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TATATPSETQHRSHRLRPWVAVAAAAFCIGWGGNQFTPLLIAYTQHSGYTRVDVDVLLGAYVLGLIPGLL VASTLSDRYGRRPVMALGVASSALGSVILAIGEYWGFSALFAGRLLSGAAVGIAMAVGSAWITELSRAPF DDAAPGSGARRASICLSLGLGVGPLCAGLLTEYAPLPLVLTYLVHAGLCLPALWAIRHRTIETRSGTPSV GVIEGLRVPAAAHRRFVRVVMPMAPWIFGSAAIAYAIVPALVADRLGHWALLYTAGLTVLTLGCGVAVQP IARRLDDHSSARAVVVSMVLMALGVFAAVATAVTRSIGMAVVVAMLLGCAYGIAIVSGLLEVQRIAEPDE LAGISGVYYSLAYAGFLLPAILAALARFFSYPAMLTVVGLLAAACTALCASGWSKHLEPRTVTARV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0534 | - | - | 100% (417) | permease, major facilitator family protein |
| M. smegmatis MC2 155 | MSMEG_5167 | - | 1e-29 | 27.47% (364) | major facilitator superfamily protein MFS_1 |
| M. smegmatis MC2 155 | MSMEG_3373 | - | 2e-18 | 24.66% (365) | major facilitator superfamily protein MFS_1 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2871c | efpA | 2e-07 | 27.83% (212) | integral membrane efflux protein EfpA |
| M. gilvum PYR-GCK | Mflv_1534 | - | 1e-84 | 42.64% (394) | major facilitator transporter |
| M. tuberculosis H37Rv | Rv2846c | efpA | 2e-07 | 27.83% (212) | integral membrane efflux protein EfpA |
| M. leprae Br4923 | MLBr_01562 | - | 4e-10 | 27.48% (353) | putative transmembrane efflux protein |
| M. abscessus ATCC 19977 | MAB_0069 | - | 7e-82 | 43.97% (373) | major facilitator transporter |
| M. marinum M | MMAR_1887 | efpA | 2e-08 | 25.56% (356) | integral membrane efflux protein EfpA |
| M. avium 104 | MAV_0138 | - | 6e-43 | 31.51% (384) | transporter, major facilitator family protein |
| M. thermoresistible (build 8) | TH_0476 | - | 6e-28 | 27.58% (359) | major facilitator superfamily protein MFS_1 |
| M. ulcerans Agy99 | MUL_2115 | efpA | 1e-08 | 26.46% (427) | integral membrane efflux protein EfpA |
| M. vanbaalenii PYR-1 | Mvan_5224 | - | 5e-89 | 44.36% (408) | major facilitator superfamily transporter |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1887|M.marinum_M MTALNDTERAVHNWTSGRQERPTSARATRETETASERASRYYPTWLPSR-
MUL_2115|M.ulcerans_Agy99 MTALNDTERAVHNWTSGRQERPTSARATRETETASERASRYYPTWLPSR-
Mb2871c|M.bovis_AF2122/97 MTALNDTERAVRNWRAGRPHRPAPMRPPRSEETASERPSRYYPTWLPSR-
Rv2846c|M.tuberculosis_H37Rv MTALNDTERAVRNWTAGRPHRPAPMRPPRSEETASERPSRYYPTWLPSR-
