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VEHMFEYVVASRSTPEAVALLDRAREAARAEARAAAARLVAVAELLVLRCRETGERADWAADAWEAVAAQ VGAALGCSVAMGHSYLRYAMAMRERLPQVGAVFAAGGIDYRAFQTLVFRTDLITDAQVLARVDATLAVLV SRRPSLTRGGLAAAVDRVVAAVDADAVRRARDAVTGRYLDVRANESGMAWVEGNVLGPDGHALDRRLDEL ASGVCAGDPRSRAQRRADALGALAAGAGRLACGCGSPDCPSAAAPAPRSTVVIHVVAEQATVAGRGATPA VVAGLDGLIPAQVIAELAASARLVPVAVPEGGPEPGYTPSARLADFIRCRDLTCRAPGCDRPAVDCDVDH TIPYAQGGPTHPSNLKCLCRGHHLLKTFWGWRDRQLPDGTVIWTLPDGDTYVTTPGSALLFPTLCTPTGA VSPAKPDTEHRCGERTAMMPLRRHTRAHNRAHRITTERNHNRRTRLTTHPATPGPAPPPDPDDEPPPF*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_3457 | - | - | 100% (489) | 13e12 repeat-containing protein |
| M. avium 104 | MAV_4456 | - | e-151 | 57.85% (484) | 13e12 repeat-containing protein |
| M. avium 104 | MAV_0536 | - | 4e-85 | 43.07% (469) | hypothetical protein MAV_0536 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0528 | - | 1e-148 | 56.06% (487) | 13E12 repeat family protein |
| M. gilvum PYR-GCK | Mflv_5065 | - | 2e-97 | 42.60% (500) | hypothetical protein Mflv_5065 |
| M. tuberculosis H37Rv | Rv0336 | - | 1e-149 | 56.26% (487) | 13E12 repeat family protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4752 | - | 3e-87 | 42.14% (477) | hypothetical protein MAB_4752 |
| M. marinum M | MMAR_2226 | - | 1e-174 | 65.10% (490) | 13e12 repeat-containing protein |
| M. smegmatis MC2 155 | MSMEG_5026 | - | 2e-92 | 41.97% (498) | hypothetical protein MSMEG_5026 |
| M. thermoresistible (build 8) | TH_0334 | - | 3e-77 | 45.07% (355) | HNH endonuclease |
| M. ulcerans Agy99 | MUL_1813 | - | 1e-156 | 68.64% (405) | 13e12 repeat-containing protein |
| M. vanbaalenii PYR-1 | Mvan_0728 | - | 6e-98 | 39.37% (536) | hypothetical protein Mvan_0728 |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2226|M.marinum_M --------MFEY---WYASRPTAESNALLERAREASRREAAAAAERLDVV
MUL_1813|M.ulcerans_Agy99 ----------------------------MERAREASRREAAAAAERLDVV
MAV_3457|M.avium_104 ----MVEHMFEY---VVASRSTPEAVALLDRAREAARAEARAAAARLVAV
Mb0528|M.bovis_AF2122/97 MPSPEAIAHFDERFECHAPRTTRVSAAFIDRICSATRAENRAAAAQLVAL
Rv0336|M.tuberculosis_H37Rv MPSPEAIAHFDERFECHAPRTTRVSAAFIDRICSATRAENRAAAAQLVAL
MAB_4752|M.abscessus_ATCC_1997 --------MFDELG----------DVELIDLIASAQRAEAQACARKLDAI
MSMEG_5026|M.smegmatis_MC2_155 MGAGILERMFDG----------TSDAGLIDAIAEAKRQENAATARRLFAI
TH_0334|M.thermoresistible__bu --------MFES----------LDDGAVVDSIAAASREQSAACGREMLAI
Mflv_5065|M.gilvum_PYR-GCK --------MFDTMHRG------LGEADLLAAIEQAAREEAQAGARRLAAI
