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VDQHIIEYVFDTDDSAPLTRITAAARAEARAAAERLAAIGDLFRLRLSQHGNREDWVADTCDAVAAEVAA ALNTSVAMGHSNLRYARAMRERLPQLGAEFRAGGIDFRLFRTIVFRTDLITESDALAAVDARLAIKAPRW PSMTSWKLATEVDRVVAKFDRDAVRRSRRDAADRYVDCAPLEPGMALVNRQVFSATAEALARRLDELAKT VCADDPRTVVQRRADALGTLAAGQDRLICDCGRTDCPAAGAPQQPSRVVIHVVAGCQTVDGAGEAPGVLP GDGIIPAEIVRELAKSAKLQPMSTPILAETGYVPSPALMDFVRARDLTCRAPGCDRPATQCDVDHTIPYS DGGATHPSNLKCLCRKHHLLKTFWGWHDEQLPDATVIWSLPDGQTYVTTPGSAWLLPGLFAPSPELPPPP RSEATGSLRKPRRDDAQTRPNSRPKLGRTHCDRTQPQHD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_2679 | - | - | 100% (459) | 13e12 repeat-containing protein |
| M. ulcerans Agy99 | MUL_1813 | - | e-132 | 56.92% (448) | 13e12 repeat-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0528 | - | 1e-122 | 54.48% (435) | 13E12 repeat family protein |
| M. gilvum PYR-GCK | Mflv_3596 | - | 2e-91 | 44.88% (430) | hypothetical protein Mflv_3596 |
| M. tuberculosis H37Rv | Rv0515 | - | 1e-122 | 54.48% (435) | 13E12 repeat family protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4752 | - | 8e-79 | 41.98% (393) | hypothetical protein MAB_4752 |
| M. marinum M | MMAR_1213 | - | 0.0 | 93.32% (449) | 13e12 repeat-containing protein |
| M. avium 104 | MAV_3457 | - | 1e-139 | 61.14% (422) | 13e12 repeat-containing protein |
| M. smegmatis MC2 155 | MSMEG_5026 | - | 5e-88 | 41.87% (449) | hypothetical protein MSMEG_5026 |
| M. thermoresistible (build 8) | TH_0334 | - | 4e-80 | 44.82% (357) | HNH endonuclease |
| M. vanbaalenii PYR-1 | Mvan_3778 | - | 4e-83 | 41.86% (430) | hypothetical protein Mvan_3778 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3596|M.gilvum_PYR-GCK ----------------------------------MDAMTSAARCESRAAA
Mvan_3778|M.vanbaalenii_PYR-1 -----------MFAYAEP-------------AELIDAMSSAARAESAAIA
MSMEG_5026|M.smegmatis_MC2_155 ---MGAGILERMFDGTSD-------------AGLIDAIAEAKRQENAATA
Mb0528|M.bovis_AF2122/97 ------MPSPEAIAHFDERFECHAPRTTRVSAAFIDRICSATRAENRAAA
Rv0515|M.tuberculosis_H37Rv ------MPSPEAIAHFDERFECHAPRTTRVSAAFIDRICSATRAENRAAA
MUL_2679|M.ulcerans_Agy99 -----------MDQHIIE--YVFDTDDS----APLTRITAAARAEARAAA
MMAR_1213|M.marinum_M MRAQALRPTVSVDQHMIE--HVFDTDSS----APLTRITAAARAEARAAA
MAV_3457|M.avium_104 -----------MVEHMFE--YVVASRSTPEAVALLDRAREAARAEARAAA
MAB_4752|M.abscessus_ATCC_1997 -----------MFDELGD-------------VELIDLIASAQRAEAQACA
TH_0334|M.thermoresistible__bu -----------MFESLDDG-------------AVVDSIAAASREQSAACG
: * * : * .
