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TVVAVAAATTRPSGRSARRWLAVAAATFAIAWGGNEFTPLLVMYRTQDGFSALTVDLLLFAYVLGIVPAL LIGGPLSDRFGRRPLMLPAPVLAAVGSAILALGAQSAPVLGVGRVFSGVALGLAMAVGGSWIKELSSPPW EDGDAGARRAAMSLTAGFGLGAGTAGVLAEWGPAPTVLPYAVNIAMALAAAVFVSTAPETRTRHDSGRPW WTDLAVPGASHRRFLLVVVPVAPWVFGAGATAYAVLPALMAGRVSSAPIAFSALMCLVALGVGFTVQQLG RHLGAGGRRGVVTALALLVVGMLLAGWAAAVLTVWSALVAAAVLGAGYGMALLAGLQEIQRIAGPDDLAG LTAVFYSLSYLGFAVPAVLAFAVRSFSYPAMFGFGAFAAAVCLLVAVLGSRRTAAIS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5224 | - | - | 100% (408) | major facilitator superfamily transporter |
| M. vanbaalenii PYR-1 | Mvan_5329 | - | 3e-22 | 25.67% (374) | major facilitator superfamily transporter |
| M. vanbaalenii PYR-1 | Mvan_5862 | - | 9e-09 | 29.15% (398) | major facilitator superfamily transporter |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0865 | - | 3e-11 | 25.47% (373) | integral membrane protein |
| M. gilvum PYR-GCK | Mflv_1534 | - | 1e-174 | 76.21% (412) | major facilitator transporter |
| M. tuberculosis H37Rv | Rv0842 | - | 3e-11 | 25.47% (373) | integral membrane protein |
| M. leprae Br4923 | MLBr_00556 | - | 6e-06 | 23.46% (358) | putative integral membrane drug transport protein |
| M. abscessus ATCC 19977 | MAB_0069 | - | 1e-115 | 59.26% (378) | major facilitator transporter |
| M. marinum M | MMAR_4785 | - | 5e-11 | 26.67% (390) | integral membrane protein |
| M. avium 104 | MAV_0138 | - | 1e-42 | 33.24% (376) | transporter, major facilitator family protein |
| M. smegmatis MC2 155 | MSMEG_0534 | - | 6e-89 | 44.36% (408) | permease, major facilitator family protein |
| M. thermoresistible (build 8) | TH_0476 | - | 3e-29 | 28.12% (384) | major facilitator superfamily protein MFS_1 |
| M. ulcerans Agy99 | MUL_0354 | - | 7e-13 | 27.02% (396) | integral membrane protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_5224|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1534|M.gilvum_PYR-GCK --------------------------------------------------
MAB_0069|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_0534|M.smegmatis_MC2_155 --------------------------------------------------
Mb0865|M.bovis_AF2122/97 --------------------------------------------------
Rv0842|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4785|M.marinum_M --------------------------------------------------
MUL_0354|M.ulcerans_Agy99 MLTSGSMTTTATIAAGEAMRVSSSSSPDLPDAGDTTKFLRPRNAALRSKA
MAV_0138|M.avium_104 --------------------------------------------------
TH_0476|M.thermoresistible__bu --------------------------------------------------
MLBr_00556|M.leprae_Br4923 --------------------------------------------------
