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MFDSGLAGLDKPALISAIEQAACEEVRAGARKTAAIAALVHDHVTYDDVRDEWVWDSWIETACELGAVLN TSHRRASAQMRIAVALRDRLPGVAALHAQGRLSARLIGQITWRTRLVQDPQALALIDAAIAEKATRWEPL SEDNLTAALDAVIERFDPDAVIRTREQLKGVDFRIGASDDPDALVTVWGKILGCDAVVLAARIAELLKGL CDADPRGIGERRSCAVGAIVRGQDHLPCRCGSPDCAAAPVVPGSSNVVISVLADPAALEAVRSLIADEDR HQQDALAEKQPHAVKAKEQGEPAAPAPSNRGRCVRDSGTALLPGVKILPIVALAEAIRAGAAIKQLWLPG PDPEPHYRPSAKLAAFVRARDLFCRYPGCNVPAEQCDIDHVVPWPYGPTHPSNLNCKCRTHHLGKTFAEG WHEEQLPDGTVIWTTPAGQRYSTVPGSRLFFPGWDTTTAELPPMAQPPPDPDRLAKMPKRRRTRAADHAA RIKAEREDNAHQRALETERAAARRSGLPPPAPPDYGDDPPPF
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1272 | - | - | 100% (532) | HNH endonuclease |
| M. gilvum PYR-GCK | Mflv_5065 | - | e-176 | 60.19% (535) | hypothetical protein Mflv_5065 |
| M. gilvum PYR-GCK | Mflv_4927 | - | e-100 | 40.81% (544) | hypothetical protein Mflv_4927 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3805 | - | 1e-120 | 46.24% (532) | hypothetical protein Mb3805 |
| M. tuberculosis H37Rv | Rv3776 | - | 1e-120 | 46.24% (532) | hypothetical protein Rv3776 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4752 | - | 1e-67 | 36.00% (525) | hypothetical protein MAB_4752 |
| M. marinum M | MMAR_5187 | - | 7e-85 | 38.17% (524) | 13e12 repeat-containing protein |
| M. avium 104 | MAV_3457 | - | 4e-88 | 38.89% (540) | 13e12 repeat-containing protein |
| M. smegmatis MC2 155 | MSMEG_3957 | - | 1e-107 | 42.03% (533) | 13e12 repeat-containing protein |
| M. thermoresistible (build 8) | TH_0334 | - | 3e-57 | 31.93% (451) | HNH endonuclease |
| M. ulcerans Agy99 | MUL_2679 | - | 4e-73 | 37.71% (480) | 13e12 repeat-containing protein |
| M. vanbaalenii PYR-1 | Mvan_5188 | - | 0.0 | 76.57% (589) | hypothetical protein Mvan_5188 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1272|M.gilvum_PYR-GCK -------------MFDSGLAG-------LDKPALISAIEQAACEEVRAGA
Mvan_5188|M.vanbaalenii_PYR-1 -------------MFDSGLAG-------LDEPALLAAIERAACEESRAGA
Mb3805|M.bovis_AF2122/97 -------------MFEISLSDP-VELRDADDAALLAAIEDCARAEVAAGA
Rv3776|M.tuberculosis_H37Rv -------------MFEISLSDP-VELRDADDAALLAAIEDCARAEVAAGA
MSMEG_3957|M.smegmatis_MC2_155 -------------MCET-----------LDDAALIAGIAGESRAESAAAA
MAB_4752|M.abscessus_ATCC_1997 -------------MFDE-----------LGDVELIDLIASAQRAEAQACA
MAV_3457|M.avium_104 ---------MVEHMFEYVVAS----RSTPEAVALLDRAREAARAEARAAA
MUL_2679|M.ulcerans_Agy99 ---------MDQHIIEYVFDT----DDS----APLTRITAAARAEARAAA
MMAR_5187|M.marinum_M MFESMGVAAGVDHPCDALAERRQLRTPTAESARWVQRIGAAARAENRAAA
TH_0334|M.thermoresistible__bu -------------MFES-----------LDDGAVVDSIAAASREQSAACG
: : : * .
