium_104 --------------------------------------------------
TH_0476|M.thermoresistible__bu --------------------------------------------------
MLBr_01562|M.leprae_Br4923 -------------------------------------------------M
Mflv_1534|M.gilvum_PYR-GCK --------------------------MDKVFTYSGGGAAPAGLDRPATIG
Mvan_5224|M.vanbaalenii_PYR-1 ------------------------------MTVVAVAAATT---RPS---
MAB_0069|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_0534|M.smegmatis_MC2_155 ------------------------------MTATATPSETQHR-------
Mb0865|M.bovis_AF2122/97 ------------------------------MRYTGPERCSGD---GQVRA
Rv0842|M.tuberculosis_H37Rv ------------------------------MRYTGPERCSGD---GQVRA
MMAR_4785|M.marinum_M -----------------------------MAAPLGGARPLGERAGGRHRP
MUL_0354|M.ulcerans_Agy99 RGGSRSAARMANTKTNRKPRSARALCARAVAAPLGGARPLGERAGGRHRP
MAV_0138|M.avium_104 -------------------------------MMSSNVRAARNRPGRTDPQ
TH_0476|M.thermoresistible__bu --------------------------------------------------
MLBr_01562|M.leprae_Br4923 VTLYDHERAVHNWTAARSDRPAPSRLTQQVEPASERTSKYPTLLPSGRFP
Mflv_1534|M.gilvum_PYR-GCK AGRGARGWVAVALATFAIAWGGNEFTPLLVMYRLDDGFSALTVDLLLFAY
Mvan_5224|M.vanbaalenii_PYR-1 -GRSARRWLAVAAATFAIAWGGNEFTPLLVMYRTQDGFSALTVDLLLFAY
MAB_0069|M.abscessus_ATCC_1997 --------------MFGIAWGGNEFTPLLVMYR-QAGQSAASVDTLLFAY
MSMEG_0534|M.smegmatis_MC2_155 -SHRLRPWVAVAAAAFCIGWGGNQFTPLLIAYTQHSGYTRVDVDVLLGAY
Mb0865|M.bovis_AF2122/97 AGDRYSTVIWLLGG-NLLVRSAGFGYPFLAYHVAGRGHGAGAVGAVVAAY
Rv0842|M.tuberculosis_H37Rv AGDRYSTVIWLLGG-NLLVRSAGFGYPFLAYHVAGRGHGAGAVGAVVAAY
MMAR_4785|M.marinum_M AREGYPAVIWLLLGGNLVVRAAGFAYPFMAFHVAGRGFAAAAVGAVLAAF
MUL_0354|M.ulcerans_Agy99 AREGYPAVIWLLLGGNLVVRAAGFAYPFMAFHVAGRGFAAAAVGAVLAAF
MAV_0138|M.avium_104 PPTGAPLFVGVLGLLLATGWVANHFVGLMPAISDRDHLATTTLDGIFGIY
TH_0476|M.thermoresistible__bu --VRRFAFPLLAYAFAAVMVGTTVPTPMYAVYAERLGFGVLTTTVVFAGY
MLBr_01562|M.leprae_Br4923 SGRFIAAVIVIGGMQLLATMDSTVAIVALPKIQNELSLSDAGRSWGITAY
. :
Mflv_1534|M.gilvum_PYR-GCK VLGIVPALLIGGPMSDRFGRRPLMLPAPLLAAIGSLILAVGADS-AWLLG
Mvan_5224|M.vanbaalenii_PYR-1 VLGIVPALLIGGPLSDRFGRRPLMLPAPVLAAVGSAILALGAQS-APVLG
MAB_0069|M.abscessus_ATCC_1997 VLGIIPALFLGGPLSDRYGRRAVMLPAPFISMLGSLVLALGAQH-FALLF
MSMEG_0534|M.smegmatis_MC2_155 VLGLIPGLLVASTLSDRYGRRPVMALGVASSALGSVILAIGEYWGFSALF
Mb0865|M.bovis_AF2122/97 GLGWAVGQLLCGWLVDRVGARVTLVSTMLVAAA--VLVLMAGLHTVPGLL
Rv0842|M.tuberculosis_H37Rv GLGWAVGQLLCGWLVDRVGARVTLVSTMLVAAA--VLVLMAGLHTVPGLL
