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LRYTGPERCSGDGQVRAAGDRYSTVIWLLGGNLLVRSAGFGYPFLAYHVAGRGHGAGAVGAVVAAYGLGW AVGQLLCGWLVDRVGARVTLVSTMLVAAAVLVLMAGLHTVPGLLVGAMIAGLVCDAPRPVLGAVIAELVA DPQRRAQLDGWRYGWVLNIGAAITGGVGGVVAGWLDTPVLYWINGIGCAIFAGLAGRCIPADVCRRTESG LRACTAMSKVGYRQALSDKRLVLLAVSGLATLTTLMGFFAAVPMLMSASGLGVGAYGWVQLINALAVVAV TPLLTPWLSKQLALGPRPDILAGAGVWVTLCMAAAGLARTTVGFSVAAAACSPGEIAWFVVAAGIVHRIA PPAHGGRYHGIWSMAVAASSVAAPILAAFNLANGGRLVLAATTVTVGFFGAALCLPLARVLAAASCGPLS SKEPSRDSYQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0842 | - | - | 100% (430) | PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN |
| M. tuberculosis H37Rv | Rv0841 | - | 2e-15 | 56.94% (72) | transmembrane protein |
| M. tuberculosis H37Rv | Rv2265 | - | 4e-10 | 31.58% (152) | integral membrane protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0865 | - | 0.0 | 100.00% (430) | integral membrane protein |
| M. gilvum PYR-GCK | Mflv_1475 | - | 4e-11 | 26.21% (393) | major facilitator transporter |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4615 | - | 1e-14 | 32.29% (192) | major facilitator transporter |
| M. marinum M | MMAR_4785 | - | 1e-138 | 60.20% (402) | integral membrane protein |
| M. avium 104 | MAV_3974 | - | 6e-09 | 28.47% (144) | permease of the major facilitator superfamily protein |
| M. smegmatis MC2 155 | MSMEG_6245 | - | 2e-10 | 24.94% (385) | chloramphenicol resistance protein |
| M. thermoresistible (build 8) | TH_1753 | - | 1e-06 | 29.38% (211) | major facilitator superfamily protein MFS_1, putative |
| M. ulcerans Agy99 | MUL_0354 | - | 1e-134 | 59.25% (400) | integral membrane protein |
| M. vanbaalenii PYR-1 | Mvan_5224 | - | 5e-11 | 25.47% (373) | major facilitator superfamily transporter |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0842|M.tuberculosis_H37Rv --------------------------------------------------
Mb0865|M.bovis_AF2122/97 --------------------------------------------------
MMAR_4785|M.marinum_M --------------------------------------------------
MUL_0354|M.ulcerans_Agy99 MLTSGSMTTTATIAAGEAMRVSSSSSPDLPDAGDTTKFLRPRNAALRSKA
Mflv_1475|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6245|M.smegmatis_MC2_155 --------------------------------------------------
TH_1753|M.thermoresistible__bu --------------------------------------------------
Mvan_5224|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_3974|M.avium_104 --------------------------------------------------
MAB_4615|M.abscessus_ATCC_1997 --------------------------------------------------
Rv0842|M.tuberculosis_H37Rv ------------------------------MRYTGPE--RCSGD---GQV
Mb0865|M.bovis_AF2122/97 ------------------------------MRYTGPE--RCSGD---GQV
MMAR_4785|M.marinum_M -----------------------------MAAPLGGA--RPLGERAGGRH
MUL_0354|M.ulcerans_Agy99 RGGSRSAARMANTKTNRKPRSARALCARAVAAPLGGA--RPLGERAGGRH