Mflv_1272|M.gilvum_PYR-GCK RKTAAIAALVHDHVTYD--DVRDEWVWDSWIETACELGAVLNTSHRRASA
Mvan_5188|M.vanbaalenii_PYR-1 RKSAAIAALVHESVTFD--DVRDQWVWDSWIETACELGAVLNTSHRRASA
Mb3805|M.bovis_AF2122/97 RRLSAIAELTSRRTGN---DQRADWACDGWDCAAAEVAAALTVSHRKASG
Rv3776|M.tuberculosis_H37Rv RRLSAIAELTSRRTGN---DQRADWACDGWDCAAAEVAAALTVSHRKASG
MSMEG_3957|M.smegmatis_MC2_155 RRFAFIAEFVDRRTADSE-DTVVWWACDDWDAASAEVAAALNIGQRSASR
MAB_4752|M.abscessus_ATCC_1997 RKLDAIGVLVDRHADLGKPDERDHHALDRWDRVASEVAAAQGITHALASS
MAV_3457|M.avium_104 ARLVAVAELLVLRCRETG--ERADWAADAWEAVAAQVGAALGCSVAMGHS
MUL_2679|M.ulcerans_Agy99 ERLAAIGDLFRLRLSQHG--NREDWVADTCDAVAAEVAAALNTSVAMGHS
MMAR_5187|M.marinum_M AQLIEIGQLFAYRLSRCS--ETEDWAVDTMEAVAAEVAAGLRISQGLAAS
TH_0334|M.thermoresistible__bu REMLAIGELYARRAPEDD-TERANWAIDGHANVVAEISAALNISRGRAAG
. :. : . * . .::.* .
Mflv_1272|M.gilvum_PYR-GCK QMRIAVALRDRLPGVAALHAQGRLSARLIGQITWRTRLVQDPQALALIDA
Mvan_5188|M.vanbaalenii_PYR-1 LMRIAVALRDRLPKVAALFAAGRLSTRLIGQVTWRTRLVQDPQLLALLDT
Mb3805|M.bovis_AF2122/97 QMHLSLTLN-RLPQVAALFLAGQLSARLVSIIAWRTYLVRDPEALSLLDA
Rv3776|M.tuberculosis_H37Rv QMHLSLTLN-RLPQVAALFLAGQLSARLVSIIAWRTYLVRDPEALSLLDA
MSMEG_3957|M.smegmatis_MC2_155 LMRIAVALRDRLPLVAAQFAEGAVSTRVVETLTWRTRLIDDTQTMAAVDA
MAB_4752|M.abscessus_ATCC_1997 QMRYAQVLRHRLRAVAERFAAGDLDFRTVALIINRTELVDDEAVVARVDA
MAV_3457|M.avium_104 YLRYAMAMRERLPQVGAVFAAGGIDYRAFQTLVFRTDLITDAQVLARVDA
MUL_2679|M.ulcerans_Agy99 NLRYARAMRERLPQLGAEFRAGGIDFRLFRTIVFRTDLITESDALAAVDA
MMAR_5187|M.marinum_M RLRYARALRERLPKTGAVFAAGQIDLRAFQTIVFRTDLIVDPQVMAAVDA
TH_0334|M.thermoresistible__bu RLQLAIDLRERLPRVAAVFAAGDIDFRMVSALVNRSRNVVDPDLLARLDA
:: : :. ** . . * :. * . : *: : : :: :*:
Mflv_1272|M.gilvum_PYR-GCK AIAEKATRWEPLSEDNLTAALDAVIERFDPDAVIRTREQLKGVDFRIGAS
Mvan_5188|M.vanbaalenii_PYR-1 AIADKATRWEPLSDDKLTAALDAVIERYDPDAVIRAREHVSGLDFRVGAS
Mb3805|M.bovis_AF2122/97 ALAKHATAWGPLSAPKLEKAIDSWIDRYDPAALRRTRISARSRDLCIGDP
Rv3776|M.tuberculosis_H37Rv ALAKHATAWGPLSAPKLEKAIDSWIDRYDPAALRRTRISARSRDLCIGDP
MSMEG_3957|M.smegmatis_MC2_155 QLASRIAEFGAMTIAELEGAVDKVVDSVDPAAVRRTRTAVRSRGVWFGHP
MAB_4752|M.abscessus_ATCC_1997 AIVRALPRWARWSHKRITAALDALVLHFDQDAVRRNRSATDKRHLEIRPL
MAV_3457|M.avium_104 TLAVLVSRRPSLTRGGLAAAVDRVVAAVDADAVRRARDAVTGRYLDVRAN
MUL_2679|M.ulcerans_Agy99 RLAIKAPRWPSMTSWKLATEVDRVVAKFDRDAVRRSRRDAADRYVDCAPL
MMAR_5187|M.marinum_M LVALNVGRWPSMTKARLSGQIDAIVARADADAVRRRKERHADREIWIGQD
TH_0334|M.thermoresistible__bu ALAAWSPKWMKLSGPTLNERIDMWVERFDPTGVREPRSPGEDRYVVVTPA
:. : : :* : * .: . : .