Mvan_0728|M.vanbaalenii_PYR-1 --------MFDVLVPDPADLAALSDAELLDAATATTRAENAVCARKLAVM
: : * : . . .: .:
MMAR_2226|M.marinum_M GALFVLRCRESG---DRAEWATDTWEAVAAQVAAALRTSVAMGSSYLRYA
MUL_1813|M.ulcerans_Agy99 GALFVLRCRESG---DRAEWATDTWEAVGAQVAAALRTSVAMGSSYLRYA
MAV_3457|M.avium_104 AELLVLRCRETG---ERADWAADAWEAVAAQVGAALGCSVAMGHSYLRYA
Mb0528|M.bovis_AF2122/97 GELFAYRWSRCG---GREEWVMDTMAAVAAEVAAALRISQGLAASRLRYA
Rv0336|M.tuberculosis_H37Rv GELFAYRWSRCG---GREEWVMDTMAAVAAEVAAALRISQGLAASRLRYA
MAB_4752|M.abscessus_ATCC_1997 G-VLVDRHADLGKPDERDHHALDRWDRVASEVAAAQGITHALASSQMRYA
MSMEG_5026|M.smegmatis_MC2_155 GELDTRRA-IDL--AECNFWRTDPFEEVCAEVSAALRISRSRANWQVHLA
TH_0334|M.thermoresistible__bu GELYARRAPEDD--TERANWAIDGHANVVAEISAALNISRGRAAGRLQLA
Mflv_5065|M.gilvum_PYR-GCK AEL-VDLTVDED--DERGMWAFDPWKNAACHIGAALSISERRASAQMCIA
Mvan_0728|M.vanbaalenii_PYR-1 AELFIRRTTLAP--QDRLDWWVDPEAAVTAELAAAHHITQGLATHQAYRA
. : * . ..:.** : . *
MMAR_2226|M.marinum_M MAMRNRLPKVGQAFRAGDIDYRAFQTIVFRTDLITDAEVLAKVDAQLAAL
MUL_1813|M.ulcerans_Agy99 MAMRNRLPKVGQAFRAEDIDYRAFQTIVFRTDLITDAEVLAKVDAQLAAL
MAV_3457|M.avium_104 MAMRERLPQVGAVFAAGGIDYRAFQTLVFRTDLITDAQVLARVDATLAVL
Mb0528|M.bovis_AF2122/97 RAMRERLPKTAEVFSAGDIGYLMFATIVYRTDLIVDPDVLAAVDAQLAAN
Rv0336|M.tuberculosis_H37Rv RAMRERLPKTAEVFSAGDIGYLMFATIVYRTDLIVDPDVLAAVDAQLAAN
MAB_4752|M.abscessus_ATCC_1997 QVLRHRLRAVAERFAAGDLDFRTVALIINRTELVDDEAVVARVDAAIVRA
MSMEG_5026|M.smegmatis_MC2_155 RVLRDRIPKVAAVFAQGDIDFRIVTKIATRT-ELVDPAAMPALDDVLARR
TH_0334|M.thermoresistible__bu IDLRERLPRVAAVFAAGDIDFRMVSALVNRSRNVVDPDLLARLDAALAAW
Mflv_5065|M.gilvum_PYR-GCK TALRYRLPQIAALYVQGRLSTRLISEITWRTGLVAD-DVIATVDAALAGK
Mvan_0728|M.vanbaalenii_PYR-1 VVLRDRLPKIGALFLQGLLSELLVRAIITRTGLITDPDLIAAVDADLATD
:* *: . : :. . : *: : * :. :* :.
MMAR_2226|M.marinum_M LARCPAVTRGRLSVAVDQVVADVDRDAVRRVAEAADGRFVDVDVIADGSG
MUL_1813|M.ulcerans_Agy99 LARCPAVTRGRLSVAVDQVVADVDRDVVRRVAEAADGRFVDVDVIADGSG
MAV_3457|M.avium_104 VSRRPSLTRGGLAAAVDRVVAAVDADAVRRARDAVTGRYLDVR--ANESG
Mb0528|M.bovis_AF2122/97 VARWPSMTKARLAGQVDKIVARADADAVRRRKEYQAQRQFWVG--ESQDG
Rv0336|M.tuberculosis_H37Rv VARWPSMTKARLAGQVDKIVARADADAVRRRKEYQAQRQFWVG--ESQDG
MAB_4752|M.abscessus_ATCC_1997 LPRWARWSHKRITAALDALVLHFDQDAVRRNRSATDKRHLEIRPLGNGEP
MSMEG_5026|M.smegmatis_MC2_155 CPNWMRLSEPKLEERIDQCILRLDPDGQRVTKRSEDSRYFTVQ-PADTPG
TH_0334|M.thermoresistible__bu SPKWMKLSGPTLNERIDMWVERFDPTGVREPRSPGEDRYVVVT-PAG-QG
Mflv_5065|M.gilvum_PYR-GCK AEKWGPLSEDKLIDAINTVIARHDPDAVRRTKEALKKRDVHIGAHEDTDD
Mvan_0728|M.vanbaalenii_PYR-1 ILDWGPLSVKATEAEIDAIIDRHDPDAVRKSRAPETGRTVQFGNPGDAPG
: :: : * * * . . .
