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FESMGVAAGVDHPCDALAERRQLRTPTAESARWVQRIGAAARAENRAAAAQLIEIGQLFAYRLSRCSETE DWAVDTMEAVAAEVAAGLRISQGLAASRLRYARALRERLPKTGAVFAAGQIDLRAFQTIVFRTDLIVDPQ VMAAVDALVALNVGRWPSMTKARLSGQIDAIVARADADAVRRRKERHADREIWIGQDADGISRIDGSMFT IDAHALDRRLSALAATVCAQDPRSREQRRADALGVLAAGGDRLGCRCGLPDCAAGARPAAQPVVIHVIAE RATLDGDGGAPAWEVGADGLVTPELVAELAKSAKLVPLRHPGDVPPEPGYVPSKALADFVRCRDLTCRWP GCDHPALNCDLDHTIPYAQGGPTHASNLKCYCRTHHLVKTFWGWHDQQLPDGTLILTSPAGHTYVTTPGS ALLFPSLCHSTGGLPAAEADPPSDHCDQRSAMMPRRQRTRAQDRARRVATERRQNHHARSTQPGGQPRSA APPTPPQSEPQSHPPPF*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_5187 | - | - | 100% (508) | 13e12 repeat-containing protein |
| M. marinum M | MMAR_1213 | - | e-139 | 55.42% (480) | 13e12 repeat-containing protein |
| M. marinum M | MMAR_2226 | - | e-139 | 54.34% (484) | 13e12 repeat-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0528 | - | 0.0 | 72.97% (492) | 13E12 repeat family protein |
| M. gilvum PYR-GCK | Mflv_1180 | - | 1e-102 | 42.97% (498) | hypothetical protein Mflv_1180 |
| M. tuberculosis H37Rv | Rv0336 | - | 0.0 | 73.17% (492) | 13E12 repeat family protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4752 | - | 4e-82 | 40.38% (468) | hypothetical protein MAB_4752 |
| M. avium 104 | MAV_4456 | - | 0.0 | 67.78% (481) | 13e12 repeat-containing protein |
| M. smegmatis MC2 155 | MSMEG_5026 | - | 9e-98 | 45.20% (458) | hypothetical protein MSMEG_5026 |
| M. thermoresistible (build 8) | TH_0334 | - | 7e-69 | 41.80% (366) | HNH endonuclease |
| M. ulcerans Agy99 | MUL_2679 | - | 1e-125 | 54.81% (447) | 13e12 repeat-containing protein |
| M. vanbaalenii PYR-1 | Mvan_0728 | - | 1e-98 | 41.72% (513) | hypothetical protein Mvan_0728 |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_5026|M.smegmatis_MC2_155 -MGAGILERMFDG---------------TSDAGLIDAIAEAKRQENAATA
TH_0334|M.thermoresistible__bu ---------MFES---------------LDDGAVVDSIAAASREQSAACG
MAB_4752|M.abscessus_ATCC_1997 ---------MFDE---------------LGDVELIDLIASAQRAEAQACA
Mb0528|M.bovis_AF2122/97 -MPSPEAIAHFDERFECHAPR-----TTRVSAAFIDRICSATRAENRAAA
Rv0336|M.tuberculosis_H37Rv -MPSPEAIAHFDERFECHAPR-----TTRVSAAFIDRICSATRAENRAAA
MMAR_5187|M.marinum_M MFESMGVAAGVDHPCDALAERRQLRTPTAESARWVQRIGAAARAENRAAA
MAV_4456|M.avium_104 --MCEDATAWFDELMERCYPS-----ATPESAALVQRIGVFARVENRAAA
MUL_2679|M.ulcerans_Agy99 ----------MDQHIIEYVFD-------TDDSAPLTRITAAARAEARAAA
Mflv_1180|M.gilvum_PYR-GCK ---------MFDNLVPEPAAL-----AGLSDAELVDAAGAAARAENAVCA
Mvan_0728|M.vanbaalenii_PYR-1 ---------MFDVLVPDPADL-----AALSDAELLDAATATTRAENAVCA
.: . : * : . .