Mflv_1272|M.gilvum_PYR-GCK DDPDALVTVWGKILGCDAVVLAARIAELLKGLCDADPRGIGERRSCAVGA
Mvan_5188|M.vanbaalenii_PYR-1 DDPDALVTVWGKILGCDAAVLAARIAELLKGLCDNDPRSVCVRRSHAVGA
Mb3805|M.bovis_AF2122/97 DEDAGTAALWGRLFATDAAMLDKRLTQLAHGVCDDDPRTIAQRRADALGA
Rv3776|M.tuberculosis_H37Rv DEDAGTAALWGRLFATDAAMLDKRLTQLAHGVCDDDPRTIAQRRADALGA
MSMEG_3957|M.smegmatis_MC2_155 DDETGITSVHARLTNVDAVALKNRVGAMSSGQCPDDPRTKGQRLSDAMGV
MAB_4752|M.abscessus_ATCC_1997 GNGEPVAEVWGTLQAVHAVALDKRLDLLAGTVCPADPRSKTQRRADAVGA
MAV_3457|M.avium_104 ES--GMAWVEGNVLGPDGHALDRRLDELASGVCAGDPRSRAQRRADALGA
MUL_2679|M.ulcerans_Agy99 EP--GMALVNRQVFSATAEALARRLDELAKTVCADDPRTVVQRRADALGT
MMAR_5187|M.marinum_M AD--GISRIDGSMFTIDAHALDRRLSALAATVCAQDPRSREQRRADALGV
TH_0334|M.thermoresistible__bu GQ--GMVDVSARLTFEAGFAFXTRLDQIAATVCRDDPRTADQRRADAMAA
: : . : *: : * *** * : *:..
Mflv_1272|M.gilvum_PYR-GCK IVRGQDHLPCRCGSPDCA-AAPVVPGSSNVVISVLADPAALEAVRSLIAD
Mvan_5188|M.vanbaalenii_PYR-1 IVRGQDHLRCRCGSPDCT-AAAVVPGSSNVVISVLADPAALDAVRQLIAD
Mb3805|M.bovis_AF2122/97 LAAGADRLTCGCGNSDCPSSAGNHRQATGVVIHVVADAAALGAAPDPRLS
Rv3776|M.tuberculosis_H37Rv LAAGADRLTCGCGNSDCPSSAGNHRQATGVVIHVVADAAALGAAPDPRLS
MSMEG_3957|M.smegmatis_MC2_155 LGHYGDRLTCRCGDPECP-AAGIDPRAANTMVHVFAEPAAVHGPVDRYLD
MAB_4752|M.abscessus_ATCC_1997 LTQGLNRMRCACGHPDCS---GRDTADVPVVVNVVINQSTLAGSDD----
MAV_3457|M.avium_104 LAAGAGRLACGCGSPDCP-SAAAPAPRSTVVIHVVAEQATVAGRGA----
MUL_2679|M.ulcerans_Agy99 LAAGQDRLICDCGRTDCP-AAGAPQQPSRVVIHVVAGCQTVDGAGE----
MMAR_5187|M.marinum_M LAAGGDRLGCRCGLPDCA-AGARPAAQP-VVIHVIAERATLDGDGG----
TH_0334|M.thermoresistible__bu MSEGQNRLVCGCGSEDCP-ADPADTAATRLVINVIAEQATVEGRSD----
: .:: * ** :*. :: *. :: .