Mflv_3596|M.gilvum_PYR-GCK ERLAAVASLYRVR--KSMYVEAGLWRTDVFEAVAAEVSAAQNISRWRAGS
Mvan_3778|M.vanbaalenii_PYR-1 RRLEAVAALFRSR--KCDYAEAGFLHTDVYEAVAAEVSAAQNISRSRAGY
MSMEG_5026|M.smegmatis_MC2_155 RRLFAIGELDTRR--AIDLAECNFWRTDPFEEVCAEVSAALRISRSRANW
Mb0528|M.bovis_AF2122/97 AQLVALGELFAYR--WSRCGGREEWVMDTMAAVAAEVAAALRISQGLAAS
Rv0515|M.tuberculosis_H37Rv AQLVALGELFAYR--WSRCGGREEWVMDTMAAVAAEVAAALRISQGLAAS
MUL_2679|M.ulcerans_Agy99 ERLAAIGDLFRLR--LSQHGNREDWVADTCDAVAAEVAAALNTSVAMGHS
MMAR_1213|M.marinum_M ERLAAIGDLFRLR--LSQHGNREDWVADTCDAVAAEVAAALNTSVAMGHS
MAV_3457|M.avium_104 ARLVAVAELLVLR--CRETGERADWAADAWEAVAAQVGAALGCSVAMGHS
MAB_4752|M.abscessus_ATCC_1997 RKLDAIGVLVDRHADLGKPDERDHHALDRWDRVASEVAAAQGITHALASS
TH_0334|M.thermoresistible__bu REMLAIGELYARR-APEDDTERANWAIDGHANVVAEISAALNISRGRAAG
.: *:. * : * * :::.** : .
Mflv_3596|M.gilvum_PYR-GCK QVRMAVSLYERLPQVAEVFYRGDIDQRMVQLTLSRTETVDD-AIIAELDA
Mvan_3778|M.vanbaalenii_PYR-1 QVEMAVSLYTRLPKVAEAFARGDIDLRMVQIVLARTKNVED-DVIGGLDK
MSMEG_5026|M.smegmatis_MC2_155 QVHLARVLRDRIPKVAAVFAQGDIDFRIVTKIATRTELVDP-AAMPALDD
Mb0528|M.bovis_AF2122/97 RLRYARAMRERLPKTAEVFSAGDIGYLMFATIVYRTDLIVDPDVLAAVDA
Rv0515|M.tuberculosis_H37Rv RLRYARAMRERLPKTAEVFSAGDIGYLMFATIVYRTDLIVDPDVLAAVDA
MUL_2679|M.ulcerans_Agy99 NLRYARAMRERLPQLGAEFRAGGIDFRLFRTIVFRTDLITESDALAAVDA
MMAR_1213|M.marinum_M NLRYARAMRERLPQLGAEFRAGGIDFRLFRTIVFRTDLITDSDALAAVDA
MAV_3457|M.avium_104 YLRYAMAMRERLPQVGAVFAAGGIDYRAFQTLVFRTDLITDAQVLARVDA
MAB_4752|M.abscessus_ATCC_1997 QMRYAQVLRHRLRAVAERFAAGDLDFRTVALIINRTELVDDEAVVARVDA
TH_0334|M.thermoresistible__bu RLQLAIDLRERLPRVAAVFAAGDIDFRMVSALVNRSRNVVDPDLLARLDA
:. * : *: . * *.:. . *: : : :*
Mflv_3596|M.gilvum_PYR-GCK ALARRIVKWMRFSKDKLRDRLDQWVAKFDPAGVRVPPAAKDNRYFDVTP-
Mvan_3778|M.vanbaalenii_PYR-1 AIAPKLSRWMRLSKNDLRDRVDLWVADFDPAAVRVPPEAKDNRYFDVTP-
MSMEG_5026|M.smegmatis_MC2_155 VLARRCPNWMRLSEPKLEERIDQCILRLDPDGQRVTKRSEDSRYFTVQPA
Mb0528|M.bovis_AF2122/97 QLAANVARWPSMTKARLAGQVDKIVARADADAVRRRKEYQAQRQFWVGE-
Rv0515|M.tuberculosis_H37Rv QLAANVARWPSMTKARLAGQVDKIVARADADAVRRRKEYQAQRQFWVGE-
MUL_2679|M.ulcerans_Agy99 RLAIKAPRWPSMTSWKLATEVDRVVAKFDRDAVRRSRRDAADRYVDCAP-
MMAR_1213|M.marinum_M RLAIKAPRWPSMTSWKLATEVDRVVAKFDRDAVRRSRRDAADRYVDCAP-
MAV_3457|M.avium_104 TLAVLVSRRPSLTRGGLAAAVDRVVAAVDADAVRRARDAVTGRYLDVRA-
MAB_4752|M.abscessus_ATCC_1997 AIVRALPRWARWSHKRITAALDALVLHFDQDAVRRNRSATDKRHLEIRP-
TH_0334|M.thermoresistible__bu ALAAWSPKWMKLSGPTLNERIDMWVERFDPTGVREPRSPGEDRYVVVTP-
:. . : : :* : * . * * .
