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MFDSGLAGLDEPALLAAIERAACEESRAGARKSAAIAALVHESVTFDDVRDQWVWDSWIETACELGAVLN TSHRRASALMRIAVALRDRLPKVAALFAAGRLSTRLIGQVTWRTRLVQDPQLLALLDTAIADKATRWEPL SDDKLTAALDAVIERYDPDAVIRAREHVSGLDFRVGASDDPDALVTVWGKILGCDAAVLAARIAELLKGL CDNDPRSVCVRRSHAVGAIVRGQDHLRCRCGSPDCTAAAVVPGSSNVVISVLADPAALDAVRQLIADQDR DQQDKLADKQAKAKEQGKAESQPQTEPIPQPEAEAEAEPEPEAEVEVEPEAETETAIESEPAPVKPVAPS NPAACVRDSGVALLPGVKILPLVALAEAIRSGAATKTLWLPGPDPEPHYRPSAKLAAFVRARDLFCRYPG CDVPAEHCDLDHVVPYPYGPTHPSNLNCKRRTHHLGKTFAEGWQEQQLPDGTVLWTTPAGQRCTTVPGSW LFFPGWDTTTAELPPMAQPPPDPDRLAKMPKRRRTRAADQAARIKVEREHNATQRALETERAKTPEQARR AEQVRYAGLPPPASPQPDYGNDPPPF
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. vanbaalenii PYR-1 | Mvan_5188 | - | - | 100% (586) | hypothetical protein Mvan_5188 |
M. vanbaalenii PYR-1 | Mvan_2714 | - | 0.0 | 83.03% (607) | hypothetical protein Mvan_2714 |
M. vanbaalenii PYR-1 | Mvan_2144 | - | 0.0 | 82.51% (606) | hypothetical protein Mvan_2144 |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb2126 | - | 1e-113 | 43.90% (549) | hypothetical protein Mb2126 |
M. gilvum PYR-GCK | Mflv_1272 | - | 0.0 | 76.74% (589) | HNH endonuclease |
M. tuberculosis H37Rv | Rv2100 | - | 1e-113 | 43.90% (549) | hypothetical protein Rv2100 |
M. leprae Br4923 | - | - | - | - | - |
M. abscessus ATCC 19977 | MAB_4752 | - | 3e-37 | 38.26% (264) | hypothetical protein MAB_4752 |
M. marinum M | MMAR_5187 | - | 4e-69 | 34.21% (573) | 13e12 repeat-containing protein |
M. avium 104 | MAV_4456 | - | 1e-57 | 33.33% (582) | 13e12 repeat-containing protein |
M. smegmatis MC2 155 | MSMEG_5583 | - | 1e-105 | 37.46% (622) | HNH endonuclease |
M. thermoresistible (build 8) | TH_0334 | - | 2e-36 | 34.44% (270) | HNH endonuclease |
M. ulcerans Agy99 | MUL_2679 | - | 7e-39 | 36.92% (260) | 13e12 repeat-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment MMAR_5187|M.marinum_M --------------------MFESMGVAAGVDHPCDALAERRQLRTPT-- MAV_4456|M.avium_104 --------------------------MCEDATAWFDELMER-CYPSAT-- MUL_2679|M.ulcerans_Agy99 ----------------------------------MDQHIIEYVFDT---- TH_0334|M.thermoresistible__bu ------------------------------------------MFES---- MAB_4752|M.abscessus_ATCC_1997 ------------------------------------------MFDE---- Mvan_5188|M.vanbaalenii_PYR-1 --------------------------------------MFDSGLAG---- Mflv_1272|M.gilvum_PYR-GCK --------------------------------------MFDSGLAG---- Mb2126|M.bovis_AF2122/97 MAGALFEPSFAAAHPAGLLRRPVTRTVVLSVAATSIAHMFEISLPDPTEL Rv2100|M.tuberculosis_H37Rv MAGALFEPSFAAAHPAGLLRRPVTRTVVLSVAATSIAHMFEISLPDPTEL MSMEG_5583|M.smegmatis_MC2_155 ---------------MCLLVVPVCDTGCMP---------FEHTFDD---- MMAR_5187|M.marinum_M --AESARWVQRIGAAARAENRAAAAQLIEIGQLFAYRLSR--CSETEDWA MAV_4456|M.avium_104 --PESAALVQRIGVFARVENRAAAEQLAAIGELFAYRLSR--CSECEDWA MUL_2679|M.ulcerans_Agy99 ---DDSAPLTRITAAARAEARAAAERLAAIGDLFRLRLSQ--HGNREDWV TH_0334|M.thermoresistible__bu --LDDGAVVDSIAAASREQSAACGREMLAIGELYARRAPED-DTERANWA MAB_4752|M.abscessus_ATCC_1997 --LGDVELIDLIASAQRAEAQACARKLDAIGVLVDRHADLGKPDERDHHA Mvan_5188|M.vanbaalenii_PYR-1 --LDEPALLAAIERAACEESRAGARKSAAIAALVHESVT--FDDVRDQWV Mflv_1272|M.gilvum_PYR-GCK --LDKPALISAIEQAACEEVRAGARKTAAIAALVHDHVT--YDDVRDEWV Mb2126|M.bovis_AF2122/97 CRSDDGALVAAIEDCARVEAAASARRLSAIAELTGRRTG---ADQRADWA Rv2100|M.tuberculosis_H37Rv CRSDDGALVAAIEDCARVEAAASARRLSAIAELTGRRTG---ADQRADWA MSMEG_5583|M.smegmatis_MC2_155 --LDDAALVAGIEGCERAQNAAAARKLALVARFTARRAAD-SEDEVLRWA . : * : * . . :. : . MMAR_5187|M.marinum_M VDTMEAVAAEVAAGLRISQGLAASRLRYARALRERLPKTGAVFAAGQIDL MAV_4456|M.avium_104 VDTEAAVSAEVAAQLRIGQGLAAAKVRYARAMRERLPRVGEVFRAGEIDF MUL_2679|M.ulcerans_Agy99 ADTCDAVAAEVAAALNTSVAMGHSNLRYARAMRERLPQLGAEFRAGGIDF TH_0334|M.thermoresistible__bu IDGHANVVAEISAALNISRGRAAGRLQLAIDLRERLPRVAAVFAAGDIDF MAB_4752|M.abscessus_ATCC_1997 LDRWDRVASEVAAAQGITHALASSQMRYAQVLRHRLRAVAERFAAGDLDF Mvan_5188|M.vanbaalenii_PYR-1 WDSWIETACELGAVLNTSHRRASALMRIAVALRDRLPKVAALFAAGRLST Mflv_1272|M.gilvum_PYR-GCK WDSWIETACELGAVLNTSHRRASAQMRIAVALRDRLPGVAALHAQGRLSA Mb2126|M.bovis_AF2122/97 CDFWDCAAAEVAAALTISHGKASGQMHLSLAL-NRLPQVAALFLAGHLGA Rv2100|M.tuberculosis_H37Rv CDFWDCAAAEVAAALTISHGKASGQMHLSLAL-NRLPQVAALFLAGHLGA MSMEG_5583|M.smegmatis_MC2_155 GDDWAATAAEVGAALNVGPAVASKWMRVAQEVGERLPRVQEMFAAGWLSA * . .*:.* . :: : : .