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MFEISLSDPVELRDADDAALLAAIEDCARAEVAAGARRLSAIAELTSRRTGNDQRADWACDGWDCAAAEV AAALTVSHRKASGQMHLSLTLNRLPQVAALFLAGQLSARLVSIIAWRTYLVRDPEALSLLDAALAKHATA WGPLSAPKLEKAIDSWIDRYDPAALRRTRISARSRDLCIGDPDEDAGTAALWGRLFATDAAMLDKRLTQL AHGVCDDDPRTIAQRRADALGALAAGADRLTCGCGNSDCPSSAGNHRQATGVVIHVVADAAALGAAPDPR LSGPEPALAPEAPATPAVKPPAALISGGGVVPAPLLAELIRGGAALSRVRHPGDLRSEPHYRPSAKLAEF VRIRDMTCRFPGCDQPTEFCDIDHTLPYPLGPTHPSNLKCLCRKHHLLKTFWTGWRDVQLPDGTIIWTAP NGHTYTTHPDSRIFLPSWHTTTAALPPAPSPPAIGPTHTLLMPRRRRTRAAELAHRIKRERAHVTQRNKP PPSGGDTAVAEGFEPPDGVSRLSLSRRVH
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3805 | - | - | 100% (519) | hypothetical protein Mb3805 |
| M. bovis AF2122 / 97 | Mb2126 | - | 0.0 | 77.84% (510) | hypothetical protein Mb2126 |
| M. bovis AF2122 / 97 | Mb0528 | - | 3e-96 | 41.00% (500) | 13E12 repeat family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_5065 | - | 1e-124 | 48.10% (501) | hypothetical protein Mflv_5065 |
| M. tuberculosis H37Rv | Rv3776 | - | 0.0 | 99.81% (519) | hypothetical protein Rv3776 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4752 | - | 2e-74 | 39.79% (485) | hypothetical protein MAB_4752 |
| M. marinum M | MMAR_1213 | - | 5e-95 | 44.09% (474) | 13e12 repeat-containing protein |
| M. avium 104 | MAV_3457 | - | 1e-99 | 44.95% (505) | 13e12 repeat-containing protein |
| M. smegmatis MC2 155 | MSMEG_3957 | - | 1e-130 | 47.78% (517) | 13e12 repeat-containing protein |
| M. thermoresistible (build 8) | TH_0334 | - | 2e-72 | 41.71% (386) | HNH endonuclease |
| M. ulcerans Agy99 | MUL_2679 | - | 5e-91 | 43.74% (455) | 13e12 repeat-containing protein |
| M. vanbaalenii PYR-1 | Mvan_2714 | - | 1e-122 | 43.61% (587) | hypothetical protein Mvan_2714 |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1213|M.marinum_M MRAQALRPTVSVDQHMIEHVFDTDSS-----------APLTRITAAARAE
MUL_2679|M.ulcerans_Agy99 -----------MDQHIIEYVFDTDDS-----------APLTRITAAARAE
MAV_3457|M.avium_104 -----------MVEHMFEYVVASRSTPE-------AVALLDRAREAARAE
TH_0334|M.thermoresistible__bu -------------------MFESLDDG----------AVVDSIAAASREQ
MAB_4752|M.abscessus_ATCC_1997 -------------------MFDELGD----------VELIDLIASAQRAE
Mb3805|M.bovis_AF2122/97 -------------------MFEISLSDPVELRDADDAALLAAIEDCARAE
Rv3776|M.tuberculosis_H37Rv -------------------MFEISLSDPVELRDADDAALLAAIEDCARAE
MSMEG_3957|M.smegmatis_MC2_155 -------------------MCET----------LDDAALIAGIAGESRAE
Mflv_5065|M.gilvum_PYR-GCK -------------------MFDTMHRG------LGEADLLAAIEQAAREE