Mflv_3596|M.gilvum_PYR-GCK DVPG--MAFAGGVLTARDAAALDQRLEAMADTVCANDPRTWNQRRADAAG
Mvan_3778|M.vanbaalenii_PYR-1 DVPG--MAFAGGLLNARDAAALDQRLEAIAATVCSNDPRSHNNLRADAAG
MSMEG_5026|M.smegmatis_MC2_155 DTPG--MANAQGYLPAHDAAGFDKRLDAIAATVCPNDPRTPDQRRADALG
Mb0528|M.bovis_AF2122/97 SQDG--VCQIGGSLLAVDAHALDARLSALAGTVCEHDPRSREQRRADALG
Rv0515|M.tuberculosis_H37Rv SQDG--VCQIGGSLLAVDAHALDARLSALAGTVCEHDPRSREQRRADALG
MUL_2679|M.ulcerans_Agy99 LEPG--MALVNRQVFSATAEALARRLDELAKTVCADDPRTVVQRRADALG
MMAR_1213|M.marinum_M LEPG--MALVNGQVFAATAEALARRLDELAKTVCADDPRTVVQRRADALG
MAV_3457|M.avium_104 NESG--MAWVEGNVLGPDGHALDRRLDELASGVCAGDPRSRAQRRADALG
MAB_4752|M.abscessus_ATCC_1997 LGNGEPVAEVWGTLQAVHAVALDKRLDLLAGTVCPADPRSKTQRRADAVG
TH_0334|M.thermoresistible__bu AGQG--MVDVSARLTFEAGFAFXTRLDQIAATVCRDDPRTADQRRADAMA
* : : . .: **. :* ** ***: : **** .
Mflv_3596|M.gilvum_PYR-GCK ALGRGEATLACQCGGDDCPAVALRESAAKVVIHILAEQATVEGRSDDPGY
Mvan_3778|M.vanbaalenii_PYR-1 ALGRGESTLTCECGAEDCPAAVLRESAAQVVIHILAEQATVDGDGDKAGY
MSMEG_5026|M.smegmatis_MC2_155 ALGRYRDTLDCQCGREDCTAVAERDAVNNAMIHVLAEQSTLDG-GNEPGY
Mb0528|M.bovis_AF2122/97 ALAGGADRLGCGCGRADCAAGKRPAAPP-VVIHLIAEAATINGTGSAPAS
Rv0515|M.tuberculosis_H37Rv ALAGGADRLGCGCGRADCAAGKRPAAPP-VVIHLIAEAATINGTGSAPAS
MUL_2679|M.ulcerans_Agy99 TLAAGQDRLICDCGRTDCPAAGAPQQPSRVVIHVVAGCQTVDGAGEAPGV
MMAR_1213|M.marinum_M TLAAGQDRLICDCGRTDCPAAGAPQQPSRVVIHVVAGRETVDGAGEAPGV
MAV_3457|M.avium_104 ALAAGAGRLACGCGSPDCPSAAAPAPRSTVVIHVVAEQATVAGRGATPAV
MAB_4752|M.abscessus_ATCC_1997 ALTQGLNRMRCACGHPDCSG--RDTADVPVVVNVVINQSTLAGSDDCPAH
TH_0334|M.thermoresistible__bu AMSEGQNRLVCGCGSEDCPADPADTAATRLVINVIAEQATVEGRSDNPGY
:: : * ** **.. ::::: *: * . ..
