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FDTMHRGLGEADLLAAIEQAAREEAQAGARRLAAIAELVDLTVDEDDERGMWAFDPWKNAACHIGAALSI SERRASAQMCIATALRYRLPQIAALYVQGRLSTRLISEITWRTGLVADDVIATVDAALAGKAEKWGPLSE DKLIDAINTVIARHDPDAVRRTKEALKKRDVHIGAHEDTDDVTTIWGLLLPPDAAAYTARIAALVKGLCD ADPRSAGERRSDAMGAIGRGENQLACRCGSPNCTASGPSTSPVVITVIADQAAVDTAQQLIADQDAEQQN TTATTAEPTCTKDPGSALLPGAQILPIPVLAEAIRSGAKITPLWLPGPDPEPHYRPSAKLAAFIRSRDLF CRFPGCDVSADRCDIDHVVPYPFGPTHASNMHCKCRSHHLMKTFWGGPDGWRERQLPDGTVLWTTPAGTT YTTTPGSRLFFPAWDTTTAELPPMTTPPPGAGREIQMPKRQRSRTADRAARIKAEREHNGTQRNLEERPR RGQPPPDYGNDPPPF*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_5065 | - | - | 100% (506) | hypothetical protein Mflv_5065 |
| M. gilvum PYR-GCK | Mflv_1272 | - | e-176 | 60.19% (535) | HNH endonuclease |
| M. gilvum PYR-GCK | Mflv_1180 | - | e-103 | 43.93% (519) | hypothetical protein Mflv_1180 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3805 | - | 1e-124 | 48.10% (501) | hypothetical protein Mb3805 |
| M. tuberculosis H37Rv | Rv3776 | - | 1e-124 | 48.10% (501) | hypothetical protein Rv3776 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4752 | - | 3e-76 | 36.67% (510) | hypothetical protein MAB_4752 |
| M. marinum M | MMAR_5187 | - | 3e-93 | 40.36% (503) | 13e12 repeat-containing protein |
| M. avium 104 | MAV_3457 | - | 1e-97 | 42.60% (500) | 13e12 repeat-containing protein |
| M. smegmatis MC2 155 | MSMEG_3957 | - | 1e-110 | 42.48% (525) | 13e12 repeat-containing protein |
| M. thermoresistible (build 8) | TH_0334 | - | 1e-59 | 37.69% (390) | HNH endonuclease |
| M. ulcerans Agy99 | MUL_1813 | - | 5e-78 | 37.45% (494) | 13e12 repeat-containing protein |
| M. vanbaalenii PYR-1 | Mvan_1291 | - | 1e-177 | 56.35% (575) | hypothetical protein Mvan_1291 |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_3457|M.avium_104 ---------MVEHMFEYVVASR----STPEAVALLDRAREAARAEARAAA
MUL_1813|M.ulcerans_Agy99 ----------------------------------MERAREASRREAAAAA
MMAR_5187|M.marinum_M MFESMGVAAGVDHPCDALAERRQLRTPTAESARWVQRIGAAARAENRAAA
MAB_4752|M.abscessus_ATCC_1997 ------------------------MFDELGDVELIDLIASAQRAEAQACA
Mflv_5065|M.gilvum_PYR-GCK --------------MFDTMHRG------LGEADLLAAIEQAAREEAQAGA
Mvan_1291|M.vanbaalenii_PYR-1 ----MSPTIGSIERMFGAMFAG------LDQPTLIAAIEQSAREEAVAGA
Mb3805|M.bovis_AF2122/97 --------------MFEISLSDPVELRDADDAALLAAIEDCARAEVAAGA
Rv3776|M.tuberculosis_H37Rv --------------MFEISLSDPVELRDADDAALLAAIEDCARAEVAAGA
MSMEG_3957|M.smegmatis_MC2_155 --------------MCET----------LDDAALIAGIAGESRAESAAAA
TH_0334|M.thermoresistible__bu --------------MFES----------LDDGAVVDSIAAASREQSAACG
: * : * .