** . * :. MMAR_5187|M.marinum_M RAFQTIVFRTDLIVDPQVMAAVDALVALNVGRWPSMTKARLSGQIDAIVA MAV_4456|M.avium_104 RLFATIVYRTDLITDRRVLAAVDAELAATAARWPSMTRARLAARVDAVVA MUL_2679|M.ulcerans_Agy99 RLFRTIVFRTDLITESDALAAVDARLAIKAPRWPSMTSWKLATEVDRVVA TH_0334|M.thermoresistible__bu RMVSALVNRSRNVVDPDLLARLDAALAAWSPKWMKLSGPTLNERIDMWVE MAB_4752|M.abscessus_ATCC_1997 RTVALIINRTELVDDEAVVARVDAAIVRALPRWARWSHKRITAALDALVL Mvan_5188|M.vanbaalenii_PYR-1 RLIGQVTWRTRLVQDPQLLALLDTAIADKATRWEPLSDDKLTAALDAVIE Mflv_1272|M.gilvum_PYR-GCK RLIGQITWRTRLVQDPQALALIDAAIAEKATRWEPLSEDNLTAALDAVIE Mb2126|M.bovis_AF2122/97 RLFSIIAWRTYLVRDPHALSLLDAALAEHAGAWGPLSAPKLEKAIDSWID Rv2100|M.tuberculosis_H37Rv RLFSIIAWRTYLVRDPHALSLLDAALAEHAGAWGPLSAPKLEKAIDSWID MSMEG_5583|M.smegmatis_MC2_155 QVVATLTWATHLVGDEQVLAIVDAQLAARAREFGPMTVDGVKAAVASLLE : . : : : : :: :*: :. : : : : : MMAR_5187|M.marinum_M RADADAVRRRKERHADREIWIGQDADG--ISRIDGSMFTIDAHALDRRLS MAV_4456|M.avium_104 KADADAVRRTEKQAASRHVWIAEMGEG--LSHLEGTVSSPDAHALDKRLD MUL_2679|M.ulcerans_Agy99 KFDRDAVRRSRRDAADRYVDCAPLEPG--MALVNRQVFSATAEALARRLD TH_0334|M.thermoresistible__bu RFDPTGVREPRSPGEDRYVVVTPAGQG--MVDVSARLTFEAGFAFXTRLD MAB_4752|M.abscessus_ATCC_1997 HFDQDAVRRNRSATDKRHLEIRPLGNGEPVAEVWGTLQAVHAVALDKRLD Mvan_5188|M.vanbaalenii_PYR-1 RYDPDAVIRAREHVSGLDFRVGASDDPDALVTVWGKILGCDAAVLAARIA Mflv_1272|M.gilvum_PYR-GCK RFDPDAVIRTREQLKGVDFRIGASDDPDALVTVWGKILGCDAVVLAARIA Mb2126|M.bovis_AF2122/97 RYDPGALRRSRISARTRDLCIGDPDEDAGTAALWGRLYATDAAMLDRRLT Rv2100|M.tuberculosis_H37Rv RYDPGALRRSRISARTRDLCIGDPDEDAGTAALWGRLYATDAAMLDRRLT MSMEG_5583|M.smegmatis_MC2_155 KYDPAAVRRSREASRDRDVRFGKPDDVTGTVSISGRVNTADAVAYQKRSA : * .: . . . : : . * MMAR_5187|M.marinum_M ALAATVCAQDPRSREQRRADALGVLAAGGDRLGCRCGLPDC--AAGARPA MAV_4456|M.avium_104 ALAATVCEHDPRTGEQRRADALGALAAGADRLGCRCGRADC--AAGTRPA MUL_2679|M.ulcerans_Agy99 ELAKTVCADDPRTVVQRRADALGTLAAGQDRLICDCGRTDCP-AAGAPQQ TH_0334|M.thermoresistible__bu QIAATVCRDDPRTADQRRADAMAAMSEGQNRLVCGCGSEDCP-ADPADTA MAB_4752|M.abscessus_ATCC_1997 LLAGTVCPADPRSKTQRRADAVGALTQGLNRMRCACGHPDC---SGRDTA Mvan_5188|M.vanbaalenii_PYR-1 ELLKGLCDNDPRSVCVRRSHAVGAIVRGQDHLRCRCGSPDCT-AAAVVPG Mflv_1272|M.gilvum_PYR-GCK ELLKGLCDADPRGIGERRSCAVGAIVRGQDHLPCRCGSPDCA-AAPVVPG Mb2126|M.bovis_AF2122/97 EMAHGVCEDDPRTLAQRRADALGALAAGADHLACGCGKPDCPSGAGNDER Rv2100|M.tuberculosis_H37Rv EMAHGVCEDDPRTLAQRRADALGALAAGADHLACGCGKPDCPSGAGNDER MSMEG_5583|M.smegmatis_MC2_155 HLTGGVCGDDPRTAGQRRADAFGVIAVQGDRLVCLCGDPQCP-WAGVDPR : :* *** **: *...: ::: * ** :* MMAR_5187|M.marinum_M