MLBr_01562|M.leprae_Br4923 MVTLYDHERAVHNWTAARSDRPAPSRLTQQVEPASERTSK-YPTLLPSGR
Mflv_1534|M.gilvum_PYR-GCK -------------MDKVFTYSGGGAAPAGLDRPATIGAGRGARGWVAVA-
Mvan_5224|M.vanbaalenii_PYR-1 -----------------MTVVAVAAATT---RPS----GRSARRWLAVA-
MAB_0069|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_0534|M.smegmatis_MC2_155 -----------------MTATATPSETQHR--------SHRLRPWVAVA-
MAV_0138|M.avium_104 ------------------MMSSNVRAARNRPGRTDPQPPTGAPLFVGVLG
TH_0476|M.thermoresistible__bu -------------------------------------VRRFAFPLLAYA-
MMAR_1887|M.marinum_M ----RFIAAVIAIGGMQLLATMDSTVAIVALPKIQDELSLSDAGRSWVIT
MUL_2115|M.ulcerans_Agy99 ----RFIAAVIAIGGMQLLATMDSTVAIVALPKIQDELSLSDAGRSWVIT
Mb2871c|M.bovis_AF2122/97 ----SFIAAVIAIGGMQLLATMDSTVAIVALPKIQNELSLSDAGRSWVIT
Rv2846c|M.tuberculosis_H37Rv ----SFIAAVIAIGGMQLLATMDSTVAIVALPKIQNELSLSDAGRSWVIT
MLBr_01562|M.leprae_Br4923 FPSGRFIAAVIVIGGMQLLATMDSTVAIVALPKIQNELSLSDAGRSWGIT
Mflv_1534|M.gilvum_PYR-GCK -----LATFAIAWGGNEFTP---------LLVMYRLDDGFSALTVDLLLF
Mvan_5224|M.vanbaalenii_PYR-1 -----AATFAIAWGGNEFTP---------LLVMYRTQDGFSALTVDLLLF
MAB_0069|M.abscessus_ATCC_1997 -------MFGIAWGGNEFTP---------LLVMYR-QAGQSAASVDTLLF
MSMEG_0534|M.smegmatis_MC2_155 -----AAAFCIGWGGNQFTP---------LLIAYTQHSGYTRVDVDVLLG
MAV_0138|M.avium_104 ------LLLATGWVANHFVG---------LMPAISDRDHLATTTLDGIFG
TH_0476|M.thermoresistible__bu -------FAAVMVGTTVPTP---------MYAVYAERLGFGVLTTTVVFA
:
MMAR_1887|M.marinum_M AYVLTFGGLMLLGGRLGDTIGRKRTFIVGVALFTISSVLCAVAWDE--AT
MUL_2115|M.ulcerans_Agy99 AYVLTFGGLMLLGGRLGDTIGRKRTFIVGVALFTISSVLCAVAWDE--AT
Mb2871c|M.bovis_AF2122/97 AYVLTFGGLMLLGGRLGDTIGRKRTFIVGVALFTISSVLCAVAWDE--AT
Rv2846c|M.tuberculosis_H37Rv AYVLTFGGLMLLGGRLGDTIGRKRTFIVGVALFTISSVLCAVAWDE--AT
MLBr_01562|M.leprae_Br4923 AYVLTFGGLMLLGGRLGDTIGRKRTFIVGVALFTISSVLCAVAWDE--VT
Mflv_1534|M.gilvum_PYR-GCK AYVLGIVPALLIGGPMSDRFGRRPLMLPAPLLAAIGSLILAVGADS-AWL
Mvan_5224|M.vanbaalenii_PYR-1 AYVLGIVPALLIGGPLSDRFGRRPLMLPAPVLAAVGSAILALGAQS-APV
MAB_0069|M.abscessus_ATCC_1997 AYVLGIIPALFLGGPLSDRYGRRAVMLPAPFISMLGSLVLALGAQH-FAL
MSMEG_0534|M.smegmatis_MC2_155 AYVLGLIPGLLVASTLSDRYGRRPVMALGVASSALGSVILAIGEYWGFSA
MAV_0138|M.avium_104 IYALGLLPGLLVGGRTSDALGRRPVALTGSAAALVGTVAMLLSQHS--PA
TH_0476|M.thermoresistible__bu GYTAGVLFALVVFGRWSDALGRRPMLLAGVGCAIVSALVFLIAGSV--PQ
*. . :.: . .* **: . :.: :.