MSMEG_5026|M.smegmatis_MC2_155 RRLFAIGELDTRRA-IDL-AECNFWRTDPFEEVCAEVSAALRISRSRANW
TH_0334|M.thermoresistible__bu REMLAIGELYARRAPEDD-TERANWAIDGHANVVAEISAALNISRGRAAG
MAB_4752|M.abscessus_ATCC_1997 RKLDAIGVLVDRHADLGKPDERDHHALDRWDRVASEVAAAQGITHALASS
Mb0528|M.bovis_AF2122/97 AQLVALGELFAYRW-SRCG-GREEWVMDTMAAVAAEVAAALRISQGLAAS
Rv0336|M.tuberculosis_H37Rv AQLVALGELFAYRW-SRCG-GREEWVMDTMAAVAAEVAAALRISQGLAAS
MMAR_5187|M.marinum_M AQLIEIGQLFAYRL-SRCS-ETEDWAVDTMEAVAAEVAAGLRISQGLAAS
MAV_4456|M.avium_104 EQLAAIGELFAYRL-SRCS-ECEDWAVDTEAAVSAEVAAQLRIGQGLAAA
MUL_2679|M.ulcerans_Agy99 ERLAAIGDLFRLRL-SQHG-NREDWVADTCDAVAAEVAAALNTSVAMGHS
Mflv_1180|M.gilvum_PYR-GCK RKLAVMAELFTRRV-DLAPEDRLNWWVDPDAAVAAEIAAAVTITQGLATH
Mvan_0728|M.vanbaalenii_PYR-1 RKLAVMAELFIRRT-TLAPQDRLDWWVDPEAAVTAELAAAHHITQGLATH
.: :. * : * * :*::* . .
MSMEG_5026|M.smegmatis_MC2_155 QVHLARVLRDRIPKVAAVFAQGDIDFRIVTKIATRT-ELVDPAAMPALDD
TH_0334|M.thermoresistible__bu RLQLAIDLRERLPRVAAVFAAGDIDFRMVSALVNRSRNVVDPDLLARLDA
MAB_4752|M.abscessus_ATCC_1997 QMRYAQVLRHRLRAVAERFAAGDLDFRTVALIINRTELVDDEAVVARVDA
Mb0528|M.bovis_AF2122/97 RLRYARAMRERLPKTAEVFSAGDIGYLMFATIVYRTDLIVDPDVLAAVDA
Rv0336|M.tuberculosis_H37Rv RLRYARAMRERLPKTAEVFSAGDIGYLMFATIVYRTDLIVDPDVLAAVDA
MMAR_5187|M.marinum_M RLRYARALRERLPKTGAVFAAGQIDLRAFQTIVFRTDLIVDPQVMAAVDA
MAV_4456|M.avium_104 KVRYARAMRERLPRVGEVFRAGEIDFRLFATIVYRTDLITDRRVLAAVDA
MUL_2679|M.ulcerans_Agy99 NLRYARAMRERLPQLGAEFRAGGIDFRLFRTIVFRTDLITESDALAAVDA
Mflv_1180|M.gilvum_PYR-GCK QTYRAVVLRDRLPKVGALFLAGLLSELLVRAIITRTDLITDPELIAAVDA
Mvan_0728|M.vanbaalenii_PYR-1 QAYRAVVLRDRLPKIGALFLQGLLSELLVRAIITRTGLITDPDLIAAVDA
. * :*.*: . * * :. . : *: : : :. :*
MSMEG_5026|M.smegmatis_MC2_155 VLARRCPNWMRLSEPKLEERIDQCILRLDPDGQRVTKRSEDSRYFTVQPA
TH_0334|M.thermoresistible__bu ALAAWSPKWMKLSGPTLNERIDMWVERFDPTGVREPRSPGEDRYVVVTPA
MAB_4752|M.abscessus_ATCC_1997 AIVRALPRWARWSHKRITAALDALVLHFDQDAVRRNRSATDKRHLEIRPL
Mb0528|M.bovis_AF2122/97 QLAANVARWPSMTKARLAGQVDKIVARADADAVRRRKEYQAQRQFWVGE-
Rv0336|M.tuberculosis_H37Rv QLAANVARWPSMTKARLAGQVDKIVARADADAVRRRKEYQAQRQFWVGE-
MMAR_5187|M.marinum_M LVALNVGRWPSMTKARLSGQIDAIVARADADAVRRRKERHADREIWIGQ-
MAV_4456|M.avium_104 ELAATAARWPSMTRARLAARVDAVVAKADADAVRRTEKQAASRHVWIAE-
MUL_2679|M.ulcerans_Agy99 RLAIKAPRWPSMTSWKLATEVDRVVAKFDRDAVRRSRRDAADRYVDCAP-
Mflv_1180|M.gilvum_PYR-GCK DLAADILRWGPQSAKKTEAAIDHIVERHDPDAVRQSRAGDLDRAIEIGNP
Mvan_0728|M.vanbaalenii_PYR-1 DLATDILDWGPLSVKATEAEIDAIIDRHDPDAVRKSRAPETGRTVQFGNP
:. * : :* : : * . * . * .