Mflv_1272|M.gilvum_PYR-GCK EDRHQQDALAEKQPHAVK-AKEQGEP-------------AAP--------
Mvan_5188|M.vanbaalenii_PYR-1 QDRDQQDKLADKQAKAKEQGKAESQPQTEPIPQPEAEAEAEPEPEAEVEV
Mb3805|M.bovis_AF2122/97 G------------PEPALAPEAPATP-----------AVKPP--------
Rv3776|M.tuberculosis_H37Rv G------------PEPALAPEAPATP-----------AVKPP--------
MSMEG_3957|M.smegmatis_MC2_155 GD-HESNPIPYFEPTPTPEPEPTPEP-----------VRKPPEPEP----
MAB_4752|M.abscessus_ATCC_1997 ----------------CP--------------------------------
MAV_3457|M.avium_104 ----------------TP--------------------------------
MUL_2679|M.ulcerans_Agy99 ----------------AP--------------------------------
MMAR_5187|M.marinum_M ----------------AP--------------------------------
TH_0334|M.thermoresistible__bu ----------------NP--------------------------------
Mflv_1272|M.gilvum_PYR-GCK --------------------APSNRGRCVRDSGTALLPGVKILPIVALAE
Mvan_5188|M.vanbaalenii_PYR-1 EPEAETETAIESEPAPVKPVAPSNPAACVRDSGVALLPGVKILPLVALAE
Mb3805|M.bovis_AF2122/97 ---------------------------------AALISGGGVVPAPLLAE
Rv3776|M.tuberculosis_H37Rv ---------------------------------AALISGGGVVPAPLLAE
MSMEG_3957|M.smegmatis_MC2_155 --------------------KPWTPQSAHPGRGGAVVLGGGVVPAPLVAQ
MAB_4752|M.abscessus_ATCC_1997 ----------------------------------AHVPGFGVLAAESARA
MAV_3457|M.avium_104 ----------------------------------AVVAGLDGLIPAQVIA
MUL_2679|M.ulcerans_Agy99 ----------------------------------GVLPG-DGIIPAEIVR
MMAR_5187|M.marinum_M ----------------------------------AWEVGADGLVTPELVA
TH_0334|M.thermoresistible__bu ----------------------------------GYLPGYGAVP-ASILR
. * :
Mflv_1272|M.gilvum_PYR-GCK AIRAGAAIKQLWLPG-PDPEPHYRPSAKLAAFVRARDLFCRYPGCNVPAE
Mvan_5188|M.vanbaalenii_PYR-1 AIRSGAATKTLWLPG-PDPEPHYRPSAKLAAFVRARDLFCRYPGCDVPAE
Mb3805|M.bovis_AF2122/97 LIRGGAALSRVRHPGDLRSEPHYRPSAKLAEFVRIRDMTCRFPGCDQPTE
Rv3776|M.tuberculosis_H37Rv LIRGGAALSRMRHPGDLRSEPHYRPSAKLAEFVRIRDMTCRFPGCDQPTE
MSMEG_3957|M.smegmatis_MC2_155 LIADGAKVKELTVPDDICAS--YRPSVAMDCFVRMRDMTCRFPGCSRPAD
MAB_4752|M.abscessus_ATCC_1997 AVAG-TPTRNLTDSR----STGYRPSAKLAAFVRSRDQLCRFPGCEAVAD
MAV_3457|M.avium_104 ELAASARLVPVAVPE-GGPEPGYTPSARLADFIRCRDLTCRAPGCDRPAV
MUL_2679|M.ulcerans_Agy99 ELAKSAKLQPMSTP--ILAETGYVPSPALMDFVRARDLTCRAPGCDRPAT
MMAR_5187|M.marinum_M ELAKSAKLVPLRHPGDVPPEPGYVPSKALADFVRCRDLTCRWPGCDHPAL
TH_0334|M.thermoresistible__bu AKAATATLRPVALPQ-PCAEAGYRPSAALTRFIRCRDLTCRFPGCDAPAA
: : . . * ** : *:* ** ** ***. :
Mflv_1272|M.gilvum_PYR-GCK QCDIDHVVPWPYG-PTHPSNLNCKCRTHHLGKTFAEGWHEEQLPDGTVIW
Mvan_5188|M.vanbaalenii_PYR-1 HCDLDHVVPYPYG-PTHPSNLNCKRRTHHLGKTFAEGWQEQQLPDGTVLW
Mb3805|M.bovis_AF2122/97 FCDIDHTLPYPLG-PTHPSNLKCLCRKHHLLKTFWTGWRDVQLPDGTIIW