Mflv_1475|M.gilvum_PYR-GCK ------------------------------MAPLSPTAQRAP--------
MSMEG_6245|M.smegmatis_MC2_155 -------------------------------MPFSLYP------------
TH_1753|M.thermoresistible__bu ------------------------------VSTSPATTTTAATDPAPPRG
Mvan_5224|M.vanbaalenii_PYR-1 ----------------------------MTVVAVAAATTRPSGR------
MAV_3974|M.avium_104 --------------------------------------------------
MAB_4615|M.abscessus_ATCC_1997 -------------------------------MPQRLSAWRFVTT------
Rv0842|M.tuberculosis_H37Rv RAAGDRYSTVIWLLGG-NLLVRSAGFGYPFLAYHVAGRGHGAGAVGAVVA
Mb0865|M.bovis_AF2122/97 RAAGDRYSTVIWLLGG-NLLVRSAGFGYPFLAYHVAGRGHGAGAVGAVVA
MMAR_4785|M.marinum_M RPAREGYPAVIWLLLGGNLVVRAAGFAYPFMAFHVAGRGFAAAAVGAVLA
MUL_0354|M.ulcerans_Agy99 RPAREGYPAVIWLLLGGNLVVRAAGFAYPFMAFHVAGRGFAAAAVGAVLA
Mflv_1475|M.gilvum_PYR-GCK ------------LLAAGFTTAFGAHAVAGTLGTTTTGTAASLLTLGAMLA
MSMEG_6245|M.smegmatis_MC2_155 ------------LAVAVFAMGTSEFMLAGLVPDIAADLGVSIGSAGLLTS
TH_1753|M.thermoresistible__bu ALGLMFDPVFGGLFWGKILSVVAVWTHGIVAAITMFNATGSAVMVGLVGV
Mvan_5224|M.vanbaalenii_PYR-1 -----SARRWLAVAAATFAIAWGGNEFTPLLVMYRTQDGFSALTVDLLLF
MAV_3974|M.avium_104 ------------------MVALGYGVISPALPTFARSFGVSIKAVTFLVT
MAB_4615|M.abscessus_ATCC_1997 ------------FGVISMLADIVYEGARSITGPLLASLGASALVVGVVTG
. :
Rv0842|M.tuberculosis_H37Rv AYGLGWAVGQLLCGWLVDR-VGARVTLVSTMLVAAA---------VLVLM
Mb0865|M.bovis_AF2122/97 AYGLGWAVGQLLCGWLVDR-VGARVTLVSTMLVAAA---------VLVLM
MMAR_4785|M.marinum_M AFGVGWAVGQLVCGWLVDS-LGPRATLAWTMTIAAG---------VLVGM
MUL_0354|M.ulcerans_Agy99 AFGVGWAVGQLVCGWLVDS-LGPRATLAWTMTIAAG---------VLVGM
Mflv_1475|M.gilvum_PYR-GCK IYDGAEVILKPLFGTLADR-IGARTVLIAGLAVFAV---------ASLSF
MSMEG_6245|M.smegmatis_MC2_155 AFAVGMVVGAPSMAALTRR-WRARVSLSAFLLTFAL---------VHVLG
TH_1753|M.thermoresistible__bu AQFGPQLILTPISGKWADVGNQARQILLGRLLCTAGSGLIAAWLFLSPHM
Mvan_5224|M.vanbaalenii_PYR-1 AYVLGIVPALLIGGPLSDRFGRRPLMLPAPVLAAVG---------SAILA
MAV_3974|M.avium_104 VFSLSRLCFAPISGLLTERLGERRIYIGGLLIVAVS----------TAAC
MAB_4615|M.abscessus_ATCC_1997 IGEAAALALRLVSGPLTDRTRKFWAWTISGYALTVV----------TVPF
. .
Rv0842|M.tuberculosis_H37Rv AGLHTVPGLLVGAMIAG-LVCDAPRPVLGAVIAELVADPQRRAQLDGWRY
Mb0865|M.bovis_AF2122/97 AGLHTVPGLLVGAMIAG-LVCDAPRPVLGAVIAELVADPQRRAQLDGWRY
MMAR_4785|M.marinum_M AEARSVAALLVGAMITG-MVYDAPRPVMGAAIAELIPEPSRRAKLDAWRF
MUL_0354|M.ulcerans_Agy99 AEARSVAALLVGAMITG-VVYDAPRPVMGAAIAELIPEPSRRAKLDAWRF
Mflv_1475|M.gilvum_PYR-GCK AVADETAWLWAARLGQG-IGAAAFSPAASALVARLAPASGQGRAFG--TY
MSMEG_6245|M.smegmatis_MC2_155 AVTTSFGVLLVTRLVAA-VANAGFLAVALSTAATLVPAGRQGRGLAVLLA
TH_1753|M.thermoresistible__bu QGVAVAVPILIGTTLVG-FGFVVGGPAMQSIVPSLIRPGELSTAMA--LN
Mvan_5224|M.vanbaalenii_PYR-1 LGAQSAPVLGVGRVFSG-VALGLAMAVGGSWIKELSSPPWEDGDAGARRA
MAV_3974|M.avium_104 AFSQAYWQLMLCRVFSG-VGSTMFYVSALGLMIHISPADARGRIAG--LF
MAB_4615|M.abscessus_ATCC_1997 LGVSSVLWIAATLVIAERVGKAVRSPAKDTLLSHATAVTGRGKGFAVHEA
: .