Mvan_5224|M.vanbaalenii_PYR-1 ------------------------------MTVVAVAAATT---RPS---
Mflv_1534|M.gilvum_PYR-GCK --------------------------MDKVFTYSGGGAAPAGLDRPATIG
MAB_0069|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_0534|M.smegmatis_MC2_155 ------------------------------MTATATPSETQHR-------
Mb0865|M.bovis_AF2122/97 ------------------------------MRYTGPERCSGD---GQVRA
Rv0842|M.tuberculosis_H37Rv ------------------------------MRYTGPERCSGD---GQVRA
MMAR_4785|M.marinum_M -----------------------------MAAPLGGARPLGERAGGRHRP
MUL_0354|M.ulcerans_Agy99 RGGSRSAARMANTKTNRKPRSARALCARAVAAPLGGARPLGERAGGRHRP
MAV_0138|M.avium_104 -------------------------------MMSSNVRAARNRPGRTDPQ
TH_0476|M.thermoresistible__bu --------------------------------------------------
MLBr_00556|M.leprae_Br4923 --------------------------------------------------
Mvan_5224|M.vanbaalenii_PYR-1 -GRSARRWLAVAAATFAIAWGGNEFTPLLVMYRTQDGFS------ALTVD
Mflv_1534|M.gilvum_PYR-GCK AGRGARGWVAVALATFAIAWGGNEFTPLLVMYRLDDGFS------ALTVD
MAB_0069|M.abscessus_ATCC_1997 --------------MFGIAWGGNEFTPLLVMYR-QAGQS------AASVD
MSMEG_0534|M.smegmatis_MC2_155 -SHRLRPWVAVAAAAFCIGWGGNQFTPLLIAYTQHSGYT------RVDVD
Mb0865|M.bovis_AF2122/97 AGDRYSTVIWLLGG-NLLVRSAGFGYPFLAYHVAGRGHG------AGAVG
Rv0842|M.tuberculosis_H37Rv AGDRYSTVIWLLGG-NLLVRSAGFGYPFLAYHVAGRGHG------AGAVG
MMAR_4785|M.marinum_M AREGYPAVIWLLLGGNLVVRAAGFAYPFMAFHVAGRGFA------AAAVG
MUL_0354|M.ulcerans_Agy99 AREGYPAVIWLLLGGNLVVRAAGFAYPFMAFHVAGRGFA------AAAVG
MAV_0138|M.avium_104 PPTGAPLFVGVLGLLLATGWVANHFVGLMPAISDRDHLA------TTTLD
TH_0476|M.thermoresistible__bu --VRRFAFPLLAYAFAAVMVGTTVPTPMYAVYAERLGFG------VLTTT
MLBr_00556|M.leprae_Br4923 MSTRAGRRVAISAGSLAVLLGALDTYVVVTIMRDIMHDVGIPVNQMQRIT
.
Mvan_5224|M.vanbaalenii_PYR-1 LLLFAYVLGIVPALLIGGPLSDRFGRRPLMLPAPVLAAVGSAILALGAQS
Mflv_1534|M.gilvum_PYR-GCK LLLFAYVLGIVPALLIGGPMSDRFGRRPLMLPAPLLAAIGSLILAVGADS
MAB_0069|M.abscessus_ATCC_1997 TLLFAYVLGIIPALFLGGPLSDRYGRRAVMLPAPFISMLGSLVLALGAQH
MSMEG_0534|M.smegmatis_MC2_155 VLLGAYVLGLIPGLLVASTLSDRYGRRPVMALGVASSALGSVILAIGEYW
Mb0865|M.bovis_AF2122/97 AVVAAYGLGWAVGQLLCGWLVDRVGARVTLVSTMLVAAA--VLVLMAGLH
Rv0842|M.tuberculosis_H37Rv AVVAAYGLGWAVGQLLCGWLVDRVGARVTLVSTMLVAAA--VLVLMAGLH
MMAR_4785|M.marinum_M AVLAAFGVGWAVGQLVCGWLVDSLGPRATLAWTMTIAAG--VLVGMAEAR
MUL_0354|M.ulcerans_Agy99 AVLAAFGVGWAVGQLVCGWLVDSLGPRATLAWTMTIAAG--VLVGMAEAR
MAV_0138|M.avium_104 GIFGIYALGLLPGLLVGGRTSDALGRRPVALTGSAAALVGTVAMLLSQHS
TH_0476|M.thermoresistible__bu VVFAGYTAGVLFALVVFGRWSDALGRRPMLLAGVGCAIVSALVFLIAGSV
MLBr_00556|M.leprae_Br4923 WIVTMYLLGYIAAMPLLSRASDRFGRKLLLQVSLAGFAIGSVMTALAGQF
:. : * . : . * * : :.
