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TGLRMGTAAGRWVLLATVLGSGIVMVDATVVNVALPHIAADLGGGFGDLQWVVNAYTLTLASLILLGGSL GDHFGRRKVFVLGVVWFALASIACGLAPSIEVLIVARALQGVGGALLTPGSLALISAAFASGDRGAAVGA WSGLGGIAGAIGPFLGGALVEWNWRAAFLINVPLAAFVIAVTLLRVPESRDPSASRRLDVGGAVLTVVGL GALTFGLTELGNRGASPAAVVSVGGGLVALVVFVLVEQRSSHPLMSPKLFADRNFGVANAVTLLIYGALG AVFLLLVLQLQTVSGFSPVAAGTALLPFTIVMLLFSSRAGALSGRIGPRLPMTVGPVLAGLGLLLMLRIG EDASWVFDVAPAALVFGAGMVLVVAPLTATVLDAAPEHMAGSASGVNNAVARAGGLLAVAVLPGVAGISG NDYADPAAFSAGFHTAVVISAVLMVAAAVLAAIGIRRAPARSDERMAVENCTHCAITGLPAHPAAETR*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. gilvum PYR-GCK | Mflv_0301 | - | - | 100% (489) | EmrB/QacA family drug resistance transporter |
M. gilvum PYR-GCK | Mflv_1730 | - | 3e-67 | 36.48% (466) | EmrB/QacA family drug resistance transporter |
M. gilvum PYR-GCK | Mflv_0642 | - | 5e-67 | 34.20% (459) | EmrB/QacA family drug resistance transporter |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb2361c | - | 7e-72 | 39.51% (405) | integral membrane transport protein |
M. tuberculosis H37Rv | Rv2333c | - | 3e-71 | 39.51% (405) | integral membrane transport protein |
M. leprae Br4923 | MLBr_01562 | - | 7e-52 | 31.04% (422) | putative transmembrane efflux protein |
M. abscessus ATCC 19977 | MAB_0945 | - | 7e-67 | 35.27% (448) | EmrB/QacA family drug resistance transporter |
M. marinum M | MMAR_3642 | - | 2e-69 | 37.78% (405) | integral membrane transport protein |
M. avium 104 | MAV_1387 | - | 1e-56 | 32.67% (453) | drug transporter |
M. smegmatis MC2 155 | MSMEG_4427 | - | 8e-77 | 39.00% (459) | transmembrane efflux pump |
M. thermoresistible (build 8) | TH_3965 | - | 1e-58 | 34.07% (408) | PUTATIVE drug transporter |
M. ulcerans Agy99 | MUL_0911 | - | 1e-61 | 35.42% (480) | integral membrane transport protein |
M. vanbaalenii PYR-1 | Mvan_5021 | - | 1e-67 | 36.46% (458) | EmrB/QacA family drug resistance transporter |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_0301|M.gilvum_PYR-GCK --------------------------------------------MTGLRM MSMEG_4427|M.smegmatis_MC2_155 --------------------------------------------MVSLRS MAV_1387|M.avium_104 -------------------------------------------------- TH_3965|M.thermoresistible__bu ----------------------------VTSVDAGRSTMSEVFTAYAPRS MAB_0945|M.abscessus_ATCC_1997 ------------------------------------------MEAAVGAL