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MSSNVRAARNRPGRTDPQPPTGAPLFVGVLGLLLATGWVANHFVGLMPAISDRDHLATTTLDGIFGIYAL GLLPGLLVGGRTSDALGRRPVALTGSAAALVGTVAMLLSQHSPALFAGRLIVGLGVGLAISAGTAWASDL RGPAGAATAGAVLTAGFAVGPFAGGVLAWAGPSGVRASFALAAAILALAAFAVVAAPQPSPVTAPADPDG EETADAAPQGISRALSWAMPLAPWVFASATLGFVTIPGRLHTALAAPVAAGTATLIVNGVSGAVQVLARA LRWGPQAGTAGAVLAALGYAVAAAAPSTLTPALGVPLFVVLGCASGLCLREGLIDLEAAAPQRLRGGLTG LFYVVTYIGFGLPLILASVRPGVATAILSGMAVLAVTAAVGRAARLRRDDHRQN*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_0138 | - | - | 100% (405) | transporter, major facilitator family protein |
| M. avium 104 | MAV_1406 | - | 2e-08 | 24.32% (403) | transporter, major facilitator family protein |
| M. avium 104 | MAV_1387 | - | 2e-07 | 34.38% (128) | drug transporter |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1288c | - | 7e-10 | 27.00% (337) | integral membrane transport protein |
| M. gilvum PYR-GCK | Mflv_1534 | - | 1e-43 | 33.25% (391) | major facilitator transporter |
| M. tuberculosis H37Rv | Rv1258c | - | 8e-10 | 27.00% (337) | integral membrane transport protein |
| M. leprae Br4923 | MLBr_01562 | - | 1e-05 | 31.19% (109) | putative transmembrane efflux protein |
| M. abscessus ATCC 19977 | MAB_0069 | - | 1e-41 | 32.47% (385) | major facilitator transporter |
| M. marinum M | MMAR_4182 | - | 1e-08 | 25.59% (383) | hypothetical protein MMAR_4182 |
| M. smegmatis MC2 155 | MSMEG_0534 | - | 8e-43 | 31.51% (384) | permease, major facilitator family protein |
| M. thermoresistible (build 8) | TH_0476 | - | 5e-28 | 30.34% (356) | major facilitator superfamily protein MFS_1 |
| M. ulcerans Agy99 | MUL_2115 | efpA | 3e-06 | 24.37% (197) | integral membrane efflux protein EfpA |
| M. vanbaalenii PYR-1 | Mvan_5224 | - | 2e-42 | 33.24% (376) | major facilitator superfamily transporter |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1534|M.gilvum_PYR-GCK ----------MDKVFTYSGGGAAPAGLDRPATIGAGRGAR----------
Mvan_5224|M.vanbaalenii_PYR-1 --------------MTVVAVAAATT---RPS----GRSAR----------
MAB_0069|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_0534|M.smegmatis_MC2_155 --------------MTATATPSETQHR--------SHRLR----------
MLBr_01562|M.leprae_Br4923 MVTLYDHERAVHNWTAARSDRPAPSRLTQQVEPASERTSK-YPTLLPSGR
MUL_2115|M.ulcerans_Agy99 MTALNDTERAVHNWTSGRQERPTSARATRETETASERASRYYPTWLPSR-
Mb1288c|M.bovis_AF2122/97 ----------------------------------MRNSNR----------
Rv1258c|M.tuberculosis_H37Rv ----------------------------------MRNSNR----------
MMAR_4182|M.marinum_M ----------------------------------MRNSSR----------
MAV_0138|M.avium_104 ---------------MMSSNVRAARNRPGRTDPQPPTGAP----------