MAV_3457|M.avium_104 ARLVAVAELLVLR--CRETGERADWAADAWEAVAAQVGAALGCSVAMGHS
MUL_1813|M.ulcerans_Agy99 ERLDVVGALFVLR--CRESGDRAEWATDTWEAVGAQVAAALRTSVAMGSS
MMAR_5187|M.marinum_M AQLIEIGQLFAYR--LSRCSETEDWAVDTMEAVAAEVAAGLRISQGLAAS
MAB_4752|M.abscessus_ATCC_1997 RKLDAIGVLVDRHADLGKPDERDHHALDRWDRVASEVAAAQGITHALASS
Mflv_5065|M.gilvum_PYR-GCK RRLAAIAELVDLT-VDE-DDERGMWAFDPWKNAACHIGAALSISERRASA
Mvan_1291|M.vanbaalenii_PYR-1 RKLAAIAQLVHSA-VTF-DDECDRWAYDSWAEAACELGAVLNMGQMRASA
Mb3805|M.bovis_AF2122/97 RRLSAIAELTSRR-TGN--DQRADWACDGWDCAAAEVAAALTVSHRKASG
Rv3776|M.tuberculosis_H37Rv RRLSAIAELTSRR-TGN--DQRADWACDGWDCAAAEVAAALTVSHRKASG
MSMEG_3957|M.smegmatis_MC2_155 RRFAFIAEFVDRR-TADSEDTVVWWACDDWDAASAEVAAALNIGQRSASR
TH_0334|M.thermoresistible__bu REMLAIGELYARR-APEDDTERANWAIDGHANVVAEISAALNISRGRAAG
.: :. : * * . ..:.* .
MAV_3457|M.avium_104 YLRYAMAMRERLPQVGAVFAAGGIDYRAFQTLVFRTDLITDAQVLARVDA
MUL_1813|M.ulcerans_Agy99 YLRYAMAMRNRLPKVGQAFRAEDIDYRAFQTIVFRTDLITDAEVLAKVDA
MMAR_5187|M.marinum_M RLRYARALRERLPKTGAVFAAGQIDLRAFQTIVFRTDLIVDPQVMAAVDA
MAB_4752|M.abscessus_ATCC_1997 QMRYAQVLRHRLRAVAERFAAGDLDFRTVALIINRTELVDDEAVVARVDA
Mflv_5065|M.gilvum_PYR-GCK QMCIATALRYRLPQIAALYVQGRLSTRLISEITWRTGLVADD-VIATVDA
Mvan_1291|M.vanbaalenii_PYR-1 QMRIAVALRDRLPKVAELFLAGRLSARLVAEITWRTCLVDDEQVLAVLDG
Mb3805|M.bovis_AF2122/97 QMHLSLTLN-RLPQVAALFLAGQLSARLVSIIAWRTYLVRDPEALSLLDA
Rv3776|M.tuberculosis_H37Rv QMHLSLTLN-RLPQVAALFLAGQLSARLVSIIAWRTYLVRDPEALSLLDA
MSMEG_3957|M.smegmatis_MC2_155 LMRIAVALRDRLPLVAAQFAEGAVSTRVVETLTWRTRLIDDTQTMAAVDA
TH_0334|M.thermoresistible__bu RLQLAIDLRERLPRVAAVFAAGDIDFRMVSALVNRSRNVVDPDLLARLDA
: : :. ** . : :. * . : *: : * :: :*.
MAV_3457|M.avium_104 TLAVLVSRRPSLTRGGLAAAVDRVVAAVDADAVRRARDAVTGRYLDVR--
MUL_1813|M.ulcerans_Agy99 QLAALLARCPAVTRGRLSVAVDQVVADVDRDVVRRVAEAADGRFVDVDVI
MMAR_5187|M.marinum_M LVALNVGRWPSMTKARLSGQIDAIVARADADAVRRRKERHADREIWIG--
MAB_4752|M.abscessus_ATCC_1997 AIVRALPRWARWSHKRITAALDALVLHFDQDAVRRNRSATDKRHLEIRPL
Mflv_5065|M.gilvum_PYR-GCK ALAGKAEKWGPLSEDKLIDAINTVIARHDPDAVRRTKEALKKRDVHIGAH
Mvan_1291|M.vanbaalenii_PYR-1 ALAQRALRWGPLSQDRLRCAIDALIERYDPDAVIRAREVINGRDFRIGAH
Mb3805|M.bovis_AF2122/97 ALAKHATAWGPLSAPKLEKAIDSWIDRYDPAALRRTRISARSRDLCIGDP
Rv3776|M.tuberculosis_H37Rv ALAKHATAWGPLSAPKLEKAIDSWIDRYDPAALRRTRISARSRDLCIGDP
MSMEG_3957|M.smegmatis_MC2_155 QLASRIAEFGAMTIAELEGAVDKVVDSVDPAAVRRTRTAVRSRGVWFGHP
TH_0334|M.thermoresistible__bu ALAAWSPKWMKLSGPTLNERIDMWVERFDPTGVREPRSPGEDRYVVVTP-
:. : : :: : * : . * . .