Rv0842|M.tuberculosis_H37Rv GWVLNIGAAITGGVGGVVAGWLDTPVLYWINGIGCAIFAGLAGRCIPADV
Mb0865|M.bovis_AF2122/97 GWVLNIGAAITGGVGGVVAGWLDTPVLYWINGIGCAIFAGLAGRCIPADV
MMAR_4785|M.marinum_M GWIVSIGRAITGGVGGLLAAWSGVPVLFWINAVACALLALVAARCIPATA
MUL_0354|M.ulcerans_Agy99 GWIVSIGRAITGGVGGLLAAWSGVPVLFWINAVACALLALVAARCIPATA
Mflv_1475|M.gilvum_PYR-GCK GSYKSVGYTLGPLIGGAIVTFGGLQALFAVMAALAAAVAVWAAVAVPR--
MSMEG_6245|M.smegmatis_MC2_155 GTTLATIAGVPG--GAVLGTMLGWRATFWAIALLCLPAVVGIATALPAGA
TH_1753|M.thermoresistible__bu SLPMTVGRIAGPAVGAYIAASFGAPTAFAVSCVLHLLFALILVALPFPAQ
Mvan_5224|M.vanbaalenii_PYR-1 AMSLTAGFGLGAGTAGVLAEWGPAPTVLPYAVNIAMALAAAVFVSTAPET
MAV_3974|M.avium_104 TTSFMVGAVGGPAVGGLAAGWG-LTAPFVVYGVAMLGVALVLFLGLRNSA
MAB_4615|M.abscessus_ATCC_1997 MDQIGAITGPLLVAGMLALTHVNYLPTFAILALPGGATLLLLFWLRRRVP
.
Rv0842|M.tuberculosis_H37Rv CRRTESGLRACTAMSKVGYRQALSDKRLVLLAVSGLATLTTLMGF-FAAV
Mb0865|M.bovis_AF2122/97 CRRTESGLRACTAMSKVGYRQALSDKRLVLLAVSGLATLTTLMGF-FAAV
MMAR_4785|M.marinum_M HR-PPVAPAVHVRAARISYRRAFSDGRLVLLFASSLATLTAVRGL-YATV
MUL_0354|M.ulcerans_Agy99 HR-PPVAPAVHVRAAHNSYRRAFSDGRLVLLFASSLATLTAVRGL-YATV
Mflv_1475|M.gilvum_PYR-GCK -----LAVLPRTRQTLLDTVRRFSESSFVTPTLALAAATAALSAG-VGFL
MSMEG_6245|M.smegmatis_MC2_155 GR----AGWPVAGASLCDELAQLGRKRLALAMLLAALVNAGTFAT-FTFL
TH_1753|M.thermoresistible__bu TP----QPAGTDYRVRTALRHVWRDRPLLLALLAVTTVGFASDPS-ITLA
Mvan_5224|M.vanbaalenii_PYR-1 RT---RHDSGRPWWTDLAVPGASHRRFLLVVVPVAPWVFGAGATA-YAVL
MAV_3974|M.avium_104 LA-----APPPPTRSTVTMREALRVRAYQSALLSNFATGWSAFGLRMALV
MAB_4615|M.abscessus_ATCC_1997 HP--------ERYEHDDYIRGAADRPHKLSLPLSFWLYSGFTAITMIGFA
Rv0842|M.tuberculosis_H37Rv P-MLMSASGLGVGAYGWVQLINALAVVAVTPLLTPWLSKQLA--LGPRPD
Mb0865|M.bovis_AF2122/97 P-MLMSASGLGVGAYGWVQLINALAVVAVTPLLTPWLSKQLA--LGPRPD
MMAR_4785|M.marinum_M P-MLMADSGLGAGEFGWTQVANAAAGIGLTPVITPWLGRKVAARINPRLD
MUL_0354|M.ulcerans_Agy99 P-MLMADSGLGAGEFGWAQVANAAAGIGLTPVITPWLGRKVAARINPRLD
Mflv_1475|M.gilvum_PYR-GCK P-VLGTDFGLSP-----VVTGAVVSVLALTTAVVQPLAGRAADSGRISLT
MSMEG_6245|M.smegmatis_MC2_155 APIVTESAGLGR-----LWVSVVLLLFGFGSFIGVTVAGRLS---DTRPG
TH_1753|M.thermoresistible__bu P-SLADNLGGGSELVGALSAAFGIGAAAGMATLALLRGRLASARVSVIGL
Mvan_5224|M.vanbaalenii_PYR-1 PALMAGRVSSAPIAFSALMCLVALGVGFTVQQLGRHLGAGGRRGVVTALA
MAV_3974|M.avium_104 PLFVSDVMGRGIG-----TIGVVLAAFAGGNALAVVPSGYLSDRMGRRTL
MAB_4615|M.abscessus_ATCC_1997 TFGVLSFHMVQRGVLPVPAVPIVYAAAMAADAVAALLSGWAYDRVGPKSL
. : : .