Mvan_5224|M.vanbaalenii_PYR-1 --APVLGVGRVFSGVALGLAMAVGGSWIKELSSPPWE--DGDAGARRAAM
Mflv_1534|M.gilvum_PYR-GCK --AWLLGVGRVFSGLALGLAMAVGGSWIKELSSPPWD--VGDAGARRAAM
MAB_0069|M.abscessus_ATCC_1997 --FALLFTGRVLSGVALGLAMAAGSSWVKELSAPPFD--RPGAGARRGAM
MSMEG_0534|M.smegmatis_MC2_155 G-FSALFAGRLLSGAAVGIAMAVGSAWITELSRAPFDDAAPGSGARRASI
Mb0865|M.bovis_AF2122/97 T-VPGLLVGAMIAGLVCDAPRPVLGAVIAELVADPQR--RAQLDGWRYGW
Rv0842|M.tuberculosis_H37Rv T-VPGLLVGAMIAGLVCDAPRPVLGAVIAELVADPQR--RAQLDGWRYGW
MMAR_4785|M.marinum_M S-VAALLVGAMITGMVYDAPRPVMGAAIAELIPEPSR--RAKLDAWRFGW
MUL_0354|M.ulcerans_Agy99 S-VAALLVGAMITGVVYDAPRPVMGAAIAELIPEPSR--RAKLDAWRFGW
MAV_0138|M.avium_104 ---PALFAGRLIVGLGVGLAISAGTAWASDLR--------GPAGAATAGA
TH_0476|M.thermoresistible__bu ---PQLIAARFVSGMSAGIFTGTATAAVIEAAPERRR----SRAAAVATV
MLBr_00556|M.leprae_Br4923 GDFHMLIAGRTIQGVASGALLPITLALGADLWAQRNR----AGVLGGIGA
* .. . * . : :
Mvan_5224|M.vanbaalenii_PYR-1 SLTAGFGLGAGTAGVLAEWGPAPTVLPYAVNIAMALAAAVFVSTAPETRT
Mflv_1534|M.gilvum_PYR-GCK SLTAGFGLGAAVAGVLAQWGPAPTVLPYAINVAMAVAAAVLLLSAPETRA
MAB_0069|M.abscessus_ATCC_1997 SLTAGFALGAAVAGALAQWGPWPQHLAFLVNIAITIPGAVLALSVPESAA
MSMEG_0534|M.smegmatis_MC2_155 CLSLGLGVGPLCAGLLTEYAPLPLVLTYLVHAGLCLP-ALWAIRHRTIET
Mb0865|M.bovis_AF2122/97 VLNIGAAITGGVGGVVAGWLDTP-VLYWINGIGCAIFAGLAGRCIPADVC
Rv0842|M.tuberculosis_H37Rv VLNIGAAITGGVGGVVAGWLDTP-VLYWINGIGCAIFAGLAGRCIPADVC
MMAR_4785|M.marinum_M IVSIGRAITGGVGGLLAAWSGVP-VLFWINAVACALLALVAARCIPATAH
MUL_0354|M.ulcerans_Agy99 IVSIGRAITGGVGGLLAAWSGVP-VLFWINAVACALLALVAARCIPATAH
MAV_0138|M.avium_104 VLTAGFAVGPFAGGVLAWAGPSGVRASFALAAAILALAAFAVVAAPQPSP
TH_0476|M.thermoresistible__bu ANIGGLGAGPLLAGILVQYAPWPLHLTFWVHIVLMVLAAAAIAVAPETSP
MLBr_00556|M.leprae_Br4923 AQELGSVLGPLYG-IFIVWLFSDWRYVFWINIPLTAIAMLMIQVSLSAHD
* . . :
Mvan_5224|M.vanbaalenii_PYR-1 RHDSGRP----WWTDLAVPGASHRRFLLVVVPVAPWVFG-----------
Mflv_1534|M.gilvum_PYR-GCK RSVSVRPAANSWWSDLAIPGASHRRFLLVVVPLAPWVFG-----------
MAB_0069|M.abscessus_ATCC_1997 ERAPGRL-----IDDLKIPAARRRRFLFVVMPLAPWVFG-----------
MSMEG_0534|M.smegmatis_MC2_155 RSGTPSVG---VIEGLRVPAAAHRRFVRVVMPMAPWIFG-----------
Mb0865|M.bovis_AF2122/97 RRTESGLRACTAMSKVGYRQALSDKRLVLLAVSGLATLT-----------
Rv0842|M.tuberculosis_H37Rv RRTESGLRACTAMSKVGYRQALSDKRLVLLAVSGLATLT-----------
MMAR_4785|M.marinum_M R-PPVAPAVHVRAARISYRRAFSDGRLVLLFASSLATLT-----------
MUL_0354|M.ulcerans_Agy99 R-PPVAPAVHVRAAHNSYRRAFSDGRLVLLFASSLATLT-----------
MAV_0138|M.avium_104 VTAPADPD---GEETADAAPQGISRALSWAMPLAPWVFA-----------
TH_0476|M.thermoresistible__bu RTGRLGVQ--------RLSLPPQVRKVFAIASLAAFAGF-----------
MLBr_00556|M.leprae_Br4923 RGDELEKVDVVGGVLLAIALGLVVIGLYNPQPDSKQVLPSYGVPVLVGGI
: .