TH_0476|M.thermoresistible__bu -------------------------------------VRR----------
Mflv_1534|M.gilvum_PYR-GCK --------GWVAVALATFAIAWGGNEFTPLLVMYRLDDGFSALTVDLLLF
Mvan_5224|M.vanbaalenii_PYR-1 --------RWLAVAAATFAIAWGGNEFTPLLVMYRTQDGFSALTVDLLLF
MAB_0069|M.abscessus_ATCC_1997 ----------------MFGIAWGGNEFTPLLVMYR-QAGQSAASVDTLLF
MSMEG_0534|M.smegmatis_MC2_155 --------PWVAVAAAAFCIGWGGNQFTPLLIAYTQHSGYTRVDVDVLLG
MLBr_01562|M.leprae_Br4923 FPSGRFIAAVIVIGGMQLLATMDSTVAIVALPKIQNELSLSDAGRSWGIT
MUL_2115|M.ulcerans_Agy99 ----RFIAAVIAIGGMQLLATMDSTVAIVALPKIQDELSLSDAGRSWVIT
Mb1288c|M.bovis_AF2122/97 -------GPAFLILFATLMAAAGDGVSIVAFPWLVLQREGSAGQASIVAS
Rv1258c|M.tuberculosis_H37Rv -------GPAFLILFATLMAAAGDGVSIVAFPWLVLQREGSAGQASIVAS
MMAR_4182|M.marinum_M -------GPAFLILFATLAACAGNGISIVAFPWLVLEREGSAGQASIVAG
MAV_0138|M.avium_104 --------LFVGVLGLLLATGWVANHFVGLMPAISDRDHLATTTLDGIFG
TH_0476|M.thermoresistible__bu -------FAFPLLAYAFAAVMVGTTVPTPMYAVYAERLGFGVLTTTVVFA
Mflv_1534|M.gilvum_PYR-GCK AYVLGIVPALLIGGPMSDRFGRRPLMLPAPLLAAIGSLILAVGADS----
Mvan_5224|M.vanbaalenii_PYR-1 AYVLGIVPALLIGGPLSDRFGRRPLMLPAPVLAAVGSAILALGAQS----
MAB_0069|M.abscessus_ATCC_1997 AYVLGIIPALFLGGPLSDRYGRRAVMLPAPFISMLGSLVLALGAQH----
MSMEG_0534|M.smegmatis_MC2_155 AYVLGLIPGLLVASTLSDRYGRRPVMALGVASSALGSVILAIGEYWG---
MLBr_01562|M.leprae_Br4923 AYVLTFGGLMLLGGRLGDTIGRKRTFIVGVALFTISSVLCAVAWDE----
MUL_2115|M.ulcerans_Agy99 AYVLTFGGLMLLGGRLGDTIGRKRTFIVGVALFTISSVLCAVAWDE----
Mb1288c|M.bovis_AF2122/97 ATMLPLLFATLVAGTAVDYFGRRRVSMVADALSGAAVAGVPLVAWGYGGD
Rv1258c|M.tuberculosis_H37Rv ATMLPLLFATLVAGTAVDYFGRRRVSMVADALSGAAVAGVPLVAWGYGGD
MMAR_4182|M.marinum_M AITLPLLFSTLVAGTAVDYFGRRPVSMVSDALSGSAVAIVPLIAWAFGDD
MAV_0138|M.avium_104 IYALGLLPGLLVGGRTSDALGRRPVALTGSAAALVGTVAMLLSQHS----
TH_0476|M.thermoresistible__bu GYTAGVLFALVVFGRWSDALGRRPMLLAGVGCAIVSALVFLIAGSVP---
. .: . * **: . . :
Mflv_1534|M.gilvum_PYR-GCK AWLLGVGRVFSGLALGLAMAVGGSWIKELSSPPWD---VGDAGARRAAMS
Mvan_5224|M.vanbaalenii_PYR-1 APVLGVGRVFSGVALGLAMAVGGSWIKELSSPPWE---DGDAGARRAAMS
MAB_0069|M.abscessus_ATCC_1997 FALLFTGRVLSGVALGLAMAAGSSWVKELSAPPFD---RPGAGARRGAMS
MSMEG_0534|M.smegmatis_MC2_155 FSALFAGRLLSGAAVGIAMAVGSAWITELSRAPFDD-AAPGSGARRASIC
MLBr_01562|M.leprae_Br4923 -VTLVIARLLQGIGSAIASPTGLALVATTFSKGSA----RNTATAVFAAM
MUL_2115|M.ulcerans_Agy99 -ATLVIARLSQGVGSAIASPTGLALVATTFPKGPT----RNAATAVFAAM
Mb1288c|M.bovis_AF2122/97 AVNVLVLAVLAALAAAFGPAGMTARDSMLPEAAARAGWSLDRINGAYEAI
Rv1258c|M.tuberculosis_H37Rv AVNVLVLAVLAALAAAFGPAGMTARDSMLPEAAARAGWSLDRINGAYEAI
MMAR_4182|M.marinum_M AVSVAVLAALGACSATFDPAGITARQSMLPEAAARAGWSLDRINSSYEAI
MAV_0138|M.avium_104 -PALFAGRLIVGLGVGLAISAGTAWASDLRG---------PAGAATAGAV
TH_0476|M.thermoresistible__bu --QLIAARFVSGMSAGIFTGTATAAVIEAAPERRR-----SRAAAVATVA