MAV_3457|M.avium_104 ANESGMAWVEGNVLGPDGHALDRRLDELASGVCAGDPRSRAQRRADALGA
MUL_1813|M.ulcerans_Agy99 ADGSGLAALAGSVLATAGRAFDRRLDELANTVCAADPRTREQRRADAVGA
MMAR_5187|M.marinum_M QDADGISRIDGSMFTIDAHALDRRLSALAATVCAQDPRSREQRRADALGV
MAB_4752|M.abscessus_ATCC_1997 GNGEPVAEVWGTLQAVHAVALDKRLDLLAGTVCPADPRSKTQRRADAVGA
Mflv_5065|M.gilvum_PYR-GCK EDTDDVTTIWGLLLPPDAAAYTARIAALVKGLCDADPRSAGERRSDAMGA
Mvan_1291|M.vanbaalenii_PYR-1 EDPDELVTVWGKVLGCDAVVLAARIAALLKGICADDPRSEGERRSCAVGA
Mb3805|M.bovis_AF2122/97 DEDAGTAALWGRLFATDAAMLDKRLTQLAHGVCDDDPRTIAQRRADALGA
Rv3776|M.tuberculosis_H37Rv DEDAGTAALWGRLFATDAAMLDKRLTQLAHGVCDDDPRTIAQRRADALGA
MSMEG_3957|M.smegmatis_MC2_155 DDETGITSVHARLTNVDAVALKNRVGAMSSGQCPDDPRTKGQRLSDAMGV
TH_0334|M.thermoresistible__bu -AGQGMVDVSARLTFEAGFAFXTRLDQIAATVCRDDPRTADQRRADAMAA
: . : . *: : * ***: :* : *:..
MAV_3457|M.avium_104 LAAGAGRLACGCGSPDCPSAA-APAPRSTVVIHVVAEQATVAGRGA----
MUL_1813|M.ulcerans_Agy99 LVAGSDRLACGCTSADCTAAA-RSAP-SKVVIHVVADQSTVDGTGH----
MMAR_5187|M.marinum_M LAAGGDRLGCRCGLPDCAAGA-RPAA-QPVVIHVIAERATLDGDGG----
MAB_4752|M.abscessus_ATCC_1997 LTQGLNRMRCACGHPDCSG---RDTADVPVVVNVVINQSTLAGSDD----
Mflv_5065|M.gilvum_PYR-GCK IGRGENQLACRCGSPNCT--ASGP-STSPVVITVIADQAAVDTAQQLIAD
Mvan_1291|M.vanbaalenii_PYR-1 IIQGQDHLPCRCGSPDCT--ASAPPASSNVVISVIADHAAVAAARQLIAT
Mb3805|M.bovis_AF2122/97 LAAGADRLTCGCGNSDCPSSAGNHRQATGVVIHVVADAAALGAAPDPRLS
Rv3776|M.tuberculosis_H37Rv LAAGADRLTCGCGNSDCPSSAGNHRQATGVVIHVVADAAALGAAPDPRLS
MSMEG_3957|M.smegmatis_MC2_155 LGHYGDRLTCRCGDPECP-AAGIDPRAANTMVHVFAEPAAVHGPVDRYLD
TH_0334|M.thermoresistible__bu MSEGQNRLVCGCGSEDCPADP-ADTAATRLVINVIAEQATVEGRSD----
: .:: * * :*. :: *. : :::
MAV_3457|M.avium_104 --------------------------------------------------
MUL_1813|M.ulcerans_Agy99 --------------------------------------------------
MMAR_5187|M.marinum_M --------------------------------------------------
MAB_4752|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_5065|M.gilvum_PYR-GCK QDAEQQNTTAT-----------TAEPT-----------------------
Mvan_1291|M.vanbaalenii_PYR-1 EDREQQQKHAQNQAKTEPAPEAEAEPTPEPDAEPAGDPVESAPLPVGEDE
Mb3805|M.bovis_AF2122/97 G----------------PEPALAPEAPATPAVKPP---------------
Rv3776|M.tuberculosis_H37Rv G----------------PEPALAPEAPATPAVKPP---------------
MSMEG_3957|M.smegmatis_MC2_155 GDHESNPIPYF-----EPTPTPEPEPTPEPVRKPPE--------------
TH_0334|M.thermoresistible__bu --------------------------------------------------
MAV_3457|M.avium_104 ----------------------TPAVVAGLDGLIPAQVIAELAASARLVP
