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CETLDDAALIAGIAGESRAESAAAARRFAFIAEFVDRRTADSEDTVVWWACDDWDAASAEVAAALNIGQR SASRLMRIAVALRDRLPLVAAQFAEGAVSTRVVETLTWRTRLIDDTQTMAAVDAQLASRIAEFGAMTIAE LEGAVDKVVDSVDPAAVRRTRTAVRSRGVWFGHPDDETGITSVHARLTNVDAVALKNRVGAMSSGQCPDD PRTKGQRLSDAMGVLGHYGDRLTCRCGDPECPAAGIDPRAANTMVHVFAEPAAVHGPVDRYLDGDHESNP IPYFEPTPTPEPEPTPEPVRKPPEPEPKPWTPQSAHPGRGGAVVLGGGVVPAPLVAQLIADGAKVKELTV PDDICASYRPSVAMDCFVRMRDMTCRFPGCSRPADFCDVDHTTPWPTGVTHPSNTKCLCRIHHLLKTFWL GWSDRQLPDGTVIWTSPTGHVYTTVPASRALFPQWDTTTAALPPPPTPPPPMTPSEIAARAAMMPRRRRT RAAEEARRLAAERARNEAYLAQRDRPPPDAHGPGMQ*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3957 | - | - | 100% (527) | 13e12 repeat-containing protein |
| M. smegmatis MC2 155 | MSMEG_5583 | - | e-161 | 49.19% (616) | HNH endonuclease |
| M. smegmatis MC2 155 | MSMEG_0144 | - | 1e-91 | 37.22% (583) | HNH endonuclease |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2126 | - | 1e-133 | 48.18% (521) | hypothetical protein Mb2126 |
| M. gilvum PYR-GCK | Mflv_5065 | - | 1e-110 | 42.48% (525) | hypothetical protein Mflv_5065 |
| M. tuberculosis H37Rv | Rv2100 | - | 1e-133 | 48.18% (521) | hypothetical protein Rv2100 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4752 | - | 1e-63 | 35.89% (521) | hypothetical protein MAB_4752 |
| M. marinum M | MMAR_5187 | - | 7e-92 | 41.37% (510) | 13e12 repeat-containing protein |
| M. avium 104 | MAV_4456 | - | 5e-89 | 40.86% (536) | 13e12 repeat-containing protein |
| M. thermoresistible (build 8) | TH_0334 | - | 3e-58 | 34.54% (414) | HNH endonuclease |
| M. ulcerans Agy99 | MUL_2679 | - | 8e-79 | 38.84% (466) | 13e12 repeat-containing protein |
| M. vanbaalenii PYR-1 | Mvan_1291 | - | 1e-113 | 44.34% (530) | hypothetical protein Mvan_1291 |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_5187|M.marinum_M ----------------MFESMGVAAGVDHPCDALAERRQLRTPT------
MAV_4456|M.avium_104 ----------------------MCEDATAWFDELMER-CYPSAT------
MUL_2679|M.ulcerans_Agy99 ------------------------------MDQHIIEYVFDT--------
TH_0334|M.thermoresistible__bu --------------------------------------MFES--------
Mb2126|M.bovis_AF2122/97 MAGALFEPSFAAAHPAGLLRRPVTRTVVLSVAATSIAHMFEISLPDPTEL
Rv2100|M.tuberculosis_H37Rv MAGALFEPSFAAAHPAGLLRRPVTRTVVLSVAATSIAHMFEISLPDPTEL
MSMEG_3957|M.smegmatis_MC2_155 --------------------------------------MCET--------
Mflv_5065|M.gilvum_PYR-GCK --------------------------------------MFDTMHRG----
Mvan_1291|M.vanbaalenii_PYR-1 ----------------------------MSPTIGSIERMFGAMFAG----
MAB_4752|M.abscessus_ATCC_1997 --------------------------------------MFDE--------
MMAR_5187|M.marinum_M --AESARWVQRIGAAARAENRAAAAQLIEIGQLFAYRLSR--CSETEDWA
MAV_4456|M.avium_104 --PESAALVQRIGVFARVENRAAAEQLAAIGELFAYRLSR--CSECEDWA
MUL_2679|M.ulcerans_Agy99 ---DDSAPLTRITAAARAEARAAAERLAAIGDLFRLRLSQ--HGNREDWV
TH_0334|M.thermoresistible__bu --LDDGAVVDSIAAASREQSAACGREMLAIGELYARRAPED-DTERANWA
Mb2126|M.bovis_AF2122/97 CRSDDGALVAAIEDCARVEAAASARRLSAIAELTGRRTG---ADQRADWA
Rv2100|M.tuberculosis_H37Rv CRSDDGALVAAIEDCARVEAAASARRLSAIAELTGRRTG---ADQRADWA
MSMEG_3957|M.smegmatis_MC2_155 --LDDAALIAGIAGESRAESAAAARRFAFIAEFVDRRTADS-EDTVVWWA
Mflv_5065|M.gilvum_PYR-GCK --LGEADLLAAIEQAAREEAQAGARRLAAIAELVDLTVDE--DDERGMWA
Mvan_1291|M.vanbaalenii_PYR-1 --LDQPTLIAAIEQSAREEAVAGARKLAAIAQLVHSAVTF--DDECDRWA
MAB_4752|M.abscessus_ATCC_1997 --LGDVELIDLIASAQRAEAQACARKLDAIGVLVDRHADLGKPDERDHHA
. : * * : * . .: *. : .