: . . : :
Mflv_1534|M.gilvum_PYR-GCK LTAGFGLGAAVAGVLAQWGPAPTVLPYAINVAMAVAAAVLLLS-APETRA
Mvan_5224|M.vanbaalenii_PYR-1 LTAGFGLGAGTAGVLAEWGPAPTVLPYAVNIAMALAAAVFVST-APETRT
MAB_0069|M.abscessus_ATCC_1997 LTAGFALGAAVAGALAQWGPWPQHLAFLVNIAITIPGAVLALS-VPESAA
MSMEG_0534|M.smegmatis_MC2_155 LSLGLGVGPLCAGLLTEYAPLPLVLTYLVHAGLCLPALWAIRHRTIETRS
MLBr_01562|M.leprae_Br4923 TAIGSVMGLVVGGALTEVS---WRLAFLVNVPIGLVMIYLARTALHETHK
MUL_2115|M.ulcerans_Agy99 TAVGSVMGLVVGGALTEVS---WRLAFMVNVPIGLVMIYLARTALRETNR
Mb1288c|M.bovis_AF2122/97 LNLAFIVGPAIGGLMIATVG-GITTMWITATAFGLSILAIAALQLEGAGK
Rv1258c|M.tuberculosis_H37Rv LNLAFIVGPAIGGLMIATVG-GITTMWITATAFGLSILAIAALQLEGAGK
MMAR_4182|M.marinum_M LNLAFVVGPGIGGLMIATVG-GITTMWITAGAFGLSLLAIGALRLEGAGR
MAV_0138|M.avium_104 LTAGFAVGPFAGGVLAWAGPSGVRASFALAAAILALAAFAVVAAPQPSPV
TH_0476|M.thermoresistible__bu NIGGLGAGPLLAGILVQYAPWPLHLTFWVHIVLMVLAAAAIAVAPETSPR
. * .* : : : :
Mflv_1534|M.gilvum_PYR-GCK RSVSVRPA------------------------------------------
Mvan_5224|M.vanbaalenii_PYR-1 RHDSGRP-------------------------------------------
MAB_0069|M.abscessus_ATCC_1997 ERAPGRL-------------------------------------------
MSMEG_0534|M.smegmatis_MC2_155 GTPSVGV-------------------------------------------
MLBr_01562|M.leprae_Br4923 ERMKLDAAGAILATLACTAAVFAFSMGPEKGWISLTTIGSGLVALVAAIA
MUL_2115|M.ulcerans_Agy99 ERMKLDAAGAILATLACTAAVFAFSMGPEKGWLSITTIGSGAVAFAAALG
Mb1288c|M.bovis_AF2122/97 PHHTSRPQG-----------------------------------------
Rv1258c|M.tuberculosis_H37Rv PHHTSRPQG-----------------------------------------
MMAR_4182|M.marinum_M PHHETRPDG-----------------------------------------
MAV_0138|M.avium_104 TAPADPDG------------------------------------------
TH_0476|M.thermoresistible__bu TGRLGVQR------------------------------------------
Mflv_1534|M.gilvum_PYR-GCK ---ANSWWSDLAIPGASHRRFLLVVVPLAPWVFGAGASAYAVLPALMTEH
Mvan_5224|M.vanbaalenii_PYR-1 ------WWTDLAVPGASHRRFLLVVVPVAPWVFGAGATAYAVLPALMAGR
MAB_0069|M.abscessus_ATCC_1997 -------IDDLKIPAARRRRFLFVVMPLAPWVFGSAAVAYAVLPTLIAPT
MSMEG_0534|M.smegmatis_MC2_155 -------IEGLRVPAAAHRRFVRVVMPMAPWIFGSAAIAYAIVPALVADR
MLBr_01562|M.leprae_Br4923 FAVVERTAENPVVPFDLFRDRNRLVTFIAIFLAGGVIFSLTVSIGLYIQD
MUL_2115|M.ulcerans_Agy99 FVLVERTAENPVVPFDLFHDRNRLVTFIAIFLAGGVMFSLTVCIGLYVQD
Mb1288c|M.bovis_AF2122/97 -------LVSGIAEGLRFVWNLRVLRTLGMIDLTVTALYLPMESVLFPKY
Rv1258c|M.tuberculosis_H37Rv -------LVSGIAEGLRFVWNLRVLRTLGMIDLTVTALYLPMESVLFPKY
MMAR_4182|M.marinum_M -------LVSGVTQGLRFVWNLRVLRALALIDLTVTALYLPMESVLFPTY
MAV_0138|M.avium_104 -------EETADAAPQGISRALSWAMPLAPWVFASATLGFVTIPGRLHTA
TH_0476|M.thermoresistible__bu -----------LSLPPQVRKVFAIASLAAFAGFAVTGLFTAVAPSFLAEV
.