AQPVVIHVIAERATLDGDGG------------------------------ MAV_4456|M.avium_104 AGPVVIHLIAERASVEGTGG------------------------------ MUL_2679|M.ulcerans_Agy99 PSRVVIHVVAGCQTVDGAGE------------------------------ TH_0334|M.thermoresistible__bu ATRLVINVIAEQATVEGRSD------------------------------ MAB_4752|M.abscessus_ATCC_1997 DVPVVVNVVINQSTLAGSDD------------------------------ Mvan_5188|M.vanbaalenii_PYR-1 SSNVVISVLADPAALDAVRQLIADQD--------------------RDQQ Mflv_1272|M.gilvum_PYR-GCK SSNVVISVLADPAALEAVRSLIADED--------------------RHQQ Mb2126|M.bovis_AF2122/97 AAGVVIHVVADASALDAQPDPHLSGD------------------------ Rv2100|M.tuberculosis_H37Rv AAGVVIHVVADASALDAQPDPHLSGD------------------------ MSMEG_5583|M.smegmatis_MC2_155 AANTMVHIFAEPSVVDAKPDPYVHGDYASNPVPFVDPEFDPWPVYPERDS :: :. : . MMAR_5187|M.marinum_M -------------------------------------------------- MAV_4456|M.avium_104 -------------------------------------------------- MUL_2679|M.ulcerans_Agy99 -------------------------------------------------- TH_0334|M.thermoresistible__bu -------------------------------------------------- MAB_4752|M.abscessus_ATCC_1997 -------------------------------------------------- Mvan_5188|M.vanbaalenii_PYR-1 DKLADKQAKAKEQGKAESQPQTEPIPQPEAEAEAEPEPEAEVEVEPEAET Mflv_1272|M.gilvum_PYR-GCK DALAEKQPHA-------------------VKAKEQGEPAAP--------- Mb2126|M.bovis_AF2122/97 ----EPPSRP-----------LTPETTLFEALTPDPEPDP---------- Rv2100|M.tuberculosis_H37Rv ----EPPSRP-----------LTPETTLFEALTPDPEPDP---------- MSMEG_5583|M.smegmatis_MC2_155 TPPPEPPSEPQWAPQWWSEIPLPPEPEPEPEPEPEPEPEPEPEPELRFES MMAR_5187|M.marinum_M -------------------------------------------------- MAV_4456|M.avium_104 -------------------------------------------------- MUL_2679|M.ulcerans_Agy99 -------------------------------------------------- TH_0334|M.thermoresistible__bu -------------------------------------------------- MAB_4752|M.abscessus_ATCC_1997 -------------------------------------------------- Mvan_5188|M.vanbaalenii_PYR-1 ETAIESEPAPVKP------------------------------------- Mflv_1272|M.gilvum_PYR-GCK -------------------------------------------------- Mb2126|M.bovis_AF2122/97 -------------------------------------------------- Rv2100|M.tuberculosis_H37Rv -------------------------------------------------- MSMEG_5583|M.smegmatis_MC2_155 EPQTASAPQPEPEPEARPEPQPKTGPEPEPVSTPKPQPQDPPAAAESWGG MMAR_5187|M.marinum_M --------APA----------WEVGADGLVTPELVAELAKSAKLVPLRHP MAV_4456|M.avium_104 --------GPA----------VEVGAEGLLPAQLVAELAASARLMPLVHP MUL_2679|M.ulcerans_Agy99 --------APG----------VLPG-DGIIPAEIVRELAKSAKLQPMSTP TH_0334|M.thermoresistible__bu --------NPG----------YLPG-YGAVPASILRAKAATATLRPVALP MAB_4752|M.abscessus_ATCC_1997 --------CPA----------HVPG-FGVLAAESARAAVAGTPTRNLTDS Mvan_5188|M.vanbaalenii_PYR-1 ----VAPSNPAACVR-DSGVALLPGVKILPLVALAEAIRSGAATKTLWLP Mflv_1272|M.gilvum_PYR-GCK -----APSNRGRCVR-DSGTALLPGVKILPIVALAEAIRAGAAIKQLWLP Mb2126|M.bovis_AF2122/97 ----PATHAPAELIT--------TGGGVVPAPLLAELIRGGATISQVRHP Rv2100|M.tuberculosis_H37Rv ----PATHAPAELIT--------TGGGVVPAPLLAELIRGGATISQVRHP MSMEG_5583|M.smegmatis_MC2_155 GGVNPLVVAPAPVVSPQRATAVIVGGGLVPASYVAQMIASGAKVKQGRVP . * : . MMAR_5187|M.marinum_M GDVPPEPGYVPSKALADFVRCRDLTCRWPGCDHPALNCDLDHTIPYAQGG MAV_4456|M.avium_104 ADAPPENRYTPSAALADFVRCRDLTCRWPGCDRPATECDLDHTIPYAEGG MUL_2679|M.ulcerans_Agy99 --ILAETGYVPSPALMDFVRARDLTCRAPGCDRPATQCDVDHTIPYSDGG TH_0334|M.thermoresistible__bu -QPCAEAGYRPSAALTRFIRCRDLTCRFPGCDAPAAVCQIDHTIPYPAG- MAB_4752|M.abscessus_ATCC_1997 ----RSTGYRPSAKLAAFVRSRDQLCRFPGCEAVADRADIDHTVPWATGG Mvan_5188|M.vanbaalenii_PYR-1 GP-DPEPHYRPSAKLAAFVRARDLFCRYPGCDVPAEHCDLDHVVPYPYG- Mflv_1272|M.gilvum_PYR-GCK GP-DPEPHYRPSAKLAAFVRARDLFCRYPGCNVPAEQCDIDHVVPWPYG- Mb2126|M.bovis_AF2122/97 GDLAAEPHYRPSAKLAEFVRMRDLTCRFPGCDVPAEFCDIDHSAPWPLG- Rv2100|M.tuberculosis_H37Rv GDLAAEPHYRPSAKLAEFVRMRDLTCRFPGCDVPAEFCDIDHSAPWPLG- MSMEG_5583|M.smegmatis_MC2_155 LE-DPESGYRPSVGLAEFVRMRDLTCRFPGCGRPAECCDIDHTEPFPGG- . * ** * *:* ** ** *** * .::** *:. * MMAR_5187|M.marinum_M PTHASNLKCYCRTHHLVKTFWG-WHDQQLPDGTLILTSPAGHTYVTTPGS MAV_4456|M.avium_104 PTHASNLKCYCRTHHLVKTFWG-WREQQLPDATLILTSPAGRTYVTTPGS MUL_2679|M.ulcerans_Agy99 ATHPSNLKCLCRKHHLLKTFWG-WHDEQLPDATVIWSLPDGQTYVTTPGS TH_0334|M.thermoresistible__bu PTHPSNLKLLCVFHCRQAELRF-THDQHKHQSSCLP------AYFQRPHG MAB_4752|M.abscessus_ATCC_1997 PTTGANLKALCRKHHLLKTFGQ-WTELQEPDGTVIWKSPTGHRYATTPVS Mvan_5188|M.vanbaalenii_PYR-1 PTHPSNLNCKRRTHHLGKTFAEGWQEQQLPDGTVLWTTPAGQRCTTVPGS Mflv_1272|M.gilvum_PYR-GCK PTHPSNLNCKCRTHHLGKTFAEGWHEEQLPDGTVIWTTPAGQRYSTVPGS