Mvan_2714|M.vanbaalenii_PYR-1 -------------------MFDRMFAG------LDEPALLAAIEQAACEE
: : :
MMAR_1213|M.marinum_M ARAAAERLAAIGDLFRLRLSQHG--NREDWVADTCDAVAAEVAAALNTSV
MUL_2679|M.ulcerans_Agy99 ARAAAERLAAIGDLFRLRLSQHG--NREDWVADTCDAVAAEVAAALNTSV
MAV_3457|M.avium_104 ARAAAARLVAVAELLVLRCRETG--ERADWAADAWEAVAAQVGAALGCSV
TH_0334|M.thermoresistible__bu SAACGREMLAIGELYARRAPEDDT-ERANWAIDGHANVVAEISAALNISR
MAB_4752|M.abscessus_ATCC_1997 AQACARKLDAIGVLVDRHADLGKPDERDHHALDRWDRVASEVAAAQGITH
Mb3805|M.bovis_AF2122/97 VAAGARRLSAIAELTSRRTGN---DQRADWACDGWDCAAAEVAAALTVSH
Rv3776|M.tuberculosis_H37Rv VAAGARRLSAIAELTSRRTGN---DQRADWACDGWDCAAAEVAAALTVSH
MSMEG_3957|M.smegmatis_MC2_155 SAAAARRFAFIAEFVDRRTADSE-DTVVWWACDDWDAASAEVAAALNIGQ
Mflv_5065|M.gilvum_PYR-GCK AQAGARRLAAIAELVDLTVDE-D-DERGMWAFDPWKNAACHIGAALSISE
Mvan_2714|M.vanbaalenii_PYR-1 SRAGARKSAAIAALVHESVTF-D-DVRDQWVWDSWAETACELGAALNTSH
* . . :. : . * . ..:.**
MMAR_1213|M.marinum_M AMGHSNLRYARAMRERLPQLGAEFRAGGIDFRLFRTIVFRTDLITDSDAL
MUL_2679|M.ulcerans_Agy99 AMGHSNLRYARAMRERLPQLGAEFRAGGIDFRLFRTIVFRTDLITESDAL
MAV_3457|M.avium_104 AMGHSYLRYAMAMRERLPQVGAVFAAGGIDYRAFQTLVFRTDLITDAQVL
TH_0334|M.thermoresistible__bu GRAAGRLQLAIDLRERLPRVAAVFAAGDIDFRMVSALVNRSRNVVDPDLL
MAB_4752|M.abscessus_ATCC_1997 ALASSQMRYAQVLRHRLRAVAERFAAGDLDFRTVALIINRTELVDDEAVV
Mb3805|M.bovis_AF2122/97 RKASGQMHLSLTLN-RLPQVAALFLAGQLSARLVSIIAWRTYLVRDPEAL
Rv3776|M.tuberculosis_H37Rv RKASGQMHLSLTLN-RLPQVAALFLAGQLSARLVSIIAWRTYLVRDPEAL
MSMEG_3957|M.smegmatis_MC2_155 RSASRLMRIAVALRDRLPLVAAQFAEGAVSTRVVETLTWRTRLIDDTQTM
Mflv_5065|M.gilvum_PYR-GCK RRASAQMCIATALRYRLPQIAALYVQGRLSTRLISEITWRTGLVAD-DVI
Mvan_2714|M.vanbaalenii_PYR-1 RRASAQMRIAVALHDRLPKVAALFAAGRLSTRLIGQITWRTRLVQDPHLL
. : : :. ** :. : * :. * . : *: : : :
MMAR_1213|M.marinum_M AAVDARLAIKAPRWPSMTSWKLATEVDRVVAKFDRDAVRRSRRDAADRYV
MUL_2679|M.ulcerans_Agy99 AAVDARLAIKAPRWPSMTSWKLATEVDRVVAKFDRDAVRRSRRDAADRYV
MAV_3457|M.avium_104 ARVDATLAVLVSRRPSLTRGGLAAAVDRVVAAVDADAVRRARDAVTGRYL
TH_0334|M.thermoresistible__bu ARLDAALAAWSPKWMKLSGPTLNERIDMWVERFDPTGVREPRSPGEDRYV
MAB_4752|M.abscessus_ATCC_1997 ARVDAAIVRALPRWARWSHKRITAALDALVLHFDQDAVRRNRSATDKRHL
Mb3805|M.bovis_AF2122/97 SLLDAALAKHATAWGPLSAPKLEKAIDSWIDRYDPAALRRTRISARSRDL
Rv3776|M.tuberculosis_H37Rv SLLDAALAKHATAWGPLSAPKLEKAIDSWIDRYDPAALRRTRISARSRDL
MSMEG_3957|M.smegmatis_MC2_155 AAVDAQLASRIAEFGAMTIAELEGAVDKVVDSVDPAAVRRTRTAVRSRGV
Mflv_5065|M.gilvum_PYR-GCK ATVDAALAGKAEKWGPLSEDKLIDAINTVIARHDPDAVRRTKEALKKRDV
Mvan_2714|M.vanbaalenii_PYR-1 ALLDTAMADKATRWEPLSDDKLTAALDAVIERYDPDAVIRAREHVSGLDF
: :*: :. : : :: : * .: . : .