MSMEG_5026|M.smegmatis_MC2_155 DT-PGMANAQGYLPAHDAAGFDKRLDAIAATVCPNDPRTPDQRRADALGA
TH_0334|M.thermoresistible__bu G--QGMVDVSARLTFEAGFAFXTRLDQIAATVCRDDPRTADQRRADAMAA
MAB_4752|M.abscessus_ATCC_1997 GNGEPVAEVWGTLQAVHAVALDKRLDLLAGTVCPADPRSKTQRRADAVGA
Mb0528|M.bovis_AF2122/97 -SQDGVCQIGGSLLAVDAHALDARLSALAGTVCEHDPRSREQRRADALGA
Rv0336|M.tuberculosis_H37Rv -SQDGVCQIGGSLLAVDAHALDARLSALAGTVCEHDPRSREQRRADALGA
MMAR_5187|M.marinum_M -DADGISRIDGSMFTIDAHALDRRLSALAATVCAQDPRSREQRRADALGV
MAV_4456|M.avium_104 -MGEGLSHLEGTVSSPDAHALDKRLDALAATVCEHDPRTGEQRRADALGA
MUL_2679|M.ulcerans_Agy99 -LEPGMALVNRQVFSATAEALARRLDELAKTVCADDPRTVVQRRADALGT
Mflv_1180|M.gilvum_PYR-GCK GDAPGYTTVWARMFAGDAAAGQRTLTAMAYSVCDNDPRTLDERRNDALTA
Mvan_0728|M.vanbaalenii_PYR-1 GDAPGYTSMWARMYASDAAAADRTLTALAYSVCDNDPRTLDERRNDAHTA
: . . * :* :** ***: :** ** .
MSMEG_5026|M.smegmatis_MC2_155 LGRYRDTLDCQCGREDCTAVAERDAVNNAMIHVLAEQSTLD---------
TH_0334|M.thermoresistible__bu MSEGQNRLVCGCGSEDCPADPADTAATRLVINVIAEQATVE---------
MAB_4752|M.abscessus_ATCC_1997 LTQGLNRMRCACGHPDCSGR--DTADVPVVVNVVINQSTLA---------
Mb0528|M.bovis_AF2122/97 LAGGADRLGCGCGRADCAAGKRPAAPP-VVIHLIAEAATIN---------
Rv0336|M.tuberculosis_H37Rv LAGGADRLGCGCGRADCAAGKRPAAPP-VVIHLIAEAATIN---------
MMAR_5187|M.marinum_M LAAGGDRLGCRCGLPDCAAGARPAAQP-VVIHVIAERATLD---------
MAV_4456|M.avium_104 LAAGADRLGCRCGRADCAAGTRPAAGP-VVIHLIAERASVE---------
MUL_2679|M.ulcerans_Agy99 LAAGQDRLICDCGRTDCPAAGAPQQPSRVVIHVVAGCQTVD---------
Mflv_1180|M.gilvum_PYR-GCK LFHGITTLACRCGHTDCDAATNPRPPRELTVYALTDQTTADSASEEPRGD
Mvan_0728|M.vanbaalenii_PYR-1 LLTGITTLACQCGNPDCHASTNPRPPRDITVYALTDHTTTT--------D
: : * ** ** . : : :
MSMEG_5026|M.smegmatis_MC2_155 -------------GGNE-P--------------GYLPGFGMLPAHMVREV
TH_0334|M.thermoresistible__bu -------------GRSDNP--------------GYLPGYGAVPASILRAK
MAB_4752|M.abscessus_ATCC_1997 -------------GSDDCP--------------AHVPGFGVLAAESARAA
Mb0528|M.bovis_AF2122/97 -------------GTGSAP-------------ASQMNADGLITAELVAEL
Rv0336|M.tuberculosis_H37Rv -------------GTGSAP-------------ASQMNADGLITAELVAEL
MMAR_5187|M.marinum_M -------------GDGGAP-------------AWEVGADGLVTPELVAEL
MAV_4456|M.avium_104 -------------GTGGGP-------------AVEVGAEGLLPAQLVAEL
MUL_2679|M.ulcerans_Agy99 -------------GAGEAP-------------GVLP-GDGIIPAEIVREL
Mflv_1180|M.gilvum_PYR-GCK ATDADASAGDAQPATPTAPKPRRSKPTLLPGRSGYLFGSGFMSAPLFDAL
Mvan_0728|M.vanbaalenii_PYR-1 TGDADTTT-DTKPPTPPAPQPRRSKPILIPGRPAYLFGAGFMPAPLFDAL
* . * :..