Mb2126|M.bovis_AF2122/97 PTHPSNLKCACRKHHLLKTFWTGWRDVQLPDGTVIWTAPNGHTYTTHPGS Rv2100|M.tuberculosis_H37Rv PTHPSNLKCACRKHHLLKTFWTGWRDVQLPDGTVIWTAPNGHTYTTHPGS MSMEG_5583|M.smegmatis_MC2_155 VTHASNIKCLCRFHHLIKTFWAGFVDTQLPDGQVVWTMPSGRTYTTVPGS * :*:: * : : : :. : * . MMAR_5187|M.marinum_M ALLFPSLCHSTGGLPAAEADPPSDHCDQRSAMMPRRQRTRAQDRARRVAT MAV_4456|M.avium_104 ALLFPSLCVPTG-EPARPVAAGSQPCGERTAMMPTRRRTRGQNRAARVAA MUL_2679|M.ulcerans_Agy99 AWLLPGLFAPSPELPPP----------------PRSEATGSLRKPRRDDA TH_0334|M.thermoresistible__bu ---------------------------------PATRRPPSARGLREAVP MAB_4752|M.abscessus_ATCC_1997 WFLFP---------------------------ALTRHHTRQQARDRRRRT Mvan_5188|M.vanbaalenii_PYR-1 WLFFPGWDTTTAELPPMAQPPPDP---DRLAKMPKRRRTRAADQAARIKV Mflv_1272|M.gilvum_PYR-GCK RLFFPGWDTTTAELPPMAQPPPDP---DRLAKMPKRRRTRAADHAARIKA Mb2126|M.bovis_AF2122/97 RIFFPTWHTTTAELPQTSTAAVNVD--ARGLMMPRRRRTRAAELAHRINA Rv2100|M.tuberculosis_H37Rv RIFFPTWHTTTAELPQTSTAAVNVD--ARGLMMPRRRRTRAAELAHRINA MSMEG_5583|M.smegmatis_MC2_155 RWVFPQWDTTTTTLPPPPPRATSP---ARGVMMPQRKLTRAEQRARQIRA . . . MMAR_5187|M.marinum_M ERRQNHHARSTQPGGQPR-----------------------SAAPPTPPQ MAV_4456|M.avium_104 ERRANRAARLARATRPAP-----------------------AASQSWPAG MUL_2679|M.ulcerans_Agy99 QTRPNSRPKLGR-----------------------------THCDRTQPQ TH_0334|M.thermoresistible__bu RQGVDPRRVSGQ-------------------------------------- MAB_4752|M.abscessus_ATCC_1997 ERNLNREQRLQREAALAA-----------------------LAAKDPPPF Mvan_5188|M.vanbaalenii_PYR-1 EREHNATQRALETERAKTPEQARRAEQVRYAGLPPPASPQPDYGNDPPPF Mflv_1272|M.gilvum_PYR-GCK EREDNAHQRALETERAAA----------RRSGLPPPAP--PDYGDDPPPF Mb2126|M.bovis_AF2122/97 ER---ALNDAYMAE-----------------------------RNKPPSF Rv2100|M.tuberculosis_H37Rv ER---ALNDAYMAE-----------------------------RNKPPSF MSMEG_5583|M.smegmatis_MC2_155 ER---ARNEKYLSE-----------------------------RNKPPPQ . MMAR_5187|M.marinum_M SEPQSHPPPF MAV_4456|M.avium_104 HGPDADPPPF MUL_2679|M.ulcerans_Agy99 HD-------- TH_0334|M.thermoresistible__bu ---------- MAB_4752|M.abscessus_ATCC_1997 ---------- Mvan_5188|M.vanbaalenii_PYR-1 ---------- Mflv_1272|M.gilvum_PYR-GCK ---------- Mb2126|M.bovis_AF2122/97 ---------- Rv2100|M.tuberculosis_H37Rv ---------- MSMEG_5583|M.smegmatis_MC2_155 ----------