MMAR_2226|M.marinum_M LAALTGSVLATAGRAFDRRLDELANTVCAADPRTREQRRADAVGALVAGS
MUL_1813|M.ulcerans_Agy99 LAALAGSVLATAGRAFDRRLDELANTVCAADPRTREQRRADAVGALVAGS
MAV_3457|M.avium_104 MAWVEGNVLGPDGHALDRRLDELASGVCAGDPRSRAQRRADALGALAAGA
Mb0528|M.bovis_AF2122/97 VCQIGGSLLAVDAHALDARLSALAGTVCEHDPRSREQRRADALGALAGGA
Rv0336|M.tuberculosis_H37Rv VCQIGGSLLAVDAHALDARLSALAGTVCEHDPRSREQRRADALGALAGGA
MAB_4752|M.abscessus_ATCC_1997 VAEVWGTLQAVHAVALDKRLDLLAGTVCPADPRSKTQRRADAVGALTQGL
MSMEG_5026|M.smegmatis_MC2_155 MANAQGYLPAHDAAGFDKRLDAIAATVCPNDPRTPDQRRADALGALGRYR
TH_0334|M.thermoresistible__bu MVDVSARLTFEAGFAFXTRLDQIAATVCRDDPRTADQRRADAMAAMSEGQ
Mflv_5065|M.gilvum_PYR-GCK VTTIWGLLLPPDAAAYTARIAALVKGLCDADPRSAGERRSDAMGAIGRGE
Mvan_0728|M.vanbaalenii_PYR-1 YTSMWARMYASDAAAADRTLTALAYSVCDNDPRTLDERRNDAHTALLTGI
. : . . : :. :* ***: :** ** *:
MMAR_2226|M.marinum_M DRLACGCTSADCTAAARSAP-SNVVIHVVADQSTVDGTGHT---------
MUL_1813|M.ulcerans_Agy99 DRLACGCTSADCTAAARSAP-SKVVIHVVADQSTVDGTGHT---------
MAV_3457|M.avium_104 GRLACGCGSPDCPSAAAPAPRSTVVIHVVAEQATVAGRGAT---------
Mb0528|M.bovis_AF2122/97 DRLGCGCGRADCAAGKRPAA-PPVVIHLIAEAATINGTGSA---------
Rv0336|M.tuberculosis_H37Rv DRLGCGCGRADCAAGKRPAA-PPVVIHLIAEAATINGTGSA---------
MAB_4752|M.abscessus_ATCC_1997 NRMRCACGHPDCSG--RDTADVPVVVNVVINQSTLAGSDDC---------
MSMEG_5026|M.smegmatis_MC2_155 DTLDCQCGREDCTAVAERDAVNNAMIHVLAEQSTLDGGNE----------
TH_0334|M.thermoresistible__bu NRLVCGCGSEDCPADPADTAATRLVINVIAEQATVEGRSDN---------
Mflv_5065|M.gilvum_PYR-GCK NQLACRCGSPNCTASGPSTSPVVITVIADQAAVDTAQQLIADQDAEQQNT
Mvan_0728|M.vanbaalenii_PYR-1 TTLACQCGNPDCHASTNPRPPRDITVYALTDHTTTTDTGDADTTTDTKPP
: * * :* . . :
MMAR_2226|M.marinum_M ------------------PAVLLGAEGLIPASLIAELAKVATLRPLMRP-
MUL_1813|M.ulcerans_Agy99 ------------------PAVLLGAEGLIPASLIAELAKVATLRPLMRP-
MAV_3457|M.avium_104 ------------------PAVVAGLDGLIPAQVIAELAASARLVPVAVP-
Mb0528|M.bovis_AF2122/97 ------------------PASQMNADGLITAELVAELAKTATLVPLVHPG
Rv0336|M.tuberculosis_H37Rv ------------------PASQMNADGLITAELVAELAKTATLVPLVHPG
MAB_4752|M.abscessus_ATCC_1997 ------------------PAHVPGFG-----VLAAESARAAVAGTPTRNL