MSMEG_5026|M.smegmatis_MC2_155 AKTATTKPVTIPK--DKAQSGYRPNAELTEFIRWRDLTCRFPGCDAPAMA
TH_0334|M.thermoresistible__bu AATATLRPVALPQ--PCAEAGYRPSAALTRFIRCRDLTCRFPGCDAPAAV
MAB_4752|M.abscessus_ATCC_1997 VAGTPTRNLTDSR--S---TGYRPSAKLAAFVRSRDQLCRFPGCEAVADR
Mb0528|M.bovis_AF2122/97 AKTATLVPLVHPG-DAPPEPGYAPSKALADFVRCRDLTCRWPGCDEPATN
Rv0336|M.tuberculosis_H37Rv AKTATLVPLVHPG-DAPPEPGYAPSKALADFVRCRDLTCRWPGCDEPATN
MMAR_5187|M.marinum_M AKSAKLVPLRHPG-DVPPEPGYVPSKALADFVRCRDLTCRWPGCDHPALN
MAV_4456|M.avium_104 AASARLMPLVHPA-DAPPENRYTPSAALADFVRCRDLTCRWPGCDRPATE
MUL_2679|M.ulcerans_Agy99 AKSAKLQPMSTP---ILAETGYVPSPALMDFVRARDLTCRAPGCDRPATQ
Mflv_1180|M.gilvum_PYR-GCK LDGAKIREIIHPG-QAGPEPRYTPSTALADFIRCRDLTCRFPGCDTPATE
Mvan_0728|M.vanbaalenii_PYR-1 LAEATIREIIHPGNRSAPEPRYTPSQALAEFIRCRDLTCRFPGCDKPATE
: : . * *. * *:* ** ** ***: *
MSMEG_5026|M.smegmatis_MC2_155 ADIDHTRPYPQG-PTHPSNTKLYCRTHHLIKTFYTGPNGWTDRQLPDGTI
TH_0334|M.thermoresistible__bu CQIDHTIPYPAG-PTHPSNLKLLCVFH-----------------CRQAEL
MAB_4752|M.abscessus_ATCC_1997 ADIDHTVPWATGGPTTGANLKALCRKHHLLKTFG----QWTELQEPDGTV
Mb0528|M.bovis_AF2122/97 CDLDHTIPYAAGGPTHASNLKCYCRTHHLVKTFW----GWRDQQLPDGTL
Rv0336|M.tuberculosis_H37Rv CDLDHTIPYAAGGPTHASNLKCYCRTHHLVKTFW----GWRDQQLPDGTL
MMAR_5187|M.marinum_M CDLDHTIPYAQGGPTHASNLKCYCRTHHLVKTFW----GWHDQQLPDGTL
MAV_4456|M.avium_104 CDLDHTIPYAEGGPTHASNLKCYCRTHHLVKTFW----GWREQQLPDATL
MUL_2679|M.ulcerans_Agy99 CDVDHTIPYSDGGATHPSNLKCLCRKHHLLKTFW----GWHDEQLPDATV
Mflv_1180|M.gilvum_PYR-GCK ADIDHTVAHPVG-PTHASNLKCLCRFHHLLKTFWTGPGGWHDRQHPDGTI
Mvan_0728|M.vanbaalenii_PYR-1 ADIDHTVPYPIG-PTHPSNLKCLCRFHHLLKTFWLGATGWHDRQHPDGTI
.::*** . . * .* :* * * * :. :
MSMEG_5026|M.smegmatis_MC2_155 EFTAPTGHIYTTEPQGAALFPVLGTPTGELNLPPQQDEPHP--NRGVMMP
TH_0334|M.thermoresistible__bu RFTHDQ-----HKHQSSCLPAYFQRPHG-----PATRRPPS--ARGLREA