MMAR_1887|M.marinum_M LVIARLSQGVGSAIASPTGLALVATTFPKGPARNAATAVFAAMTAVGSVM
MUL_2115|M.ulcerans_Agy99 LVIARLSQGVGSAIASPTGLALVATTFPKGPTRNAATAVFAAMTAVGSVM
Mb2871c|M.bovis_AF2122/97 LVIARLSQGVGSAIASPTGLALVATTFPKGPARNAATAVFAAMTAIGSVM
Rv2846c|M.tuberculosis_H37Rv LVIARLSQGVGSAIASPTGLALVATTFPKGPARNAATAVFAAMTAIGSVM
MLBr_01562|M.leprae_Br4923 LVIARLLQGIGSAIASPTGLALVATTFSKGSARNTATAVFAAMTAIGSVM
Mflv_1534|M.gilvum_PYR-GCK LGVGRVFSGLALGLAMAVGGSWIK-ELSSPPWD--VGDAGARRAAMSLTA
Mvan_5224|M.vanbaalenii_PYR-1 LGVGRVFSGVALGLAMAVGGSWIK-ELSSPPWE--DGDAGARRAAMSLTA
MAB_0069|M.abscessus_ATCC_1997 LFTGRVLSGVALGLAMAAGSSWVK-ELSAPPFD--RPGAGARRGAMSLTA
MSMEG_0534|M.smegmatis_MC2_155 LFAGRLLSGAAVGIAMAVGSAWIT-ELSRAPFDDAAPGSGARRASICLSL
MAV_0138|M.avium_104 LFAGRLIVGLGVGLAISAGTAWAS---------DLRGPAGAATAGAVLTA
TH_0476|M.thermoresistible__bu LIAARFVSGMSAGIFTGTATAAVIEAAPER-----RRSRAAAVATVANIG
* .*. * . .: .. : *
MMAR_1887|M.marinum_M GLVVGGALTEVSWRLAFMVNVPIGLVMIYLARTALRETNRERMKLDAAGA
MUL_2115|M.ulcerans_Agy99 GLVVGGALTEVSWRLAFMVNVPIGLVMIYLARTALRETNRERMKLDAAGA
Mb2871c|M.bovis_AF2122/97 GLVVGGALTEVSWRWAFLVNVPIGLVMIYLARTALRETNKERMKLDATGA
Rv2846c|M.tuberculosis_H37Rv GLVVGGALTEVSWRWAFLVNVPIGLVMIYLARTALRETNKERMKLDATGA
MLBr_01562|M.leprae_Br4923 GLVVGGALTEVSWRLAFLVNVPIGLVMIYLARTALHETHKERMKLDAAGA
Mflv_1534|M.gilvum_PYR-GCK GFGLGAAVAGVLAQWG-----PAPTVLPYAIN------------------
Mvan_5224|M.vanbaalenii_PYR-1 GFGLGAGTAGVLAEWG-----PAPTVLPYAVN------------------
MAB_0069|M.abscessus_ATCC_1997 GFALGAAVAGALAQWG-----PWPQHLAFLVN------------------
MSMEG_0534|M.smegmatis_MC2_155 GLGVGPLCAGLLTEYA-----PLPLVLTYLVH------------------
MAV_0138|M.avium_104 GFAVGPFAGGVLAWAG-----PSGVRASFALA------------------
TH_0476|M.thermoresistible__bu GLGAGPLLAGILVQYA-----PWPLHLTFWVH------------------
*: * . * :
MMAR_1887|M.marinum_M ILATLACTAAVFAFSMGPEKGWLSITTIGSGAVAFAAALGFVLVERTAEN
MUL_2115|M.ulcerans_Agy99 ILATLACTAAVFAFSMGPEKGWLSITTIGSGAVAFAAALGFVLVERTAEN
Mb2871c|M.bovis_AF2122/97 ILATLACTAAVFAFSIGPEKGWMSGITIGSGLVALAAAVAFVIVERTAEN
Rv2846c|M.tuberculosis_H37Rv ILATLACTAAVFAFSIGPEKGWMSGITIGSGLVALAAAVAFVIVERTAEN
MLBr_01562|M.leprae_Br4923 ILATLACTAAVFAFSMGPEKGWISLTTIGSGLVALVAAIAFAVVERTAEN
Mflv_1534|M.gilvum_PYR-GCK --VAMAVAAAVLLLS-APETRARSVSVRPA-------------ANSWWSD
Mvan_5224|M.vanbaalenii_PYR-1 --IAMALAAAVFVST-APETRTRHDSGRP-----------------WWTD
MAB_0069|M.abscessus_ATCC_1997 --IAITIPGAVLALS-VPESAAERAPGRL------------------IDD
MSMEG_0534|M.smegmatis_MC2_155 --AGLCLPALWAIRHRTIETRSGTPSVGV------------------IEG
MAV_0138|M.avium_104 ---AAILALAAFAVVAAPQPSPVTAPADPDG----------------EET
TH_0476|M.thermoresistible__bu ---IVLMVLAAAAIAVAPETSPRTGRLGVQR-------------------