Mvan_5021|M.vanbaalenii_PYR-1 -------------------------------------------------M Mb2361c|M.bovis_AF2122/97 -------------------------------------------------- Rv2333c|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_3642|M.marinum_M -------------------------------------------------- MUL_0911|M.ulcerans_Agy99 --------------------------------------------MRIQPV MLBr_01562|M.leprae_Br4923 MVTLYDHERAVHNWTAARSDRPAPSRLTQQVEPASERTSKYPTLLPSGRF Mflv_0301|M.gilvum_PYR-GCK GTAAGRWVLLATVLGSGIVMVDATVVNVALPHIAADLGGGFGDLQWVVNA MSMEG_4427|M.smegmatis_MC2_155 -VAPTHRAMVVAVTVSMVAFLDSTVINLALTAIEHDLGGGLPLQQWIVDG MAV_1387|M.avium_104 -----------MMIGFFMIMVDSTIVAIANPTIMADLHIGYDTVVWVTSA TH_3965|M.thermoresistible__bu AAANPWHALWAMLIGFFMILVDATIVPVANLEIMADLGADYTAVIWVTSA MAB_0945|M.abscessus_ATCC_1997 SERRKIVILGSCCLSLLIVSMDSTIVNVALPTIRADFGATTSQLQWVIDI Mvan_5021|M.vanbaalenii_PYR-1 TPRRKAIILVSCCLSLLIVSMDATIVNVAIPSIRDDLSATPAQMQWVVDV Mb2361c|M.bovis_AF2122/97 MNRTQLLTLIATGLGLFMIFLDALIVNVALPDIQRSFAVGEDGLQWVVAS Rv2333c|M.tuberculosis_H37Rv MNRTQLLTLIATGLGLFMIFLDALIVNVALPDIQRSFAVGEDGLQWVVAS MMAR_3642|M.marinum_M MNRTQLLTIFATGLGLFMIFLDAFIVNVALPDIQNTFGVGEDGLQWVVAA MUL_0911|M.ulcerans_Agy99 FRDHPILALAVICLSVFVISVDATIVNVALPTLSRELGADTAQLQWIVDA MLBr_01562|M.leprae_Br4923 PSGRFIAAVIVIGGMQLLATMDSTVAIVALPKIQNELSLSDAGRSWGITA : :*: : :* : : * Mflv_0301|M.gilvum_PYR-GCK YTLTLASLILLGGSLGDHFGRRKVFVLGVVWFALASIACGLAPSIEVLIV MSMEG_4427|M.smegmatis_MC2_155 YLLTMAAAILPGGSISDLFGRVPVMRFGLVVFGAGSVLGAVAASAEVLIA MAV_1387|M.avium_104 YLLGYAVVLLVAGRLGDRFGTKNLYLIGLAVFTVASVWCGLAGSAAMLIA TH_3965|M.thermoresistible__bu YLLAYAVPLLIAGRLGDRFGPRTMYLIGLAIFTAASLWCGLAGTIGMLIA MAB_0945|M.abscessus_ATCC_1997 YTLGLASLLMLSGAAGDRLGRRKVFHLGLSIFAIGSLLCSVAPTVGLLIA Mvan_5021|M.vanbaalenii_PYR-1 YTLVLASLLMLSGATGDRFGRRRVFQIGLAVFALGSLACSLAPTIDALIG Mb2361c|M.bovis_AF2122/97 YSLGMAVFIMSAATLADLYGRRRWYLIGVSLFTLGSIACGLAPSIAVLTT Rv2333c|M.tuberculosis_H37Rv YSLGMAVFIMSAATLADLDGRRRWYLIGVSLFTLGSIACGLAPSIAVLTT MMAR_3642|M.marinum_M YSLGMAVFIMSAATLADRYGRRRWYLMGIALFTLGSIACGLAPSIAMLTA MUL_0911|M.ulcerans_Agy99 YTLVMSGLLLSAGSLSDRYGRRGWLSAGLILFALTSALAAQVNSADTLVA MLBr_01562|M.leprae_Br4923 YVLTFGGLMLLGGRLGDTIGRKRTFIVGVALFTISSVLCAVAWDEVTLVI * * . :: .. .