MSMEG_5026|M.smegmatis_MC2_155 ------------------PGYLPGFG-MLPAHMVREVAKTATTKPVTIP-
TH_0334|M.thermoresistible__bu ------------------PGYLPGYG-AVPASILRAKAATATLRPVALP-
Mflv_5065|M.gilvum_PYR-GCK TATTAEPTCTK---DPG-SALLPGAQILPIPVLAEAIRSGAKITPLWLPG
Mvan_0728|M.vanbaalenii_PYR-1 TPPAPQPRRSKPILIPGRPAYLFGAGFMPAP-LFDALLAEATIREIIHPG
.. . : *
MMAR_2226|M.marinum_M -SGRPESGYAPSAGLAEFVRCRDLTCRAPGCDQPAVCCDLDHTVAYGDGG
MUL_1813|M.ulcerans_Agy99 -SGRPESGYAPSAGLAEFVRCRDLTCRARGCDQPAVCCDLDHTVAYGDGG
MAV_3457|M.avium_104 -EGGPEPGYTPSARLADFIRCRDLTCRAPGCDRPAVDCDVDHTIPYAQGG
Mb0528|M.bovis_AF2122/97 -DAPPEPGYAPSKALADFVRCRDLTCRWPGCDEPATNCDLDHTIPYAAGG
Rv0336|M.tuberculosis_H37Rv -DAPPEPGYAPSKALADFVRCRDLTCRWPGCDEPATNCDLDHTIPYAAGG
MAB_4752|M.abscessus_ATCC_1997 -TDSRSTGYRPSAKLAAFVRSRDQLCRFPGCEAVADRADIDHTVPWATGG
MSMEG_5026|M.smegmatis_MC2_155 -KDKAQSGYRPNAELTEFIRWRDLTCRFPGCDAPAMAADIDHTRPYPQG-
TH_0334|M.thermoresistible__bu -QPCAEAGYRPSAALTRFIRCRDLTCRFPGCDAPAAVCQIDHTIPYPAG-
Mflv_5065|M.gilvum_PYR-GCK --PDPEPHYRPSAKLAAFIRSRDLFCRFPGCDVSADRCDIDHVVPYPFG-
Mvan_0728|M.vanbaalenii_PYR-1 NRSAPEPRYTPSQALAEFIRCRDLTCRFPGCDKPATEADIDHTVPYPIG-
.. * *. *: *:* ** ** **: * .::**. .: *
MMAR_2226|M.marinum_M HTHASNLKCLCRKHHLLKTFWD----WRDLQLPDGTVIWLLPDGHTYVTT
MUL_1813|M.ulcerans_Agy99 HTHASNLKCLCRKHHLLKTFWG----WRDLQLPDGTVIWLLPDGHTYVTT
MAV_3457|M.avium_104 PTHPSNLKCLCRGHHLLKTFWG----WRDRQLPDGTVIWTLPDGDTYVTT
Mb0528|M.bovis_AF2122/97 PTHASNLKCYCRTHHLVKTFWG----WRDQQLPDGTLILTSPSGHTYVST
Rv0336|M.tuberculosis_H37Rv PTHASNLKCYCRTHHLVKTFWG----WRDQQLPDGTLILTSPSGHTYVST
MAB_4752|M.abscessus_ATCC_1997 PTTGANLKALCRKHHLLKTFGQ----WTELQEPDGTVIWKSPTGHRYATT
MSMEG_5026|M.smegmatis_MC2_155 PTHPSNTKLYCRTHHLIKTFYTGPNGWTDRQLPDGTIEFTAPTGHIYTTE
TH_0334|M.thermoresistible__bu PTHPSNLKLLCVFH-----------------CRQAELRFTHDQ-----HK
Mflv_5065|M.gilvum_PYR-GCK PTHASNMHCKCRSHHLMKTFWGGPDGWRERQLPDGTVLWTTPAGTTYTTT
Mvan_0728|M.vanbaalenii_PYR-1 PTHPSNLKCLCRFHHLLKTFWLGATGWHDRQHPDGTITWTAPTGHTYTTH
* :* : * * :. :
MMAR_2226|M.marinum_M PGSALLFPNLCVPTGGLPPIVGTAG---------------SPRAGRAARM
MUL_1813|M.ulcerans_Agy99 PGSALLFPNLCVPTGELPPIVGTAGKPPRWPSGEDADPCPNPRTKPGESH