Rv0842|M.tuberculosis_H37Rv ILAGAGVWVTLCMAAAGLART---TVGFSVAAAACSPGEIAWFVVAAGIV
Mb0865|M.bovis_AF2122/97 ILAGAGVWVTLCMAAAGLART---TVGFSVAAAACSPGEIAWFVVAAGIV
MMAR_4785|M.marinum_M ILAIAGGWTALTMAGAALAHT---TFGFAIAVAASAPGEIAWFVIAAGIV
MUL_0354|M.ulcerans_Agy99 ILAIAGGWTALTMAGAALAHT---TFGFAIAVAASAAGEIAWFVIAVGTV
Mflv_1475|M.gilvum_PYR-GCK SGLFTGVVVTAAGVAAAALPG---LVGLLGGAVVIGVGCGLITPLAFTML
MSMEG_6245|M.smegmatis_MC2_155 IVIGAGGPALLAGWAALALLS---SQPVALLPLAFVQG-ALSFAVGSTLI
TH_1753|M.thermoresistible__bu WLLGAGSLVLALSTVTAVALAGFVVAGVGFGWAMTGLSTVVQERAPDELR
Mvan_5224|M.vanbaalenii_PYR-1 LLVVG---MLLAGWAAAVLTV----WSALVAAAVLGAGYGMALLAGLQEI
MAV_3974|M.avium_104 LIVGLVTSGAATVWLGFVASLPVFLVAAGVVGVVTGIYMSPLQAAVADIL
MAB_4615|M.abscessus_ATCC_1997 AALPIVGATVPMLAFTDSLPG------IVLGALLWGAAVGIQESTLRAVV
Rv0842|M.tuberculosis_H37Rv HRIAPPAHGGRYHG--IWSMAVAASSVAAPILAAFNLANGGRLVLAATTV
Mb0865|M.bovis_AF2122/97 HRIAPPAHGGRYHG--IWSMAVAASSVAAPILAAFNLANGGRLVLAATTV
MMAR_4785|M.marinum_M HRIAPPASGGRYHG--IWSMTLAIASVVAPIVSSCSLTHGGHRLVALVTV
MUL_0354|M.ulcerans_Agy99 HRIAPPASGGRYHG--IWSMTLAIASVVAPIVSSCSLTHGGHRLVALVTV
Mflv_1475|M.gilvum_PYR-GCK ARSTPEERLGQTMG--AAEIGRECGDAAGPLVVAA--------IAAASTV
MSMEG_6245|M.smegmatis_MC2_155 TRVLYEASAAPTMGGAYATAALNVGAAGGPVAAAAALGNHAN-VVAPVWV
TH_1753|M.thermoresistible__bu GRIMALWLVGFLGSRPIAAAVLGGTADTISVAAAFALAALSVAVIAVLCR
Mvan_5224|M.vanbaalenii_PYR-1 QRIAGPDDLAGLTAVFYSLSYLGFAVPAVLAFAVRSFSYPAMFGFGAFAA
MAV_3974|M.avium_104 GNEARAGLPVATVQMMSDLGAIVGSMAVG--WAAEQIGYGWGFFISGVVL
MAB_4615|M.abscessus_ATCC_1997 ADLVPPPRRATAYG--VYAAVLGTATAIGGALTGYLYGVSIPMLIAVVGV
.
Rv0842|M.tuberculosis_H37Rv TVGFFGAALCLPLARVLAAAS-CGPLSSKEPSRDSYQ
Mb0865|M.bovis_AF2122/97 TVGFFGAALCLPLARVLAAAS-CGPLSSKEPSRDSYQ
MMAR_4785|M.marinum_M TVGLAGAALCLPLARALNRSGDVGVRDSQYTAVAGAA
MUL_0354|M.ulcerans_Agy99 TVGLAGAALCLP----LNRSGDVGVRDSQYTAVAAAA
Mflv_1475|M.gilvum_PYR-GCK PFGFLGLAAVVA-------ASGVGVRRGRGRVGGVG-
MSMEG_6245|M.smegmatis_MC2_155 SSVMVALALLIAVPMLKIVAPRPNPATSTPPLGGNCG
TH_1753|M.thermoresistible__bu PATLGRPAPFEPVPVGGGSTGADRARSNMVVTNPAEL
Mvan_5224|M.vanbaalenii_PYR-1 AVCLL--------------VAVLGSRRTAAIS-----
MAV_3974|M.avium_104 LIAAVGWVMAPETRTATELEADLMAASRTSSRCEQQL
MAB_4615|M.abscessus_ATCC_1997 IQLVALIT-----------AAPTLLRHAGQV------