Mflv_3596|M.gilvum_PYR-GCK LSG-FGVLPAEEVRAAARTAKLVPVSQPG-TEPETGYKPSAKLRDYLRWR
Mvan_3778|M.vanbaalenii_PYR-1 LPG-FGVLPAEEVRAAAKTAKLKPVRLPG-AEPEKGYRPSAGLKDFLQWR
MSMEG_5026|M.smegmatis_MC2_155 LPG-FGMLPAHMVREVAKTATTKPVTIPK-DKAQSGYRPNAELTEFIRWR
Mb0528|M.bovis_AF2122/97 QMNADGLITAELVAELAKTATLVPLVHPGDAPPEPGYAPSKALADFVRCR
Rv0515|M.tuberculosis_H37Rv QMNADGLITAELVAELAKTATLVPLVHPGDAPPEPGYAPSKALADFVRCR
MUL_2679|M.ulcerans_Agy99 LPG-DGIIPAEIVRELAKSAKLQPMSTP--ILAETGYVPSPALMDFVRAR
MMAR_1213|M.marinum_M LPG-DGIIPAEIVRELAKSAKLQPMSTP--ILAETGYVPSPALMDFVRAR
MAV_3457|M.avium_104 VAGLDGLIPAQVIAELAASARLVPVAVPE-GGPEPGYTPSARLADFIRCR
MAB_4752|M.abscessus_ATCC_1997 VPG-FGVLAAESARAAVAGTPTRNLTDS----RSTGYRPSAKLAAFVRSR
TH_0334|M.thermoresistible__bu LPG-YGAVPASILRAKAATATLRPVALPQ-PCAEAGYRPSAALTRFIRCR
. * :.* . : : . . ** *. * ::: *
Mflv_3596|M.gilvum_PYR-GCK DLTCRFPGCDAPVEGCDVDHTTPWPFG-VTHASGTKHYCRTHHLIKTFYG
Mvan_3778|M.vanbaalenii_PYR-1 DLTCRFPGCDAPVERCDVDHTTRWPFG-VTHASGLKHYCRTHHVIKTFLT
MSMEG_5026|M.smegmatis_MC2_155 DLTCRFPGCDAPAMAADIDHTRPYPQG-PTHPSNTKLYCRTHHLIKTFYT
Mb0528|M.bovis_AF2122/97 DLTCRWPGCDEPATNCDLDHTIPYAAGGPTHASNLKCYCRTHHLVKTFW-
Rv0515|M.tuberculosis_H37Rv DLTCRWPGCDEPATNCDLDHTIPYAAGGPTHASNLKCYCRTHHLVKTFW-
MUL_2679|M.ulcerans_Agy99 DLTCRAPGCDRPATQCDVDHTIPYSDGGATHPSNLKCLCRKHHLLKTFW-
MMAR_1213|M.marinum_M DLTCRAPGCDRPATQCDVDHTIPYSDGGATHPSNLKCLCRKHHLLKTFW-
MAV_3457|M.avium_104 DLTCRAPGCDRPAVDCDVDHTIPYAQGGPTHPSNLKCLCRGHHLLKTFW-
MAB_4752|M.abscessus_ATCC_1997 DQLCRFPGCEAVADRADIDHTVPWATGGPTTGANLKALCRKHHLLKTFG-
TH_0334|M.thermoresistible__bu DLTCRFPGCDAPAAVCQIDHTIPYPAG-PTHPSNLKLLCVFHCRQAELR-
* ** ***: . .::*** :. * * :. * * * :
Mflv_3596|M.gilvum_PYR-GCK GPSGWRDAQSPDGTVVVIAPTGHVYSTEAHGAGLFPKLAEPTAPLPPPTS
Mvan_3778|M.vanbaalenii_PYR-1 GVYGWRDEQRRDGTVVLTAPTGHVYTTEPLGGLLFPTLATPTAPLPDVEV
MSMEG_5026|M.smegmatis_MC2_155 GPNGWTDRQLPDGTIEFTAPTGHIYTTEPQGAALFPVLGTPTGELNLPPQ