MUL_1813|M.ulcerans_Agy99 ----------------------TPAVLLGAEGLIPASLIAELAKVATLRP
MMAR_5187|M.marinum_M ----------------------APAWEVGADGLVTPELVAELAKSAKLVP
MAB_4752|M.abscessus_ATCC_1997 ----------------------CPAHVPGFG-----VLAAESARAAVAGT
Mflv_5065|M.gilvum_PYR-GCK -----------------CTKDPGSALLPGAQILPIPVLAEAIRSGAKITP
Mvan_1291|M.vanbaalenii_PYR-1 SPEPGPAAGPEVANPVRCLRDSGVALLPGVKVLPIVALAEAIRAGAAIKS
Mb3805|M.bovis_AF2122/97 -----------------------AALISGGGVVPAPLLAELIRGGAALSR
Rv3776|M.tuberculosis_H37Rv -----------------------AALISGGGVVPAPLLAELIRGGAALSR
MSMEG_3957|M.smegmatis_MC2_155 -------PEPKPWTPQSAHPGRGGAVVLGGGVVPAPLVAQLIADGAKVKE
TH_0334|M.thermoresistible__bu ----------------------NPGYLPGYGAVPASILRAKAAT-ATLRP
. * : *
MAV_3457|M.avium_104 VAVP-EGGPEPGYTPSARLADFIRCRDLTCRAPGCDRPAVDCDVDHTIPY
MUL_1813|M.ulcerans_Agy99 LMRP-SGRPESGYAPSAGLAEFVRCRDLTCRARGCDQPAVCCDLDHTVAY
MMAR_5187|M.marinum_M LRHPGDVPPEPGYVPSKALADFVRCRDLTCRWPGCDHPALNCDLDHTIPY
MAB_4752|M.abscessus_ATCC_1997 PTRNLTDSRSTGYRPSAKLAAFVRSRDQLCRFPGCEAVADRADIDHTVPW
Mflv_5065|M.gilvum_PYR-GCK LWLPG-PDPEPHYRPSAKLAAFIRSRDLFCRFPGCDVSADRCDIDHVVPY
Mvan_1291|M.vanbaalenii_PYR-1 LWLPG-PDPEPHYRPSAKLAAFVRARDLFCRYPGCDVPAEHCDIDHVVPY
Mb3805|M.bovis_AF2122/97 VRHPGDLRSEPHYRPSAKLAEFVRIRDMTCRFPGCDQPTEFCDIDHTLPY
Rv3776|M.tuberculosis_H37Rv MRHPGDLRSEPHYRPSAKLAEFVRIRDMTCRFPGCDQPTEFCDIDHTLPY
MSMEG_3957|M.smegmatis_MC2_155 LTVPDDICAS--YRPSVAMDCFVRMRDMTCRFPGCSRPADFCDVDHTTPW
TH_0334|M.thermoresistible__bu VALP-QPCAEAGYRPSAALTRFIRCRDLTCRFPGCDAPAAVCQIDHTIPY
. * ** : *:* ** ** **. : .::**. .:
MAV_3457|M.avium_104 AQGGPTHPSNLKCLCRGHHLLKTFWG----WRDRQLPDGTVIWTLPDGDT
MUL_1813|M.ulcerans_Agy99 GDGGHTHASNLKCLCRKHHLLKTFWG----WRDLQLPDGTVIWLLPDGHT
MMAR_5187|M.marinum_M AQGGPTHASNLKCYCRTHHLVKTFWG----WHDQQLPDGTLILTSPAGHT
MAB_4752|M.abscessus_ATCC_1997 ATGGPTTGANLKALCRKHHLLKTFGQ----WTELQEPDGTVIWKSPTGHR
Mflv_5065|M.gilvum_PYR-GCK PFG-PTHASNMHCKCRSHHLMKTFWGGPDGWRERQLPDGTVLWTTPAGTT
Mvan_1291|M.vanbaalenii_PYR-1 PFG-PTHASNLNCTCRTHHLGKTFAEG---WQVEQLPDGTVTWTTPAGQH
Mb3805|M.bovis_AF2122/97 PLG-PTHPSNLKCLCRKHHLLKTFWTG---WRDVQLPDGTIIWTAPNGHT
Rv3776|M.tuberculosis_H37Rv PLG-PTHPSNLKCLCRKHHLLKTFWTG---WRDVQLPDGTIIWTAPNGHT
MSMEG_3957|M.smegmatis_MC2_155 PTG-VTHPSNTKCLCRIHHLLKTFWLG---WSDRQLPDGTVIWTSPTGHV
TH_0334|M.thermoresistible__bu PAG-PTHPSNLKLLCVFHCRQAELRFT-HDQHKHQSSCLPAYFQRPHGPA
* * :* : * * : * . . * *
MAV_3457|M.avium_104 YVTTPGSALLFPTLCTPTGAVSP------------------------AKP
MUL_1813|M.ulcerans_Agy99 YVTTPGSALLFPNLCVPTGELPPIVGTAGKPPRWPSGEDADPCPNPRTKP