* * *: * * . . * Mflv_0301|M.gilvum_PYR-GCK ARALQGVGGALLTPGSLALISAAFASG-DRGAAVGAWSGLGGIAGAIGPF MSMEG_4427|M.smegmatis_MC2_155 ARLIQGLGAAFLVPGSLALINTVFDKA-HQSAAIGVWTAWTGTAFALGPL MAV_1387|M.avium_104 ARVVQGVGAGVMTPQTLSTITRIFPAE-RRGVAVSVWSATAGAASLAGPL TH_3965|M.thermoresistible__bu ARVLQGLGAALLTPQTLSMITRIFPAD-RRGVPMGVWGATAGVATLIGPL MAB_0945|M.abscessus_ATCC_1997 ARLLQAVGGSMLNPVALSIISQVFTGRVERARALGFWGAVVGISMALGPI Mvan_5021|M.vanbaalenii_PYR-1 ARLLQGIGGSMLNPVALSIISQIFTQPVERARALGIWGGVTGISMAAGPI Mb2361c|M.bovis_AF2122/97 ARGAQGLGAAAVSVTSLALVSAAFPEAKEKARAIGIWTAIASIGTTTGPT Rv2333c|M.tuberculosis_H37Rv ARGAQGLGAAAVSVTSLALVSAAFPEAKEKARAIGIWTAIASIGTTTGPT MMAR_3642|M.marinum_M ARGIQGFGAATVSVTSLALVSAAFPNPKEKARAIGIWTAVASVGTATGPT MUL_0911|M.ulcerans_Agy99 ARAAMGVGAAVIFPTTLGLITNIFTDPVPRAKAIGLWTAMVGVGVAVGPI MLBr_01562|M.leprae_Br4923 ARLLQGIGSAIASPTGLALVATTFSKGSARNTATAVFAAMTAIGSVMGLV ** ..*.. *. : * : . . : . . . * Mflv_0301|M.gilvum_PYR-GCK LGGALVEWN-WRAAFLINVPLAAFVIAVTLLRVPESRDPSASRRLDVGGA MSMEG_4427|M.smegmatis_MC2_155 LGGLCVDLLGWRWVFVLSAIPMAAGYALTFWLCPVSG-RVAHARIDIVGV MAV_1387|M.avium_104 AGGVLVDGLGWQWIFFVNVPIGVLGLVLAYWLVPVLP--TQSHRFDLVGV TH_3965|M.thermoresistible__bu AGGVLVDGLGWQWIFIVNVPIGIAGLVLGARLMPRLP--RQDQGFDVLGM MAB_0945|M.abscessus_ATCC_1997 VGGLLIQWVGWRAVFWINLPVCVLAFVLTAVFVPETK-SATMRDIDPVGQ Mvan_5021|M.vanbaalenii_PYR-1 VGGLLIDTIGWRSVFWINLPICAAAILLTAIFVPESK-SQTMRNVDPIGQ Mb2361c|M.bovis_AF2122/97 LGGLLVDQWGWRSIFYVNLPMGALVLFLTLCYVEESC-NERARRFDLSGQ Rv2333c|M.tuberculosis_H37Rv LGGLLVDQWGWRSIFYVNLPMGALVLFLTLCYVEESC-NERARRFDLSGQ MMAR_3642|M.marinum_M LGGLLVDTWGWRSIFYVNVPMGVFVILLTVGFVAESR-NARAGRLDLSGQ MUL_0911|M.ulcerans_Agy99 TGGWLLEHFSWGSIFLVNVPIAVAAMAGAILFVPTSR-DPAAPRVDVPGL MLBr_01562|M.leprae_Br4923 VGGALTEVS-WRLAFLVNVPIGLVMIYLARTALHETH--KERMKLDAAGA ** : * * :. .* * Mflv_0301|M.gilvum_PYR-GCK VLTVVGLGALTFGLTELGNRGASPAAVVS-VGGGLVALVVFVLVEQRSSH MSMEG_4427|M.smegmatis_MC2_155 VLSSVGLAAIVFALIESQRRGWTDLVVGTPAVLGAAALSGFVSRQRRSGH MAV_1387|M.avium_104 GLSGVGMLLIVFGLQQGQAAHWQPWIWALIVAGVGFVTVFVFWQSVNVRE TH_3965|M.thermoresistible__bu VLSAVGLFLIVFALQEAQTHRWAPWIWGTLAGGAGVMAMFVIWQSANRRH MAB_0945|M.abscessus_ATCC_1997 ALAVLFLFGIVFALIEGPSLGWATPGLIVVLAVALAAFAVFLRYESRRRH Mvan_5021|M.vanbaalenii_PYR-1 GLAIMFLFGTVFTLIEGPVLGWTNPRVVVAAVVVALALVAFLRFESRRHD Mb2361c|M.bovis_AF2122/97 LLFIVAVGALVYAVIEGPQIGWTSVQTIVMLWTAAVGCALFVWLERRSSN Rv2333c|M.tuberculosis_H37Rv LLFIVAVGALVYAVIEGPQIGWTSVQTIVMLWTAAVGCALFVWLERRSSN MMAR_3642|M.marinum_M ALFIVTVGAFVYAVIEGPQIGWTSPLILTLLMTAAVGCALFLWLEGRSAD