MMAR_4785|M.marinum_M GVGWAVGQLVCGWLVDSLGPRATLAWTMTIAAG--VLVGMAEARSVAALL
MUL_0354|M.ulcerans_Agy99 GVGWAVGQLVCGWLVDSLGPRATLAWTMTIAAG--VLVGMAEARSVAALL
MAV_0138|M.avium_104 ALGLLPGLLVGGRTSDALGRRPVALTGSAAALVGTVAMLLSQHS--PALF
TH_0476|M.thermoresistible__bu TAGVLFALVVFGRWSDALGRRPMLLAGVGCAIVSALVFLIAGSV--PQLI
MLBr_01562|M.leprae_Br4923 VLTFGGLMLLGGRLGDTIGRKRTFIVGVALFTISSVLCAVAWDE--VTLV
.: . * * : :. *
Mflv_1534|M.gilvum_PYR-GCK VGRVFSGLALGLAMAVGGSWIKELSSPPWD--VGDAGARRAAMSLTAGFG
Mvan_5224|M.vanbaalenii_PYR-1 VGRVFSGVALGLAMAVGGSWIKELSSPPWE--DGDAGARRAAMSLTAGFG
MAB_0069|M.abscessus_ATCC_1997 TGRVLSGVALGLAMAAGSSWVKELSAPPFD--RPGAGARRGAMSLTAGFA
MSMEG_0534|M.smegmatis_MC2_155 AGRLLSGAAVGIAMAVGSAWITELSRAPFDDAAPGSGARRASICLSLGLG
Mb0865|M.bovis_AF2122/97 VGAMIAGLVCDAPRPVLGAVIAELVADPQR--RAQLDGWRYGWVLNIGAA
Rv0842|M.tuberculosis_H37Rv VGAMIAGLVCDAPRPVLGAVIAELVADPQR--RAQLDGWRYGWVLNIGAA
MMAR_4785|M.marinum_M VGAMITGMVYDAPRPVMGAAIAELIPEPSR--RAKLDAWRFGWIVSIGRA
MUL_0354|M.ulcerans_Agy99 VGAMITGVVYDAPRPVMGAAIAELIPEPSR--RAKLDAWRFGWIVSIGRA
MAV_0138|M.avium_104 AGRLIVGLGVGLAISAGTAWASDLR--------GPAGAATAGAVLTAGFA
TH_0476|M.thermoresistible__bu AARFVSGMSAGIFTGTATAAVIEAAPERRR----SRAAAVATVANIGGLG
MLBr_01562|M.leprae_Br4923 IARLLQGIGSAIASPTGLALVATTFSKGSAR---NTATAVFAAMTAIGSV
. .. * . : *
Mflv_1534|M.gilvum_PYR-GCK LGAAVAGVLAQWGPAPTVLPYAINVAMAVAAAVLLLS-APETRARSVSVR
Mvan_5224|M.vanbaalenii_PYR-1 LGAGTAGVLAEWGPAPTVLPYAVNIAMALAAAVFVST-APETRTRHDSGR
MAB_0069|M.abscessus_ATCC_1997 LGAAVAGALAQWGPWPQHLAFLVNIAITIPGAVLALS-VPESAAERAPGR
MSMEG_0534|M.smegmatis_MC2_155 VGPLCAGLLTEYAPLPLVLTYLVHAGLCLPALWAIRHRTIETRSGTPSVG
Mb0865|M.bovis_AF2122/97 ITGGVGGVVAGWLDTP-VLYWINGIGCAIFAGLAGRC-IPADVCRRTESG
Rv0842|M.tuberculosis_H37Rv ITGGVGGVVAGWLDTP-VLYWINGIGCAIFAGLAGRC-IPADVCRRTESG
MMAR_4785|M.marinum_M ITGGVGGLLAAWSGVP-VLFWINAVACALLALVAARC-IPATAHR-PPVA
MUL_0354|M.ulcerans_Agy99 ITGGVGGLLAAWSGVP-VLFWINAVACALLALVAARC-IPATAHR-PPVA
MAV_0138|M.avium_104 VGPFAGGVLAWAGPSGVRASFALAAAILALAAFAVVA-APQPSPVTAPAD
TH_0476|M.thermoresistible__bu AGPLLAGILVQYAPWPLHLTFWVHIVLMVLAAAAIAV-APETSPRTGRLG
MLBr_01562|M.leprae_Br4923 MGLVVGGALT---EVSWRLAFLVNVPIGLVMIYLARTALHETHKERMKLD
.* :. :
Mflv_1534|M.gilvum_PYR-GCK PA------ANSWWSDLAIPGASHRRFLLVVVPLAPWVFGAGASAYAVLPA
Mvan_5224|M.vanbaalenii_PYR-1 P----------WWTDLAVPGASHRRFLLVVVPVAPWVFGAGATAYAVLPA
MAB_0069|M.abscessus_ATCC_1997 L-----------IDDLKIPAARRRRFLFVVMPLAPWVFGSAAVAYAVLPT
MSMEG_0534|M.smegmatis_MC2_155 V-----------IEGLRVPAAAHRRFVRVVMPMAPWIFGSAAIAYAIVPA
Mb0865|M.bovis_AF2122/97 LR------ACTAMSKVGYRQALSDKRLVLLAVSGLATLTTLMGFFAAVPM
Rv0842|M.tuberculosis_H37Rv LR------ACTAMSKVGYRQALSDKRLVLLAVSGLATLTTLMGFFAAVPM
MMAR_4785|M.marinum_M PA------VHVRAARISYRRAFSDGRLVLLFASSLATLTAVRGLYATVPM
MUL_0354|M.ulcerans_Agy99 PA------VHVRAAHNSYRRAFSDGRLVLLFASSLATLTAVRGLYATVPM
MAV_0138|M.avium_104 PD---------GEETADAAPQGISRALSWAMPLAPWVFASATLGFVTIPG
TH_0476|M.thermoresistible__bu VQ--------------RLSLPPQVRKVFAIASLAAFAGFAVTGLFTAVAP
MLBr_01562|M.leprae_Br4923 AAGAILATLACTAAVFAFSMGPEKGWISLTTIGSGLVALVAAIAFAVVER
: . :. :
Mflv_1534|M.gilvum_PYR-GCK LMTEH-VAAAPIA----FSALLCAVTLG--VAFGVQHLGRSLL-SGGALG
Mvan_5224|M.vanbaalenii_PYR-1 LMAGR-VSSAPIA----FSALMCLVALG--VGFTVQQLGRHLG-AGGRRG
MAB_0069|M.abscessus_ATCC_1997 LIAPT-LPGDRIA----FSALCCLVCLG--CGFTAQMLAPRLDRAGTARL
MSMEG_0534|M.smegmatis_MC2_155 LVADR-LGHWALL----YTAGLTVLTLG--CGVAVQPIARRLDDHSSARA
Mb0865|M.bovis_AF2122/97 LMSASGLGVGAYG----WVQLINALAVVAVTPLLTPWLSKQLA--LGPRP
Rv0842|M.tuberculosis_H37Rv LMSASGLGVGAYG----WVQLINALAVVAVTPLLTPWLSKQLA--LGPRP
MMAR_4785|M.marinum_M LMADSGLGAGEFG----WTQVANAAAGIGLTPVITPWLGRKVAARINPRL
MUL_0354|M.ulcerans_Agy99 LMADSGLGAGEFG----WAQVANAAAGIGLTPVITPWLGRKVAARINPRL
MAV_0138|M.avium_104 RLHTALAAPVAAG----TATLIVNGVSG-----AVQVLARALR--WGPQA
TH_0476|M.thermoresistible__bu SFLAEVIGVRNHA----VAGAVAASIFA--ASAVTQVLGASVS---PRRA
MLBr_01562|M.leprae_Br4923 TAENPVVPFDLFRDRNRLVTFIAIFLAGGVIFSLTVSIGLYIQDILGYSA
. :. :
Mflv_1534|M.gilvum_PYR-GCK V-----------VVALGLVAAGMALAAWASASLTIW--------------
Mvan_5224|M.vanbaalenii_PYR-1 V-----------VTALALLVVGMLLAGWAAAVLTVW--------------
MAB_0069|M.abscessus_ATCC_1997 G-----------IIGLALVAVGMALAALAAHQLTIP--------------
MSMEG_0534|M.smegmatis_MC2_155 V-----------VVSMVLMALGVFAAVATAVTRSIG--------------
Mb0865|M.bovis_AF2122/97 D-----------ILAGAGVWVTLCMAAAGLARTTVG--------------
Rv0842|M.tuberculosis_H37Rv D-----------ILAGAGVWVTLCMAAAGLARTTVG--------------
MMAR_4785|M.marinum_M D-----------ILAIAGGWTALTMAGAALAHTTFG--------------
MUL_0354|M.ulcerans_Agy99 D-----------ILAIAGGWTALTMAGAALAHTTFG--------------
MAV_0138|M.avium_104 G-----------TAGAVLAALGYAVAAAAPSTLTPA--------------
TH_0476|M.thermoresistible__bu V-----------AVGCALLIVGMVFLAAALVWSSLP--------------
MLBr_01562|M.leprae_Br4923 LRAGIGFIPFVIAMGIGLGVSSQLVSRFSPRVLTIGGGWLLMVAMLYGWA
. :
Mflv_1534|M.gilvum_PYR-GCK ----------ATVVAAAVLGAGYGMALVAGLQEIQRIATPDDLAGLTAVF
Mvan_5224|M.vanbaalenii_PYR-1 ----------SALVAAAVLGAGYGMALLAGLQEIQRIAGPDDLAGLTAVF