Mb0528|M.bovis_AF2122/97 ---GWRDQQLPDGTLILTSPSGHTYVSTPGSALLFPSLCHFSGGIPAPEA
Rv0515|M.tuberculosis_H37Rv ---GWRDQQLPDGTLILTSPSGHTYVSTPGSALLFPSLCHFSGGIPAPEA
MUL_2679|M.ulcerans_Agy99 ---GWHDEQLPDATVIWSLPDGQTYVTTPGSAWLLPGLFAPSPELPPPPR
MMAR_1213|M.marinum_M ---GWHDKQLPDATVIWSLPDGQTYVTTPGSAWLLPGLFAPSPELPPPAR
MAV_3457|M.avium_104 ---GWRDRQLPDGTVIWTLPDGDTYVTTPGSALLFPTLCTPTGAVSPAKP
MAB_4752|M.abscessus_ATCC_1997 ---QWTELQEPDGTVIWKSPTGHRYATTPVSWFLFPALTR----------
TH_0334|M.thermoresistible__bu ----FTHDQHKHQSSCLP-----AYFQRPHGPATRRP-------------
: . * . : * . .
Mflv_3596|M.gilvum_PYR-GCK T--QEP-SDKSAMMPRRKRTREQDRRARIERERRQRIELDAEEERQR---
Mvan_3778|M.vanbaalenii_PYR-1 P--EDD-PDKAAMMPRR-RTREQERRARIARERRQRIEINAERERQH---
MSMEG_5026|M.smegmatis_MC2_155 Q--DEPHPNRGVMMPKRRQTREQDRADRINAERRERAELNAEQQRQR---
Mb0528|M.bovis_AF2122/97 DPPYDHCDQRTAMMPKRRRTRAQDRAYRIATERRQNHAARQRAQVLTQTA
Rv0515|M.tuberculosis_H37Rv DPPYDHCDQRTAMMPKRRRTRAQDRAYRIATERRQNHAARQRAQVLTQTA
MUL_2679|M.ulcerans_Agy99 ---------------------SEATGSLRKPRR--DDAQTRPNSRPK---
MMAR_1213|M.marinum_M KP-QDHCGNRDAMMPKRARTRAQSSAARIAAER--NHNMTSRQARRRRWE
MAV_3457|M.avium_104 DT-EHRCGERTAMMPLRRHTRAHNRAHRITTER--NHNRRTRLTTHP---
MAB_4752|M.abscessus_ATCC_1997 -----------------HHTRQQARDRRRRTER--NLNREQRLQREA---
TH_0334|M.thermoresistible__bu ---------------------PSARGLREAVPR---QGVDPRRVSGQ---
*
Mflv_3596|M.gilvum_PYR-GCK ------QAWLAETYEPPPF-
Mvan_3778|M.vanbaalenii_PYR-1 ------QAWLAATYEPPPF-
MSMEG_5026|M.smegmatis_MC2_155 ------QAWLADNYEPPPF-
Mb0528|M.bovis_AF2122/97 AATDTHGPPPDHNDDPPPF-
Rv0515|M.tuberculosis_H37Rv AATDTHGPPPDHNDDPPPF-
MUL_2679|M.ulcerans_Agy99 ---LGRTHCDRTQPQHD---
MMAR_1213|M.marinum_M ECYFGPRDASASDDEEPPPF
MAV_3457|M.avium_104 -ATPGPAPPPDPDDEPPPF-
MAB_4752|M.abscessus_ATCC_1997 ------ALAALAAKDPPPF-
TH_0334|M.thermoresistible__bu --------------------