Mflv_1534|M.gilvum_PYR-GCK VA-----AAPIAFSALLCAVTLGVAFGVQHLG---RSLL-SGGALGVVVA
Mvan_5224|M.vanbaalenii_PYR-1 VS-----SAPIAFSALMCLVALGVGFTVQQLG---RHLG-AGGRRGVVTA
MAB_0069|M.abscessus_ATCC_1997 LP-----GDRIAFSALCCLVCLGCGFTAQMLA---PRLDRAGTARLGIIG
MSMEG_0534|M.smegmatis_MC2_155 LG-----HWALLYTAGLTVLTLGCGVAVQPIA---RRLDDHSSARAVVVS
MLBr_01562|M.leprae_Br4923 ILGYSALRAGIGFIPFVIAMGIGLGVSSQLVSRFSPRVLTIGGGWLLMVA
MUL_2115|M.ulcerans_Agy99 VLGYSALRAGVGFIPFVIAMGIGLGVSSQLVSRFSPRVLTIGGGYLLVCA
Mb1288c|M.bovis_AF2122/97 FTDH---QQPVQLGWALMAIAGGGLVGALGYAVLAIRVPRRVTMSTAVLT
Rv1258c|M.tuberculosis_H37Rv FTDH---QQPVQLGWALMAIAGGGLVGALGYAVLAIRVPRRVTMSTAVLT
MMAR_4182|M.marinum_M FSDR---QQPAQLGSVLVALSLGSLVGALGYGMLSNYVSRRTIMLTAVLT
MAV_0138|M.avium_104 LAAP-------VAAGTATLIVNGVSGAVQVLARALRWGPQAGTAGAVLAA
TH_0476|M.thermoresistible__bu IGVR----NHAVAGAVAASIFAASAVTQVLGASVSPRRAVAVGCALLIVG
. : . . :
Mflv_1534|M.gilvum_PYR-GCK LGL--------------VAAGMALAAWASASLTIWATVVAAAVLGAGYGM
Mvan_5224|M.vanbaalenii_PYR-1 LAL--------------LVVGMLLAGWAAAVLTVWSALVAAAVLGAGYGM
MAB_0069|M.abscessus_ATCC_1997 LAL--------------VAVGMALAALAAHQLTIPLVLIAALALGAGYGT
MSMEG_0534|M.smegmatis_MC2_155 MVL--------------MALGVFAAVATAVTRSIGMAVVVAMLLGCAYGI
MLBr_01562|M.leprae_Br4923 MLYGWAFMNRGVPYFPNLLAPIVVGGIGIGMAVVPLTLSAIAGVGFDRIG
MUL_2115|M.ulcerans_Agy99 MIYGWAFMQRGVPYFPNLVAPIVIGGIGIGMAVVPLTLAAIAGVGFDRIG
Mb1288c|M.bovis_AF2122/97 LG--------------------LASMVIAFLPPLPVIMVLCAVVGLVYGP
Rv1258c|M.tuberculosis_H37Rv LG--------------------LASMVIAFLPPLPVIMVLCAVVGLVYGP
MMAR_4182|M.marinum_M LG--------------------AATTGIALLPPLPVILVLCALIGVVYGP
MAV_0138|M.avium_104 LGY-------------------AVAAAAPSTLTPALGVPLFVVLGCASGL
TH_0476|M.thermoresistible__bu MVF---------------------LAAALVWSSLPALIATAVVAGAGQGL
: : *
Mflv_1534|M.gilvum_PYR-GCK ALVAGLQEIQRIATPDDLAGLTAVFYS-LCYLG-------FGVPAAMVFL
Mvan_5224|M.vanbaalenii_PYR-1 ALLAGLQEIQRIAGPDDLAGLTAVFYS-LSYLG-------FAVPAVLAFA