:
MMAR_1887|M.marinum_M PVVPFDLFHDRNRLVTFIAIFLAGGVMFSLTVCIGLYVQDVLGYSALRAG
MUL_2115|M.ulcerans_Agy99 PVVPFDLFHDRNRLVTFIAIFLAGGVMFSLTVCIGLYVQDVLGYSALRAG
Mb2871c|M.bovis_AF2122/97 PVVPFHLFRDRNRLVTFSAILLAGGVMFSLTVCIGLYVQDILGYSALRAG
Rv2846c|M.tuberculosis_H37Rv PVVPFHLFRDRNRLVTFSAILLAGGVMFSLTVCIGLYVQDILGYSALRAG
MLBr_01562|M.leprae_Br4923 PVVPFDLFRDRNRLVTFIAIFLAGGVIFSLTVSIGLYIQDILGYSALRAG
Mflv_1534|M.gilvum_PYR-GCK LAIPGASHRRFLLVVVPLAPWVFGAGASAYAVLPALMTEHVA-----AAP
Mvan_5224|M.vanbaalenii_PYR-1 LAVPGASHRRFLLVVVPVAPWVFGAGATAYAVLPALMAGRVS-----SAP
MAB_0069|M.abscessus_ATCC_1997 LKIPAARRRRFLFVVMPLAPWVFGSAAVAYAVLPTLIAPTLP-----GDR
MSMEG_0534|M.smegmatis_MC2_155 LRVPAAAHRRFVRVVMPMAPWIFGSAAIAYAIVPALVADRLG-----HWA
MAV_0138|M.avium_104 ADAAPQGISRALSWAMPLAPWVFASATLGFVTIPGRLHTALA-------A
TH_0476|M.thermoresistible__bu -LSLPPQVRKVFAIASLAAFAGFAVTGLFTAVAPSFLAEVIG-----VRN
. * . . :
MMAR_1887|M.marinum_M VGFIPFVIAMGIGLGVSSQLVSRFSPRVLTIGGGYLLVCAMIYGWAFMQR
MUL_2115|M.ulcerans_Agy99 VGFIPFVIAMGIGLGVSSQLVSRFSPRVLTIGGGYLLVCAMIYGWAFMQR
Mb2871c|M.bovis_AF2122/97 VGFIPFVIAMGIGLGVSSQLVSRFSPRVLTIGGGYLLFGAMLYGSFFMHR
Rv2846c|M.tuberculosis_H37Rv VGFIPFVIAMGIGLGVSSQLVSRFSPRVLTIGGGYLLFGAMLYGSFFMHR
MLBr_01562|M.leprae_Br4923 IGFIPFVIAMGIGLGVSSQLVSRFSPRVLTIGGGWLLMVAMLYGWAFMNR
Mflv_1534|M.gilvum_PYR-GCK IAFSALLCAVTLGVAFGVQHLGRSLL-SGGALGVVVALGLVAAGMALAAW
Mvan_5224|M.vanbaalenii_PYR-1 IAFSALMCLVALGVGFTVQQLGRHLG-AGGRRGVVTALALLVVGMLLAGW
MAB_0069|M.abscessus_ATCC_1997 IAFSALCCLVCLGCGFTAQMLAPRLDRAGTARLGIIGLALVAVGMALAAL
MSMEG_0534|M.smegmatis_MC2_155 LLYTAGLTVLTLGCGVAVQPIARRLDDHSSARAVVVSMVLMALGVFAAVA
MAV_0138|M.avium_104 PVAAGTATLIVNGVSGAVQVLARALR--WGPQAGTAGAVLAALGYAVAAA
TH_0476|M.thermoresistible__bu HAVAGAVAASIFAASAVTQVLGASVS---PRRAVAVGCALLIVGMVFLAA
. . * :. *
MMAR_1887|M.marinum_M GVPYFPNLVAPIVIGGIGIGMAVVPLTLAAIAGVGFDRIGPVSALTLMLQ
MUL_2115|M.ulcerans_Agy99 GVPYFPNLVAPIVIGGIGIGMAVVPLTLAAIAGVGFDRIGPVSALTLMLQ
Mb2871c|M.bovis_AF2122/97 GVPYFPNLVMPIVVGGIGIGMAVVPLTLSAIAGVGFDQIGPVSAIALMLQ
Rv2846c|M.tuberculosis_H37Rv GVPYFPNLVMPIVVGGIGIGMAVVPLTLSAIAGVGFDQIGPVSAIALMLQ
MLBr_01562|M.leprae_Br4923 GVPYFPNLLAPIVVGGIGIGMAVVPLTLSAIAGVGFDRIGPVSAIALMLQ
Mflv_1534|M.gilvum_PYR-GCK ASASLTIWATVVAAAVLGAGYGMALVAG-----------------LQEIQ
Mvan_5224|M.vanbaalenii_PYR-1 AAAVLTVWSALVAAAVLGAGYGMALLAG-----------------LQEIQ
MAB_0069|M.abscessus_ATCC_1997 AAHQLTIPLVLIAALALGAGYGTALVSG-----------------LQEVN
MSMEG_0534|M.smegmatis_MC2_155 TAVTRSIGMAVVVAMLLGCAYGIAIVSG-----------------LLEVQ
MAV_0138|M.avium_104 APSTLTPALGVPLFVVLGCASGLCLREG-----------------LIDLE
TH_0476|M.thermoresistible__bu ALVWSSLPALIATAVVAGAGQGLSFSRG------------------LAAV
. * . .