MMAR_5187|M.marinum_M VDTMEAVAAEVAAGLRISQGLAASRLRYARALRERLPKTGAVFAAGQIDL
MAV_4456|M.avium_104 VDTEAAVSAEVAAQLRIGQGLAAAKVRYARAMRERLPRVGEVFRAGEIDF
MUL_2679|M.ulcerans_Agy99 ADTCDAVAAEVAAALNTSVAMGHSNLRYARAMRERLPQLGAEFRAGGIDF
TH_0334|M.thermoresistible__bu IDGHANVVAEISAALNISRGRAAGRLQLAIDLRERLPRVAAVFAAGDIDF
Mb2126|M.bovis_AF2122/97 CDFWDCAAAEVAAALTISHGKASGQMHLSLALN-RLPQVAALFLAGHLGA
Rv2100|M.tuberculosis_H37Rv CDFWDCAAAEVAAALTISHGKASGQMHLSLALN-RLPQVAALFLAGHLGA
MSMEG_3957|M.smegmatis_MC2_155 CDDWDAASAEVAAALNIGQRSASRLMRIAVALRDRLPLVAAQFAEGAVST
Mflv_5065|M.gilvum_PYR-GCK FDPWKNAACHIGAALSISERRASAQMCIATALRYRLPQIAALYVQGRLST
Mvan_1291|M.vanbaalenii_PYR-1 YDSWAEAACELGAVLNMGQMRASAQMRIAVALRDRLPKVAELFLAGRLSA
MAB_4752|M.abscessus_ATCC_1997 LDRWDRVASEVAAAQGITHALASSQMRYAQVLRHRLRAVAERFAAGDLDF
* . ..:.* . : : :. ** . : * :.
MMAR_5187|M.marinum_M RAFQTIVFRTDLIVDPQVMAAVDALVALNVGRWPSMTKARLSGQIDAIVA
MAV_4456|M.avium_104 RLFATIVYRTDLITDRRVLAAVDAELAATAARWPSMTRARLAARVDAVVA
MUL_2679|M.ulcerans_Agy99 RLFRTIVFRTDLITESDALAAVDARLAIKAPRWPSMTSWKLATEVDRVVA
TH_0334|M.thermoresistible__bu RMVSALVNRSRNVVDPDLLARLDAALAAWSPKWMKLSGPTLNERIDMWVE
Mb2126|M.bovis_AF2122/97 RLFSIIAWRTYLVRDPHALSLLDAALAEHAGAWGPLSAPKLEKAIDSWID
Rv2100|M.tuberculosis_H37Rv RLFSIIAWRTYLVRDPHALSLLDAALAEHAGAWGPLSAPKLEKAIDSWID
MSMEG_3957|M.smegmatis_MC2_155 RVVETLTWRTRLIDDTQTMAAVDAQLASRIAEFGAMTIAELEGAVDKVVD
Mflv_5065|M.gilvum_PYR-GCK RLISEITWRTGLVADD-VIATVDAALAGKAEKWGPLSEDKLIDAINTVIA
Mvan_1291|M.vanbaalenii_PYR-1 RLVAEITWRTCLVDDEQVLAVLDGALAQRALRWGPLSQDRLRCAIDALIE
MAB_4752|M.abscessus_ATCC_1997 RTVALIINRTELVDDEAVVARVDAAIVRALPRWARWSHKRITAALDALVL
* . : *: : : :: :*. :. : : : :: :
MMAR_5187|M.marinum_M RADADAVRRRKERHADREIWIGQDADG--ISRIDGSMFTIDAHALDRRLS
MAV_4456|M.avium_104 KADADAVRRTEKQAASRHVWIAEMGEG--LSHLEGTVSSPDAHALDKRLD
MUL_2679|M.ulcerans_Agy99 KFDRDAVRRSRRDAADRYVDCAPLEPG--MALVNRQVFSATAEALARRLD
TH_0334|M.thermoresistible__bu RFDPTGVREPRSPGEDRYVVVTPAGQG--MVDVSARLTFEAGFAFXTRLD
Mb2126|M.bovis_AF2122/97 RYDPGALRRSRISARTRDLCIGDPDEDAGTAALWGRLYATDAAMLDRRLT
Rv2100|M.tuberculosis_H37Rv RYDPGALRRSRISARTRDLCIGDPDEDAGTAALWGRLYATDAAMLDRRLT
MSMEG_3957|M.smegmatis_MC2_155 SVDPAAVRRTRTAVRSRGVWFGHPDDETGITSVHARLTNVDAVALKNRVG