MMAR_5187|M.marinum_M YVTTPGSALLFPSLCHSTGGLPA----------------------AEADP
MAB_4752|M.abscessus_ATCC_1997 YATTPVSWFLFPALTR----------------------------------
Mflv_5065|M.gilvum_PYR-GCK YTTTPGSRLFFPAWDTTTAELPP----------------------MTTPP
Mvan_1291|M.vanbaalenii_PYR-1 HTTMPGSRLLFPGWDTTTAALPP----------------------MAQPP
Mb3805|M.bovis_AF2122/97 YTTHPDSRIFLPSWHTTTAALPP----------------------APSPP
Rv3776|M.tuberculosis_H37Rv YTTHPDSRIFLPSWHTTTAALPP----------------------APSPP
MSMEG_3957|M.smegmatis_MC2_155 YTTVPASRALFPQWDTTTAALPP----------------------PPTPP
TH_0334|M.thermoresistible__bu TRRPPSARGLR---------------------------------------
* : :
MAV_3457|M.avium_104 DTEHR--CGERTAMMPLRRHTRAHNRAHRITTERNHNRR-----------
MUL_1813|M.ulcerans_Agy99 GESHR--HRAPMQSQGTGSRRRRPRRPVRHPGAGNRSRRAAALLAA----
MMAR_5187|M.marinum_M PSDH---CDQRSAMMPRRQRTRAQDRARRVATERRQNHH------A----
MAB_4752|M.abscessus_ATCC_1997 ------------------HHTRQQARDRRRRTERNLNRE-----------
Mflv_5065|M.gilvum_PYR-GCK PGA------GREIQMPKRQRSRTADRAARIKAEREHNGTQRNLEER----
Mvan_1291|M.vanbaalenii_PYR-1 PDP------DRVAKMPKRRRTRAAEEAARIKAERECNAVQRALERQRALD
Mb3805|M.bovis_AF2122/97 -AIGP----THTLLMPRRRRTRAAELAHRIKRERAH----VTQRNK----
Rv3776|M.tuberculosis_H37Rv -AIGP----THTLLMPRRRRTRAAELAHRIKRERAH----VTQRNK----
MSMEG_3957|M.smegmatis_MC2_155 PPMTPSEIAARAAMMPRRRRTRAAEEARRLAAERARNEAYLAQRDR----
TH_0334|M.thermoresistible__bu -----------------EAVPRQGVDPRRVSGQ-----------------
* *
MAV_3457|M.avium_104 ----TRLTTHPATPGPAPPPDPDDEPPPF---------------------
MUL_1813|M.ulcerans_Agy99 ----TSLGTCQIPRRIAPRPGPSRSSRGCTDSGTRMGESSMSARPRACVA
MMAR_5187|M.marinum_M ----RSTQPGGQPRSAAPPTPPQSEPQSHPPPF-----------------
MAB_4752|M.abscessus_ATCC_1997 ---------QRLQREAALAALAAKDPPPF---------------------
Mflv_5065|M.gilvum_PYR-GCK ------------PRRGQPPPDYGNDPPPF---------------------
Mvan_1291|M.vanbaalenii_PYR-1 QQAAEHNRQAGLPPPAPPPPDYGDDPPPF---------------------
Mb3805|M.bovis_AF2122/97 ------------PPPSGGDTAVAEGFEPPDGVSRLSLSRRVH--------
Rv3776|M.tuberculosis_H37Rv ------------PPPSGGDTAVAEGFEPPDGVSRLSLSRRVH--------
MSMEG_3957|M.smegmatis_MC2_155 ------------PPPD----AHGPGMQ-----------------------
TH_0334|M.thermoresistible__bu --------------------------------------------------
MAV_3457|M.avium_104 -
MUL_1813|M.ulcerans_Agy99 G
MMAR_5187|M.marinum_M -
MAB_4752|M.abscessus_ATCC_1997 -
Mflv_5065|M.gilvum_PYR-GCK -
Mvan_1291|M.vanbaalenii_PYR-1 -
Mb3805|M.bovis_AF2122/97 -
Rv3776|M.tuberculosis_H37Rv -
MSMEG_3957|M.smegmatis_MC2_155 -
TH_0334|M.thermoresistible__bu -