MMAR_1213|M.marinum_M DCAPLEPG--MALVNGQVFAATAEALARRLDELAKTVCADDPRTVVQRRA
MUL_2679|M.ulcerans_Agy99 DCAPLEPG--MALVNRQVFSATAEALARRLDELAKTVCADDPRTVVQRRA
MAV_3457|M.avium_104 DVRANESG--MAWVEGNVLGPDGHALDRRLDELASGVCAGDPRSRAQRRA
TH_0334|M.thermoresistible__bu VVTPAGQG--MVDVSARLTFEAGFAFXTRLDQIAATVCRDDPRTADQRRA
MAB_4752|M.abscessus_ATCC_1997 EIRPLGNGEPVAEVWGTLQAVHAVALDKRLDLLAGTVCPADPRSKTQRRA
Mb3805|M.bovis_AF2122/97 CIGDPDEDAGTAALWGRLFATDAAMLDKRLTQLAHGVCDDDPRTIAQRRA
Rv3776|M.tuberculosis_H37Rv CIGDPDEDAGTAALWGRLFATDAAMLDKRLTQLAHGVCDDDPRTIAQRRA
MSMEG_3957|M.smegmatis_MC2_155 WFGHPDDETGITSVHARLTNVDAVALKNRVGAMSSGQCPDDPRTKGQRLS
Mflv_5065|M.gilvum_PYR-GCK HIGAHEDTDDVTTIWGLLLPPDAAAYTARIAALVKGLCDADPRSAGERRS
Mvan_2714|M.vanbaalenii_PYR-1 RVGASDDPDALVTVWGKILGCDAAVLAARIAELLKGLCDNDPRSVCVRRS
. : : . *: : * ***: * :
MMAR_1213|M.marinum_M DALGTLAAGQDRLICDCGRTDCPAAGAPQQPSR-VVIHVVAGRETVDGAG
MUL_2679|M.ulcerans_Agy99 DALGTLAAGQDRLICDCGRTDCPAAGAPQQPSR-VVIHVVAGCQTVDGAG
MAV_3457|M.avium_104 DALGALAAGAGRLACGCGSPDCPSAAAPAPRST-VVIHVVAEQATVAGRG
TH_0334|M.thermoresistible__bu DAMAAMSEGQNRLVCGCGSEDCPADPADTAATR-LVINVIAEQATVEGRS
MAB_4752|M.abscessus_ATCC_1997 DAVGALTQGLNRMRCACGHPDCSGR--DTADVP-VVVNVVINQSTLAGSD
Mb3805|M.bovis_AF2122/97 DALGALAAGADRLTCGCGNSDCPSSAGNHRQATGVVIHVVADAAALGAAP
Rv3776|M.tuberculosis_H37Rv DALGALAAGADRLTCGCGNSDCPSSAGNHRQATGVVIHVVADAAALGAAP
MSMEG_3957|M.smegmatis_MC2_155 DAMGVLGHYGDRLTCRCGDPECP-AAGIDPRAANTMVHVFAEPAAVHGPV
Mflv_5065|M.gilvum_PYR-GCK DAMGAIGRGENQLACRCGSPNCT-ASG--PSTSPVVITVIADQAAVDTAQ
Mvan_2714|M.vanbaalenii_PYR-1 HAVGAIVRGQDHLRCRCGSPDCT-AAAVVPGSSNVVISVLADPAALDAVR
.*:..: .:: * ** :*. :: *. ::
MMAR_1213|M.marinum_M EA------------------------------------------------
MUL_2679|M.ulcerans_Agy99 EA------------------------------------------------
MAV_3457|M.avium_104 AT------------------------------------------------
TH_0334|M.thermoresistible__bu DN------------------------------------------------
MAB_4752|M.abscessus_ATCC_1997 DC------------------------------------------------
Mb3805|M.bovis_AF2122/97 DPRLSG--------------------PEPALAP-----------------
Rv3776|M.tuberculosis_H37Rv DPRLSG--------------------PEPALAP-----------------
MSMEG_3957|M.smegmatis_MC2_155 DRYLDGDHESNPIP---------YFEPTPTPEP-----------------
Mflv_5065|M.gilvum_PYR-GCK QLIADQDAEQQN--------------------------------------
Mvan_2714|M.vanbaalenii_PYR-1 QLIADQDRDQQDKLADKHAQAKGKAEPEPEPEPAVEAEPEAGASEVGEDE