MUL_0911|M.ulcerans_Agy99 MLSAVGITALVYTIIEAPNWGWTSTRASGGFIAAAIVLVGFALWERRSSH MLBr_01562|M.leprae_Br4923 ILATLACTAAVFAFSMGPEKGWISLTTIGSGLVALVAAIAFAVVERTAEN * : .: . . . . Mflv_0301|M.gilvum_PYR-GCK PLMSPKLFADRNFGVANAVTLLIYGALGAVFLLLVLQLQTVSGFSPVAAG MSMEG_4427|M.smegmatis_MC2_155 PLLPLSLFTARNFAAVNLVTVFVYSALTLGSLAVVLYAQEIGGYSATSAG MAV_1387|M.avium_104 PLIPLVIFSDRDFSLCNIGVAIISFAATAMMLPLTFYAQAVCGLSPTRSA TH_3965|M.thermoresistible__bu PLVPLQIFADRNFMLANVGVATIGFVVTAMVLPAMFFAQAVCGLSPTGSA MAB_0945|M.abscessus_ATCC_1997 PFIDLRFFRSIPFASATLTAICACMAWSAFLFTMSLYLQGQRHFSAMHTG Mvan_5021|M.vanbaalenii_PYR-1 PFLDLRFFRSIPFTTATVIAISAFAAWGAFLFLMSLYLQGERGFSAMHTG Mb2361c|M.bovis_AF2122/97 PMMDLTLFRDTSYALAIATICTVFFAVYGMLLLTTQFLQNVRGYTPSVTG Rv2333c|M.tuberculosis_H37Rv PMMDLTLFRDTSYALAIATICTVFFAVYGMLLLTTQFLQNVRGYTPSVTG MMAR_3642|M.marinum_M PMMDLTLFRDSSYALSIGTICTVFFAVYGMLLLTTQFLQNVRGYTPGATG MUL_0911|M.ulcerans_Agy99 PMLDVSVFANRRFSGGSLAVTAGFLTLFGFIFVITQYFQFIKDYTALQTG MLBr_01562|M.leprae_Br4923 PVVPFDLFRDRNRLVTFIAIFLAGGVIFSLTVSIGLYIQDILGYSALRAG *.: .* . . * :. :. Mflv_0301|M.gilvum_PYR-GCK TALLPFTIVMLLFSSRAGALSGRIGPR-LPMTVGPVLAGLGLLLMLRIGE MSMEG_4427|M.smegmatis_MC2_155 LATLPIPVMSFVLARRVGRIAARTGPR-MFLIAGPALSGLGMILIRLKDD MAV_1387|M.avium_104 LLIAPMAIANGVFAPFVGKIVDRYHPR-PVLGFGFSLLAIALTWLTFEMS TH_3965|M.thermoresistible__bu LLIAPMAVASGVLAPMAGRIVDRSHPT-PVVGFGFSVVAVGLTWLAVEMA MAB_0945|M.abscessus_ATCC_1997 LIYLPIAVGALVFSPISGRMVGRFGARPSLLAAGTLFLTASLLLTRVS-- Mvan_5021|M.vanbaalenii_PYR-1 LIYLPIAIGALLFSPLSGRLVGRYGARPSLVIAGVTITAAATMLTFLT-- Mb2361c|M.bovis_AF2122/97 LMILPFSAAVAIVSPLVGHLVGRIGAR-VPILAGLCMLMLGLLMLIFS-- Rv2333c|M.tuberculosis_H37Rv LMILPFSAAVAIVSPLVGHLVGRIGAR-VPILAGLCMLMLGLLMLIFS-- MMAR_3642|M.marinum_M LMILPFSAGVAVVSPLVGSLVARVGAR-VLILIGLGLLMLGLLTLIAS-- MUL_0911|M.ulcerans_Agy99 VRLLPVAFSIALAAILGPRLVERVGTT-AVVAAGLAVFAAALAWASTAD- MLBr_01562|M.leprae_Br4923 IGFIPFVIAMGIGLGVSSQLVSRFSPRVLTIGGGWLLMVAMLYGWAFMNR *. : : * . : * . Mflv_0301|M.gilvum_PYR-GCK DASWVFDVAPAALVFGAGMVLVVAPLTATVLDAAPEHMAGSASGVNNAVA MSMEG_4427|M.smegmatis_MC2_155 GFHAMTDLLPGMTVLALGLVLTVTPLTSVALASVPTEHSGLASAVNNAAA MAV_1387|M.avium_104 PATPIWRLVLPFFAMGVGMAFVWSPLTATATRNLSAQLAGAGSAVYNSVR TH_3965|M.thermoresistible__bu PTTPIWRLVLPFVAVGVGMAFIWSPLATTATRQLPLHLSGAGSGVYNTTR MAB_0945|M.abscessus_ATCC_1997 EATPIWELLVTFAIFGAGFAMVNAPITNAAVSGMPLDRAGAASAVTSTSR