MAB_4752|M.abscessus_ATCC_1997 IWKSPTGHRYATTPVSWFLFPALTRHHT-----RQQARDRR--RRTERNL
Mb0528|M.bovis_AF2122/97 ILTSPSGHTYVSTPGSALLFPSLCHFSGGIPAPEADPPYDHCDQRTAMMP
Rv0336|M.tuberculosis_H37Rv ILTSPSGHTYVSTPGSALLFPSLCHFSGGIPAPEADPPYDHCDQRTAMMP
MMAR_5187|M.marinum_M ILTSPAGHTYVTTPGSALLFPSLCHSTGGLPAAEADPPSDHCDQRSAMMP
MAV_4456|M.avium_104 ILTSPAGRTYVTTPGSALLFPSLCVPTG-EPARPVAAGSQPCGERTAMMP
MUL_2679|M.ulcerans_Agy99 IWSLPDGQTYVTTPGSAWLLPGLFAPSPELPPPPRS-------EATGSLR
Mflv_1180|M.gilvum_PYR-GCK TWTSPTGHTYITHPGSRLLFPTLCKPTATLWTGNPPQNPTN-NNRGSMMP
Mvan_0728|M.vanbaalenii_PYR-1 TWTAPTGHTYTTHPGSRLLFPTLCQPTATLWTGEPPQVPQS-QQRGAMMP
. . * . :
MSMEG_5026|M.smegmatis_MC2_155 KRRQTREQDRADRINAERRERAELNAEQQRQRQAWLAD------------
TH_0334|M.thermoresistible__bu VPRQGVD---PRRVSGQ---------------------------------
MAB_4752|M.abscessus_ATCC_1997 NREQRLQREAALAALAAK--------------------------------
Mb0528|M.bovis_AF2122/97 KRRRTRAQDRAYRIATERRQNHAARQRAQVLTQTAAATDTHGPPPDH---
Rv0336|M.tuberculosis_H37Rv KRRRTRAQDRAYRIATERRQNHAARQRAQVLTQTAAATDTHGPPPDP---
MMAR_5187|M.marinum_M RRQRTRAQDRARRVATERRQNHHARS-TQPGGQPRSAAPPTPPQSEP---
MAV_4456|M.avium_104 TRRRTRGQNRAARVAAERRANRAARL-ARATRPAPAASQSWPAGHGP---
MUL_2679|M.ulcerans_Agy99 KPRRDDAQTRPNSRPKLGR--------------------THCDRTQP---
Mflv_1180|M.gilvum_PYR-GCK RRTRTRAQNRATYITAERTRNAAHRTDS--------PR------------
Mvan_0728|M.vanbaalenii_PYR-1 RRRNTRAHNHAAYITAERRRNAQTRYATTGNTPPYLPRDHIPYQSSTGWR
. .
MSMEG_5026|M.smegmatis_MC2_155 ----NYEPPPF
TH_0334|M.thermoresistible__bu -----------
MAB_4752|M.abscessus_ATCC_1997 ------DPPPF
Mb0528|M.bovis_AF2122/97 ----NDDPPPF
Rv0336|M.tuberculosis_H37Rv ----NDDPPPF
MMAR_5187|M.marinum_M ----QSHPPPF
MAV_4456|M.avium_104 ----DADPPPF
MUL_2679|M.ulcerans_Agy99 ----QHD----
Mflv_1180|M.gilvum_PYR-GCK ----GNDPPPF
Mvan_0728|M.vanbaalenii_PYR-1 EPDYGNDPPPF