MAB_0069|M.abscessus_ATCC_1997 ALVSGLQEVNRIAGPTDLAGLTAVFYG-LTYLG-------FGVPMMLTML
MSMEG_0534|M.smegmatis_MC2_155 AIVSGLLEVQRIAEPDELAGISGVYYS-LAYAG-------FLLPAILAAL
MLBr_01562|M.leprae_Br4923 PVSAIALMLQSLGGPLVLAVIQAVITSRTLYLGGTTGPVKFMNDAQLRAL
MUL_2115|M.ulcerans_Agy99 PVSALTLMLQSLGGPLVLAGIQAVITSRTLYLGGTTGPVKFMNDAQLHAL
Mb1288c|M.bovis_AF2122/97 IQPIYNYVIQTRAAQHLRGRVVGVMTSLAYAAG--------PLGLLLAGP
Rv1258c|M.tuberculosis_H37Rv IQPIYNYVIQTRAAQHLRGRVVGVMTSLAYAAG--------PLGLLLAGP
MMAR_4182|M.marinum_M IQPIYNYVMQTRAPHYLRGRVVGVMTSLAYAAG--------PLGLLLAGP
MAV_0138|M.avium_104 CLREGLIDLEAAAPQRLRGGLTGLFYV-VTYIG-------FGLPLILASV
TH_0476|M.thermoresistible__bu SFSRGLAAVSARTPSDQRGEVSSTYFVVAYVA--------LLVPVIGEGW
:. . : .
Mflv_1534|M.gilvum_PYR-GCK SDY---ASYPSMFGFGAVAAVGCLAVAVTGLR--------RTPAIS----
Mvan_5224|M.vanbaalenii_PYR-1 VRS---FSYPAMFGFGAFAAAVCLLVAVLGSR--------RTAAIS----
MAB_0069|M.abscessus_ATCC_1997 SDASPLLTHPVLLCGGALLATVCLVVLMLNSRTDVGARPGTTAAVPADET
MSMEG_0534|M.smegmatis_MC2_155 ARF---FSYPAMLTVVGLLAAACTALCASGWSKHLEP---RTVTARV---
MLBr_01562|M.leprae_Br4923 DHG---YTYGLLWVAGAVVIVGVAALFIGYTPEQVAYAQEVKEAVDAGEL
MUL_2115|M.ulcerans_Agy99 DHG---YTYGLLWVAGAAVIVGGAAVFIGYTPEQVAHAQEVKEAIDAGEL
Mb1288c|M.bovis_AF2122/97 LTDAAGLHATFLALALPIVCTGLVAIRLPALRELDLAPQADIDRPVGSAQ
Rv1258c|M.tuberculosis_H37Rv LTDAAGLHATFLALALPIVCTGLVAIRLPALRELDLAPQADIDRPVGSAQ
MMAR_4182|M.marinum_M VADAAGLKVAFFALALPIAITGLMCIRLPSLRELDHAPTQDISETSLL--
MAV_0138|M.avium_104 RPG----VATAILSGMAVLAVTAAVGRAARLR--------RDDHRQN---
TH_0476|M.thermoresistible__bu AAHHWGLRTAGISFAVGVAVLAIGCLIAILIQE-------SRDPQAI---
:
Mflv_1534|M.gilvum_PYR-GCK ------
Mvan_5224|M.vanbaalenii_PYR-1 ------
MAB_0069|M.abscessus_ATCC_1997 REPVLR
MSMEG_0534|M.smegmatis_MC2_155 ------
MLBr_01562|M.leprae_Br4923 ------
MUL_2115|M.ulcerans_Agy99 ------
Mb1288c|M.bovis_AF2122/97 ------
Rv1258c|M.tuberculosis_H37Rv ------
MMAR_4182|M.marinum_M ------
MAV_0138|M.avium_104 ------
TH_0476|M.thermoresistible__bu ------