MAB_0069|M.abscessus_ATCC_1997 ----------LVLIAALALGAGYGTALVSGLQEVNRIAGPTDLAGLTAVF
MSMEG_0534|M.smegmatis_MC2_155 ----------MAVVVAMLLGCAYGIAIVSGLLEVQRIAEPDELAGISGVY
Mb0865|M.bovis_AF2122/97 ----------FSVAAAACS-PGEIAWFVVAAGIVHRIAPPAHGGRYHGIW
Rv0842|M.tuberculosis_H37Rv ----------FSVAAAACS-PGEIAWFVVAAGIVHRIAPPAHGGRYHGIW
MMAR_4785|M.marinum_M ----------FAIAVAASA-PGEIAWFVIAAGIVHRIAPPASGGRYHGIW
MUL_0354|M.ulcerans_Agy99 ----------FAIAVAASA-AGEIAWFVIAVGTVHRIAPPASGGRYHGIW
MAV_0138|M.avium_104 ----------LGVPLFVVLGCASGLCLREGLIDLEAAAPQRLRGGLTGLF
TH_0476|M.thermoresistible__bu ----------ALIATAVVAGAGQGLSFSRGLAAVSARTPSDQRGEVSSTY
MLBr_01562|M.leprae_Br4923 FMNRGVPYFPNLLAPIVVGGIGIGMAVVPLTLSAIAGVGFDRIGPVSAIA
: . . . . .
Mflv_1534|M.gilvum_PYR-GCK YSLCYLG--FGVPAAMVFLSDY-------------------------ASY
Mvan_5224|M.vanbaalenii_PYR-1 YSLSYLG--FAVPAVLAFAVRS-------------------------FSY
MAB_0069|M.abscessus_ATCC_1997 YGLTYLG--FGVPMMLTMLSDAS--PL--------------------LTH
MSMEG_0534|M.smegmatis_MC2_155 YSLAYAG--FLLPAILAALARF-------------------------FSY
Mb0865|M.bovis_AF2122/97 SMAVAAS--SVAAPILAAFNLANGGRL--------------------VLA
Rv0842|M.tuberculosis_H37Rv SMAVAAS--SVAAPILAAFNLANGGRL--------------------VLA
MMAR_4785|M.marinum_M SMTLAIA--SVVAPIVSSCSLTHGGHR--------------------LVA
MUL_0354|M.ulcerans_Agy99 SMTLAIA--SVVAPIVSSCSLTHGGHR--------------------LVA
MAV_0138|M.avium_104 YVVTYIG--FGLPLILASVRPG-------------------------VAT
TH_0476|M.thermoresistible__bu FVVAYVA--LLVPVIGEGWAAHHWGLR--------------------TAG
MLBr_01562|M.leprae_Br4923 LMLQSLGGPLVLAVIQAVITSRTLYLGGTTGPVKFMNDAQLRALDHGYTY
. .
Mflv_1534|M.gilvum_PYR-GCK PSMFGFGAVAAVGCLAVAVTGLR--------RTPAIS----------
Mvan_5224|M.vanbaalenii_PYR-1 PAMFGFGAFAAAVCLLVAVLGSR--------RTAAIS----------
MAB_0069|M.abscessus_ATCC_1997 PVLLCGGALLATVCLVVLMLNSRTDVGARPGTTAAVPADETREPVLR
MSMEG_0534|M.smegmatis_MC2_155 PAMLTVVGLLAAACTALCASGWSKHLEP---RTVTARV---------
Mb0865|M.bovis_AF2122/97 ATTVTVGFFGAALCLPLARVLAAAS-CGPLSSKEPSRDSYQ------
Rv0842|M.tuberculosis_H37Rv ATTVTVGFFGAALCLPLARVLAAAS-CGPLSSKEPSRDSYQ------
MMAR_4785|M.marinum_M LVTVTVGLAGAALCLPLARALNRSGDVGVRDSQYTAVAGAA------
MUL_0354|M.ulcerans_Agy99 LVTVTVGLAGAALCLP----LNRSGDVGVRDSQYTAVAAAA------
MAV_0138|M.avium_104 AILSGMAVLAVTAAVGRAARLRRDD------HRQN------------
TH_0476|M.thermoresistible__bu ISFAVGVAVLAIGCLIAILIQESRD-------PQAI-----------
MLBr_01562|M.leprae_Br4923 GLLWVAGAVVIVGVAALFIGYTPEQVAYAQEVKEAVDAGEL------