Mflv_5065|M.gilvum_PYR-GCK RHDPDAVRRTKEALKKRDVHIGAHEDTDDVTTIWGLLLPPDAAAYTARIA
Mvan_1291|M.vanbaalenii_PYR-1 RYDPDAVIRAREVINGRDFRIGAHEDPDELVTVWGKVLGCDAVVLAARIA
MAB_4752|M.abscessus_ATCC_1997 HFDQDAVRRNRSATDKRHLEIRPLGNGEPVAEVWGTLQAVHAVALDKRLD
* .: . . * . : : . *:
MMAR_5187|M.marinum_M ALAATVCAQDPRSREQRRADALGVLAAGGDRLGCRCGLPDC--AAGARPA
MAV_4456|M.avium_104 ALAATVCEHDPRTGEQRRADALGALAAGADRLGCRCGRADC--AAGTRPA
MUL_2679|M.ulcerans_Agy99 ELAKTVCADDPRTVVQRRADALGTLAAGQDRLICDCGRTDCP-AAGAPQQ
TH_0334|M.thermoresistible__bu QIAATVCRDDPRTADQRRADAMAAMSEGQNRLVCGCGSEDCP-ADPADTA
Mb2126|M.bovis_AF2122/97 EMAHGVCEDDPRTLAQRRADALGALAAGADHLACGCGKPDCPSGAGNDER
Rv2100|M.tuberculosis_H37Rv EMAHGVCEDDPRTLAQRRADALGALAAGADHLACGCGKPDCPSGAGNDER
MSMEG_3957|M.smegmatis_MC2_155 AMSSGQCPDDPRTKGQRLSDAMGVLGHYGDRLTCRCGDPECP-AAGIDPR
Mflv_5065|M.gilvum_PYR-GCK ALVKGLCDADPRSAGERRSDAMGAIGRGENQLACRCGSPNCT--ASGP-S
Mvan_1291|M.vanbaalenii_PYR-1 ALLKGICADDPRSEGERRSCAVGAIIQGQDHLPCRCGSPDCT--ASAPPA
MAB_4752|M.abscessus_ATCC_1997 LLAGTVCPADPRSKTQRRADAVGALTQGLNRMRCACGHPDCS---GRDTA
: * ***: :* : *:..: ::: * ** :*
MMAR_5187|M.marinum_M AQPVVIHVIAERATLDGDGG------------------------------
MAV_4456|M.avium_104 AGPVVIHLIAERASVEGTGG------------------------------
MUL_2679|M.ulcerans_Agy99 PSRVVIHVVAGCQTVDGAGE------------------------------
TH_0334|M.thermoresistible__bu ATRLVINVIAEQATVEGRSD------------------------------
Mb2126|M.bovis_AF2122/97 AAGVVIHVVADASALDAQPDPHLSGDEP--PSRPLT-----PETTLFEAL
Rv2100|M.tuberculosis_H37Rv AAGVVIHVVADASALDAQPDPHLSGDEP--PSRPLT-----PETTLFEAL
MSMEG_3957|M.smegmatis_MC2_155 AANTMVHVFAEPAAVHGPVDRYLDGDHESNPIPYFE-----PTPTPEPEP
Mflv_5065|M.gilvum_PYR-GCK TSPVVITVIADQAAVDTAQQLIADQDAEQQNTTAT-----------TAEP
Mvan_1291|M.vanbaalenii_PYR-1 SSNVVISVIADHAAVAAARQLIATEDREQQQKHAQNQAKTEPAPEAEAEP
MAB_4752|M.abscessus_ATCC_1997 DVPVVVNVVINQSTLAGSDD------------------------------
:: :. ::
MMAR_5187|M.marinum_M ----------------------------------------------APAW
MAV_4456|M.avium_104 ----------------------------------------------GPAV
MUL_2679|M.ulcerans_Agy99 ----------------------------------------------APGV
TH_0334|M.thermoresistible__bu ----------------------------------------------NPGY