Rv3776|M.tuberculosis_H37Rv FCDIDHTLPYPLG-PTHPSNLKCLCRKHHLLKTFWTGWRDVQLPDGTIIW
MSMEG_3957|M.smegmatis_MC2_155 FCDVDHTTPWPTG-VTHPSNTKCLCRIHHLLKTFWLGWSDRQLPDGTVIW
MAB_4752|M.abscessus_ATCC_1997 RADIDHTVPWATGGPTTGANLKALCRKHHLLKTFGQ-WTELQEPDGTVIW
MAV_3457|M.avium_104 DCDVDHTIPYAQGGPTHPSNLKCLCRGHHLLKTFWG-WRDRQLPDGTVIW
MUL_2679|M.ulcerans_Agy99 QCDVDHTIPYSDGGATHPSNLKCLCRKHHLLKTFWG-WHDEQLPDATVIW
MMAR_5187|M.marinum_M NCDLDHTIPYAQGGPTHASNLKCYCRTHHLVKTFWG-WHDQQLPDGTLIL
TH_0334|M.thermoresistible__bu VCQIDHTIPYPAG-PTHPSNLKLLCVFHCRQAELRFTHDQHK--------
.::**. *:. * * :* : * : : :
Mflv_1272|M.gilvum_PYR-GCK TTPAGQRYSTVPGSRLFFPGWDTTTAELPPMAQPP--PDP----DRLAKM
Mvan_5188|M.vanbaalenii_PYR-1 TTPAGQRCTTVPGSWLFFPGWDTTTAELPPMAQPP--PDP----DRLAKM
Mb3805|M.bovis_AF2122/97 TAPNGHTYTTHPDSRIFLPSWHTTTAALPPAPSPP-AIGP----THTLLM
Rv3776|M.tuberculosis_H37Rv TAPNGHTYTTHPDSRIFLPSWHTTTAALPPAPSPP-AIGP----THTLLM
MSMEG_3957|M.smegmatis_MC2_155 TSPTGHVYTTVPASRALFPQWDTTTAALPPPPTPPPPMTPSEIAARAAMM
MAB_4752|M.abscessus_ATCC_1997 KSPTGHRYATTPVSWFLFPALTRHHTR------------------QQARD
MAV_3457|M.avium_104 TLPDGDTYVTTPGSALLFPTLCTPTGAVSPAKPDT----EHRCGERTAMM
MUL_2679|M.ulcerans_Agy99 SLPDGQTYVTTPGSAWLLPGLFAPSPELPPPP---------RSEATGSLR
MMAR_5187|M.marinum_M TSPAGHTYVTTPGSALLFPSLCHSTGGLPAAEADP---PSDHCDQRSAMM
TH_0334|M.thermoresistible__bu -----HQSSCLP---AYFQRPHGPATRRPP----------------SARG
. * :
Mflv_1272|M.gilvum_PYR-GCK PKRRRTRAADHAARIKAEREDNAHQRALETERAAA----------RRSGL
Mvan_5188|M.vanbaalenii_PYR-1 PKRRRTRAADQAARIKVEREHNATQRALETERAKTPEQARRAEQVRYAGL
Mb3805|M.bovis_AF2122/97 PRRRRTRAAELAHRIKRERAH----VTQRNKPPPSG-----GDTAVAEGF
Rv3776|M.tuberculosis_H37Rv PRRRRTRAAELAHRIKRERAH----VTQRNKPPPSG-----GDTAVAEGF
MSMEG_3957|M.smegmatis_MC2_155 PRRRRTRAAEEARRLAAERARNEAYLAQRDRPPPD---------AHGPGM
MAB_4752|M.abscessus_ATCC_1997 RRRRTERNLNREQRLQREAAL----AALAAKDPPPF--------------
MAV_3457|M.avium_104 PLRRHTRAHNRAHRITTER-------NHNRRTRLTT---------HPATP
MUL_2679|M.ulcerans_Agy99 KPRRDDAQTRPNSRPKLGR-------THCDRT------------------
MMAR_5187|M.marinum_M PRRQRTRAQDRARRVATERRQ----NHHARSTQPGG---------QPRSA
TH_0334|M.thermoresistible__bu LREAVPRQGVDPRRVSGQ--------------------------------
. *
Mflv_1272|M.gilvum_PYR-GCK PPPAPP--DYGDDPPPF
Mvan_5188|M.vanbaalenii_PYR-1 PPPASPQPDYGNDPPPF
Mb3805|M.bovis_AF2122/97 EPPDGVSRLSLSRRVH-
Rv3776|M.tuberculosis_H37Rv EPPDGVSRLSLSRRVH-
MSMEG_3957|M.smegmatis_MC2_155 Q----------------
MAB_4752|M.abscessus_ATCC_1997 -----------------
MAV_3457|M.avium_104 GPAPPPDPDDE--PPPF
MUL_2679|M.ulcerans_Agy99 ----QPQHD--------
MMAR_5187|M.marinum_M APPTPPQSEPQSHPPPF
TH_0334|M.thermoresistible__bu -----------------