MMAR_1887|M.marinum_M SLGGPLVLAVIQAVITSRTLYLGGTTGPVKFMNDAQLHALDHG---YTYG
MUL_2115|M.ulcerans_Agy99 SLGGPLVLAGIQAVITSRTLYLGGTTGPVKFMNDAQLHALDHG---YTYG
Mb2871c|M.bovis_AF2122/97 SLGGPLVLAVIQAVITSRTLYLGGTTGPVKFMNDVQLAALDHA---YTYG
Rv2846c|M.tuberculosis_H37Rv SLGGPLVLAVIQAVITSRTLYLGGTTGPVKFMNDVQLAALDHA---YTYG
MLBr_01562|M.leprae_Br4923 SLGGPLVLAVIQAVITSRTLYLGGTTGPVKFMNDAQLRALDHG---YTYG
Mflv_1534|M.gilvum_PYR-GCK RIATPDDLAGLTAVFYS-LCYLG-------FGVPAAMVFLSDY---ASYP
Mvan_5224|M.vanbaalenii_PYR-1 RIAGPDDLAGLTAVFYS-LSYLG-------FAVPAVLAFAVRS---FSYP
MAB_0069|M.abscessus_ATCC_1997 RIAGPTDLAGLTAVFYG-LTYLG-------FGVPMMLTMLSDASPLLTHP
MSMEG_0534|M.smegmatis_MC2_155 RIAEPDELAGISGVYYS-LAYAG-------FLLPAILAALARF---FSYP
MAV_0138|M.avium_104 AAAPQRLRGGLTGLFYV-VTYIG-------FGLPLILASVRPG----VAT
TH_0476|M.thermoresistible__bu SARTPSDQRGEVSSTYFVVAYVA-------LLVPVIGEGWAAH-----HW
. * . :
MMAR_1887|M.marinum_M LLWVAGAAVIVGGAAVFIGYTPEQVAHAQEVKEAIDAGEL------
MUL_2115|M.ulcerans_Agy99 LLWVAGAAVIVGGAAVFIGYTPEQVAHAQEVKEAIDAGEL------
Mb2871c|M.bovis_AF2122/97 LLWVAGAAIIVGGMALFIGYTPQQVAHAQEVKEAIDAGEL------
Rv2846c|M.tuberculosis_H37Rv LLWVAGAAIIVGGMALFIGYTPQQVAHAQEVKEAIDAGEL------
MLBr_01562|M.leprae_Br4923 LLWVAGAVVIVGVAALFIGYTPEQVAYAQEVKEAVDAGEL------
Mflv_1534|M.gilvum_PYR-GCK SMFGFGAVAAVGCLAVAVTGLR--------RTPAIS----------
Mvan_5224|M.vanbaalenii_PYR-1 AMFGFGAFAAAVCLLVAVLGSR--------RTAAIS----------
MAB_0069|M.abscessus_ATCC_1997 VLLCGGALLATVCLVVLMLNSRTDVGARPGTTAAVPADETREPVLR
MSMEG_0534|M.smegmatis_MC2_155 AMLTVVGLLAAACTALCASGWSKHLEP---RTVTARV---------
MAV_0138|M.avium_104 AILSGMAVLAVTAAVGRAARLR--------RDDHRQN---------
TH_0476|M.thermoresistible__bu GLRTAGISFAVGVAVLAIGCLIAILIQESRDPQAI-----------
: .