Mvan_5224|M.vanbaalenii_PYR-1 AGATAYAVLPALMAGR-VSSAPIAFSALMCLVALG--VGFTVQQLGR---
Mflv_1534|M.gilvum_PYR-GCK AGASAYAVLPALMTEH-VAAAPIAFSALLCAVTLG--VAFGVQHLGR---
MAB_0069|M.abscessus_ATCC_1997 SAAVAYAVLPTLIAPT-LPGDRIAFSALCCLVCLG--CGFTAQMLAP---
MSMEG_0534|M.smegmatis_MC2_155 SAAIAYAIVPALVADR-LGHWALLYTAGLTVLTLG--CGVAVQPIAR---
Mb0865|M.bovis_AF2122/97 TLMGFFAAVPMLMSASGLGVGAYGWVQLINALAVVAVTPLLTPWLSK---
Rv0842|M.tuberculosis_H37Rv TLMGFFAAVPMLMSASGLGVGAYGWVQLINALAVVAVTPLLTPWLSK---
MMAR_4785|M.marinum_M AVRGLYATVPMLMADSGLGAGEFGWTQVANAAAGIGLTPVITPWLGR---
MUL_0354|M.ulcerans_Agy99 AVRGLYATVPMLMADSGLGAGEFGWAQVANAAAGIGLTPVITPWLGR---
MAV_0138|M.avium_104 SATLGFVTIPGRLHTALAAPVAAGTATLIVNGVSG-----AVQVLAR---
TH_0476|M.thermoresistible__bu AVTGLFTAVAPSFLAEVIGVRNHAVAGAVAASIFA--ASAVTQVLGA---
MLBr_00556|M.leprae_Br4923 VATVAFAVWERCARTRLIDPAGVHIRPFLSALGASVAAGAALMVTLVNVE
:.
Mvan_5224|M.vanbaalenii_PYR-1 -------HLG-AGGRRGVVTALALLVVGMLLAGWAAAVL-----------
Mflv_1534|M.gilvum_PYR-GCK -------SLL-SGGALGVVVALGLVAAGMALAAWASASL-----------
MAB_0069|M.abscessus_ATCC_1997 -------RLDRAGTARLGIIGLALVAVGMALAALAAHQL-----------
MSMEG_0534|M.smegmatis_MC2_155 -------RLDDHSSARAVVVSMVLMALGVFAAVATAVTR-----------
Mb0865|M.bovis_AF2122/97 -------QLA--LGPRPDILAGAGVWVTLCMAAAGLART-----------
Rv0842|M.tuberculosis_H37Rv -------QLA--LGPRPDILAGAGVWVTLCMAAAGLART-----------
MMAR_4785|M.marinum_M -------KVAARINPRLDILAIAGGWTALTMAGAALAHT-----------
MUL_0354|M.ulcerans_Agy99 -------KVAARINPRLDILAIAGGWTALTMAGAALAHT-----------
MAV_0138|M.avium_104 -------ALR--WGPQAGTAGAVLAALGYAVAAAAPSTL-----------
TH_0476|M.thermoresistible__bu -------SVS---PRRAVAVGCALLIVGMVFLAAALVWS-----------
MLBr_00556|M.leprae_Br4923 LFGQGVLGMDQTQAAGLLVWFLIALPIGAVLGGWGATKAGDRTMTFVGLL
:
Mvan_5224|M.vanbaalenii_PYR-1 ---------------------------TVWSALVAAAVLGAGYGMALLAG
Mflv_1534|M.gilvum_PYR-GCK ---------------------------TIWATVVAAAVLGAGYGMALVAG
MAB_0069|M.abscessus_ATCC_1997 ---------------------------TIPLVLIAALALGAGYGTALVSG
MSMEG_0534|M.smegmatis_MC2_155 ---------------------------SIGMAVVVAMLLGCAYGIAIVSG
Mb0865|M.bovis_AF2122/97 ---------------------------TVGFSVAAAACS-PGEIAWFVVA
Rv0842|M.tuberculosis_H37Rv ---------------------------TVGFSVAAAACS-PGEIAWFVVA
MMAR_4785|M.marinum_M ---------------------------TFGFAIAVAASA-PGEIAWFVIA
MUL_0354|M.ulcerans_Agy99 ---------------------------TFGFAIAVAASA-AGEIAWFVIA
MAV_0138|M.avium_104 ---------------------------TPALGVPLFVVLGCASGLCLREG