MMAR_1213|M.marinum_M --------------------------------------------------
MUL_2679|M.ulcerans_Agy99 --------------------------------------------------
MAV_3457|M.avium_104 --------------------------------------------------
TH_0334|M.thermoresistible__bu --------------------------------------------------
MAB_4752|M.abscessus_ATCC_1997 --------------------------------------------------
Mb3805|M.bovis_AF2122/97 -----------------------------EAPATPAVKPP----------
Rv3776|M.tuberculosis_H37Rv -----------------------------EAPATPAVKPP----------
MSMEG_3957|M.smegmatis_MC2_155 -----------------------------EPTPEPVRKPPEPEPKPWTPQ
Mflv_5065|M.gilvum_PYR-GCK ------------------------------TTATT--AEPT---------
Mvan_2714|M.vanbaalenii_PYR-1 ELRPEPQTEPRASEVDEDEEPESESEPAAETTPATPAVEPVPSPSPVNRV
MMAR_1213|M.marinum_M -------PGVLPG-DGIIPAEIVRELAKS-AKLQPMSTP--ILAETGYVP
MUL_2679|M.ulcerans_Agy99 -------PGVLPG-DGIIPAEIVRELAKS-AKLQPMSTP--ILAETGYVP
MAV_3457|M.avium_104 -------PAVVAGLDGLIPAQVIAELAAS-ARLVPVAVPE-GGPEPGYTP
TH_0334|M.thermoresistible__bu -------PGYLPG-YGAVPASILRAKAAT-ATLRPVALPQ-PCAEAGYRP
MAB_4752|M.abscessus_ATCC_1997 -------PAHVPG-FGVLAAESARAAVAG-TPTRNLTDS----RSTGYRP
Mb3805|M.bovis_AF2122/97 -------AALISG-GGVVPAPLLAELIRGGAALSRVRHPGDLRSEPHYRP
Rv3776|M.tuberculosis_H37Rv -------AALISG-GGVVPAPLLAELIRGGAALSRMRHPGDLRSEPHYRP
MSMEG_3957|M.smegmatis_MC2_155 SAHPGRGGAVVLG-GGVVPAPLVAQLIADGAKVKELTVPDDICAS--YRP
Mflv_5065|M.gilvum_PYR-GCK -CTKDPGSALLPG-AQILPIPVLAEAIRSGAKITPLWLPG-PDPEPHYRP
Mvan_2714|M.vanbaalenii_PYR-1 RCVRDSGVALLPG-VKILPIVALAEAIRSGAAIKTLWLPG-PDPEPHYRP
. : * :. : : . . * *
MMAR_1213|M.marinum_M SPALMDFVRARDLTCRAPGCDRPATQCDVDHTIPYSDGGATHPSNLKCLC
MUL_2679|M.ulcerans_Agy99 SPALMDFVRARDLTCRAPGCDRPATQCDVDHTIPYSDGGATHPSNLKCLC
MAV_3457|M.avium_104 SARLADFIRCRDLTCRAPGCDRPAVDCDVDHTIPYAQGGPTHPSNLKCLC
TH_0334|M.thermoresistible__bu SAALTRFIRCRDLTCRFPGCDAPAAVCQIDHTIPYPAG-PTHPSNLKLLC
MAB_4752|M.abscessus_ATCC_1997 SAKLAAFVRSRDQLCRFPGCEAVADRADIDHTVPWATGGPTTGANLKALC
Mb3805|M.bovis_AF2122/97 SAKLAEFVRIRDMTCRFPGCDQPTEFCDIDHTLPYPLG-PTHPSNLKCLC
Rv3776|M.tuberculosis_H37Rv SAKLAEFVRIRDMTCRFPGCDQPTEFCDIDHTLPYPLG-PTHPSNLKCLC
MSMEG_3957|M.smegmatis_MC2_155 SVAMDCFVRMRDMTCRFPGCSRPADFCDVDHTTPWPTG-VTHPSNTKCLC
Mflv_5065|M.gilvum_PYR-GCK SAKLAAFIRSRDLFCRFPGCDVSADRCDIDHVVPYPFG-PTHASNMHCKC
Mvan_2714|M.vanbaalenii_PYR-1 SAKLAAFVRARDLFCRYPGCDVPAEHCDLDHVVPYPYG-PTHPSNLNCKC