MAV_3457|M.avium_104 PGSALLFPTLCTPTGAVSPAKPDTE---------------HRCGERTAMM
Mb0528|M.bovis_AF2122/97 PGSALLFPSLCHFSGGIPAPEADPP--------------YDHCDQRTAMM
Rv0336|M.tuberculosis_H37Rv PGSALLFPSLCHFSGGIPAPEADPP--------------YDHCDQRTAMM
MAB_4752|M.abscessus_ATCC_1997 PVSWFLFPALT---------------------------------------
MSMEG_5026|M.smegmatis_MC2_155 PQGAALFPVLGTPTGELNLPPQQDE----------------PHPNRGVMM
TH_0334|M.thermoresistible__bu HQSSCLPAYFQRPHG-----PATRR----------------PPSARGLRE
Mflv_5065|M.gilvum_PYR-GCK PGSRLFFPAWDTTTAELPPMTTP-----------------PPGAGREIQM
Mvan_0728|M.vanbaalenii_PYR-1 PGSRLLFPTLCQPTATLWTGEPPQV---------------PQSQQRGAMM
. : .
MMAR_2226|M.marinum_M PTRARTRAQNRANRIDTERR---------CNRRALEAVGGVHADRYDTP-
MUL_1813|M.ulcerans_Agy99 RHRAPMQSQGTGSRRRRPRRPVRHPGAGNRSRRAAALLAATSLGTCQIPR
MAV_3457|M.avium_104 PLRRHTRAHNRAHRITTERN---------HNRRTRLTTHPATPG----P-
Mb0528|M.bovis_AF2122/97 PKRRRTRAQDRAYRIATERRQ-------NHAARQRAQVLTQTAAATDTH-
Rv0336|M.tuberculosis_H37Rv PKRRRTRAQDRAYRIATERRQ-------NHAARQRAQVLTQTAAATDTH-
MAB_4752|M.abscessus_ATCC_1997 --RHHTRQQARDRRRRTERN---------LNREQRLQREAALAAL-----
MSMEG_5026|M.smegmatis_MC2_155 PKRRQTREQDRADRINAERRERA-----ELNAEQQRQRQAWLADN-----
TH_0334|M.thermoresistible__bu AVPRQGVD---PRRVSGQ--------------------------------
Mflv_5065|M.gilvum_PYR-GCK PKRQRSRTADRAARIKAERE---------HNGTQRNLEE-----------
Mvan_0728|M.vanbaalenii_PYR-1 PRRRNTRAHNHAAYITAERR---------RNAQTRYATTGNTPPYLPRDH
MMAR_2226|M.marinum_M --------EPTIGPDEPPPF-----------------------
MUL_1813|M.ulcerans_Agy99 ------RIAPRPGPSRSSRGCTDSGTRMGESSMSARPRACVAG
MAV_3457|M.avium_104 --------APPPDPDDEPPPF----------------------
Mb0528|M.bovis_AF2122/97 --------GPPPDHNDDPPPF----------------------
Rv0336|M.tuberculosis_H37Rv --------GPPPDPNDDPPPF----------------------
MAB_4752|M.abscessus_ATCC_1997 -------------AAKDPPPF----------------------
MSMEG_5026|M.smegmatis_MC2_155 ---------------YEPPPF----------------------
TH_0334|M.thermoresistible__bu -------------------------------------------
Mflv_5065|M.gilvum_PYR-GCK ---RPRRGQPPPDYGNDPPPF----------------------
Mvan_0728|M.vanbaalenii_PYR-1 IPYQSSTGWREPDYGNDPPPF----------------------