Mb2126|M.bovis_AF2122/97 TPD--------------------------PEPDP----PATHAP--AELI
Rv2100|M.tuberculosis_H37Rv TPD--------------------------PEPDP----PATHAP--AELI
MSMEG_3957|M.smegmatis_MC2_155 TPEPVRKP---------------------PEPEPKPWTPQSAHPGRGGAV
Mflv_5065|M.gilvum_PYR-GCK T----------------------------------------CTKDPGSAL
Mvan_1291|M.vanbaalenii_PYR-1 TPEPDAEPAGDPVESAPLPVGEDESPEPGPAAGPEVANPVRCLRDSGVAL
MAB_4752|M.abscessus_ATCC_1997 ----------------------------------------------CPAH
MMAR_5187|M.marinum_M EVGADGLVTPELVAELAKSAKLVPLRHPGDVPPEPGYVPSKALADFVRCR
MAV_4456|M.avium_104 EVGAEGLLPAQLVAELAASARLMPLVHPADAPPENRYTPSAALADFVRCR
MUL_2679|M.ulcerans_Agy99 LPG-DGIIPAEIVRELAKSAKLQPMSTP--ILAETGYVPSPALMDFVRAR
TH_0334|M.thermoresistible__bu LPG-YGAVPASILRAKAATATLRPVALP-QPCAEAGYRPSAALTRFIRCR
Mb2126|M.bovis_AF2122/97 TTGGGVVPAPLLAELIRGGATISQVRHPGDLAAEPHYRPSAKLAEFVRMR
Rv2100|M.tuberculosis_H37Rv TTGGGVVPAPLLAELIRGGATISQVRHPGDLAAEPHYRPSAKLAEFVRMR
MSMEG_3957|M.smegmatis_MC2_155 VLGGGVVPAPLVAQLIADGAKVKELTVPDDICAS--YRPSVAMDCFVRMR
Mflv_5065|M.gilvum_PYR-GCK LPGAQILPIPVLAEAIRSGAKITPLWLPG-PDPEPHYRPSAKLAAFIRSR
Mvan_1291|M.vanbaalenii_PYR-1 LPGVKVLPIVALAEAIRAGAAIKSLWLPG-PDPEPHYRPSAKLAAFVRAR
MAB_4752|M.abscessus_ATCC_1997 VPGFGVLAAESARAAVAG-TPTRNLTDSR----STGYRPSAKLAAFVRSR
* : : . . * ** : *:* *
MMAR_5187|M.marinum_M DLTCRWPGCDHPALNCDLDHTIPYAQGGPTHASNLKCYCRTHHLVKTFWG
MAV_4456|M.avium_104 DLTCRWPGCDRPATECDLDHTIPYAEGGPTHASNLKCYCRTHHLVKTFWG
MUL_2679|M.ulcerans_Agy99 DLTCRAPGCDRPATQCDVDHTIPYSDGGATHPSNLKCLCRKHHLLKTFWG
TH_0334|M.thermoresistible__bu DLTCRFPGCDAPAAVCQIDHTIPYPAG-PTHPSNLKLLCVFHCRQAELRF
Mb2126|M.bovis_AF2122/97 DLTCRFPGCDVPAEFCDIDHSAPWPLG-PTHPSNLKCACRKHHLLKTFWT
Rv2100|M.tuberculosis_H37Rv DLTCRFPGCDVPAEFCDIDHSAPWPLG-PTHPSNLKCACRKHHLLKTFWT
MSMEG_3957|M.smegmatis_MC2_155 DMTCRFPGCSRPADFCDVDHTTPWPTG-VTHPSNTKCLCRIHHLLKTFWL
Mflv_5065|M.gilvum_PYR-GCK DLFCRFPGCDVSADRCDIDHVVPYPFG-PTHASNMHCKCRSHHLMKTFWG
Mvan_1291|M.vanbaalenii_PYR-1 DLFCRYPGCDVPAEHCDIDHVVPYPFG-PTHASNLNCTCRTHHLGKTFAE
MAB_4752|M.abscessus_ATCC_1997 DQLCRFPGCEAVADRADIDHTVPWATGGPTTGANLKALCRKHHLLKTFG-
* ** ***. * .::** *:. * * :* : * * :