Mvan_5021|M.vanbaalenii_PYR-1 ATTPVWSLLMVFAVFGIGFSMVNAPVTNAAVSGMPLDRAGAASAVTSTSR Mb2361c|M.bovis_AF2122/97 EHRSSALVLVGLGLCGSGVALCLTPITTVAMTAVPAERAGMASGIMSAQR Rv2333c|M.tuberculosis_H37Rv EHRSSALVLVGLGLCGSGVALCLTPITTVAMTAVPAERAGMASGIMSAQR MMAR_3642|M.marinum_M EHRSWALVLVGLGFCGTGVALCLTPITTVAMTAVPPERAGMASGIMSAQR MUL_0911|M.ulcerans_Agy99 ATTPYTQITLQMLLLGGGLGLTTAPATEAIMGSLPADRAGVGSAVNDTTR MLBr_01562|M.leprae_Br4923 GVPYFPNLLAPIVVGGIGIGMAVVPLTLSAIAGVGFDRIGPVSAIALMLQ : . *. : * : . * *.: Mflv_0301|M.gilvum_PYR-GCK RAGGLLAVAVLPGVAGISGNDYADPAAFSAG------------------- MSMEG_4427|M.smegmatis_MC2_155 RLAALVSIGSMG---------LITVGASAAG------------------- MAV_1387|M.avium_104 QLGAVLGSAGMAAFMTWRIGAEMPGQPGGGGEDSAGPVLPEFLRGPFAAA TH_3965|M.thermoresistible__bu QIGSVLGSAGMAAFLTGRLSAELPFGATAVPAGEQTRVLPEFLHAPYAAA MAB_0945|M.abscessus_ATCC_1997 QVGVSIGVALCGSIG--------------TPALW---------------- Mvan_5021|M.vanbaalenii_PYR-1 QVGVSIGVALCGSLAGSAMATGGADFAAAARPLW---------------- Mb2361c|M.bovis_AF2122/97 AIGSTIGFAVLGSVLAAWLSATLEPHLERAVPDP---------------- Rv2333c|M.tuberculosis_H37Rv AIGSTIGFAVLGSVLAAWLSATLEPHLERAVPDP---------------- MMAR_3642|M.marinum_M AIGSTIGFAVLGSVLAAWLSATLEPHLEPAVPDP---------------- MUL_0911|M.ulcerans_Agy99 ELGGTLGVAIAGSVFASVYSGQLGSASALATLPSDVR-----------SA MLBr_01562|M.leprae_Br4923 SLGGPLVLAVIQAVITSRTLYLGGTTGPVKFMND---------------A . : . Mflv_0301|M.gilvum_PYR-GCK FHTAVVISAVLMVAAAVLAAIGIRRAPARSDE------------------ MSMEG_4427|M.smegmatis_MC2_155 FADVLKVSAALFVLGSLCAALWISDSLDGYG------------------- MAV_1387|M.avium_104 MSQSVLLPAFIALFGIVAALFLVGFRPWAHRDGGTDAFGPDDYGGDYHDD TH_3965|M.thermoresistible__bu MAQSMLLPAFVALFGVLAAIFLAGIVLSTPQP---------DADAQYLDE MAB_0945|M.abscessus_ATCC_1997 -FMCAGLGLLIATLG---IVSTSPAAVRSAQR------------------ Mvan_5021|M.vanbaalenii_PYR-1 -FVCMALGLVILGLG---LFATSQRALRSAER------------------ Mb2361c|M.bovis_AF2122/97 -VQRHVLAEIIIDSANPRAHVGGIVPRRHIEH------------------ Rv2333c|M.tuberculosis_H37Rv -VQRHVLAEIIIDSANPRAHVGGIVPRRHIEH------------------ MMAR_3642|M.marinum_M -VQRHTIAEVIIDSANPRAHVGGIVPRREIVH------------------ MUL_0911|M.ulcerans_Agy99 MKGSMAVAHKVIDQLPAGPAAGVRDAVNHAFLDG---------------- MLBr_01562|M.leprae_Br4923 QLRALDHGYTYGLLWVAGAVVIVGVAALFIGY------------------ Mflv_0301|M.gilvum_PYR-GCK ---------------------------------RMAVENCTHC-AITGLP MSMEG_4427|M.smegmatis_MC2_155 ---------------------------------PVPCDLATSCRDRPGVQ MAV_1387|M.avium_104 YDDDDAYVELILVREPEPEAQQRAGQPRRPQPTPAPPADVRRRDPVESRR TH_3965|M.thermoresistible__bu HDD---YLVIELAR-----------------PDPNPRTDIAVTAVIPALR MAB_0945|M.abscessus_ATCC_1997 ----------------------------------LAPLIEGT-TAREMSR Mvan_5021|M.vanbaalenii_PYR-1 ----------------------------------LAPLVSGAPEPVGGAH Mb2361c|M.bovis_AF2122/97 ----------------------------------RDPVAIAEEDFIEGIR Rv2333c|M.tuberculosis_H37Rv ----------------------------------RDPVAIAEEDFIEGIR MMAR_3642|M.marinum_M ----------------------------------RDPVAIAEEDFIEGIR MUL_0911|M.ulcerans_Agy99 --------------------------------LQVATLVCAGIALAAAIV MLBr_01562|M.leprae_Br4923 ----------------------------------TPEQVAYAQEVKEAVD Mflv_0301|M.gilvum_PYR-GCK AHPAAETR------------------------------------------ MSMEG_4427|M.smegmatis_MC2_155 PALAEQSPPQ---------------------------------------- MAV_1387|M.avium_104 SVLDERPAQVQPIGFAHNGSHVDGGKRLRQVAVRRAPKPGPPADRFTRPP TH_3965|M.thermoresistible__bu PTLRP--------------------------TLR--PSLGPPGGPVVQP- MAB_0945|M.abscessus_ATCC_1997 VG------------------------------------------------ Mvan_5021|M.vanbaalenii_PYR-1 VR------------------------------------------------ Mb2361c|M.bovis_AF2122/97 VALLVATATLAVVFLAGWRWFPRDVQTAGSDAKR--EAAYSDDRRVRG-- Rv2333c|M.tuberculosis_H37Rv VALLVATATLAVVFLAGWRWFPRDVHTAGSDLSERLPTAMTVECAVSHMP MMAR_3642|M.marinum_M VAFFIATASLGFVFLAGWRWFPRGGAGMLGDAER--------EADAVGL- MUL_0911|M.ulcerans_Agy99 VGWLLPARAGQPTPAQTEPALAQV-------------------------- MLBr_01562|M.leprae_Br4923 AGEL---------------------------------------------- Mflv_0301|M.gilvum_PYR-GCK ----------------------------------------- MSMEG_4427|M.smegmatis_MC2_155 ----------------------------------------- MAV_1387|M.avium_104 RRHHPGPAGHHLGEGESLRGQHHRPDPDDDPTGYGRHSSGN TH_3965|M.thermoresistible__bu ------------NNTAALR---------------------- MAB_0945|M.abscessus_ATCC_1997 ----------------------------------------- Mvan_5021|M.vanbaalenii_PYR-1 ----------------------------------------- Mb2361c|M.bovis_AF2122/97 ----------------------------------------- Rv2333c|M.tuberculosis_H37Rv GATWCRLWPA------------------------------- MMAR_3642|M.marinum_M ----------------------------------------- MUL_0911|M.ulcerans_Agy99 ----------------------------------------- MLBr_01562|M.leprae_Br4923 -----------------------------------------