* : *:* ** ** ***. : .::**. *:. * * :* : *
MMAR_1213|M.marinum_M RKHHLLKTFWG----WHDKQLPDATVIWSLPDGQTYVTTPGSAWLLPGLF
MUL_2679|M.ulcerans_Agy99 RKHHLLKTFWG----WHDEQLPDATVIWSLPDGQTYVTTPGSAWLLPGLF
MAV_3457|M.avium_104 RGHHLLKTFWG----WRDRQLPDGTVIWTLPDGDTYVTTPGSALLFPTLC
TH_0334|M.thermoresistible__bu VFHCRQAELRF----THDQHKHQSSCLP------AYFQRP---------H
MAB_4752|M.abscessus_ATCC_1997 RKHHLLKTFGQ----WTELQEPDGTVIWKSPTGHRYATTPVSWFLFPALT
Mb3805|M.bovis_AF2122/97 RKHHLLKTFWT---GWRDVQLPDGTIIWTAPNGHTYTTHPDSRIFLPSWH
Rv3776|M.tuberculosis_H37Rv RKHHLLKTFWT---GWRDVQLPDGTIIWTAPNGHTYTTHPDSRIFLPSWH
MSMEG_3957|M.smegmatis_MC2_155 RIHHLLKTFWL---GWSDRQLPDGTVIWTSPTGHVYTTVPASRALFPQWD
Mflv_5065|M.gilvum_PYR-GCK RSHHLMKTFWGGPDGWRERQLPDGTVLWTTPAGTTYTTTPGSRLFFPAWD
Mvan_2714|M.vanbaalenii_PYR-1 RTHHLGKTFA---DGWHEEQLPDGTVIWTTPAGQRNTTVPGSRLFFPAWD
* : : : :.: : *
MMAR_1213|M.marinum_M APSPELPPPARKPQDHCG----NRDAMMPKRARTRAQSSAARIAAERNHN
MUL_2679|M.ulcerans_Agy99 APSPELPPPPR------------------------SEATGSLRKPRRDDA
MAV_3457|M.avium_104 TPTGAVSPAKPDTEHRCG----ERTAMMPLRRHTRAHNRAHRITTERNHN
TH_0334|M.thermoresistible__bu GPATRRPPSAR----------------------------GLREAVPRQGV
MAB_4752|M.abscessus_ATCC_1997 RHHTRQQARDR------------------------------RRRTERNLN
Mb3805|M.bovis_AF2122/97 TTTAALPPAPSPP-AIGP----THTLLMPRRRRTRAAELAHRIKRERAH-
Rv3776|M.tuberculosis_H37Rv TTTAALPPAPSPP-AIGP----THTLLMPRRRRTRAAELAHRIKRERAH-
MSMEG_3957|M.smegmatis_MC2_155 TTTAALPPPPTPPPPMTPSEIAARAAMMPRRRRTRAAEEARRLAAERARN
Mflv_5065|M.gilvum_PYR-GCK TTTAELPPMTTPPPGA------GREIQMPKRQRSRTADRAARIKAEREHN
Mvan_2714|M.vanbaalenii_PYR-1 TTTAELPPMTAPPPDP------NRLAKMPKRRRTRAADQAARIKTEREHN
. *
MMAR_1213|M.marinum_M MTSRQARRRR----------WEECYFGPRDASASDDEEPPPF--
MUL_2679|M.ulcerans_Agy99 QTRPNSRPK----------------LGRTHCDRTQPQHD-----
MAV_3457|M.avium_104 RRTRLTTHP--------------ATPGPAPPPDPDDEPPPF---
TH_0334|M.thermoresistible__bu DPRRVSGQ------------------------------------
MAB_4752|M.abscessus_ATCC_1997 REQRLQREA-------------------ALAALAAKDPPPF---
Mb3805|M.bovis_AF2122/97 ---VTQRNKP-----PPSGGDTAVAEGFEPPDGVSRLSLSRRVH
Rv3776|M.tuberculosis_H37Rv ---VTQRNKP-----PPSGGDTAVAEGFEPPDGVSRLSLSRRVH
MSMEG_3957|M.smegmatis_MC2_155 EAYLAQRDRP-----PPD----AHGPGMQ---------------
Mflv_5065|M.gilvum_PYR-GCK GTQRNLEER------PRRGQ---------PPPDYGNDPPPF---
Mvan_2714|M.vanbaalenii_PYR-1 ATQRALERQQALDRQPRTEAGRIGCEGLPPPPGYGDDPPPF---