TH_0476|M.thermoresistible__bu ---------------------------SLPALIATAVVAGAGQGLSFSRG
MLBr_00556|M.leprae_Br4923 ITAGGYWLISHWPVDLLNYRRSIFGLFSVPTMYADLLVAGLGLGLVIGPL
: . :
Mvan_5224|M.vanbaalenii_PYR-1 LQEIQRIAGPDDLAGLTAVFYSLSYLGFAV--------------------
Mflv_1534|M.gilvum_PYR-GCK LQEIQRIATPDDLAGLTAVFYSLCYLGFGV--------------------
MAB_0069|M.abscessus_ATCC_1997 LQEVNRIAGPTDLAGLTAVFYGLTYLGFGV--------------------
MSMEG_0534|M.smegmatis_MC2_155 LLEVQRIAEPDELAGISGVYYSLAYAGFLL--------------------
Mb0865|M.bovis_AF2122/97 AGIVHRIAPPAHGGRYHGIWSMAVAASSVA--------------------
Rv0842|M.tuberculosis_H37Rv AGIVHRIAPPAHGGRYHGIWSMAVAASSVA--------------------
MMAR_4785|M.marinum_M AGIVHRIAPPASGGRYHGIWSMTLAIASVV--------------------
MUL_0354|M.ulcerans_Agy99 VGTVHRIAPPASGGRYHGIWSMTLAIASVV--------------------
MAV_0138|M.avium_104 LIDLEAAAPQRLRGGLTGLFYVVTYIGFGL--------------------
TH_0476|M.thermoresistible__bu LAAVSARTPSDQRGEVSSTYFVVAYVALLV--------------------
MLBr_00556|M.leprae_Br4923 SSATLRVVPTAQHGIASAAVVVARMTGMLIGVAALTAWGLYRFNQILAGL
. . . .
Mvan_5224|M.vanbaalenii_PYR-1 --------PAVLAFAVRS-----FSYPAMFGFGAFAAAVCLLVAVLGSR-
Mflv_1534|M.gilvum_PYR-GCK --------PAAMVFLSDY-----ASYPSMFGFGAVAAVGCLAVAVTGLR-
MAB_0069|M.abscessus_ATCC_1997 --------PMMLTMLSDAS--PLLTHPVLLCGGALLATVCLVVLMLNSRT
MSMEG_0534|M.smegmatis_MC2_155 --------PAILAALARF-----FSYPAMLTVVGLLAAACTALCASGWSK
Mb0865|M.bovis_AF2122/97 --------APILAAFNLANGGRLVLAATTVTVGFFGAALCLPLARVLAAA
Rv0842|M.tuberculosis_H37Rv --------APILAAFNLANGGRLVLAATTVTVGFFGAALCLPLARVLAAA
MMAR_4785|M.marinum_M --------APIVSSCSLTHGGHRLVALVTVTVGLAGAALCLPLARALNRS
MUL_0354|M.ulcerans_Agy99 --------APIVSSCSLTHGGHRLVALVTVTVGLAGAALCLP----LNRS
MAV_0138|M.avium_104 --------PLILASVRPG-----VATAILSGMAVLAVTAAVGRAARLRRD
TH_0476|M.thermoresistible__bu --------PVIGEGWAAHHWGLRTAGISFAVGVAVLAIGCLIAILIQESR
MLBr_00556|M.leprae_Br4923 STAVPPDATLIERAAAVADQAKRAYTMMYSDIFMITAIVCVIGALLGLLI
. . .
Mvan_5224|M.vanbaalenii_PYR-1 -------RTAAIS----------
Mflv_1534|M.gilvum_PYR-GCK -------RTPAIS----------
MAB_0069|M.abscessus_ATCC_1997 DVGARPGTTAAVPADETREPVLR
MSMEG_0534|M.smegmatis_MC2_155 HLEP---RTVTARV---------
Mb0865|M.bovis_AF2122/97 S-CGPLSSKEPSRDSYQ------
Rv0842|M.tuberculosis_H37Rv S-CGPLSSKEPSRDSYQ------
MMAR_4785|M.marinum_M GDVGVRDSQYTAVAGAA------
MUL_0354|M.ulcerans_Agy99 GDVGVRDSQYTAVAAAA------
MAV_0138|M.avium_104 D------HRQN------------
TH_0476|M.thermoresistible__bu D-------PQAI-----------
MLBr_00556|M.leprae_Br4923 SSRKEHASEPKVPE---------