MMAR_5187|M.marinum_M ----WHDQQLPDGTLILTSPAGHTYVTTPGSALLFPSLCHSTGGLPAAEA
MAV_4456|M.avium_104 ----WREQQLPDATLILTSPAGRTYVTTPGSALLFPSLCVPTG-EPARPV
MUL_2679|M.ulcerans_Agy99 ----WHDEQLPDATVIWSLPDGQTYVTTPGSAWLLPGLFAPSPELPPP--
TH_0334|M.thermoresistible__bu ----THDQHKHQSSCLP------AYFQRPHG-------------------
Mb2126|M.bovis_AF2122/97 G---WRDVQLPDGTVIWTAPNGHTYTTHPGSRIFFPTWHTTTAELPQTST
Rv2100|M.tuberculosis_H37Rv G---WRDVQLPDGTVIWTAPNGHTYTTHPGSRIFFPTWHTTTAELPQTST
MSMEG_3957|M.smegmatis_MC2_155 G---WSDRQLPDGTVIWTSPTGHVYTTVPASRALFPQWDTTTAALPPPPT
Mflv_5065|M.gilvum_PYR-GCK GPDGWRERQLPDGTVLWTTPAGTTYTTTPGSRLFFPAWDTTTAELPPMTT
Mvan_1291|M.vanbaalenii_PYR-1 G---WQVEQLPDGTVTWTTPAGQHHTTMPGSRLLFPGWDTTTAALPPMAQ
MAB_4752|M.abscessus_ATCC_1997 ---QWTELQEPDGTVIWKSPTGHRYATTPVSWFLFPALTRHHTRQQARDR
: :.: : * .
MMAR_5187|M.marinum_M DP---PSDHCDQRSAMMPRRQRTRAQDRARRVATERRQNHHARSTQPGGQ
MAV_4456|M.avium_104 AA---GSQPCGERTAMMPTRRRTRGQNRAARVAAERRANRAARLARATRP
MUL_2679|M.ulcerans_Agy99 -----------------PRSEATGSLRKPRRDDAQTRPNSRPKLGR----
TH_0334|M.thermoresistible__bu -----------------PATRRPPSARGLREAVPRQGVDPRRVSGQ----
Mb2126|M.bovis_AF2122/97 -----AAVNVDARGLMMPRRRRTRAAELAHRINAERALNDAYMAERNK--
Rv2100|M.tuberculosis_H37Rv -----AAVNVDARGLMMPRRRRTRAAELAHRINAERALNDAYMAERNK--
MSMEG_3957|M.smegmatis_MC2_155 PPPPMTPSEIAARAAMMPRRRRTRAAEEARRLAAERARNEAYLAQRDR--
Mflv_5065|M.gilvum_PYR-GCK ------PPPGAGREIQMPKRQRSRTADRAARIKAEREHNGTQRNLEER--
Mvan_1291|M.vanbaalenii_PYR-1 ------PPPDPDRVAKMPKRRRTRAAEEAARIKAERECNAVQRALERQRA
MAB_4752|M.abscessus_ATCC_1997 ------------------RRRTERNLNREQRLQREAALAALAAK------
. . .
MMAR_5187|M.marinum_M PRSAAPP------------TPPQSEPQSHPPPF
MAV_4456|M.avium_104 APAASQS------------WPAGHGPDADPPPF
MUL_2679|M.ulcerans_Agy99 --THCDR------------TQPQHD--------
TH_0334|M.thermoresistible__bu ---------------------------------
Mb2126|M.bovis_AF2122/97 --------------------PPSF---------
Rv2100|M.tuberculosis_H37Rv --------------------PPSF---------
MSMEG_3957|M.smegmatis_MC2_155 --------------------PPPDAHGPGMQ--
Mflv_5065|M.gilvum_PYR-GCK --------------PRRGQPPPDYGNDPPPF--
Mvan_1291|M.vanbaalenii_PYR-1 LDQQAAEHNRQAGLPPPAPPPPDYGDDPPPF--
MAB_4752|M.abscessus_ATCC_1997 -------------------DPPPF---------